Published in Open Neurosci J on January 01, 2010
Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS One (2013) 0.90
Ketogenic diet sensitizes glucose control of hippocampal excitability. J Lipid Res (2014) 0.83
Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches. Front Mol Neurosci (2017) 0.75
Acetate supplementation modulates brain adenosine metabolizing enzymes and adenosine A₂A receptor levels in rats subjected to neuroinflammation. J Neuroinflammation (2014) 0.75
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet (2005) 16.79
Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia (2005) 9.32
Astrocytic purinergic signaling coordinates synaptic networks. Science (2005) 6.55
Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron (2009) 5.22
The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol (2008) 3.51
Uniquely hominid features of adult human astrocytes. J Neurosci (2009) 3.49
Metabolic coupling between glia and neurons. J Neurosci (1996) 3.07
Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann Neurol (2006) 2.74
The effect of a plant-based low-carbohydrate ("Eco-Atkins") diet on body weight and blood lipid concentrations in hyperlipidemic subjects. Arch Intern Med (2009) 2.68
Ketogenic diet: effects on expression of kindled seizures and behavior in adult rats. Epilepsia (1997) 2.65
Adenosine in the central nervous system: release mechanisms and extracellular concentrations. J Neurochem (2001) 2.63
Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor. Nat Med (2007) 2.59
Adult epilepsy. Lancet (2006) 2.36
Adenosine: a potential mediator of seizure arrest and postictal refractoriness. Ann Neurol (1992) 2.11
Anticonvulsant mechanisms of the ketogenic diet. Epilepsia (2007) 2.04
Adenine nucleotides undergo rapid, quantitative conversion to adenosine in the extracellular space in rat hippocampus. J Neurosci (1997) 2.03
Adenosine and brain function. Int Rev Neurobiol (2005) 1.97
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest (2008) 1.86
Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res (1976) 1.86
Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels. J Neurosci (2007) 1.83
Adenosine kinase, epilepsy and stroke: mechanisms and therapies. Trends Pharmacol Sci (2006) 1.83
Acetoacetate, acetone, and dibenzylamine (a contaminant in l-(+)-beta-hydroxybutyrate) exhibit direct anticonvulsant actions in vivo. Epilepsia (2002) 1.82
Epidemiology of posttraumatic epilepsy: a critical review. Epilepsia (2003) 1.80
Chronic ketosis and cerebral metabolism. Ann Neurol (1978) 1.76
Adenosine and ATP link PCO2 to cortical excitability via pH. Neuron (2005) 1.68
The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics (1998) 1.65
Neuroprotective and disease-modifying effects of the ketogenic diet. Behav Pharmacol (2006) 1.65
Comparison of the actions of adenosine at pre- and postsynaptic receptors in the rat hippocampus in vitro. J Physiol (1992) 1.61
Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo. Epilepsia (2003) 1.59
Adenosine receptors in the nervous system: pathophysiological implications. Prog Neurobiol (2002) 1.59
The ketogenic diet: one decade later. Pediatrics (2007) 1.54
Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response. J Neurosci (2005) 1.54
Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies. Neuroscientist (2005) 1.48
Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Proc Natl Acad Sci U S A (2001) 1.47
Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy. Epilepsia (2003) 1.38
The electrophysiology of adenosine in the mammalian central nervous system. Prog Neurobiol (1991) 1.34
Clinical aspects of the ketogenic diet. Epilepsia (2007) 1.31
Metabolic autocrine regulation of neurons involves cooperation among pannexin hemichannels, adenosine receptors, and KATP channels. J Neurosci (2010) 1.31
The ketogenic diet in a pill: is this possible? Epilepsia (2008) 1.28
Efficacy of the ketogenic diet as a treatment option for epilepsy: meta-analysis. J Child Neurol (2006) 1.26
An animal model for the ketogenic diet. Epilepsia (1974) 1.24
Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models. Ann Neurol (2009) 1.22
Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet. Epilepsy Res (1999) 1.20
Adenosine augmentation therapies (AATs) for epilepsy: prospect of cell and gene therapies. Epilepsy Res (2009) 1.17
Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner. Eur J Neurosci (2004) 1.16
A1 adenosine receptor agonists and their potential therapeutic applications. Expert Opin Investig Drugs (2008) 1.15
Ketogenic diets: evidence for short- and long-term efficacy. Neurotherapeutics (2009) 1.14
Endogenously released adenosine regulates excitability in the in vitro hippocampus. Epilepsia (1980) 1.14
