Neuronal autophagy and neurodegenerative diseases.

FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci (2014) 1.32

Essential role for autophagy in life span extension. J Clin Invest (2015) 1.25

Insulin action in brain regulates systemic metabolism and brain function. Diabetes (2014) 1.18

Autophagic/lysosomal dysfunction in Alzheimer's disease. Alzheimers Res Ther (2013) 1.01

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells. Autophagy (2013) 0.96

Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells. Mol Vis (2012) 0.94

Ion channels and apoptosis in cancer. Philos Trans R Soc Lond B Biol Sci (2014) 0.91

Calcium regulation of neural rhythms, memory and Alzheimer's disease. J Physiol (2013) 0.91

Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1. Hum Mol Genet (2014) 0.90

Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis. J Biol Chem (2012) 0.89

Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders. Autophagy (2016) 0.88

Rapid generation of mitochondrial superoxide induces mitochondrion-dependent but caspase-independent cell death in hippocampal neuronal cells that morphologically resembles necroptosis. Toxicol Appl Pharmacol (2012) 0.88

Increased carbonylation, protein aggregation and apoptosis in the spinal cord of mice with experimental autoimmune encephalomyelitis. ASN Neuro (2013) 0.88

RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis. Front Mol Neurosci (2013) 0.87

p62 expression and autophagy in αB-crystallin R120G mutant knock-in mouse model of hereditary cataract. Exp Eye Res (2013) 0.87

Autophagy in Drosophila: from historical studies to current knowledge. Biomed Res Int (2014) 0.85

Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease. Neurobiol Dis (2014) 0.83

Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion. Sci Rep (2015) 0.81

Moderate Hypothermia Significantly Decreases Hippocampal Cell Death Involving Autophagy Pathway after Moderate Traumatic Brain Injury. J Neurotrauma (2015) 0.81

Cellular prion protein (PrP(C)) and its role in stress responses. Int J Clin Exp Med (2015) 0.81

Autophagy dysregulation in cell culture and animals models of spinal muscular atrophy. Mol Cell Neurosci (2014) 0.80

E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy. PLoS One (2014) 0.80

Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal. World J Diabetes (2015) 0.80

Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons. Oxid Med Cell Longev (2014) 0.79

KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses. Dev Cell (2016) 0.79

Plasmodium falciparum erythrocytic stage parasites require the putative autophagy protein PfAtg7 for normal growth. PLoS One (2013) 0.79

TBK1: a new player in ALS linking autophagy and neuroinflammation. Mol Brain (2017) 0.78

Not on the menu: autophagy-independent clearance of prions. Prion (2013) 0.78

Protein recycling pathways in neurodegenerative diseases. Alzheimers Res Ther (2014) 0.77

Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')--induced neurotoxicity in cultured cortical neurons. PLoS One (2014) 0.77

Identification of novel autophagic Radix Polygalae fraction by cell membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins. Sci Rep (2015) 0.77

Nigrostriatal dynein changes in A53T alpha-synuclein transgenic mice. F1000Res (2014) 0.76

Intermittent fasting is neuroprotective in focal cerebral ischemia by minimizing autophagic flux disturbance and inhibiting apoptosis. Exp Ther Med (2016) 0.76

TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin. Aging (Albany NY) (2016) 0.75

Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model. Int J Mol Sci (2016) 0.75

Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid. J Parkinsons Dis (2016) 0.75

TSC but not PTEN loss in starving cones of retinitis pigmentosa mice leads to an autophagy defect and mTORC1 dissociation from the lysosome. Cell Death Dis (2016) 0.75

The Temporal Pattern, Flux, and Function of Autophagy in Spinal Cord Injury. Int J Mol Sci (2017) 0.75

Lack of collagen VI promotes neurodegeneration by impairing autophagy and inducing apoptosis during aging. Aging (Albany NY) (2016) 0.75

Atomic force microscopy as an advanced tool in neuroscience. Transl Neurosci (2015) 0.75

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities? Front Mol Neurosci (2017) 0.75

Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling. J Neuroendocrinol (2016) 0.75

Tribbles Pseudokinase 3 Induces Both Apoptosis and Autophagy in Amyloid-β induced Neuronal Death. J Biol Chem (2016) 0.75

Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson's Disease. Parkinsons Dis (2016) 0.75

Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases. Int J Cell Biol (2012) 0.75

Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death. Front Mol Neurosci (2017) 0.75

14-3-3 Proteins in the regulation of rotenone-induced neurotoxicity might be via its isoform 14-3-3epsilon's involvement in autophagy. Cell Mol Neurobiol (2013) 0.75

A novel dual luciferase based high throughput assay to monitor autophagy in real time in yeast S. cerevisiae. Biochem Biophys Rep (2017) 0.75

Autophagy in the Vertebrate Inner Ear. Front Cell Dev Biol (2017) 0.75

Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications. Viruses (2017) 0.75

Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms. Autophagy (2017) 0.75

L-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia-Reperfusion Injury. Neurochem Res (2017) 0.75

Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39

Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (1999) 13.19

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol (2010) 12.26

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol (2010) 11.85

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science (2004) 8.71

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci U S A (2003) 7.57

Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem (2003) 6.84

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol (2005) 6.16

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol (2007) 5.78

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell (2010) 5.09

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol (2005) 4.91

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci (2008) 4.63

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A (2008) 4.50

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat Neurosci (2010) 4.22

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest (2008) 4.09

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem (2008) 3.86

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol (1997) 3.80

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol (2010) 3.68

α-Synuclein impairs macroautophagy: implications for Parkinson's disease. J Cell Biol (2010) 3.67

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One (2010) 3.62

Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol (2007) 3.29

Induction of autophagy in axonal dystrophy and degeneration. J Neurosci (2006) 3.28

HEAT repeats in the Huntington's disease protein. Nat Genet (1995) 3.24

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem (2010) 3.16

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. J Neurosci (2000) 3.16

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. J Neurosci (2002) 3.12

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J Neurosci (2001) 3.10

Autophagy, amyloidogenesis and Alzheimer disease. J Cell Sci (2007) 2.96

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem (2008) 2.86

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci (2009) 2.82

Highwire regulates synaptic growth in Drosophila. Neuron (2000) 2.70

FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus. J Biol Chem (2003) 2.27

Autophagic stress in neuronal injury and disease. J Neuropathol Exp Neurol (2006) 2.17

Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science (2009) 2.13

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS One (2009) 1.88

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum Mol Genet (2010) 1.83

Autophagy promotes synapse development in Drosophila. J Cell Biol (2009) 1.79

The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. Cell Death Differ (2010) 1.63

Increased autophagy in transgenic mice with a G93A mutant SOD1 gene. Brain Res (2007) 1.43

Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells. J Neurosci Res (2003) 1.41

A light and electron microscopic study of the cellular response to axonal injury in the superior cervical ganglion of the rat. Proc R Soc Lond B Biol Sci (1972) 1.40

Altered macroautophagy in the spinal cord of SOD1 mutant mice. Autophagy (2008) 1.37

Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. J Neuropathol Exp Neurol (2004) 1.36

Regulation of amyloid precursor protein processing by the Beclin 1 complex. PLoS One (2010) 1.22

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet (2003) 1.19

Unc-51 controls active zone density and protein composition by downregulating ERK signaling. J Neurosci (2009) 1.19

Studies on brain biopsies of patients with Huntington's chorea. J Neuropathol Exp Neurol (1974) 1.18

A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death. J Neurochem (2009) 1.09

"Phagocytic" lysosomes in chromatolytic neurones. Nature (1967) 1.07

A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy. Autophagy (2007) 1.07

Protein turnover and inclusion body formation. Autophagy (2009) 1.03

siRNA-mediated inhibition of endogenous Huntington disease gene expression induces an aberrant configuration of the ER network in vitro. Biochem Biophys Res Commun (2005) 1.01

