Tumor metastasis: molecular insights and evolving paradigms.

PubWeight™: 10.34‹?› | Rank: Top 0.1%

🔗 View Article (PMC 3261217)

Published in Cell on October 14, 2011


Scott Valastyan1, Robert A Weinberg

Author Affiliations

1: Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. scott_valastyan@hms.harvard.edu

Articles citing this

(truncated to the top 100)

Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77

Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. Cell (2015) 3.58

Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell (2013) 3.33

Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell (2014) 3.04

Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. Cancer Cell (2012) 2.94

The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell (2012) 2.84

MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer (2012) 2.78

Tumor metastasis: moving new biological insights into the clinic. Nat Med (2013) 2.71

Origins of metastatic traits. Cancer Cell (2013) 2.49

Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol (2012) 2.46

TGF-β upregulates miR-181a expression to promote breast cancer metastasis. J Clin Invest (2012) 2.44

TGF-β Tumor Suppression through a Lethal EMT. Cell (2016) 2.37

Can we safely target the WNT pathway? Nat Rev Drug Discov (2014) 2.31

Soft fibrin gels promote selection and growth of tumorigenic cells. Nat Mater (2012) 2.15

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol (2013) 2.03

Macrophages and therapeutic resistance in cancer. Cancer Cell (2015) 1.95

Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis. Hum Mol Genet (2013) 1.95

The role of tumour-stromal interactions in modifying drug response: challenges and opportunities. Nat Rev Drug Discov (2013) 1.93

Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell (2014) 1.88

Mechanisms governing metastatic dormancy and reactivation. Cell (2013) 1.81

miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol (2013) 1.79

Translational control in cancer etiology. Cold Spring Harb Perspect Biol (2013) 1.71

Cancer genomics: one cell at a time. Genome Biol (2014) 1.70

Retracted Epithelial mesenchymal transition is required for acquisition of anoikis resistance and metastatic potential in adenoid cystic carcinoma. PLoS One (2012) 1.64

Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression. Dev Cell (2015) 1.63

Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer. Int J Biol Sci (2013) 1.62

The calcineurin-NFAT-angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases. Cell Rep (2013) 1.61

Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells. Cancer Cell (2014) 1.60

MiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast cancer. Carcinogenesis (2012) 1.55

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell (2016) 1.53

Regulation of microRNAs in cancer metastasis. Biochim Biophys Acta (2014) 1.53

KLF6-SV1 drives breast cancer metastasis and is associated with poor survival. Sci Transl Med (2013) 1.53

In vivo animal models for studying brain metastasis: value and limitations. Clin Exp Metastasis (2013) 1.52

Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients. EMBO Mol Med (2014) 1.51

Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment. Mol Cancer (2016) 1.51

The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. Nat Med (2015) 1.50

P2X7 mediates ATP-driven invasiveness in prostate cancer cells. PLoS One (2014) 1.48

Selection and adaptation during metastatic cancer progression. Nature (2013) 1.46

Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Res (2012) 1.43

Endothelial-mesenchymal transition of brain endothelial cells: possible role during metastatic extravasation. PLoS One (2015) 1.43

NCI's provocative questions on cancer: some answers to ignite discussion. Oncotarget (2011) 1.42

Myeloma as a model for the process of metastasis: implications for therapy. Blood (2012) 1.36

A Rab10-dependent mechanism for polarized basement membrane secretion during organ morphogenesis. Dev Cell (2013) 1.34

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone. Biomaterials (2013) 1.34

Dystrophin is a tumor suppressor in human cancers with myogenic programs. Nat Genet (2014) 1.31

EBV-driven LMP1 and IFN-γ up-regulate PD-L1 in nasopharyngeal carcinoma: Implications for oncotargeted therapy. Oncotarget (2014) 1.29

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells. J Clin Invest (2013) 1.28

Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro. J Exp Clin Cancer Res (2012) 1.28

Cadm1 is a metastasis susceptibility gene that suppresses metastasis by modifying tumor interaction with the cell-mediated immunity. PLoS Genet (2012) 1.27

ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer. Proc Natl Acad Sci U S A (2013) 1.26

Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness. Proc Natl Acad Sci U S A (2013) 1.26

Direct reprogramming by oncogenic Ras and Myc. Proc Natl Acad Sci U S A (2013) 1.26

A systematic evaluation of miRNA:mRNA interactions involved in the migration and invasion of breast cancer cells. J Transl Med (2013) 1.25

Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules. Proc Natl Acad Sci U S A (2013) 1.23

Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors. Intravital (2013) 1.22

Early dissemination seeds metastasis in breast cancer. Nature (2016) 1.20

Microenvironmental regulation of cancer metastasis by miRNAs. Trends Cell Biol (2013) 1.20

Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer. Oncotarget (2014) 1.19

After insufficient radiofrequency ablation, tumor-associated endothelial cells exhibit enhanced angiogenesis and promote invasiveness of residual hepatocellular carcinoma. J Transl Med (2012) 1.18

Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis. Cancer Res (2013) 1.18

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat Commun (2014) 1.17

Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer. J Natl Cancer Inst (2014) 1.16

Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol (2014) 1.16

Genomic Profiling of Thyroid Cancer Reveals a Role for Thyroglobulin in Metastasis. Am J Hum Genet (2016) 1.15

Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature. Matrix Biol (2015) 1.15

Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step. EMBO J (2013) 1.14

Seventeen-gene signature from enriched Her2/Neu mammary tumor-initiating cells predicts clinical outcome for human HER2+:ERα- breast cancer. Proc Natl Acad Sci U S A (2012) 1.14

Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer. Nat Commun (2013) 1.13

Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue. BMC Med (2012) 1.13

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation. Proc Natl Acad Sci U S A (2014) 1.13

New horizons in tumor microenvironment biology: challenges and opportunities. BMC Med (2015) 1.12

mRNA-Seq of single prostate cancer circulating tumor cells reveals recapitulation of gene expression and pathways found in prostate cancer. PLoS One (2012) 1.12

Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion. Cancer Res (2012) 1.11

Traversing the basement membrane in vivo: a diversity of strategies. J Cell Biol (2014) 1.11

The heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancer. Mol Cancer Res (2013) 1.11

The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo. J Cell Biol (2013) 1.11

Cancer metabolism and elevated O-GlcNAc in oncogenic signaling. J Biol Chem (2014) 1.11

Monocytes mediate metastatic breast tumor cell adhesion to endothelium under flow. FASEB J (2013) 1.10

SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition. EMBO J (2013) 1.09

The H19 Long non-coding RNA in cancer initiation, progression and metastasis - a proposed unifying theory. Mol Cancer (2015) 1.08

Real-time motion analysis reveals cell directionality as an indicator of breast cancer progression. PLoS One (2013) 1.08

The role of vimentin intermediate filaments in the progression of lung cancer. Am J Respir Cell Mol Biol (2014) 1.08

Recent trends in multifunctional liposomal nanocarriers for enhanced tumor targeting. J Drug Deliv (2013) 1.06

Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model. Br J Cancer (2014) 1.06

MiRNA-296-3p-ICAM-1 axis promotes metastasis of prostate cancer by possible enhancing survival of natural killer cell-resistant circulating tumour cells. Cell Death Dis (2013) 1.04

Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation. Oncogene (2015) 1.04

Oncogenic alternative splicing switches: role in cancer progression and prospects for therapy. Int J Cell Biol (2013) 1.04

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut. Nat Commun (2014) 1.04

Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression. Nat Commun (2014) 1.04

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy. Redox Biol (2014) 1.04

Tumour cell invasion: an emerging role for basal epithelial cell extrusion. Nat Rev Cancer (2014) 1.03

GSK3β controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug. Oncogene (2013) 1.03

Preoperative platelet count associates with survival and distant metastasis in surgically resected colorectal cancer patients. J Gastrointest Cancer (2013) 1.03

Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor. Dev Cell (2014) 1.03

The primacy of β1 integrin activation in the metastatic cascade. PLoS One (2012) 1.03

Insufficient radiofrequency ablation promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells through Akt and ERK signaling pathways. J Transl Med (2013) 1.02

Rab25 regulates invasion and metastasis in head and neck cancer. Clin Cancer Res (2013) 1.02

14q32-encoded microRNAs mediate an oligometastatic phenotype. Oncotarget (2015) 1.02

The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis. Nat Genet (2016) 1.01

Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development. J Biol Chem (2013) 1.01

Articles cited by this

(truncated to the top 100)

Gene expression profiling predicts clinical outcome of breast cancer. Nature (2002) 71.36

MicroRNA expression profiles classify human cancers. Nature (2005) 69.12

A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med (2004) 41.02

Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17

Immunity, inflammation, and cancer. Cell (2010) 28.27

Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med (2004) 27.92

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature (2010) 23.55

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer (2003) 22.78

A molecular signature of metastasis in primary solid tumors. Nat Genet (2002) 21.36

Genes that mediate breast cancer metastasis to lung. Nature (2005) 19.85

Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature (2010) 19.68

Cancer metastasis: building a framework. Cell (2006) 19.67

Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature (2007) 19.33

Tumour evolution inferred by single-cell sequencing. Nature (2011) 19.13

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science (2009) 18.40

Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer (2002) 17.49

Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature (2010) 17.38

A multigenic program mediating breast cancer metastasis to bone. Cancer Cell (2003) 16.86

