Published in Mol Carcinog on January 01, 2012
Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium. Ann Oncol (2014) 2.24
Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. Pancreatology (2013) 1.67
New insights into pancreatic cancer-induced paraneoplastic diabetes. Nat Rev Gastroenterol Hepatol (2013) 1.54
Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). Ann Oncol (2012) 1.35
Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells. PLoS One (2013) 1.29
Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop. Pancreas (2013) 1.15
Regional differences in islet distribution in the human pancreas--preferential beta-cell loss in the head region in patients with type 2 diabetes. PLoS One (2013) 1.13
Advances in pancreatic cancer research: moving towards early detection. World J Gastroenterol (2014) 1.02
Pancreatic Cancer-Derived Exosomes Cause Paraneoplastic β-cell Dysfunction. Clin Cancer Res (2014) 0.98
Obesity and cancer pathogenesis. Ann N Y Acad Sci (2014) 0.93
Diabetes, pancreatic cancer, and metformin therapy. Front Physiol (2014) 0.92
Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages. PLoS One (2015) 0.91
Structural similarities and differences between the human and the mouse pancreas. Islets (2015) 0.88
Blood glucose concentration and risk of pancreatic cancer: systematic review and dose-response meta-analysis. BMJ (2015) 0.88
Macrophage migration inhibitory factor is overexpressed in pancreatic cancer tissues and impairs insulin secretion function of β-cell. J Transl Med (2014) 0.88
Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells. Carcinogenesis (2013) 0.88
Genes-environment interactions in obesity- and diabetes-associated pancreatic cancer: a GWAS data analysis. Cancer Epidemiol Biomarkers Prev (2013) 0.86
Discovering the route from inflammation to pancreatic cancer. Minerva Gastroenterol Dietol (2012) 0.85
Impact of diabetes type II and chronic inflammation on pancreatic cancer. BMC Cancer (2015) 0.84
Pancreatic cancer: translational research aspects and clinical implications. World J Gastroenterol (2012) 0.83
The relationship between lymphatic vascular density and vascular endothelial growth factor A (VEGF-A) expression with clinical-pathological features and survival in pancreatic adenocarcinomas. Diagn Pathol (2013) 0.83
Impacts of new-onset and long-term diabetes on clinical outcome of pancreatic cancer. Am J Cancer Res (2015) 0.82
Retracted The early diagnosis of pancreatic cancer and diabetes: what's the relationship? J Gastrointest Oncol (2014) 0.82
Diabetes mellitus stimulates pancreatic cancer growth and epithelial-mesenchymal transition-mediated metastasis via a p38 MAPK pathway. Oncotarget (2016) 0.81
Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma: A systematic review. World J Gastroenterol (2015) 0.80
Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer. Oncotarget (2015) 0.80
Early detection of pancreatic cancer. Chin J Cancer Res (2015) 0.80
A population-based study of the epidemiology of pancreatic cancer: a brief report. Curr Oncol (2015) 0.79
Diabetes and cancer: A critical appraisal of the pathogenetic and therapeutic links. Biomed Rep (2014) 0.79
Impact of diabetes mellitus on the survival of pancreatic cancer: a meta-analysis. Onco Targets Ther (2016) 0.78
Surveillance for neoplasia in the pancreas. Best Pract Res Clin Gastroenterol (2016) 0.78
Effects of Metformin and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line. Metabolomics (Los Angel) (2016) 0.77
Preoperative glucose abnormalities in patients with pancreatic tumours. Prz Gastroenterol (2014) 0.77
Obesity and cancer: inflammation bridges the two. Curr Opin Pharmacol (2016) 0.76
Pancreatic cancer in chronic pancreatitis. Indian J Surg Oncol (2015) 0.76
Diabetes mellitus and cancer in Werner syndrome. Acta Diabetol (2013) 0.76
Bis(acetylacetonato)-oxidovanadium(IV) and sodium metavanadate inhibit cell proliferation via ROS-induced sustained MAPK/ERK activation but with elevated AKT activity in human pancreatic cancer AsPC-1 cells. J Biol Inorg Chem (2016) 0.76
Blood Glucose Homeostasis in the Course of Partial Pancreatectomy--Evidence for Surgically Reversible Diabetes Induced by Cholestasis. PLoS One (2015) 0.75
Pancreatic Islet Protein Complexes and Their Dysregulation in Type 2 Diabetes. Front Genet (2017) 0.75
Effect of glycemic control on the risk of pancreatic cancer: A nationwide cohort study. Medicine (Baltimore) (2016) 0.75
Metformin reduces serum CA199 levels in type 2 diabetes Chinese patients with time-effect and gender difference. Diabetes Technol Ther (2014) 0.75
Editorial on "Cancer and the microbiota" published in Science. Ann Transl Med (2015) 0.75
Racial disparities of pancreatic cancer in Georgia: a county-wide comparison of incidence and mortality across the state, 2000-2011. Cancer Med (2015) 0.75
Diabetes, plasma glucose and incidence of pancreatic cancer: A prospective study of 0.5 million Chinese adults and a meta-analysis of 22 cohort studies. Int J Cancer (2017) 0.75
Epidemiology of Pancreatic and Periampullary Cancer. Indian J Surg (2015) 0.75