MECHANISM OF ANTICONVULSANT ACTION OF KETOGENIC DIET. STUDIES IN ANIMALS WITH EXPERIMENTAL SEIZURES AND IN CHILDREN WITH PETIT MAL EPILEPSY. Am J Dis Child (1964) 1.13
Ketogenic diet reduces spontaneous seizures and mossy fiber sprouting in the kainic acid model. Neuroreport (1999) 1.10
Temperature-dependent modulation of excitatory transmission in hippocampal slices is mediated by extracellular adenosine. J Neurosci (1999) 1.10
Ketosis and epilepsy: 31P spectroscopic imaging at 4.1 T. Epilepsia (1999) 1.09
Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets? Trends Neurosci (2008) 1.07
Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity. Curr Neuropharmacol (2009) 1.04
Anticonvulsant properties of the ketogenic diet in mice. J Pharmacol Exp Ther (1972) 1.04
Therapeutic epilepsy research: from pharmacological rationale to focal adenosine augmentation. Biochem Pharmacol (2009) 1.03
Involvement of adenosine in depression of synaptic transmission during hypercapnia in isolated spinal cord of neonatal rats. J Physiol (2006) 1.03
Alkylxanthines elevate hippocampal excitability. Evidence for a role of endogenous adenosine. Naunyn Schmiedebergs Arch Pharmacol (1981) 1.02
The ketogenic diet for intractable epilepsy in adults: preliminary results. Epilepsia (1999) 1.00
Assessing the efficacy of antiepileptic treatments: the ketogenic diet. Epilepsia (2003) 1.00
Timing of ketogenic diet initiation in an experimental epilepsy model. Brain Res Dev Brain Res (2000) 1.00
Intracellular acidification causes adenosine release during states of hyperexcitability in the hippocampus. J Neurophysiol (2009) 0.99
An anticonvulsant profile of the ketogenic diet in the rat. Epilepsy Res (2002) 0.99
Levels of adenosine and adenine nucleotides in slices of rat hippocampus. Brain Res (1984) 0.98
Kidney stones and the ketogenic diet: risk factors and prevention. J Child Neurol (2007) 0.97
Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice. Neuron Glia Biol (2009) 0.96
Effects of ketogenic diet on electroconvulsive threshold and brain contents of adenosine nucleotides. Brain Dev (1983) 0.96
Adenosine formation. Evidence for a direct biochemical link with energy metabolism. Adv Myocardiol (1985) 0.96
Ketogenic diet in patients with myoclonic-astatic epilepsy. Epileptic Disord (2006) 0.96
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. Brain Res (2000) 0.95
Focally injected adenosine prevents seizures in the rat. Exp Neurol (2004) 0.95
Cardiac complications in pediatric patients on the ketogenic diet. Neurology (2000) 0.94
Deletion of the adenosine A1 receptor gene does not alter neuronal damage following ischaemia in vivo or in vitro. Eur J Neurosci (2004) 0.94
Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis. Epilepsy Res (2009) 0.93
Adenosine release is a major cause of failure of synaptic transmission during hypoglycaemia in rat hippocampal slices. Neurosci Lett (1993) 0.91
Fasting prior to transient cerebral ischemia reduces delayed neuronal necrosis. Metab Brain Dis (1990) 0.91
Purine release and inhibition of synaptic transmission during hypoxia and hypoglycemia in rat hippocampal slices. Neurosci Lett (1993) 0.90
Minimizing AED adverse effects: improving quality of life in the interictal state in epilepsy care. Curr Neuropharmacol (2009) 0.90
The ketogenic diet. Neurologist (2005) 0.90
Purinergic mechanisms in epilepsy. Prog Neurobiol (1988) 0.89
2-Deoxy-D-glucose-induced changes in membrane potential, input resistance, and excitatory postsynaptic potentials of CA1 hippocampal neurons. Can J Physiol Pharmacol (1997) 0.89
Pharmacotherapy of epilepsy: new armamentarium, new issues. J Clin Neurosci (2007) 0.88
Ketogenic diet is antiepileptogenic in pentylenetetrazole kindled mice and decrease levels of N-acylethanolamines in hippocampus. Neurochem Int (2008) 0.86
Glia, adenosine, and sleep. Neuron (2009) 0.85
A purinergic component in the anticonvulsant action of carbamazepine? Eur J Pharmacol (1982) 0.84
Epilepsy in the elderly. Semin Neurol (2008) 0.84
Seizure control and biochemical profile on the ketogenic diet in young children with refractory epilepsy--Indian experience. Seizure (2009) 0.82
Sudden cardiac death in association with the ketogenic diet. Pediatr Neurol (2008) 0.82
Discontinuing the ketogenic diet in seizure-free children: recurrence and risk factors. Epilepsia (2007) 0.82
Changes in hippocampal adenosine efflux, ATP levels, and synaptic transmission induced by increased temperature. Synapse (2001) 0.82
Rapid temperature changes induce adenosine-mediated depression of synaptic transmission in hippocampal slices from rats (non-hibernators) but not in slices from golden hamsters (hibernators). Neuroscience (1998) 0.82
