Role of T cell-nuclear factor κB in transplantation.

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Published in Transplant Rev (Orlando) on November 08, 2011

Authors

Luciana L Molinero1, Maria-Luisa Alegre

Author Affiliations

1: Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637, USA. lmoliner@medicine.bsd.uchicago.edu

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Signaling to NF-kappaB. Genes Dev (2004) 19.78

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IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79

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IAPs, RINGs and ubiquitylation. Nat Rev Mol Cell Biol (2005) 3.68

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The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell (1993) 3.35

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Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science (2003) 3.28

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells. EMBO J (1996) 2.68

The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity (2003) 2.67

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature (2002) 2.60

The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding. Proc Natl Acad Sci U S A (1992) 2.56

Inhibiting NF-κB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta (2010) 2.55

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TRAF6 is a critical factor for dendritic cell maturation and development. Immunity (2003) 2.36

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Dendritic cell development and survival require distinct NF-kappaB subunits. Immunity (2002) 2.31

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Immunosuppression: evolution in practice and trends, 1994-2004. Am J Transplant (2006) 2.22

Mature T cells depend on signaling through the IKK complex. Immunity (2003) 2.21

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Long-term allograft tolerance is characterized by the accumulation of B cells exhibiting an inhibited profile. Am J Transplant (2010) 1.88

Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB. J Exp Med (1997) 1.85

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Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Mol Cell (2006) 1.78

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