Published in Science on January 05, 2012
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TALENs: a widely applicable technology for targeted genome editing. Nat Rev Mol Cell Biol (2012) 7.01
TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction. Nucleic Acids Res (2012) 4.45
Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome. PLoS Genet (2012) 4.42
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains. Nat Commun (2012) 3.60
TAL effector RVD specificities and efficiencies. Nat Biotechnol (2012) 3.12
Engineering synthetic TAL effectors with orthogonal target sites. Nucleic Acids Res (2012) 2.25
Overcoming transcription activator-like effector (TALE) DNA binding domain sensitivity to cytosine methylation. J Biol Chem (2012) 2.25
Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Nucleic Acids Res (2012) 2.09
Advances in targeted genome editing. Curr Opin Chem Biol (2012) 1.97
Quantitative analysis of TALE-DNA interactions suggests polarity effects. Nucleic Acids Res (2013) 1.88
Single molecule real-time sequencing of Xanthomonas oryzae genomes reveals a dynamic structure and complex TAL (transcription activator-like) effector gene relationships. Microb Genom (2015) 1.72
Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology. PLoS One (2012) 1.52
A cut above the rest: targeted genome editing technologies in human pluripotent stem cells. J Biol Chem (2013) 1.47
The TAL effector PthA4 interacts with nuclear factors involved in RNA-dependent processes including a HMG protein that selectively binds poly(U) RNA. PLoS One (2012) 1.44
Genome-editing Technologies for Gene and Cell Therapy. Mol Ther (2016) 1.41
Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities. PLoS Biol (2016) 1.38
Targeting G with TAL effectors: a comparison of activities of TALENs constructed with NN and NK repeat variable di-residues. PLoS One (2012) 1.38
Chimeric TALE recombinases with programmable DNA sequence specificity. Nucleic Acids Res (2012) 1.38
Transcription activator-like effector hybrids for conditional control and rewiring of chromosomal transgene expression. Sci Rep (2012) 1.37
Dissection of TALE-dependent gene activation reveals that they induce transcription cooperatively and in both orientations. PLoS One (2017) 1.37
Precision editing of large animal genomes. Adv Genet (2012) 1.34
Crystal structure of a TALE protein reveals an extended N-terminal DNA binding region. Cell Res (2012) 1.26
Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering. PLoS One (2014) 1.24
TAL effectors: highly adaptable phytobacterial virulence factors and readily engineered DNA-targeting proteins. Trends Cell Biol (2013) 1.24
Human pluripotent stem cells: an emerging model in developmental biology. Development (2013) 1.22
Type II restriction endonucleases--a historical perspective and more. Nucleic Acids Res (2014) 1.22
Nuclease-mediated gene editing by homologous recombination of the human globin locus. Nucleic Acids Res (2013) 1.22
High-throughput genomic sequencing of cassava bacterial blight strains identifies conserved effectors to target for durable resistance. Proc Natl Acad Sci U S A (2012) 1.20
Structural basis for RNA recognition by a dimeric PPR-protein complex. Nat Struct Mol Biol (2013) 1.12
Advances in genome editing technology and its promising application in evolutionary and ecological studies. Gigascience (2014) 1.11
Spontaneous dominant mutations in chlamydomonas highlight ongoing evolution by gene diversification. Plant Cell (2015) 1.09
Directed evolution of the TALE N-terminal domain for recognition of all 5' bases. Nucleic Acids Res (2013) 1.08
An improved method for TAL effectors DNA-binding sites prediction reveals functional convergence in TAL repertoires of Xanthomonas oryzae strains. PLoS One (2013) 1.07
Compact designer TALENs for efficient genome engineering. Nat Commun (2013) 1.06
Computational predictions provide insights into the biology of TAL effector target sites. PLoS Comput Biol (2013) 1.04
Comprehensive analysis of the specificity of transcription activator-like effector nucleases. Nucleic Acids Res (2014) 1.04
