Published in Proc Natl Acad Sci U S A on December 06, 2011
From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma. Curr Eye Res (2013) 1.31
ATP signaling is deficient in cultured Pannexin1-null mouse astrocytes. Glia (2012) 1.22
Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury. J Cereb Blood Flow Metab (2014) 1.20
Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations. Nat Rev Neurosci (2014) 1.20
Neuronal gap junctions: making and breaking connections during development and injury. Trends Neurosci (2012) 1.13
Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury. PLoS One (2012) 1.10
A comparative antibody analysis of pannexin1 expression in four rat brain regions reveals varying subcellular localizations. Front Pharmacol (2013) 1.09
Physiological mechanisms for the modulation of pannexin 1 channel activity. J Physiol (2012) 1.07
Differentiating connexin hemichannels and pannexin channels in cellular ATP release. FEBS Lett (2014) 1.01
Posttranslational modifications in connexins and pannexins. J Membr Biol (2012) 1.00
Functional outcome of pannexin-deficient mice after cerebral ischemia. Channels (Austin) (2012) 0.99
Promises and pitfalls of a Pannexin1 transgenic mouse line. Front Pharmacol (2013) 0.97
Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacol Rev (2014) 0.90
Ionotropic receptors and ion channels in ischemic neuronal death and dysfunction. Acta Pharmacol Sin (2012) 0.89
Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity. Nat Neurosci (2016) 0.89
Pannexin 2 protein expression is not restricted to the CNS. Front Cell Neurosci (2014) 0.89
Connexons and pannexons: newcomers in neurophysiology. Front Cell Neurosci (2014) 0.88
Ionic regulation of cell volume changes and cell death after ischemic stroke. Transl Stroke Res (2013) 0.88
Neuronal gap junction coupling as the primary determinant of the extent of glutamate-mediated excitotoxicity. J Neural Transm (Vienna) (2013) 0.86
Pannexins form gap junctions with electrophysiological and pharmacological properties distinct from connexins. Sci Rep (2014) 0.86
Coupling of P2Y receptors to G proteins and other signaling pathways. Wiley Interdiscip Rev Membr Transp Signal (2015) 0.86
Opening of pannexin- and connexin-based channels increases the excitability of nodose ganglion sensory neurons. Front Cell Neurosci (2014) 0.85
Pannexin-1 is blocked by its C-terminus through a delocalized non-specific interaction surface. PLoS One (2014) 0.84
Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin. PLoS One (2015) 0.84
Amplification of human platelet activation by surface pannexin-1 channels. J Thromb Haemost (2014) 0.83
Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases. Front Physiol (2014) 0.83
Activation, permeability, and inhibition of astrocytic and neuronal large pore (hemi)channels. J Biol Chem (2014) 0.83
Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes. Cell Death Differ (2016) 0.82
DCPIB, the proposed selective blocker of volume-regulated anion channels, inhibits several glutamate transport pathways in glial cells. Mol Pharmacol (2012) 0.82
Intrinsic properties and regulation of Pannexin 1 channel. Channels (Austin) (2014) 0.82
Inflammasomes link vascular disease with neuroinflammation and brain disorders. J Cereb Blood Flow Metab (2016) 0.82
Pannexin channels and ischaemia. J Physiol (2014) 0.81
Molecular regulation of cell fate in cerebral ischemia: role of the inflammasome and connected pathways. J Cereb Blood Flow Metab (2014) 0.80
Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing. Sci Rep (2015) 0.80
Pannexin-1 as a potentiator of ligand-gated receptor signaling. Channels (Austin) (2014) 0.80
Functional implications of axon initial segment cytoskeletal disruption in stroke. Acta Pharmacol Sin (2015) 0.79
Investigation of olfactory function in a Panx1 knock out mouse model. Front Cell Neurosci (2014) 0.79
Diverse post-translational modifications of the pannexin family of channel-forming proteins. Channels (Austin) (2014) 0.79
Pannexin 1 channels: new actors in the regulation of catecholamine release from adrenal chromaffin cells. Front Cell Neurosci (2014) 0.79
Pannexin1 channels act downstream of P2X 7 receptors in ATP-induced murine T-cell death. Channels (Austin) (2014) 0.79
The emerging Pannexin 1 signalome: a new nexus revealed? Front Cell Neurosci (2014) 0.78
Brainstem neurons survive the identical ischemic stress that kills higher neurons: insight to the persistent vegetative state. PLoS One (2014) 0.78
Emerging concepts regarding pannexin 1 in the vasculature. Biochem Soc Trans (2015) 0.78