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell (2009) 16.06

Microenvironmental regulation of metastasis. Nat Rev Cancer (2008) 15.76

Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell (2009) 14.40

Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer (2009) 14.17

Concordance among gene-expression-based predictors for breast cancer. N Engl J Med (2006) 13.50

Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 13.41

Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell (2009) 13.09

Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer (2003) 13.01

Matrix metalloproteinases: regulators of the tumor microenvironment. Cell (2010) 12.90

The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature (2010) 12.43

Tumor metastasis: mechanistic insights and clinical challenges. Nat Med (2006) 11.06

Stromal gene expression predicts clinical outcome in breast cancer. Nat Med (2008) 10.68

Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A (2008) 10.52

Retracted A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell (2009) 10.51

Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol (2004) 9.38

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature (2011) 8.62

CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell (2009) 8.54

Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell (2009) 8.33

Genes that mediate breast cancer metastasis to the brain. Nature (2009) 8.23

Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer (2008) 7.99

Systemic spread is an early step in breast cancer. Cancer Cell (2008) 7.91

Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci U S A (2010) 7.77

Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer (2011) 7.69

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell (2008) 7.60

Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell (2009) 7.09

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature (2007) 7.05

A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med (2005) 6.86

The cancer stem cell: premises, promises and challenges. Nat Med (2011) 6.73

Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell (2009) 6.66

Tumor self-seeding by circulating cancer cells. Cell (2009) 6.66

Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer. Nat Med (2009) 6.61

Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res (2007) 6.60

Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer (2007) 6.58

Integrin signalling during tumour progression. Nat Rev Mol Cell Biol (2004) 6.53

Glioblastoma stem-like cells give rise to tumour endothelium. Nature (2010) 6.18

Exploring the genomes of cancer cells: progress and promise. Science (2011) 6.16

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature (2010) 6.13

Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes. Clin Cancer Res (2008) 5.88

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov (2011) 5.59

Parallel progression of primary tumours and metastases. Nat Rev Cancer (2009) 5.55

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med (2011) 5.54

MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell (2008) 5.34

Seeding and propagation of untransformed mouse mammary cells in the lung. Science (2008) 5.33

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature (2009) 5.32

The metastatic niche: adapting the foreign soil. Nat Rev Cancer (2009) 5.28

Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell (2009) 5.24

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol (2010) 4.80

From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci U S A (2003) 4.79

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature (2004) 4.53

Circulating tumor cells in patients with breast cancer dormancy. Clin Cancer Res (2004) 4.48

Gene expression profiles of primary breast tumors maintained in distant metastases. Proc Natl Acad Sci U S A (2003) 4.47

Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46

Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol (1998) 4.41

Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol (2009) 4.39

Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nat Med (2000) 4.36

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med (2011) 4.25

Cancer to bone: a fatal attraction. Nat Rev Cancer (2011) 4.08

Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res (2004) 4.04

Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer Cell (2011) 4.02

Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell (2008) 3.95

Illuminating the metastatic process. Nat Rev Cancer (2007) 3.80

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev (2010) 3.56

Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis. J Cell Biol (2004) 3.47

GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell (2008) 3.44

Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell (2011) 3.37

Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell (2011) 3.32

Suppression of lung adenocarcinoma progression by Nkx2-1. Nature (2011) 3.27

Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell (2004) 3.09

DNA damage-mediated induction of a chemoresistant niche. Cell (2010) 2.94

R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res (2010) 2.87

ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc Natl Acad Sci U S A (2007) 2.85

Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res (2011) 2.85

Migrastatin analogues target fascin to block tumour metastasis. Nature (2010) 2.84

Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A (2009) 2.75

Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res (2008) 2.63

Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer. J Natl Cancer Inst (2005) 2.60

Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling. Cancer Cell (2011) 2.45

A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancer. Cancer Cell (2011) 2.29

Disease course patterns after discontinuation of bevacizumab: pooled analysis of randomized phase III trials. J Clin Oncol (2010) 2.19

Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis. Cancer Res (2009) 1.99

Role of organ selectivity in the determination of metastatic patterns of B16 melanoma. Cancer Res (1980) 1.97

Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment. Cancer Res (2010) 1.95

Articles by these authors

Hallmarks of cancer: the next generation. Cell (2011) 140.01

The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08

The basics of epithelial-mesenchymal transition. J Clin Invest (2009) 32.82

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature (2007) 21.53

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 18.53

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet (2008) 17.67

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell (2008) 14.80

A perspective on cancer cell metastasis. Science (2011) 13.31

Retracted A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell (2009) 10.51

A progression puzzle. Nature (2002) 9.56

Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07

Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A (2004) 7.96

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res (2008) 7.91

Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol (2010) 6.67

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53

Modelling the molecular circuitry of cancer. Nat Rev Cancer (2002) 5.43

Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24

Cancer stem cells: mirage or reality? Nat Med (2009) 5.20

The signals and pathways activating cellular senescence. Int J Biochem Cell Biol (2004) 5.00

