Published in Cancer Microenviron on December 22, 2011
Crosstalk of Oncogenic Signaling Pathways during Epithelial-Mesenchymal Transition. Front Oncol (2014) 1.04
Macrophages and chemokines as mediators of angiogenesis. Front Physiol (2013) 0.98
Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway. Stem Cell Res Ther (2015) 0.90
Putative role of adipose tissue in growth and metabolism of colon cancer cells. Front Oncol (2014) 0.87
Inflammatory factors of the tumor microenvironment induce plasticity in nontransformed breast epithelial cells: EMT, invasion, and collapse of normally organized breast textures. Neoplasia (2013) 0.84
Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice. Oncotarget (2014) 0.84
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression. Nat Med (2015) 0.81
Crosstalk between Tumor Cells and Macrophages in Stroma Renders Tumor Cells as the Primary Source of MCP-1/CCL2 in Lewis Lung Carcinoma. Front Immunol (2015) 0.80
Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis. PLoS One (2014) 0.80
Neem leaf glycoprotein activates CD8(+) T cells to promote therapeutic anti-tumor immunity inhibiting the growth of mouse sarcoma. PLoS One (2013) 0.80
Increased circulating myeloid-derived suppressor cells correlate with cancer stages, interleukin-8 and -6 in prostate cancer. Int J Clin Exp Med (2014) 0.80
Immunosuppression through constitutively activated NF-κB signalling in human ovarian cancer and its reversal by an NF-κB inhibitor. Br J Cancer (2014) 0.80
Core needle biopsy of breast cancer tumors increases distant metastases in a mouse model. Neoplasia (2014) 0.80
Minimal changes in the systemic immune response after nephrectomy of localized renal masses. Urol Oncol (2014) 0.78
Fluoxetine modulates breast cancer metastasis to the brain in a murine model. BMC Cancer (2014) 0.77
Progression of luminal breast tumors is promoted by ménage à trois between the inflammatory cytokine TNFα and the hormonal and growth-supporting arms of the tumor microenvironment. Mediators Inflamm (2013) 0.77
The synthetic parasite-derived peptide GK1 increases survival in a preclinical mouse melanoma model. Cancer Biother Radiopharm (2013) 0.77
A Multifaceted Role for Myd88-Dependent Signaling in Progression of Murine Mammary Carcinoma. Breast Cancer (Auckl) (2016) 0.75
CBP501 suppresses macrophage induced cancer stem cell like features and metastases. Oncotarget (2017) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
Immunity, inflammation, and cancer. Cell (2010) 28.27
Fibroblasts in cancer. Nat Rev Cancer (2006) 18.95
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20
Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 13.41
A perspective on cancer cell metastasis. Science (2011) 13.31
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene (2010) 9.66
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature (2011) 8.62
Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell (2009) 8.21
Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res (2009) 7.83
The interleukin-8 pathway in cancer. Clin Cancer Res (2008) 7.12
Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol (2010) 6.85
Tumor self-seeding by circulating cancer cells. Cell (2009) 6.66
Tumour necrosis factor and cancer. Nat Rev Cancer (2009) 6.27
Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol (2004) 5.07
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell (2009) 4.73
Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle (2006) 4.67
Macrophage polarization in tumour progression. Semin Cancer Biol (2008) 4.62
Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood (2000) 4.34
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest (2010) 4.22
Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia (2010) 3.93
Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res (2000) 3.86
The role of CXC chemokines and their receptors in cancer. Cancer Lett (2008) 3.84
TNF-alpha in promotion and progression of cancer. Cancer Metastasis Rev (2006) 3.14
Chemokines and chemokine receptors: new insights into cancer-related inflammation. Trends Mol Med (2010) 3.10
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis. Cancer Res (2011) 2.96
Tuning inflammation and immunity by chemokine sequestration: decoys and more. Nat Rev Immunol (2006) 2.92
Cancer related inflammation: the macrophage connection. Cancer Lett (2008) 2.88
The inflammatory chemokines CCL2 and CCL5 in breast cancer. Cancer Lett (2008) 2.64
The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies. J Mammary Gland Biol Neoplasia (2009) 2.60
Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma. Cancer (2001) 2.51
CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers. Cancer Lett (2007) 2.43
The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biol (2006) 2.42
Tumor-associated neutrophils: new targets for cancer therapy. Cancer Res (2011) 2.40
Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases. Carcinogenesis (2004) 2.35
Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development. Breast Cancer Res (2003) 2.30
MCP-1: chemoattractant with a role beyond immunity: a review. Clin Chim Acta (2010) 2.29
Macrophages and tissue injury: agents of defense or destruction? Annu Rev Pharmacol Toxicol (2011) 2.28
Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing. BMC Genomics (2010) 2.19
The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia (2010) 2.12
CCL2 (monocyte chemoattractant protein-1) and cancer. Semin Cancer Biol (2004) 2.11
Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell (2003) 2.11
Epithelial to mesenchymal transition and breast cancer. Breast Cancer Res (2009) 2.05
The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity. Cancer Res (2002) 1.99