Spatial modelling of type II diabetes outcomes: a systematic review of approaches used. R Soc Open Sci (2015) 0.75
Pancreatic cancer risk in relation to sex, lifestyle factors, and pre-diagnostic anthropometry in the Malmö Diet and Cancer Study. Biol Sex Differ (2016) 0.75
The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer. Br J Cancer (2016) 0.75
Changes in diet associated with cancer: An evolutionary perspective. Evol Appl (2017) 0.75
The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks. Aging Dis (2017) 0.75
Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes. JCI Insight (2017) 0.75
Pancreatic Cancer Heralded by Worsening Glycemic Control: A Report of Two Cases. J Investig Med High Impact Case Rep (2017) 0.75
Metformin Inhibits Gemcitabine Induced Apoptosis in Pancreatic Cancer Cell Lines. J Cancer (2017) 0.75
Biochemistry and molecular cell biology of diabetic complications. Nature (2001) 25.43
AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72
Metformin and reduced risk of cancer in diabetic patients. BMJ (2005) 13.04
Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer (2008) 11.50
The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia (2009) 10.95
Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature (2009) 8.09
Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care (2006) 7.99
Obesity, inflammation, and insulin resistance. Gastroenterology (2007) 7.54
Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw (2006) 7.19
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol (2007) 6.22
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care (2009) 6.17
Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer (2005) 6.06
Metformin: an update. Ann Intern Med (2002) 5.62
Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology (2000) 5.40
Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am J Epidemiol (2004) 5.29
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology (2009) 4.72
Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. JAMA (2008) 4.48
Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res (Phila) (2010) 4.36
Abnormal glucose metabolism and pancreatic cancer mortality. JAMA (2000) 4.01
Diabetes and cancer: a consensus report. CA Cancer J Clin (2010) 3.95
Metformin prevents tobacco carcinogen--induced lung tumorigenesis. Cancer Prev Res (Phila) (2010) 3.86
Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. JAMA (2009) 3.86
Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. JAMA (1995) 3.83
Coffee and cancer of the pancreas. N Engl J Med (1981) 3.79
Diabetes and the risk of pancreatic cancer. N Engl J Med (1994) 3.78
Does diabetes therapy influence the risk of cancer? Diabetologia (2009) 3.66
Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst (1997) 3.57
Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology (2001) 3.38
Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell Cycle (2009) 3.34
Obesity and cancer: the role of dysfunctional adipose tissue. Cancer Epidemiol Biomarkers Prev (2009) 3.25
Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer. Gastroenterology (2007) 3.20
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol (2005) 3.06
Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16. Diabetes Care (2009) 2.90
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem (2002) 2.87
Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers. JAMA (2005) 2.71
Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer. Br J Cancer (1999) 2.66
Probability of pancreatic cancer following diabetes: a population-based study. Gastroenterology (2005) 2.60
Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res (Phila) (2010) 2.60
Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus. Gastroenterology (2008) 2.58
Impact of diabetes mellitus on outcomes in patients with colon cancer. J Clin Oncol (2003) 2.52
Risk factors for pancreatic cancer: case-control study. Am J Gastroenterol (2007) 2.40
Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth. Cancer Res (2009) 2.36
A multifactorial model for pancreatic cancer in man. Epidemiologic evidence. JAMA (1981) 2.35
A prospective study of pancreatic cancer in the elderly. Int J Cancer (1994) 2.25
Cancer risk in patients with diabetes mellitus. Cancer Causes Control (1991) 2.18
Therapy insight: Influence of type 2 diabetes on the development, treatment and outcomes of cancer. Nat Clin Pract Oncol (2005) 2.15
Clinical usefulness of carbohydrate antigen 19-9 as a screening test for pancreatic cancer in an asymptomatic population. J Gastroenterol Hepatol (2004) 2.12
Improved endothelial function with metformin in type 2 diabetes mellitus. J Am Coll Cardiol (2001) 2.10
Cancer mortality among diabetics. J Natl Cancer Inst (1970) 2.03
Subsequent cancer risk in the incidence cohort of Rochester, Minnesota, residents with diabetes mellitus. J Chronic Dis (1982) 1.99
Exocrine pancreatic cancer, cigarette smoking, and diabetes mellitus: a case-control study in northern Italy. Pancreas (2003) 1.98
Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells. Arterioscler Thromb Vasc Biol (2005) 1.98
Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. Cancer Res (1995) 1.89
Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies. Arch Physiol Biochem (2008) 1.89
Pancreatic cancer, alcohol, diabetes mellitus and gall-bladder disease. Int J Cancer (1989) 1.88
Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. Cancer Prev Res (Phila) (2010) 1.86
Metformin: new understandings, new uses. Drugs (2003) 1.82
Diabetes mellitus and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California. Cancer Epidemiol Biomarkers Prev (2006) 1.81
A case-control study of diabetes mellitus and cancer risk. Br J Cancer (1994) 1.76
Diabetes status and post-load plasma glucose concentration in relation to site-specific cancer mortality: findings from the original Whitehall study. Cancer Causes Control (2004) 1.74
Dietary habits and past medical history as related to fatal pancreas cancer risk among Adventists. Cancer (1988) 1.73
LKB1 and AMPK in cell polarity and division. Trends Cell Biol (2008) 1.72
Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase. Mol Carcinog (2010) 1.69
Effect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects. Diabetes Care (2004) 1.68
Diabetes mellitus and cancer risk: a multisite case-control study. J Chronic Dis (1985) 1.63
Risk of pancreatic cancer following diabetes mellitus: a nationwide cohort study in Sweden. J Natl Cancer Inst (1995) 1.62
Improved glucose metabolism after subtotal pancreatectomy for pancreatic cancer. Br J Surg (1993) 1.62
Diabetes and pancreatic carcinoma. Diabete Metab (1994) 1.59
Risk factors for the development of pancreatic cancer in familial pancreatic cancer kindreds. Gastroenterology (2003) 1.59
Pancreatic cancer is associated with impaired glucose metabolism. Eur J Surg (1993) 1.57
Sulphonylureas and cancer: a case-control study. Acta Diabetol (2008) 1.56
Leptin beyond body weight regulation--current concepts concerning its role in immune function and inflammation. Cell Immunol (2008) 1.55
Tobacco, ethanol, coffee, pancreatitis, diabetes mellitus, and cholelithiasis as risk factors for pancreatic carcinoma. Cancer Causes Control (1993) 1.49
Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. Mol Cell Biol (2003) 1.48
Diet and other risk factors for cancer of the pancreas. Cancer (1985) 1.47
Inflammation and pancreatic cancer: an evidence-based review. Curr Opin Pharmacol (2009) 1.46
Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. Am J Pathol (2003) 1.45
Insulin secretion and action in patients with pancreatic cancer. Cancer (1991) 1.41
Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med (2005) 1.40
Risk of pancreatic cancer in relation to medical history and the use of tobacco, alcohol and coffee. Int J Cancer (1990) 1.40
Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases? Pharmacol Rev (2010) 1.39
Insulin-like growth factor I and transforming growth factor alpha as autocrine growth factors in human pancreatic cancer cell growth. Cancer Res (1990) 1.38
Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. Proc Natl Acad Sci U S A (2002) 1.36
Influence of insulin deprivation on growth of the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats subjected to alloxan diabetes and food restriction. Cancer Res (1972) 1.35
Islet amyloid polypeptide is not a satisfactory marker for detecting pancreatic cancer. Gastroenterology (2001) 1.35
Physiological concentrations of insulin augment pancreatic cancer cell proliferation and glucose utilization by activating MAP kinase, PI3 kinase and enhancing GLUT-1 expression. Pancreas (2000) 1.33
Socio-economic and lifestyle factors associated with the risk of prostate cancer. Br J Cancer (2000) 1.33
Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression. Am J Physiol Endocrinol Metab (2004) 1.33
Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1. J Biol Chem (1991) 1.32
Peroxisome proliferator-activated receptor gamma (PPARgamma) and immunoregulation: enhancement of regulatory T cells through PPARgamma-dependent and -independent mechanisms. J Immunol (2007) 1.32
Aspects of medical history and exocrine carcinoma of the pancreas: a population-based case-control study in The Netherlands. Int J Cancer (1992) 1.31
Diabetes and risk of pancreatic cancer: a pooled analysis of three large case-control studies. Cancer Causes Control (2010) 1.29
A prospective study of medical conditions, anthropometry, physical activity, and pancreatic cancer in male smokers (Finland). Cancer Causes Control (2002) 1.28
Obesity adversely affects survival in pancreatic cancer patients. Cancer (2010) 1.28
Factors influencing survival after total pancreatectomy in patients with pancreatic cancer. Ann Surg (1983) 1.27
Risk of pancreatic cancer in relation to alcohol drinking, coffee consumption and medical history: findings from the Japan collaborative cohort study for evaluation of cancer risk. Int J Cancer (2002) 1.27
Early precursors of pancreatic cancer in college men. J Chronic Dis (1983) 1.26