Rules for making human tumor cells. N Engl J Med (2002) 4.84

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol (2010) 4.80

Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell (2011) 4.79

Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol (2002) 4.77

Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77

The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet (2005) 4.70

Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle (2006) 4.67

Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell (2007) 4.30

Species- and cell type-specific requirements for cellular transformation. Cancer Cell (2004) 4.25

Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol (2012) 3.98

Exploring a new twist on tumor metastasis. Cancer Res (2006) 3.96

The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96

Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell (2008) 3.95

Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene (2002) 3.80

Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell (2008) 3.75

The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Proc Natl Acad Sci U S A (2006) 3.64

Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell (2013) 3.61

Retracted Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell (2003) 3.56

Telomerase maintains telomere structure in normal human cells. Cell (2003) 3.29

Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer (2003) 3.23

Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res (2007) 3.04

Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci U S A (2010) 3.03

Telomeres: cancer to human aging. Annu Rev Cell Dev Biol (2006) 2.88

Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci U S A (2002) 2.82

Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A (2009) 2.75

Tumor-host interactions: a far-reaching relationship. J Clin Oncol (2010) 2.48

Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia (2010) 2.38

When cells get stressed: an integrative view of cellular senescence. J Clin Invest (2004) 2.37

A mouse model of human breast cancer metastasis to human bone. Cancer Res (2005) 2.24

Adaptation versus selection: the origins of metastatic behavior. Cancer Res (2007) 2.08

Micromanagers of malignancy: role of microRNAs in regulating metastasis. Trends Genet (2008) 2.03

Taking the study of cancer cell survival to a new dimension. Cell (2002) 2.03

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest (2011) 1.96

Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell (2013) 1.86

IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell (2002) 1.79

Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer (2011) 1.79

Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet (2003) 1.78

Cell plasticity and heterogeneity in cancer. Clin Chem (2012) 1.74

Retracted Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis. Genes Dev (2009) 1.74

MicroRNAs in malignant progression. Cell Cycle (2007) 1.74

Retracted Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis. Cancer Res (2010) 1.73

Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov (2012) 1.71

Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers. Cancer Res (2007) 1.66

MicroRNAs: Crucial multi-tasking components in the complex circuitry of tumor metastasis. Cell Cycle (2009) 1.63

Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol (2003) 1.59

miR-31: a crucial overseer of tumor metastasis and other emerging roles. Cell Cycle (2010) 1.51

The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions. Cancer Discov (2012) 1.45

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A (2008) 1.41

Retracted Activation of miR-31 function in already-established metastases elicits metastatic regression. Genes Dev (2011) 1.40

An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell (2013) 1.36

Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Semin Cancer Biol (2010) 1.36

Roles for microRNAs in the regulation of cell adhesion molecules. J Cell Sci (2011) 1.25

Heterogeneity of stromal fibroblasts in tumors. Cancer Biol Ther (2007) 1.21

Chemokine networks and breast cancer metastasis. Breast Dis (2007) 1.17

AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res (2010) 1.17

Coevolution in the tumor microenvironment. Nat Genet (2008) 1.16

Senescence: does it all happen at the ends? Oncogene (2002) 0.98

High efficiency creation of human monoclonal antibody-producing hybridomas. J Immunol Methods (2004) 0.94

Assaying microRNA loss-of-function phenotypes in mammalian cells: emerging tools and their potential therapeutic utility. RNA Biol (2009) 0.90

Of mice and (wo)men: mouse models of breast cancer metastasis to bone. J Bone Miner Res (2010) 0.89

Functional genomics and the breast cancer problem. Cancer Cell (2002) 0.86

Cancer cell of origin: spotlight on luminal progenitors. Cell Stem Cell (2010) 0.83

Filling the mosaic of p53 actions: p53 represses RHAMM expression. Cell Cycle (2008) 0.82

Poised with purpose: cell plasticity enhances tumorigenicity. Cell Cycle (2013) 0.81

Cancer Biology and Therapy: the road ahead. Cancer Biol Ther (2002) 0.81

Is metastasis predetermined? Mol Oncol (2007) 0.81

Metastasis suppression: a role of the Dice(r). Genome Biol (2010) 0.78

Retrospective: Judah Folkman (1933-2008). Science (2008) 0.77

Addendum: A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol (2015) 0.76

Health for life. Your lifestyle, your genes, and cancer. Newsweek (2008) 0.75

All You Need Is Mentorship. Cell (2016) 0.75