Published in Nature on June 28, 1979
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Direct transfer of cloned genes from bacteria to mammalian cells. Proc Natl Acad Sci U S A (1980) 6.21
Construction of infectious potato spindle tuber viroid cDNA clones. Nucleic Acids Res (1983) 2.21
Cloned single- and double-stranded DNA copies of potato spindle tuber viroid (PSTV) RNA and co-inoculated subgenomic DNA fragments are infectious. EMBO J (1984) 1.51
The construction of cosmid libraries of eukaryotic DNA using the Homer series of vectors. Nucleic Acids Res (1982) 1.47
In vivo recombination of cauliflower mosaic virus DNA. Proc Natl Acad Sci U S A (1982) 1.46
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Electron microscopic demonstration of the presence of amplified sequences at the 5'-ends of the polyoma virus late mRNAs. Nucleic Acids Res (1980) 0.94
Replication and expression in mammalian cells of transfected DNA; description of an improved erythrocyte ghost fusion technique. Nucleic Acids Res (1983) 0.84
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. Nucleic Acids Res (1981) 35.39
A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal Biochem (1973) 31.32
Mapping of RNA by a modification of the Berk-Sharp procedure: the 5' termini of 15 S beta-globin mRNA precursor and mature 10 s beta-globin mRNA have identical map coordinates. Nucleic Acids Res (1979) 31.23
A specific endonuclease from Arthrobacter luteus. J Mol Biol (1976) 25.89
Lambdoid phages that simplify the recovery of in vitro recombinants. Mol Gen Genet (1977) 16.76
The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med (2001) 11.48
Mice devoid of PrP are resistant to scrapie. Cell (1993) 11.46
Hepatitis B virus genes and their expression in E. coli. Nature (1979) 10.83
Phage lambda receptor chromosomes for DNA fragments made with restriction endonuclease III of Haemophilus influenzae and restriction endonuclease I of Escherichia coli. J Mol Biol (1975) 10.57
Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit beta-globin gene in mouse 3T6 cells. Cell (1983) 9.51
Metabolism of benzoate and the methylbenzoates by Pseudomonas putida (arvilla) mt-2: evidence for the existence of a TOL plasmid. J Bacteriol (1974) 9.37
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature (1992) 9.01
Packaging recombinant DNA molecules into bacteriophage particles in vitro. Proc Natl Acad Sci U S A (1977) 7.42
Polyoma DNA: a physical map. Proc Natl Acad Sci U S A (1974) 7.36
Manipulation of restriction targets in phage lambda to form receptor chromosomes for DNA fragments. Nature (1974) 7.22
Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence. Science (1979) 6.94
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J (1996) 6.66
Recognition sequence of restriction endonuclease III from Hemophilus influenzae. J Mol Biol (1975) 6.23
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A (1978) 6.20
The metabolism of benzoate and methylbenzoates via the meta-cleavage pathway by Pseudomonas arvilla mt-2. Eur J Biochem (1972) 5.98
Molecular cloning of the DNA ligase gene from bacteriophage T4. II. Amplification and preparation of the gene product. J Mol Biol (1979) 5.86
A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J Gen Virol (2000) 5.76
Maternal antibodies block malaria. Nature (1998) 5.67
Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1. Nucleic Acids Res (1979) 5.55
Nucleotide sequence heterogeneity of an RNA phage population. Cell (1978) 5.55
A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron. Cell (1984) 5.37
DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus. Proc Natl Acad Sci U S A (1981) 5.26
Recognition sequence of a restriction enzyme. Nat New Biol (1973) 5.14
Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell (1986) 4.92
Nucleotide sequence analysis with polynucleotide kinase and nucleotide "mapping" methods. 5'-Terminal sequences of deoxyribonucleic acid from bacteriophages lambda and 424. Biochem J (1973) 4.86
The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha. Nature (1980) 4.82
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell (1986) 4.82
Infection of humans and horses by a newly described morbillivirus. Med J Aust (1995) 4.68
Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA. Cell (1986) 4.40
Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene. Nature (1983) 4.38
Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature (1996) 4.25
The metabolic divergence in the meta cleavage of catechols by Pseudomonas putida NCIB 10015. Physiological significance and evolutionary implications. Eur J Biochem (1972) 4.16
Mapping of biological functions on RNA of avian tumor viruses: location of regions required for transformation and determination of host range. Proc Natl Acad Sci U S A (1975) 4.01
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc Natl Acad Sci U S A (1997) 3.88
Rabbit beta-globin mRNA production in mouse L cells transformed with cloned rabbit beta-globin chromosomal DNA. Nature (1979) 3.88
Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns. Nature (1978) 3.86
Precise gene fusion by PCR. Nucleic Acids Res (1989) 3.83
Specific excision of the inserted DNA segment from hybrid plasmids constructed by the poly(dA). poly (dT) method. Biochim Biophys Acta (1976) 3.79
Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes. J Immunol (1987) 3.78
Nucleotide sequence analysis of the leader segments in a cloned copy of adenovirus 2 fiber mRNA. Cell (1979) 3.78
Protein kinase activity associated with polyoma virus middle T antigen in vitro. Cell (1979) 3.78
Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature (1980) 3.78
Inhibitory control in young children and its role in emerging internalization. Child Dev (1996) 3.60
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell (1998) 3.59
Human leukocyte and fibroblast interferons are structurally related. Nature (1980) 3.57
Organization of the genomes of polyoma virus and SV40. Adv Cancer Res (1977) 3.53
High-resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry. Neurogastroenterol Motil (2004) 3.44
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J (1997) 3.34
Retracted Identification by anti-idiotype antibodies of an intracellular membrane protein that recognizes a mammalian endoplasmic reticulum retention signal. Nature (1990) 3.33
Competitive facilitation of drug-resistant Plasmodium falciparum malaria parasites in pregnant women who receive preventive treatment. Proc Natl Acad Sci U S A (2009) 3.30
Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter. Mol Cell Biol (1988) 3.19
Inhibitory control as a contributor to conscience in childhood: from toddler to early school age. Child Dev (1997) 3.16
QB DNA-containing hybrid plasmids giving rise to QB phage formation in the bacterial host. Nature (1978) 3.11
Evidence of functional lymphocytes in some (leaky) scid mice. J Exp Med (1988) 3.09
Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322. Nature (1979) 3.03
Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases. Int J Radiat Oncol Biol Phys (2000) 3.00
The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei. Gene (1980) 2.99
Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell. Nature (1988) 2.99
Nucleotide 'maps' of digests of deoxyribonucleic acid. Biochem J (1970) 2.95
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions. Proc Natl Acad Sci U S A (2003) 2.94
A specific endonuclease from Haemophilus haemolyticus. J Mol Biol (1976) 2.92
Localization of Q-beta maturation cistron ribosome binding site. Nat New Biol (1971) 2.91
Conscious sedation for gastroscopy: patient tolerance and cardiorespiratory parameters. Gastroenterology (1995) 2.91
Helicobacter pylori and symptomatic relapse of gastro-oesophageal reflux disease: a randomised controlled trial. Lancet (2001) 2.88
Health and race in California. Am J Public Health (1971) 2.85
Dental practitioners and ill health retirement: causes, outcomes and re-employment. Br Dent J (2010) 2.83
Restriction and modification in B. subtilis. Purification and general properties of a restriction endonuclease from strain R. Mol Gen Genet (1975) 2.79
Role of catechol and the methylcatechols as inducers of aromatic metabolism in Pseudomonas putida. J Bacteriol (1974) 2.78
The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate. Gene (1976) 2.77
Expression of the hepatitis B virus surface, core and E antigen genes by stable rat and mouse cell lines. J Mol Biol (1982) 2.75
5' cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved 5' GU. Cell (1987) 2.69
A 46-nucleotide promoter segment from an IFN-alpha gene renders an unrelated promoter inducible by virus. Cell (1985) 2.65
Replication of coronavirus MHV-A59 in sac- cells: determination of the first site of budding of progeny virions. Eur J Cell Biol (1984) 2.61
Avian myeloblastosis virus RNA is terminally redundant: implications for the mechanism of retrovirus replication. Cell (1977) 2.55
Appropriateness and diagnostic yield of upper gastrointestinal endoscopy in an open-access endoscopy unit. Endoscopy (1996) 2.55
Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease. Brain (2006) 2.54
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc Natl Acad Sci U S A (2001) 2.53
A mouse locus at which transcription from both DNA strands produces mRNAs complementary at their 3' ends. Nature (1986) 2.53
The nucleotide sequence of a cloned human leukocyte interferon cDNA. Gene (1980) 2.51
Structure and function of phage RNA. Annu Rev Biochem (1973) 2.50
Site of addition of N-acetyl-galactosamine to the E1 glycoprotein of mouse hepatitis virus-A59. J Cell Biol (1988) 2.49
Construction of the genetic map of the polyoma genome. J Virol (1976) 2.49
State and organization of polyoma virus DNA sequences in transformed rat cell lines. J Virol (1979) 2.47
Replication of viral ribonucleic acid. IX. Properties of double-stranded RNA from Escherichia coli infected with bacteriophage MS2. J Mol Biol (1966) 2.45
Quantitative determination and location of newly synthesized virus-specific ribonucleic acid in chicken cells infected with Rous sarcoma virus. J Virol (1973) 2.45
PrP expression in B lymphocytes is not required for prion neuroinvasion. Nat Med (1998) 2.40
Clathrin-coated vesicular transport of secretory proteins during the formation of ACTH-containing secretory granules in AtT20 cells. J Cell Biol (1986) 2.40
At least three human type alpha interferons: structure of alpha 2. Science (1980) 2.38
Structure and expression of cloned murine IFN-alpha genes. Nucleic Acids Res (1983) 2.35