Why not treat human cancer with interleukin-1 blockade? Cancer Metastasis Rev (2010) 1.96
Oestrogen receptor negative breast cancers exhibit high cytokine content. Breast Cancer Res (2007) 1.95
Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma. Cancer Res (1999) 1.93
Tumor microenvironments direct the recruitment and expansion of human Th17 cells. J Immunol (2009) 1.91
The multifaceted roles of chemokines in malignancy. Cancer Metastasis Rev (2006) 1.90
Vasculogenesis and angiogenesis. Cancer Treat Res (2004) 1.83
Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem (2009) 1.81
Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression. Int J Cancer (2009) 1.80
Expression of CCR2 by endothelial cells : implications for MCP-1 mediated wound injury repair and In vivo inflammatory activation of endothelium. Arterioscler Thromb Vasc Biol (1999) 1.80
Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1. Int J Cancer (1999) 1.79
A chemokine receptor antagonist inhibits experimental breast tumor growth. Cancer Res (2003) 1.78
Tumor necrosis factor alpha as a new target for renal cell carcinoma: two sequential phase II trials of infliximab at standard and high dose. J Clin Oncol (2007) 1.78
Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J Neurosci (2007) 1.77
Involvement of a novel chemokine decoy receptor CCX-CKR in breast cancer growth, metastasis and patient survival. Clin Cancer Res (2009) 1.77
Molecular profiling of inflammatory breast cancer: identification of a poor-prognosis gene expression signature. Clin Cancer Res (2004) 1.77
TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunol Rev (2009) 1.76
Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism. Blood (1994) 1.76
Is interleukin-1 a good or bad 'guy' in tumor immunobiology and immunotherapy? Immunol Rev (2008) 1.76
IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells. Oncogene (2003) 1.72
Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression. Cancer Res (2005) 1.72
Chemokines as mediators of neovascularization. Arterioscler Thromb Vasc Biol (2008) 1.71
NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Cancer Lett (2010) 1.67
Tumor necrosis factor: a master-regulator of leukocyte movement. Immunol Today (2000) 1.65
TGFbeta/TNF(alpha)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype. Cancer Res (2011) 1.65
Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition. BMC Cancer (2011) 1.63
Expression of monocyte chemotactic protein-1 in human invasive ductal breast cancer. Pathol Res Pract (1998) 1.60
A phase II study of etanercept (Enbrel), a tumor necrosis factor alpha inhibitor in patients with metastatic breast cancer. Clin Cancer Res (2004) 1.56
Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction. J Biol Chem (2009) 1.56
Tumor necrosis factor, cancer and anticancer therapy. Cytokine Growth Factor Rev (2004) 1.55
Cancer and inflammation: implications for pharmacology and therapeutics. Clin Pharmacol Ther (2010) 1.54
Expression of interleukin-1beta in human breast carcinoma. Cancer (1997) 1.52
A potential role for interleukin-8 in the metastatic phenotype of breast carcinoma cells. Am J Pathol (2001) 1.51
A clinical study assessing the tolerability and biological effects of infliximab, a TNF-alpha inhibitor, in patients with advanced cancer. Ann Oncol (2008) 1.50
Chemokines: novel targets for breast cancer metastasis. Cancer Metastasis Rev (2007) 1.49
Expression of cytokine messenger RNA in normal and neoplastic human breast tissue: identification of interleukin-8 as a potential regulatory factor in breast tumours. Int J Cancer (1997) 1.47
Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma. Br J Cancer (1998) 1.46
CCL2 regulates angiogenesis via activation of Ets-1 transcription factor. J Immunol (2006) 1.44
CXC chemokines in cancer angiogenesis and metastases. Adv Cancer Res (2010) 1.44
Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy. J Leukoc Biol (2010) 1.42
ERalpha-negative and triple negative breast cancer: molecular features and potential therapeutic approaches. Biochim Biophys Acta (2009) 1.41
The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci. Int J Exp Pathol (2007) 1.39
Epithelial-mesenchymal transition. Cancer Res (2008) 1.37
Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-alpha. Fibrogenesis Tissue Repair (2010) 1.37
Cancer: Macrophages limit chemotherapy. Nature (2011) 1.36
Identification of interleukin-8 as estrogen receptor-regulated factor involved in breast cancer invasion and angiogenesis by protein arrays. Int J Cancer (2004) 1.36
Expression of tumour necrosis factor (TNF alpha) and its receptors in benign and malignant breast tissue. Int J Cancer (1994) 1.35
Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype. Breast Cancer Res (2008) 1.35
The interleukin-1 family of cytokines and receptors in human breast cancer: implications for tumor progression. Int J Oncol (2003) 1.33
Chemokines and their receptors guiding T lymphocyte recruitment in lung inflammation. Am J Respir Crit Care Med (2001) 1.32
The chemokine receptors CXCR4 and CXCR3 in cancer. Curr Oncol Rep (2009) 1.29
Human neutrophils facilitate tumor cell transendothelial migration. Am J Physiol Cell Physiol (2001) 1.29
Interleukin-8 modulates growth and invasiveness of estrogen receptor-negative breast cancer cells. Int J Cancer (2007) 1.26
Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation. Thorax (2009) 1.26
Concomitant expression of the chemokines RANTES and MCP-1 in human breast cancer: a basis for tumor-promoting interactions. Cytokine (2008) 1.25
Breast-cancer-associated metastasis is significantly increased in a model of autoimmune arthritis. Breast Cancer Res (2009) 1.25