Published in Genes Dev on January 01, 2012
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell (2012) 6.80
The Hippo pathway and human cancer. Nat Rev Cancer (2013) 5.17
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β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell (2012) 3.33
Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell (2014) 3.15
Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol (2012) 3.07
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov (2013) 3.03
The emerging roles of YAP and TAZ in cancer. Nat Rev Cancer (2015) 2.74
The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Proc Natl Acad Sci U S A (2012) 2.51
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell (2015) 2.31
The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway. Semin Cell Dev Biol (2012) 2.21
Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell (2013) 2.16
Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells. Nat Mater (2014) 2.09
Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex. Cell (2014) 1.98
MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis. Dev Cell (2013) 1.95
Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol (2013) 1.86
Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes Dev (2012) 1.86
The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep (2014) 1.73
Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis. J Cell Sci (2013) 1.63
Protein kinases of the Hippo pathway: regulation and substrates. Semin Cell Dev Biol (2012) 1.61
Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila. Cell (2016) 1.54
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol (2015) 1.53
AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat Cell Biol (2015) 1.47
Mechanisms of Hippo pathway regulation. Genes Dev (2016) 1.45
cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. EMBO J (2013) 1.42
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev (2013) 1.40
Angiomotins link F-actin architecture to Hippo pathway signaling. Mol Biol Cell (2014) 1.32
The Hippo-YAP signaling pathway and contact inhibition of growth. J Cell Sci (2014) 1.29
YAP and TAZ: a nexus for Hippo signaling and beyond. Trends Cell Biol (2015) 1.29
Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein. Cell Rep (2014) 1.28
Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases. Proc Natl Acad Sci U S A (2013) 1.27
Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis. J Biol Chem (2013) 1.27
Growth control by committee: intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signaling. Dev Cell (2012) 1.26
PTPN14 is required for the density-dependent control of YAP1. Genes Dev (2012) 1.23
Alternative Wnt Signaling Activates YAP/TAZ. Cell (2015) 1.21
Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase. Nat Commun (2013) 1.12
Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes Dev (2015) 1.12
Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J (2015) 1.11
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun (2015) 1.11
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. Mol Syst Biol (2013) 1.10
Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling. Cell Biosci (2013) 1.09
Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms. Nat Commun (2013) 1.09
Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway. Cell Res (2015) 1.09
Regulation of the Hippo pathway and implications for anticancer drug development. Trends Pharmacol Sci (2013) 1.07
Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway. J Cell Biol (2015) 1.05
The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl. Cell Death Differ (2013) 1.04
Bringing balance by force: live cell extrusion controls epithelial cell numbers. Trends Cell Biol (2012) 1.04
Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression. Cancer Discov (2015) 0.98
The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila. Dev Cell (2014) 0.98
Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila. EMBO Rep (2012) 0.98
Regulation of YAP by mechanical strain through Jnk and Hippo signaling. Curr Biol (2014) 0.98
Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion. Mol Biol Cell (2014) 0.96
Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer. Cell Oncol (Dordr) (2013) 0.96
Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Oncogene (2014) 0.96
Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration. Oncogene (2014) 0.95
Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst. Dev Biol (2014) 0.95
Interplay of Stem Cell Characteristics, EMT, and Microtentacles in Circulating Breast Tumor Cells. Cancers (Basel) (2013) 0.94
Elevated YAP and its downstream targets CCN1 and CCN2 in basal cell carcinoma: impact on keratinocyte proliferation and stromal cell activation. Am J Pathol (2014) 0.93
ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors. Cancer Cell (2015) 0.93
Control of organ growth by patterning and hippo signaling in Drosophila. Cold Spring Harb Perspect Biol (2015) 0.92
Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers. FEBS Open Bio (2015) 0.92
Upstream regulators of the Hippo pathway. Cell Cycle (2012) 0.91
The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells. Mol Cell Biol (2015) 0.91
Integration of mechanical and chemical signals by YAP and TAZ transcription coactivators. Cell Biosci (2013) 0.91
Actin cytoskeleton regulates Hippo signaling. PLoS One (2013) 0.91
Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells. Biophys J (2015) 0.91
Estrogen regulates Hippo signaling via GPER in breast cancer. J Clin Invest (2015) 0.91
The hippo pathway in heart development, regeneration, and diseases. Circ Res (2015) 0.91
ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence. Cell Death Differ (2013) 0.91
What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease. Exp Eye Res (2013) 0.90
The role of the hippo pathway in melanocytes and melanoma. Front Oncol (2013) 0.90