Two- and three-input TALE-based AND logic computation in embryonic stem cells. Nucleic Acids Res (2013) 1.03
Structure of the AvrBs3-DNA complex provides new insights into the initial thymine-recognition mechanism. Acta Crystallogr D Biol Crystallogr (2013) 1.01
Code-assisted discovery of TAL effector targets in bacterial leaf streak of rice reveals contrast with bacterial blight and a novel susceptibility gene. PLoS Pathog (2014) 1.00
An efficient strategy for TALEN-mediated genome engineering in Drosophila. Nucleic Acids Res (2013) 0.99
Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA. Nat Protoc (2013) 0.99
TAL effectors: function, structure, engineering and applications. Curr Opin Struct Biol (2012) 0.99
Plant microRNAs display differential 3' truncation and tailing modifications that are ARGONAUTE1 dependent and conserved across species. Plant Cell (2013) 0.98
Rational design of α-helical tandem repeat proteins with closed architectures. Nature (2015) 0.97
New and TALENted genome engineering toolbox. Circ Res (2013) 0.96
On the front line: structural insights into plant-pathogen interactions. Nat Rev Microbiol (2013) 0.95
Control of repeat-protein curvature by computational protein design. Nat Struct Mol Biol (2015) 0.95
High efficiency In Vivo genome engineering with a simplified 15-RVD GoldyTALEN design. PLoS One (2013) 0.95
Molecular dynamics simulations of DNA-free and DNA-bound TAL effectors. PLoS One (2013) 0.94
Targeted genome modification technologies and their applications in crop improvements. Plant Cell Rep (2013) 0.93
Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression. Methods (2014) 0.93
Combinatorial gene editing in mammalian cells using ssODNs and TALENs. Sci Rep (2014) 0.92
Programmable DNA-binding proteins from Burkholderia provide a fresh perspective on the TALE-like repeat domain. Nucleic Acids Res (2014) 0.92
Activities and specificities of homodimeric TALENs in Saccharomyces cerevisiae. Curr Genet (2013) 0.92
Expanding the scope of site-specific recombinases for genetic and metabolic engineering. Biotechnol Bioeng (2013) 0.92
Characterization and DNA-binding specificities of Ralstonia TAL-like effectors. Mol Plant (2013) 0.92
Structural modeling of TAL effector-DNA interactions. Protein Sci (2012) 0.91
Using defined finger-finger interfaces as units of assembly for constructing zinc-finger nucleases. Nucleic Acids Res (2013) 0.91
Enabling functional genomics with genome engineering. Genome Res (2015) 0.90
Pentatricopeptide repeats: modular blocks for building RNA-binding proteins. RNA Biol (2013) 0.90
TALEN and CRISPR/Cas Genome Editing Systems: Tools of Discovery. Acta Naturae (2014) 0.89
Homing endonucleases: from genetic anomalies to programmable genomic clippers. Methods Mol Biol (2014) 0.89
Atomistic modeling of protein-DNA interaction specificity: progress and applications. Curr Opin Struct Biol (2012) 0.88
Repeat 1 of TAL effectors affects target specificity for the base at position zero. Nucleic Acids Res (2014) 0.88
Precise gene modification mediated by TALEN and single-stranded oligodeoxynucleotides in human cells. PLoS One (2014) 0.88
BurrH: a new modular DNA binding protein for genome engineering. Sci Rep (2014) 0.88
Identification of putative TAL effector targets of the citrus canker pathogens shows functional convergence underlying disease development and defense response. BMC Genomics (2014) 0.88
Continuous directed evolution of DNA-binding proteins to improve TALEN specificity. Nat Methods (2015) 0.88
Predicting promoters targeted by TAL effectors in plant genomes: from dream to reality. Front Plant Sci (2013) 0.87
Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells. Nucleic Acids Res (2013) 0.87
TAL effector specificity for base 0 of the DNA target is altered in a complex, effector- and assay-dependent manner by substitutions for the tryptophan in cryptic repeat -1. PLoS One (2013) 0.87
Revisiting the TALE repeat. Protein Cell (2014) 0.86
Imaging Specific Genomic DNA in Living Cells. Annu Rev Biophys (2016) 0.86
