Current Status of Poly(ADP-ribose) Polymerase Inhibitors as Novel Therapeutic Agents for Triple-Negative Breast Cancer.

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Published in Int J Breast Cancer on October 25, 2011

Authors

David J Hiller1, Quyen D Chu

Author Affiliations

1: Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

Associated clinical trials:

I-SPY 2 TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (I-SPY 2) | NCT01042379

Cediranib Maleate and Olaparib in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Peritoneal Cancer or Recurrent Triple-Negative Breast Cancer | NCT01116648

Phase II Study of AZD2281 in Patients With Known BRCA Mutation Status or Recurrent High Grade Ovarian Cancer or Patients With Known BRCA Mutation Status/ Triple Neg Breast Cancer | NCT00679783

Phase II ABT-888 With Cyclophosphamide | NCT01306032

A Phase 2 Study of Standard Chemotherapy Plus BSI-201 (a PARP Inhibitor) in the Neoadjuvant Treatment of Triple Negative Breast Cancer | NCT00813956

Study to Assess the Safety and Tolerability of a PARP Inhibitor in Combination With Carboplatin and/or Paclitaxel | NCT00516724

Veliparib, Cisplatin, and Vinorelbine Ditartrate in Treating Patients With Recurrent and/or Metastatic Breast Cancer | NCT01104259

ABT-888 and Temozolomide for Metastatic Breast Cancer and BRCA1/2 Breast Cancer | NCT01009788

NCT00647062

Two Regimens of SAR240550/Weekly Paclitaxel and Paclitaxel Alone as Neoadjuvant Therapy in Triple Negative Breast Cancer Patients (SOLTI NEOPARP) | NCT01204125

A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis | NCT01173497

Veliparib and Carboplatin in Treating Patients With HER2-Negative Metastatic Breast Cancer | NCT01251874

Phase I/II Study of AZD2281 Given in Combination With Paclitaxel in Metastatic Triple Negative Breast Cancer | NCT00707707

Study of SAR240550 (BSI-201) in Combination With Gemcitabine/Carboplatin, in Patients With Metastatic Triple Negative Breast Cancer | NCT01045304

An Open-Label, Expanded Access Protocol of Iniparib Breast Cancer | NCT01130259

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