Molecular Pathways: Hippo Signaling, a Critical Tumor Suppressor. Clin Cancer Res (2015) 0.90
microRNA 31 functions as an endometrial cancer oncogene by suppressing Hippo tumor suppressor pathway. Mol Cancer (2014) 0.90
Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation. EMBO J (2015) 0.89
Impact of the physical microenvironment on tumor progression and metastasis. Curr Opin Biotechnol (2016) 0.89
Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression. Oncotarget (2015) 0.89
Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade. Dev Cell (2015) 0.89
Mechanical force sensing in tissues. Prog Mol Biol Transl Sci (2014) 0.89
A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis. Cell Res (2015) 0.89
Prioritizing therapeutic targets using patient-derived xenograft models. Biochim Biophys Acta (2015) 0.88
A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas. Front Oncol (2015) 0.88
Stochastic profiling of transcriptional regulatory heterogeneities in tissues, tumors and cultured cells. Nat Protoc (2013) 0.88
Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network. Trends Cell Biol (2016) 0.88
Mutual regulation between Hippo signaling and actin cytoskeleton. Protein Cell (2013) 0.87
The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway. Oncotarget (2014) 0.87
Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep (2016) 0.86
Structural basis for the phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein crumbs and the actin-binding protein moesin. J Biol Chem (2015) 0.86
The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation. Protein Cell (2012) 0.86
miR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells. Br J Cancer (2015) 0.85
Tead and AP1 Coordinate Transcription and Motility. Cell Rep (2016) 0.85
Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci U S A (2016) 0.84
YAP Nuclear Localization in the Absence of Cell-Cell Contact Is Mediated by a Filamentous Actin-dependent, Myosin II- and Phospho-YAP-independent Pathway during Extracellular Matrix Mechanosensing. J Biol Chem (2016) 0.83
Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix. Mol Carcinog (2013) 0.83
The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol (2016) 0.82
mTORC2 regulates cardiac response to stress by inhibiting MST1. Cell Rep (2015) 0.82
Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Sci Signal (2015) 0.81
Arhgef7 promotes activation of the Hippo pathway core kinase Lats. EMBO J (2014) 0.81
β-Spectrin regulates the hippo signaling pathway and modulates the basal actin network. J Biol Chem (2015) 0.81
Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy. Structure (2015) 0.81
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Integrative genomic profiling of human prostate cancer. Cancer Cell (2010) 23.61
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Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell (2007) 13.04
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72
Role of YAP/TAZ in mechanotransduction. Nature (2011) 11.56
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell (2005) 10.61
The hippo signaling pathway in development and cancer. Dev Cell (2010) 10.54
TEAD mediates YAP-dependent gene induction and growth control. Genes Dev (2008) 9.88
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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell (2003) 7.43
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39
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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell (2003) 6.48
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Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol (2003) 5.50
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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev (1995) 5.27
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The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell (2009) 5.19
Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development (1995) 5.18
Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell (2005) 5.10
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol (2008) 5.02
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A (2010) 4.95
Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell (2011) 4.85
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol (2003) 4.84
Expression of Yes-associated protein in common solid tumors. Hum Pathol (2008) 4.61
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell (2010) 4.59
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A (2010) 4.17
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene (2005) 3.64
The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev (2003) 3.53
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The extracellular matrix at a glance. J Cell Sci (2010) 3.37
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol (2009) 3.26
The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci U S A (2010) 3.18
Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev (2011) 3.15
Anoikis: a necessary death program for anchorage-dependent cells. Biochem Pharmacol (2008) 2.96
Hippo pathway regulation by cell morphology and stress fibers. Development (2011) 2.94
Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development (2002) 2.82
Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J (2011) 2.75
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol (2008) 2.62
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc Natl Acad Sci U S A (2011) 2.61
Hippo pathway-independent restriction of TAZ and YAP by angiomotin. J Biol Chem (2011) 2.47
The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem (2010) 2.27
Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res (2011) 2.21
Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Development (2011) 2.20
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TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem (2009) 3.20
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