Genome-editing technologies and their potential application in horticultural crop breeding. Hortic Res (2015) 0.86
Screening for protein-DNA interactions by automatable DNA-protein interaction ELISA. PLoS One (2013) 0.86
Complete decoding of TAL effectors for DNA recognition. Cell Res (2014) 0.85
TAL effectors specificity stems from negative discrimination. PLoS One (2013) 0.85
TALEN gene editing takes aim on HIV. Hum Genet (2016) 0.84
TAL effectors: tools for DNA targeting. Brief Funct Genomics (2014) 0.83
Precision genetic modifications: a new era in molecular biology and crop improvement. Planta (2014) 0.83
Direct observation of TALE protein dynamics reveals a two-state search mechanism. Nat Commun (2015) 0.83
Origins of Programmable Nucleases for Genome Engineering. J Mol Biol (2015) 0.83
TAL effectors and the executor R genes. Front Plant Sci (2015) 0.82
CRISPR-Cas9: Tool for Qualitative and Quantitative Plant Genome Editing. Front Plant Sci (2016) 0.82
QueTAL: a suite of tools to classify and compare TAL effectors functionally and phylogenetically. Front Plant Sci (2015) 0.82
Generation of GFP Reporter Human Induced Pluripotent Stem Cells Using AAVS1 Safe Harbor Transcription Activator-Like Effector Nuclease. Curr Protoc Stem Cell Biol (2014) 0.81
Application of TALEs, CRISPR/Cas and sRNAs as trans-acting regulators in prokaryotes. Curr Opin Biotechnol (2014) 0.81
Consensus design of a NOD receptor leucine rich repeat domain with binding affinity for a muramyl dipeptide, a bacterial cell wall fragment. Protein Sci (2014) 0.81
TAL effectors target the C-terminal domain of RNA polymerase II (CTD) by inhibiting the prolyl-isomerase activity of a CTD-associated cyclophilin. PLoS One (2012) 0.81
AnnoTALE: bioinformatics tools for identification, annotation, and nomenclature of TALEs from Xanthomonas genomic sequences. Sci Rep (2016) 0.81
Behind the lines-actions of bacterial type III effector proteins in plant cells. FEMS Microbiol Rev (2016) 0.80
TALE-PvuII fusion proteins--novel tools for gene targeting. PLoS One (2013) 0.80
Exploiting pathogens' tricks of the trade for engineering of plant disease resistance: challenges and opportunities. Microb Biotechnol (2013) 0.80
Transcription activator-like effectors: a toolkit for synthetic biology. ACS Synth Biol (2014) 0.80
TALEs from a spring--superelasticity of Tal effector protein structures. PLoS One (2014) 0.80
BuD, a helix-loop-helix DNA-binding domain for genome modification. Acta Crystallogr D Biol Crystallogr (2014) 0.80
Emerging aspects of treatment in mitochondrial disorders. J Inherit Metab Dis (2015) 0.79
Optimized tuning of TALEN specificity using non-conventional RVDs. Sci Rep (2015) 0.79
Refined requirements for protein regions important for activity of the TALE AvrBs3. PLoS One (2015) 0.79
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
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A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
WHAT IF: a molecular modeling and drug design program. J Mol Graph (1990) 24.35
Breaking the code of DNA binding specificity of TAL-type III effectors. Science (2009) 22.33
A simple cipher governs DNA recognition by TAL effectors. Science (2009) 19.99
Macromolecular TLS refinement in REFMAC at moderate resolutions. Methods Enzymol (2003) 9.69
TAL effectors: customizable proteins for DNA targeting. Science (2011) 9.47
Xanthomonas AvrBs3 family-type III effectors: discovery and function. Annu Rev Phytopathol (2010) 7.70
The RCSB Protein Data Bank: redesigned web site and web services. Nucleic Acids Res (2010) 7.68
TPR proteins: the versatile helix. Trends Biochem Sci (2003) 7.37
ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules. Methods Enzymol (2011) 7.33
TAL effectors: finding plant genes for disease and defense. Curr Opin Plant Biol (2010) 7.13
Origins of specificity in protein-DNA recognition. Annu Rev Biochem (2010) 4.43
Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene. Science (2007) 4.39
A bacterial effector acts as a plant transcription factor and induces a cell size regulator. Science (2007) 4.27
SuperPose: a simple server for sophisticated structural superposition. Nucleic Acids Res (2004) 4.09