Pannexin2 oligomers localize in the membranes of endosomal vesicles in mammalian cells while Pannexin1 channels traffic to the plasma membrane. Front Cell Neurosci (2015) 0.78
TRPM7, the cytoskeleton and neuronal death. Channels (Austin) (2012) 0.77
A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction. J Biol Chem (2016) 0.77
P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential. CNS Neurol Disord Drug Targets (2012) 0.77
Astroglial integrins in the development and regulation of neurovascular units. Pain Res Treat (2012) 0.77
Pore positioning: current concepts in Pannexin channel trafficking. Channels (Austin) (2013) 0.76
Connexin and pannexin channels in cancer. BMC Cell Biol (2016) 0.76
The pharmacokinetics and pharmacodynamics of Kollidon VA64 dissociate its protective effects from membrane resealing after controlled cortical impact in mice. J Cereb Blood Flow Metab (2014) 0.75
Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease. BMC Cell Biol (2017) 0.75
Emerging role of pannexins in seizures and status epilepticus. Epilepsy Curr (2012) 0.75
Large Pore Ion and Metabolite-Permeable Channel Regulation of Postnatal Ventricular Zone Neural Stem and Progenitor Cells: Interplay between Aquaporins, Connexins, and Pannexins? Stem Cells Int (2012) 0.75
Pannexins after stroke: knocking-out membrane channels to improve neurological function. Channels (Austin) (2013) 0.75
Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone. BMC Cell Biol (2016) 0.75
Pannexin 3 is required for late stage bone growth but not for initiation of ossification in avian embryos. Dev Dyn (2016) 0.75
Purinergic Signaling in Gut Inflammation: The Role of Connexins and Pannexins. Front Neurosci (2016) 0.75
Connexins, Pannexins, and Their Channels in Fibroproliferative Diseases. J Membr Biol (2016) 0.75
UTP activates small-conductance Ca2+-activated K+ channels in murine detrusor PDGFRα+ cells. Am J Physiol Renal Physiol (2015) 0.75
The role of Pannexin gene variants in schizophrenia: systematic analysis of phenotypes. Eur Arch Psychiatry Clin Neurosci (2015) 0.75
Gap junction gene and protein families: Connexins, innexins, and pannexins. Biochim Biophys Acta (2017) 0.75
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol Rev (2017) 0.75
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J (2006) 8.12
Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett (2004) 4.73
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov (2010) 4.25
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature (2010) 4.10
Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci U S A (2006) 4.03
Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci U S A (2003) 3.96
Interleukin-1 and neuronal injury. Nat Rev Immunol (2005) 3.85
Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiol Rev (2001) 3.41
Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. J Biol Chem (2006) 3.36
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci U S A (2001) 3.17
P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling. J Neurosci (2006) 3.14
Ischemia opens neuronal gap junction hemichannels. Science (2006) 3.00
The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem (2009) 2.90
P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol (2008) 2.72
Pannexin 1: the molecular substrate of astrocyte "hemichannels". J Neurosci (2009) 2.48
Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science (2008) 2.46
Non-junction functions of pannexin-1 channels. Trends Neurosci (2009) 2.33
Cell-cell communication beyond connexins: the pannexin channels. Physiology (Bethesda) (2006) 2.13
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. Proc Natl Acad Sci U S A (2008) 2.01
Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes. Am J Physiol Heart Circ Physiol (2010) 1.81
Tumor-suppressive effects of pannexin 1 in C6 glioma cells. Cancer Res (2007) 1.70
Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am J Physiol Cell Physiol (2007) 1.60
Glycosylation regulates pannexin intermixing and cellular localization. Mol Biol Cell (2009) 1.45
Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment. FASEB J (2009) 1.44
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc Natl Acad Sci U S A (2002) 1.36
Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia. Stroke (2005) 1.36
Global ischemia-induced increases in the gap junctional proteins connexin 32 (Cx32) and Cx36 in hippocampus and enhanced vulnerability of Cx32 knock-out mice. J Neurosci (2001) 1.29
Different mechanisms promote astrocyte Ca2+ waves and spreading depression in the mouse neocortex. J Neurosci (2003) 1.27
Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia. Stroke (2003) 1.21
Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery. J Neurosci Methods (2009) 1.11
The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials. FEBS J (2009) 1.07
Hemichannels in cerebral ischemia. Curr Mol Med (2009) 1.07
Blockade of microglial glutamate release protects against ischemic brain injury. Exp Neurol (2008) 1.06
Gap junctions are required for the propagation of spreading depression. J Neurobiol (1995) 1.03
Role for nitric oxide in permeability of hippocampal neuronal hemichannels during oxygen glucose deprivation. J Neurosci Res (2008) 1.02
Heptanol but not fluoroacetate prevents the propagation of spreading depression in rat hippocampal slices. J Neurophysiol (1997) 0.88
The connexin 36 blockers quinine, quinidine and mefloquine inhibit cortical spreading depression in a rat neocortical slice model in vitro. Brain Res Bull (2006) 0.83
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature (2010) 4.10
Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci U S A (2003) 3.96
Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem (2005) 3.87
A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci U S A (2003) 3.82
Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior. Neuron (2007) 3.67
Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nat Med (2012) 3.31
CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus. Science (2010) 3.17
Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. Proc Natl Acad Sci U S A (2002) 2.92
New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat Rev Neurosci (2013) 2.65
Multiple levels of regulation of the interleukin-6 system in stroke. Stroke (2003) 2.61
In vivo labeling of parvalbumin-positive interneurons and analysis of electrical coupling in identified neurons. J Neurosci (2002) 2.38
Targeted whole-cell recordings in the mammalian brain in vivo. Neuron (2003) 2.35
Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons. Proc Natl Acad Sci U S A (2009) 2.34
Connexin36 mediates spike synchrony in olfactory bulb glomeruli. Neuron (2005) 2.26
Improving outcome after stroke: overcoming the translational roadblock. Cerebrovasc Dis (2008) 2.26
NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory. Neuron (2010) 2.21
Influenza virus infection aggravates stroke outcome. Stroke (2011) 2.13
Cell-cell communication beyond connexins: the pannexin channels. Physiology (Bethesda) (2006) 2.13
High-frequency network oscillations in cerebellar cortex. Neuron (2008) 2.12
Functional characterization of intrinsic cholinergic interneurons in the cortex. J Neurosci (2007) 2.08
A novel network of multipolar bursting interneurons generates theta frequency oscillations in neocortex. Neuron (2003) 2.05
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. Proc Natl Acad Sci U S A (2008) 2.01
Differential involvement of oriens/pyramidale interneurones in hippocampal network oscillations in vitro. J Physiol (2004) 2.00
Parvalbumin-containing fast-spiking basket cells generate the field potential oscillations induced by cholinergic receptor activation in the hippocampus. J Neurosci (2010) 1.93
Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily. J Clin Invest (2004) 1.92
Selective impairment of hippocampal gamma oscillations in connexin-36 knock-out mouse in vivo. J Neurosci (2003) 1.91
Ca2+ buffer saturation underlies paired pulse facilitation in calbindin-D28k-containing terminals. Neuron (2003) 1.88
Pannexin channels are not gap junction hemichannels. Channels (Austin) (2011) 1.84
IKK mediates ischemia-induced neuronal death. Nat Med (2005) 1.83
A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro. Proc Natl Acad Sci U S A (2004) 1.80
GABAergic interneurons shape the functional maturation of the cortex. Neuron (2013) 1.79
Neurogenesis and widespread forebrain migration of distinct GABAergic neurons from the postnatal subventricular zone. Proc Natl Acad Sci U S A (2008) 1.78
Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks. Neuron (2008) 1.78
Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia. J Biol Chem (2011) 1.76
Orthogonal arrangement of rhythm-generating microcircuits in the hippocampus. Proc Natl Acad Sci U S A (2005) 1.71
A2A adenosine receptor signaling in lymphocytes and the central nervous system regulates inflammation during experimental autoimmune encephalomyelitis. J Immunol (2012) 1.67
Role of olivary electrical coupling in cerebellar motor learning. Neuron (2008) 1.67
Pannexin1 and Pannexin2 expression in the developing and mature rat brain. Brain Res Mol Brain Res (2005) 1.67