Risk factors for epilepsy. Epilepsy Res Suppl (1991) 0.82
Adenosine modulation of amygdala kindling. Exp Neurol (1984) 0.82
ATP- and adenosine-mediated signaling in the central nervous system: synaptic purinoceptors: the stage for ATP to play its "dual-role". J Pharmacol Sci (2004) 0.81
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain. J Pharmacol Exp Ther (1993) 0.81
Antiepileptic drug therapy: when is epilepsy truly intractable? Epilepsia (1996) 0.80
Systemic administration of adenosine ameliorates pentylenetetrazol-induced chemical kindling and secondary behavioural and biochemical changes in mice. Fundam Clin Pharmacol (2007) 0.80
Adenosine involvement in postictal events in amygdala-kindled rats. Epilepsy Res (1990) 0.80
The ketogenic diet: proposed mechanisms of action. Neurotherapeutics (2009) 0.80
Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC). Life Sci (1989) 0.80
Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann Neurol (2006) 2.74
A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors. J Clin Invest (2011) 1.79
TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. J Bone Miner Res (2005) 1.68
Brain glycogen decreases with increased periods of wakefulness: implications for homeostatic drive to sleep. J Neurosci (2002) 1.58
Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors. J Neurochem (2009) 1.45
Metabolic autocrine regulation of neurons involves cooperation among pannexin hemichannels, adenosine receptors, and KATP channels. J Neurosci (2010) 1.31
GABA(B) receptor activation inhibits neuronal excitability and spatial learning in the entorhinal cortex by activating TREK-2 K+ channels. Neuron (2009) 1.27
Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment. Chem Biol (2011) 1.25
Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. J Neuroinflammation (2008) 1.22
Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet. PLoS One (2009) 1.19
Presence and functional significance of presynaptic ryanodine receptors. Prog Neurobiol (2003) 1.12
Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-alpha-mediated neurotoxicity. Neurobiol Dis (2007) 1.09
Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets? Trends Neurosci (2008) 1.07
Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability. J Neurosci (2010) 1.06
Doping-control urinalysis of a ginseng extract, Cold-FX, in athletes. Int J Sport Nutr Exerc Metab (2004) 1.06
Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum. J Neurochem (2008) 1.04
Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors. J Neurosci (2010) 1.03
Ethanol alters glutamate but not adenosine uptake in rat astrocytes: evidence for protein kinase C involvement. Neurochem Res (2002) 1.02
Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. J Alzheimers Dis (2010) 1.01
Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radic Biol Med (2010) 0.99
Activation of adenosine receptors inhibits tumor necrosis factor-alpha release by decreasing TNF-alpha mRNA stability and p38 activity. Eur J Pharmacol (2004) 0.97
Carbamazepine promotes Her-2 protein degradation in breast cancer cells by modulating HDAC6 activity and acetylation of Hsp90. Mol Cell Biochem (2010) 0.93
Angiotensin II/angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathway. J Cell Physiol (2010) 0.93
Role of endolysosomes in HIV-1 Tat-induced neurotoxicity. ASN Neuro (2012) 0.92
A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease. Physiol Behav (2011) 0.92
Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS One (2013) 0.90
Behavioral synergism between D(1) and D(2) dopamine receptors in mice does not depend on gap junctions. Synapse (2007) 0.90
Evidence of oxidative stress-induced BNIP3 expression in amyloid beta neurotoxicity. Brain Res (2007) 0.90
The PTHrP functional domain is at the gates of endochondral bones. Ann N Y Acad Sci (2007) 0.89
Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production. Neurobiol Aging (2013) 0.89
Assessment of post-mortem-induced changes to the mouse brain proteome. J Neurochem (2007) 0.89
Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. J Neurochem (2003) 0.89
Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet. J Alzheimers Dis (2010) 0.88
Neurotensin enhances GABAergic activity in rat hippocampus CA1 region by modulating L-type calcium channels. J Neurophysiol (2008) 0.88
Homeostatic bioenergetic network regulation - a novel concept to avoid pharmacoresistance in epilepsy. Expert Opin Drug Discov (2011) 0.88
Ontogeny and dopaminergic regulation in brain of Ras homolog enriched in striatum (Rhes). Brain Res (2008) 0.88
A ketogenic diet reduces long-term potentiation in the dentate gyrus of freely behaving rats. J Neurophysiol (2011) 0.87