Os8N3 is a host disease-susceptibility gene for bacterial blight of rice. Proc Natl Acad Sci U S A (2006) 3.94
Promoter elements of rice susceptibility genes are bound and activated by specific TAL effectors from the bacterial blight pathogen, Xanthomonas oryzae pv. oryzae. New Phytol (2010) 3.27
Two new complete genome sequences offer insight into host and tissue specificity of plant pathogenic Xanthomonas spp. J Bacteriol (2011) 1.80
Colonization of rice leaf blades by an African strain of Xanthomonas oryzae pv. oryzae depends on a new TAL effector that induces the rice nodulin-3 Os11N3 gene. Mol Plant Microbe Interact (2011) 1.54
The repeat domain of the type III effector protein PthA shows a TPR-like structure and undergoes conformational changes upon DNA interaction. Proteins (2010) 1.51
Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat. Nat Struct Mol Biol (2010) 1.12
The interaction of RNA with TRAP: the role of triplet repeats and separating spacer nucleotides. J Mol Biol (2004) 1.11
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A simple cipher governs DNA recognition by TAL effectors. Science (2009) 19.99
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting. Nucleic Acids Res (2011) 16.53
Targeting DNA double-strand breaks with TAL effector nucleases. Genetics (2010) 14.49
Design of a novel globular protein fold with atomic-level accuracy. Science (2003) 13.06
High-resolution structure prediction and the crystallographic phase problem. Nature (2007) 7.67
De novo computational design of retro-aldol enzymes. Science (2008) 7.62
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Res (2003) 7.56
ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules. Methods Enzymol (2011) 7.33
TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction. Nucleic Acids Res (2012) 4.45
Protein-protein docking with backbone flexibility. J Mol Biol (2007) 4.32
Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction. Science (2010) 4.32
Computational redesign of endonuclease DNA binding and cleavage specificity. Nature (2006) 4.06
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Understanding the functions of plant disease resistance proteins. Annu Rev Plant Biol (2003) 3.57
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Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home. Proteins (2007) 3.01
Computational thermostabilization of an enzyme. Science (2005) 2.79
Structure of a tRNA repair enzyme and molecular biology workhorse: T4 polynucleotide kinase. Structure (2002) 2.56
Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99A. BMC Genomics (2008) 2.51
Transcription activator-like effector nucleases enable efficient plant genome engineering. Plant Physiol (2012) 2.36
Prediction of the structure of symmetrical protein assemblies. Proc Natl Acad Sci U S A (2007) 2.35
Design, activity, and structure of a highly specific artificial endonuclease. Mol Cell (2002) 2.25
Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor. Genes Dev (2003) 2.23
Increased Diels-Alderase activity through backbone remodeling guided by Foldit players. Nat Biotechnol (2012) 2.19
Xanthomonas oryzae pathovars: model pathogens of a model crop. Mol Plant Pathol (2006) 2.14
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The tertiary structure and domain organization of coagulation factor VIII. Blood (2007) 1.96
Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface. J Mol Biol (2006) 1.93
Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI. J Mol Biol (2003) 1.93
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The structure of Escherichia coli cytosine deaminase. J Mol Biol (2002) 1.81
Pathogenomics of Xanthomonas: understanding bacterium-plant interactions. Nat Rev Microbiol (2011) 1.81
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Homing endonuclease I-CreI derivatives with novel DNA target specificities. Nucleic Acids Res (2006) 1.75
Natural and engineered nicking endonucleases--from cleavage mechanism to engineering of strand-specificity. Nucleic Acids Res (2010) 1.66