Nuclear factor-kappaB contributes to infarction after permanent focal ischemia. Stroke (2004) 1.58
Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex. Science (2012) 1.58
Adenosine receptor signaling modulates permeability of the blood-brain barrier. J Neurosci (2011) 1.55
Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons. J Neurosci (2005) 1.53
Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB. Hypertension (2010) 1.50
Severe forward flexion of the trunk in Parkinson's disease: focal myopathy of the paraspinal muscles mimicking camptocormia. Mov Disord (2003) 1.49
Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemia. J Cereb Blood Flow Metab (2005) 1.49
Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors. Nat Methods (2010) 1.48
The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2-1. Eur J Neurosci (2011) 1.46
Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis. J Mol Med (Berl) (2015) 1.45
AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis. J Leukoc Biol (2009) 1.45
Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors. Neuropharmacology (2007) 1.44
Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment. FASEB J (2009) 1.44
Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia. J Neurosci (2006) 1.40
Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations. Proc Natl Acad Sci U S A (2003) 1.38
Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. J Neurosci (2008) 1.35
IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors. Neurobiol Dis (2006) 1.33
Serotonin 3A receptor subtype as an early and protracted marker of cortical interneuron subpopulations. Cereb Cortex (2010) 1.33
Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks. Biochim Biophys Acta (2004) 1.31
GABAergic excitation in the basolateral amygdala. J Neurosci (2006) 1.30
A molecular basis of analgesic tolerance to cannabinoids. J Neurosci (2007) 1.28
Two calretinin-positive GABAergic cell types in layer 2/3 of the mouse neocortex provide different forms of inhibition. Cereb Cortex (2008) 1.28
Connexin36 mediates gap junctional coupling of alpha-ganglion cells in mouse retina. J Comp Neurol (2005) 1.26
Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE. J Clin Invest (2014) 1.24
Effects of electrically coupled inhibitory networks on local neuronal responses to intracortical microstimulation. J Neurophysiol (2006) 1.22
The N-terminal region of reelin regulates postnatal dendritic maturation of cortical pyramidal neurons. Proc Natl Acad Sci U S A (2009) 1.22
Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction. Circ Res (2011) 1.21
Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina. J Neurosci (2004) 1.18
Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration. J Neurosci (2004) 1.18
Bergmann glial AMPA receptors are required for fine motor coordination. Science (2012) 1.18
Transient depression of excitatory synapses on interneurons contributes to epileptiform bursts during gamma oscillations in the mouse hippocampal slice. J Neurophysiol (2005) 1.18
Diazepam binding inhibitor promotes progenitor proliferation in the postnatal SVZ by reducing GABA signaling. Cell Stem Cell (2012) 1.17
Sharp wave-like activity in the hippocampus in vitro in mice lacking the gap junction protein connexin 36. J Neurophysiol (2003) 1.16
Features of neuronal synchrony in mouse visual cortex. J Neurophysiol (2003) 1.16
Regulation of body temperature and neuroprotection by endogenous interleukin-6 in cerebral ischemia. J Cereb Blood Flow Metab (2003) 1.13
Hyperbaric oxygen reduces blood-brain barrier damage and edema after transient focal cerebral ischemia. Stroke (2005) 1.13
Mice with a deletion in the first intron of the Col1a1 gene develop age-dependent aortic dissection and rupture. Circ Res (2003) 1.12
NF-kappaB p50/RelA and c-Rel-containing dimers: opposite regulators of neuron vulnerability to ischaemia. J Neurochem (2009) 1.11
Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery. J Neurosci Methods (2009) 1.11
Two variants of the rat brain sodium-driven chloride bicarbonate exchanger (NCBE): developmental expression and addition of a PDZ motif. Eur J Neurosci (2003) 1.10
Interleukin-6 (IL-6): a possible neuromodulator induced by neuronal activity. Neuroscientist (2002) 1.09
The long and short of GABAergic neurons. Curr Opin Neurobiol (2013) 1.09
Inhibition of TNF-α protects against hepatic ischemia-reperfusion injury in rats via NF-κB dependent pathway. Naunyn Schmiedebergs Arch Pharmacol (2012) 1.09
Hemichannels in cerebral ischemia. Curr Mol Med (2009) 1.07