Electron microscope and enzyme studies in cerebral biopsies of Huntington's chorea. Trans Am Neurol Assoc (1974) 0.95

The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells. Mitochondrion (2011) 0.94

Clinical trials for neuroprotection in ALS. CNS Neurol Disord Drug Targets (2010) 0.87

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease. Eur Arch Psychiatry Clin Neurosci (1999) 0.84

Whole blood Epstein-Barr virus DNA load as a diagnostic and prognostic surrogate: extranodal natural killer/T-cell lymphoma. Leuk Lymphoma (2009) 1.83

Autophagy-related proteins, LC3 and Beclin-1, in placentas from pregnancies complicated by preeclampsia. Reprod Sci (2008) 1.29

Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation. Proc Natl Acad Sci U S A (2007) 1.16

Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice. J Clin Invest (2009) 1.15

Filamentous Fungi Isolated from Platypus koryoensis, the Insect Vector of Oak Wilt Disease in Korea. Mycobiology (2011) 1.07

Evolution of rosmarinic acid biosynthesis. Phytochemistry (2009) 1.01

[Comparison of diagnostic utility between procalcitonin and C-reactive protein for the patients with blood culture-positive sepsis]. Korean J Lab Med (2009) 0.99

Syntheses of new spirocarbocyclic nucleoside analogs using iminonitroso Diels-Alder reactions. Org Lett (2009) 0.95

Transcriptional induction of cyclooxygenase-2 in osteoclast precursors is involved in RANKL-induced osteoclastogenesis. Blood (2005) 0.94

The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells. Mitochondrion (2011) 0.94

Lipoteichoic acid partially contributes to the inflammatory responses to Enterococcus faecalis. J Endod (2008) 0.93

Inhibitory effects of active compounds isolated from safflower (Carthamus tinctorius L.) seeds for melanogenesis. Biol Pharm Bull (2004) 0.93

Enrichment of cancer cells from whole blood using a microfabricated porous filter. Anal Biochem (2013) 0.92

A case of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma in a Korean child. Ann Lab Med (2012) 0.90

Enhanced expression of hedgehog signaling molecules in squamous cell carcinoma of uterine cervix and its precursor lesions. Mod Pathol (2006) 0.89

Involvement of iNOS-dependent NO production in the stimulation of osteoclast survival by TNF-alpha. Exp Cell Res (2004) 0.88

Immunolocalization of 8-OHdG and OGG1 in pancreatic islets of streptozotocin-induced diabetic rats. Acta Histochem (2008) 0.85

Lipoteichoic acid of Enterococcus faecalis induces the expression of chemokines via TLR2 and PAFR signaling pathways. J Leukoc Biol (2013) 0.85

Furosin, an ellagitannin, suppresses RANKL-induced osteoclast differentiation and function through inhibition of MAP kinase activation and actin ring formation. Biochem Biophys Res Commun (2004) 0.84

Proteomic analysis of methamphetamine-induced reinforcement processes within the mesolimbic dopamine system. Addict Biol (2008) 0.84

Association between Estrogen Receptor Gene Polymorphisms and Depression in Post-Menopausal Women: A Preliminary Study. Psychiatry Investig (2010) 0.84

DJ-1 mediates paraquat-induced dopaminergic neuronal cell death. Toxicol Lett (2011) 0.83

Superior long-term outcomes after surgery in child-pugh class a patients with single small hepatocellular carcinoma compared to radiofrequency ablation. Hepatol Int (2010) 0.83

Thyroid nodules with repeat nondiagnostic cytologic results: the role of clinical and ultrasonographic findings. World J Surg (2015) 0.83

Amelioration of streptozotocin-induced diabetes by Agrocybe chaxingu polysaccharide. Mol Cells (2010) 0.82

Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia. Cancer Genet Cytogenet (2010) 0.81

Dose ascites mean more severe Crohn's disease? Korean J Gastroenterol (2004) 0.81

Prevalence of and risk factors for gastrointestinal diseases in korean americans and native koreans undergoing screening endoscopy. Gut Liver (2013) 0.81

