Prostaglandin E2 EP receptors as therapeutic targets in breast cancer.

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Published in Cancer Metastasis Rev on December 01, 2011

Authors

Jocelyn Reader1, Dawn Holt, Amy Fulton

Author Affiliations

1: University of Maryland Marlene and Stewart Greenebaum Cancer Center, 655 W Baltimore, St Baltimore, MD 21201, USA.

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Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med (2005) 15.46

Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med (2005) 12.46

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology (1994) 8.79

Genes that mediate breast cancer metastasis to the brain. Nature (2009) 8.23

Aspirin use and reduced risk of fatal colon cancer. N Engl J Med (1991) 7.85

Eicosanoids and cancer. Nat Rev Cancer (2010) 5.96

Heterotrimeric G protein activation by G-protein-coupled receptors. Nat Rev Mol Cell Biol (2008) 5.30

Prostaglandin E receptors. J Biol Chem (2007) 5.29

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis (2009) 5.01

Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. Cancer Res (2007) 4.69

Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res (1995) 4.52

Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest (2006) 4.50

Aspirin intake and survival after breast cancer. J Clin Oncol (2010) 4.50

Prostanoid receptors: subtypes and signaling. Annu Rev Pharmacol Toxicol (2001) 4.40

Prostaglandins as modulators of immunity. Trends Immunol (2002) 4.15

Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res (2002) 3.70

Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J Biol Chem (2001) 3.69

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A large cohort study of long-term daily use of adult-strength aspirin and cancer incidence. J Natl Cancer Inst (2007) 2.95

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Targeting cyclooxygenase-2 in human neoplasia: rationale and promise. Cancer Cell (2003) 2.71

Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat Med (2009) 2.68

Prostaglandins and breast cancer. Lancet (1977) 2.54

Breast cancer and nonsteroidal anti-inflammatory drugs: prospective results from the Women's Health Initiative. Cancer Res (2003) 2.49

Breast cancer and use of nonsteroidal anti-inflammatory drugs: a meta-analysis. J Natl Cancer Inst (2008) 2.44

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Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene. Endocrinology (1996) 2.30

Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci U S A (2003) 2.23

Breast cancer and NSAID use: a meta-analysis. Br J Cancer (2001) 2.21

Nonsteroidal antiinflammatory drugs and breast cancer. Epidemiology (1996) 2.11

Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer. Breast Cancer Res (2007) 2.03

Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse. J Clin Invest (2001) 1.99

Prostaglandin in human breast cancer: Evidence suggesting that an elevated prostaglandin production is a marker of high metastatic potential for neoplastic cells. J Natl Cancer Inst (1980) 1.93

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Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase. Eur J Biochem (1993) 1.33

Initial screening for carcinogenicity of commonly used drugs. J Natl Cancer Inst (1980) 1.32

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Nuclear localization of prostaglandin E2 receptors. Proc Natl Acad Sci U S A (1998) 1.29

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Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope. J Biol Chem (1999) 1.27

Reduced risk of large-bowel adenomas among aspirin users. The Polyp Prevention Study Group. J Natl Cancer Inst (1993) 1.26

Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer. Int J Cancer (2001) 1.24

Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances. Int J Biochem Cell Biol (2009) 1.23

Association between frequent use of nonsteroidal anti-inflammatory drugs and breast cancer. BMC Cancer (2005) 1.21

Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals. Biochemistry (1994) 1.20

Prostaglandin receptors: advances in the study of EP3 receptor signaling. J Biochem (2002) 1.16

Prostaglandin E2 selectively enhances the IgE-mediated production of IL-6 and granulocyte-macrophage colony-stimulating factor by mast cells through an EP1/EP3-dependent mechanism. J Immunol (2000) 1.15

Low-dose aspirin and breast cancer risk: results by tumour characteristics from a randomised trial. Br J Cancer (2008) 1.14

Prostaglandin E2 promotes B lymphocyte Ig isotype switching to IgE. J Immunol (1995) 1.14

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PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Mol Pharmacol (2007) 1.13

Retracted Modulation of Stat3 activation by the cytosolic phospholipase A2alpha and cyclooxygenase-2-controlled prostaglandin E2 signaling pathway. J Biol Chem (2006) 1.13

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Characterization of the signal transduction of prostaglandin E receptor EP1 subtype in cDNA-transfected Chinese hamster ovary cells. Biochim Biophys Acta (1995) 1.09

Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions. Mol Pharmacol (1995) 1.09

Elevated prostaglandin E2 production by monocytes is responsible for the depressed levels of natural killer and lymphokine-activated killer cell function in patients with breast cancer. Cancer (1993) 1.09

Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model. Cancer Res (2010) 1.08

EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein. Mol Pharmacol (2005) 1.08

Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression. Cancer Immunol Immunother (2008) 1.08

Cyclo-oxygenase inhibition reduces tumour growth and metastasis in an orthotopic model of breast cancer. Br J Cancer (2002) 1.07

mPGES-1 as a target for cancer suppression: A comprehensive invited review "Phospholipase A2 and lipid mediators". Biochimie (2010) 1.07

Regulation of eNOS expression in brain endothelial cells by perinuclear EP(3) receptors. Circ Res (2002) 1.07

Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function. Breast Cancer Res Treat (2008) 1.07

Prostaglandin E2 stimulates human lung carcinoma cell growth through induction of integrin-linked kinase: the involvement of EP4 and Sp1. Cancer Res (2009) 1.06

Elevated cyclooxygenase-2 expression correlates with distant metastases in breast cancer. Anticancer Res (2004) 1.05

The modulation of human natural killer cell activity by prostaglandins. J Clin Lab Immunol (1982) 1.05

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