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus. Nat Immunol (2013) 1.66
Structures of the rare-cutting restriction endonuclease NotI reveal a unique metal binding fold involved in DNA binding. Structure (2008) 1.64
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs. Nucleic Acids Res (2010) 1.58
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Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. Nat Chem Biol (2012) 1.50
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Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template. Nucleic Acids Res (2010) 1.32
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Extensive protein and DNA backbone sampling improves structure-based specificity prediction for C2H2 zinc fingers. Nucleic Acids Res (2011) 1.27
TALEN-mediated editing of the mouse Y chromosome. Nat Biotechnol (2013) 1.26
The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy. Structure (2003) 1.26
TAL effectors: highly adaptable phytobacterial virulence factors and readily engineered DNA-targeting proteins. Trends Cell Biol (2013) 1.24
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NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. J Biol Chem (2002) 1.15
The restriction fold turns to the dark side: a bacterial homing endonuclease with a PD-(D/E)-XK motif. EMBO J (2007) 1.15
Combined covalent-electrostatic model of hydrogen bonding improves structure prediction with Rosetta. J Chem Theory Comput (2015) 1.15
Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Eng Des Sel (2004) 1.14
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RosettaDock in CAPRI rounds 6-12. Proteins (2007) 1.08
The crystal structure and mutational analysis of human NUDT9. J Mol Biol (2003) 1.07
Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases. Nucleic Acids Res (2007) 1.07
Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease family. Nucleic Acids Res (2009) 1.05
Inhibition of resistance gene-mediated defense in rice by Xanthomonas oryzae pv. oryzicola. Mol Plant Microbe Interact (2006) 1.05
Characterization and crystal structure of the type IIG restriction endonuclease RM.BpuSI. Nucleic Acids Res (2011) 1.03
Arabidopsis and Brachypodium distachyon transgenic plants expressing Aspergillus nidulans acetylesterases have decreased degree of polysaccharide acetylation and increased resistance to pathogens. Plant Physiol (2013) 1.02
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases. Nucleic Acids Res (2012) 1.02
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Analyses of the secretomes of Erwinia amylovora and selected hrp mutants reveal novel type III secreted proteins and an effect of HrpJ on extracellular harpin levels. Mol Plant Pathol (2007) 0.98
The role of horizontal transfer in the evolution of a highly variable lipopolysaccharide biosynthesis locus in xanthomonads that infect rice, citrus and crucifers. BMC Evol Biol (2007) 0.98
Alanine-scanning mutagenesis reveals a cytosine deaminase mutant with altered substrate preference. Biochemistry (2004) 0.98
Host-induced gene silencing in barley powdery mildew reveals a class of ribonuclease-like effectors. Mol Plant Microbe Interact (2013) 0.96
I-BasI and I-HmuI: two phage intron-encoded endonucleases with homologous DNA recognition sequences but distinct DNA specificities. J Mol Biol (2006) 0.96
Mutability of an HNH nuclease imidazole general base and exchange of a deprotonation mechanism. Biochemistry (2007) 0.95
Novel candidate virulence factors in rice pathogen Xanthomonas oryzae pv. oryzicola as revealed by mutational analysis. Appl Environ Microbiol (2007) 0.95
Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic design. PLoS One (2013) 0.94
Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases. Nucleic Acids Res (2008) 0.94
Computational design of an unnatural amino acid dependent metalloprotein with atomic level accuracy. J Am Chem Soc (2013) 0.93
Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution. J Mol Biol (2006) 0.93
Structure-based prediction of protein-peptide specificity in Rosetta. Proteins (2010) 0.92