Comparison of sputum and nasopharyngeal swabs for detection of respiratory viruses. J Med Virol (2014) 0.80

[Prevalence and risk factors of colorectal adenoma in 14,932 koreans undergoing screening colonoscopy]. Korean J Gastroenterol (2013) 0.80

Association of estrogen receptor genes and schizophrenia: a preliminary study. Prog Neuropsychopharmacol Biol Psychiatry (2011) 0.80

Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation. Mol Cells (2004) 0.79

Gene discovery analysis from mouse embryonic stem cells based on time course microarray data. Mol Cells (2008) 0.78

Subjective and objective caregiver burden in Parkinson's disease. Taehan Kanho Hakhoe Chi (2007) 0.78

Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells. Cancer Sci (2008) 0.78

Molecular cloning and biochemical characterization of three Concord grape (Vitis labrusca) flavonol 7-O-glucosyltransferases. Planta (2011) 0.78

Oligonucleotide chip for the diagnosis of HNF-1 alpha mutations. Biosens Bioelectron (2005) 0.77

Needs analysis and development of a tailored mobile message program linked with electronic health records for weight reduction. Int J Med Inform (2013) 0.77

A new method of fabricating a blend scaffold using an indirect three-dimensional printing technique. Biofabrication (2015) 0.77

[A prediction model for internet game addiction in adolescents: using a decision tree analysis]. J Korean Acad Nurs (2010) 0.77

Relationships between the effect of sunitinib and immature blood vessels in metastatic renal cell cancer. Urol Int (2014) 0.76

Profiling and semiquantitative analysis of the cell surface proteome in human mesenchymal stem cells. Anal Bioanal Chem (2013) 0.76

[Evaluation of platelet indices for differential diagnosis of thrombocytosis by ADVIA 120]. Korean J Lab Med (2009) 0.76

Efficacy of functional electrical stimulation-biofeedback with sexual cognitive-behavioral therapy as treatment of vaginismus. Urology (2005) 0.76

Gamma oscillatory activity in relation to memory ability in older adults. Int J Psychophysiol (2012) 0.76

Estrogen receptor α gene analysis in girls with central precocious puberty. J Pediatr Endocrinol Metab (2013) 0.75

Severity of pulmonary emphysema and lung cancer: analysis using quantitative lobar emphysema scoring. Medicine (Baltimore) (2016) 0.75

Prognosis in patients having chronic obstructive pulmonary disease with significant coronary artery lesion angina. Korean J Intern Med (2012) 0.75

Pharmacokinetic evaluation of formulated levodopa methyl ester nasal delivery systems. Eur J Drug Metab Pharmacokinet (2013) 0.75

N-ras mutation detection by pyrosequencing in adult patients with acute myeloid leukemia at a single institution. Ann Lab Med (2013) 0.75

A case of therapy-related acute myeloid leukemia with inv(16)(p13.1q22) after single low-dose iodine-131 treatment for thyroid cancer. Korean J Hematol (2012) 0.75

Corrigendum: IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses. Nat Commun (2016) 0.75

Association of aromatase (TTTA)n repeat polymorphisms with central precocious puberty in girls. Clin Endocrinol (Oxf) (2014) 0.75

Artesunate inhibits proliferation of naïve CD4(+) T cells but enhances function of effector T cells. Arch Pharm Res (2014) 0.75

Clinical characteristics and mutation spectrum of GLA in Korean patients with Fabry disease by a nationwide survey: Underdiagnosis of late-onset phenotype. Medicine (Baltimore) (2017) 0.75

Application of a solid-phase fluorescence immunoassay to determine oxytetracycline and tetracycline residues in tissue of olive flounder (Paralichthys olivaceus). J Vet Med Sci (2006) 0.75

Pulmonary Tuberculosis in Patients With Emphysema: Computed Tomography Findings. J Comput Assist Tomogr (2016) 0.75

[Hematologic and clinical features of 3q21q26 syndrome: extremely poor prognosis and association with central diabetes insipidus]. Korean J Lab Med (2007) 0.75