A sensitive HPLC-based method to quantify adenine nucleotides in primary astrocyte cell cultures. J Chromatogr B Analyt Technol Biomed Life Sci (2012) 0.86
Endolysosome involvement in LDL cholesterol-induced Alzheimer's disease-like pathology in primary cultured neurons. Life Sci (2012) 0.86
Angiotensin II suppresses adriamycin-induced apoptosis through activation of phosphatidylinositol 3-kinase/Akt signaling in human breast cancer cells. Acta Biochim Biophys Sin (Shanghai) (2008) 0.85
Knockdown of osteopontin chemosensitizes MDA-MB-231 cells to cyclophosphamide by enhancing apoptosis through activating p38 MAPK pathway. Cancer Biother Radiopharm (2011) 0.85
Attenuation of gap-junction-mediated signaling facilitated anesthetic effect of sevoflurane in the central nervous system of rats. Anesth Analg (2004) 0.84
Baseline staging tests based on molecular subtype is necessary for newly diagnosed breast cancer. J Exp Clin Cancer Res (2014) 0.84
Informed decision-making on sympathomimetic use in sport and health. Clin J Sport Med (2002) 0.83
Multisecond periodicities in basal ganglia firing rates correlate with theta bursts in transcortical and hippocampal EEG. J Neurophysiol (2002) 0.82
The relationship between the neuromodulator adenosine and behavioral symptoms of autism. Neurosci Lett (2011) 0.82
Rabbits fed cholesterol-enriched diets exhibit pathological features of inclusion body myositis. Am J Physiol Regul Integr Comp Physiol (2008) 0.81
ATP- and adenosine-mediated signaling in the central nervous system: synaptic purinoceptors: the stage for ATP to play its "dual-role". J Pharmacol Sci (2004) 0.81
Homeostatic control of brain function - new approaches to understand epileptogenesis. Front Cell Neurosci (2013) 0.81
Aβ42-binding peptoids as amyloid aggregation inhibitors and detection ligands. ACS Chem Neurosci (2013) 0.81
Microwave irradiation decreases ATP, increases free [Mg²⁺], and alters in vivo intracellular reactions in rat brain. J Neurochem (2012) 0.80
Ketone bodies protection against HIV-1 Tat-induced neurotoxicity. J Neurochem (2012) 0.80
Targeted glycomics by selected reaction monitoring for highly sensitive glycan compositional analysis. Proteomics (2012) 0.79
Adenosine and autism: a spectrum of opportunities. Neuropharmacology (2012) 0.79
The ketogenic diet and epilepsy: is adenosine the missing link? Epilepsia (2009) 0.78
Neuroprotective actions of pyridoxine. Biochim Biophys Acta (2003) 0.78
Creatine protects against mitochondrial dysfunction associated with HIV-1 Tat-induced neuronal injury. Curr HIV Res (2014) 0.77
Computational methods for DNA-binding protein and binding residue prediction. Protein Pept Lett (2013) 0.77
Purine level regulation during energy depletion associated with graded excitatory stimulation in brain. Neurol Res (2005) 0.77
Impaired agonist-dependent myosin phosphorylation and decreased RhoA in rat portal hypertensive mesenteric vasculature. Am J Physiol Gastrointest Liver Physiol (2004) 0.77
Ketogenic diets and pain. J Child Neurol (2013) 0.77
Caffeine, Through Adenosine A3 Receptor-Mediated Actions, Suppresses Amyloid-β Protein Precursor Internalization and Amyloid-β Generation. J Alzheimers Dis (2015) 0.76
Altered Cholesterol Intracellular Trafficking and the Development of Pathological Hallmarks of Sporadic AD. J Parkinsons Dis Alzheimers Dis (2015) 0.76
Cellular Interactions and Signaling in neuroAIDS: Emerging Issues Colloquium. J Neuroimmune Pharmacol (2014) 0.76
Acetate supplementation modulates brain adenosine metabolizing enzymes and adenosine A₂A receptor levels in rats subjected to neuroinflammation. J Neuroinflammation (2014) 0.75
Ryanodine receptor modulation by diadenosine polyphosphates in synaptosomal and microsomal preparations of rat brain. Eur J Pharmacol (2003) 0.75
Magnesium lithospermate B protects neurons from N-methyl-D-aspartic acid injury and attenuates kainic acid-induced neurodegeration in FVB mice. J Mol Neurosci (2013) 0.75
[Application of portable esophageal dilator in treatment of esophageal stenosis at home]. Lin Chuang Er Bi Yan Hou Ke Za Zhi (2006) 0.75
Analysis of the molecular mechanisms controlling synaptic transmission by patch-clamp recording in brainstem slices. Nihon Yakurigaku Zasshi (2003) 0.75
Shared gene regulation during human somatic cell reprogramming. J Genet Genomics (2012) 0.75
Survival analysis of patients with unilateral and bilateral primary breast cancer in Northeast China. Breast Cancer (2014) 0.75
Computational simulation study on the anion recognition properties of functionalized tetraphenyl porphyrins. J Mol Model (2015) 0.75
[Analysis of diagnosis and treatment for blunt trauma in the neck]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (2013) 0.75