Published in Aging (Albany NY) on January 01, 2012
iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2013) 1.23
Aging and reprogramming: a two-way street. Curr Opin Cell Biol (2012) 1.14
Transgene-free disease-specific induced pluripotent stem cells from patients with type 1 and type 2 diabetes. Stem Cells Transl Med (2012) 1.02
Current status of drug screening and disease modelling in human pluripotent stem cells. Bioessays (2012) 0.98
New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism. Cell Metab (2013) 0.90
Concise review: pluripotent stem cell-based regenerative applications for failing β-cell function. Stem Cells Transl Med (2014) 0.88
Toward beta cell replacement for diabetes. EMBO J (2015) 0.86
Reprogramming of fibroblasts from older women with pelvic floor disorders alters cellular behavior associated with donor age. Stem Cells Transl Med (2013) 0.86
Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells. Stem Cell Res Ther (2011) 0.85
Human pluripotent stem cell-derived cardiomyocytes as research and therapeutic tools. Biomed Res Int (2014) 0.83
Modelling human disease with pluripotent stem cells. Curr Gene Ther (2013) 0.83
Stem cell transplantation improves aging-related diseases. Front Cell Dev Biol (2014) 0.81
A poor imitation of a natural process: a call to reconsider the iPSC engineering technique. Cell Cycle (2012) 0.80
Advances and challenges in the differentiation of pluripotent stem cells into pancreatic β cells. World J Stem Cells (2015) 0.78
Concise review: modeling multiple sclerosis with stem cell biological platforms: toward functional validation of cellular and molecular phenotypes in inflammation-induced neurodegeneration. Stem Cells Transl Med (2015) 0.76
Recent Advances in Disease Modeling and Drug Discovery for Diabetes Mellitus Using Induced Pluripotent Stem Cells. Int J Mol Sci (2016) 0.76
Modeling Kidney Disease with iPS Cells. Biomark Insights (2015) 0.76
Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration. Stem Cells Transl Med (2016) 0.76
Embryonic stem cells and inducible pluripotent stem cells: two faces of the same coin? Aging (Albany NY) (2012) 0.76
SATB2-Nanog axis links age-related intrinsic changes of mesenchymal stem cells from craniofacial bone. Aging (Albany NY) (2016) 0.75
Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells. Mol Metab (2017) 0.75
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Oxidants, oxidative stress and the biology of ageing. Nature (2000) 23.21
Disease-specific induced pluripotent stem cells. Cell (2008) 16.95
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science (2008) 14.26
Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A (2008) 13.09
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02
Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature (2008) 12.21
Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol (2006) 10.95
Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes Care (2008) 10.90
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell (2008) 10.68
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat Biotechnol (2008) 10.63
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol (2008) 10.60
Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science (2008) 10.55
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature (2009) 9.75
p16INK4a induces an age-dependent decline in islet regenerative potential. Nature (2006) 9.09
Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature (2009) 8.70
The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature (2009) 7.39
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature (2009) 6.85
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56
Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology (2010) 6.40
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature (2009) 5.37
Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev (2009) 4.69
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell (2010) 4.59
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature (2010) 4.38
Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells. Cell (2010) 4.24
Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metab (2011) 4.15
Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43
Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation (2009) 2.93
Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells (2007) 2.63
Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy. Proc Natl Acad Sci U S A (2011) 2.41
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature (2010) 2.36
Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J Clin Invest (2011) 2.23
Generation of insulin-secreting islet-like clusters from human skin fibroblasts. J Biol Chem (2008) 2.04
Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages. Stem Cells (2008) 1.83
iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. Circ Res (2009) 1.77
Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nat Protoc (2010) 1.67
Functional recapitulation of smooth muscle cells via induced pluripotent stem cells from human aortic smooth muscle cells. Circ Res (2009) 1.34
Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny. Gene Ther (2010) 1.21
Induced pluripotent reprogramming from promiscuous human stemness related factors. Clin Transl Sci (2009) 1.20
Chronic diseases: the emerging pandemic. Clin Transl Sci (2011) 1.13
Characterization of retroviral and lentiviral vectors pseudotyped with xenotropic murine leukemia virus-related virus envelope glycoprotein. Hum Gene Ther (2010) 0.93
iPS cells in type 1 diabetes research and treatment. Clin Pharmacol Ther (2011) 0.82
Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics. J Am Coll Cardiol (2013) 5.11
Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metab (2011) 4.15
Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature (2002) 3.60
Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat Med (2005) 3.59
Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Hum Mol Genet (2006) 3.15
Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation (2009) 2.93
ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nat Genet (2004) 2.85
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol (2008) 2.81
Phosphotransfer networks and cellular energetics. J Exp Biol (2003) 2.79
Kir6.2 is required for adaptation to stress. Proc Natl Acad Sci U S A (2002) 2.60
Stem cell differentiation requires a paracrine pathway in the heart. FASEB J (2002) 2.55
Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure. Circulation (2005) 2.42
Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase. Arterioscler Thromb Vasc Biol (2004) 2.39
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med (2002) 2.37
Metabolic plasticity in stem cell homeostasis and differentiation. Cell Stem Cell (2012) 2.36
Rhesus monkey TRIM5alpha restricts HIV-1 production through rapid degradation of viral Gag polyproteins. Nat Med (2007) 2.32
Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol (2006) 2.24
Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells. Nat Clin Pract Cardiovasc Med (2007) 2.21
Cardiac system bioenergetics: metabolic basis of the Frank-Starling law. J Physiol (2006) 2.06
Cardiac KATP channels in health and disease. J Mol Cell Cardiol (2005) 2.04
Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury. Am J Physiol Heart Circ Physiol (2006) 2.01
Cardiopoietic programming of embryonic stem cells for tumor-free heart repair. J Exp Med (2007) 1.97
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol (2012) 1.94
Use of CD134 as a primary receptor by the feline immunodeficiency virus. Science (2004) 1.93
Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction. J Am Coll Cardiol (2010) 1.82
Pro-B-type natriuretic peptide(1-108) circulates in the general community: plasma determinants and detection of left ventricular dysfunction. J Am Coll Cardiol (2011) 1.78
iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. Circ Res (2009) 1.77
KATP channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart. Am J Physiol Heart Circ Physiol (2006) 1.74
Recommendations for successful training on methods of delivery of biologics for cardiac regeneration: a report of the International Society for Cardiovascular Translational Research. JACC Cardiovasc Interv (2010) 1.74
New onset hyperglycemia and diabetes are associated with increased cardiovascular risk after kidney transplantation. Kidney Int (2005) 1.73
Stable benefit of embryonic stem cell therapy in myocardial infarction. Am J Physiol Heart Circ Physiol (2004) 1.73
Coupling of cell energetics with membrane metabolic sensing. Integrative signaling through creatine kinase phosphotransfer disrupted by M-CK gene knock-out. J Biol Chem (2002) 1.72
Induced pluripotent stem cells: developmental biology to regenerative medicine. Nat Rev Cardiol (2010) 1.71
Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant. J Physiol (2006) 1.70
Altered intracellular Ca2+ handling in heart failure. J Clin Invest (2005) 1.70
Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing. Int J Mol Sci (2009) 1.67
CXCR4+/FLK-1+ biomarkers select a cardiopoietic lineage from embryonic stem cells. Stem Cells (2008) 1.63
Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc (2009) 1.62
Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor. Circ Res (2010) 1.61
Human hypertension is characterized by a lack of activation of the antihypertensive cardiac hormones ANP and BNP. J Am Coll Cardiol (2012) 1.61
KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation. Nat Clin Pract Cardiovasc Med (2007) 1.56
Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics. Am J Physiol Heart Circ Physiol (2003) 1.56
Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action. Circulation (2012) 1.56
KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension. Hum Mol Genet (2006) 1.53
ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits. Diabetes (2004) 1.53
Tongue muscle-derived stem cells express connexin 43 and improve cardiac remodeling and survival after myocardial infarction in mice. Circ J (2010) 1.50
The use of a tropism-modified measles virus in folate receptor-targeted virotherapy of ovarian cancer. Clin Cancer Res (2006) 1.50
Alpha interferon enhances TRIM5alpha-mediated antiviral activities in human and rhesus monkey cells. J Virol (2007) 1.49
Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion. Cardiovasc Res (2008) 1.49
Lentiviral vectors: basic to translational. Biochem J (2012) 1.49
Mitochondrial tolerance to stress impaired in failing heart. J Mol Cell Cardiol (2003) 1.45
Mechanisms of Disease: ryanodine receptor defects in heart failure and fatal arrhythmia. Nat Clin Pract Cardiovasc Med (2006) 1.41
Cellular remodeling in heart failure disrupts K(ATP) channel-dependent stress tolerance. EMBO J (2003) 1.40
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer. Proc Natl Acad Sci U S A (2002) 1.40
Embryonic stem cell therapy of heart failure in genetic cardiomyopathy. Stem Cells (2008) 1.39
ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart. J Mol Cell Cardiol (2005) 1.38
Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation. J Mol Cell Cardiol (2010) 1.37
Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration. Proc Natl Acad Sci U S A (2012) 1.37
The mechanism of Axl-mediated Ebola virus infection. J Infect Dis (2007) 1.36
Platelet lysate consisting of a natural repair proteome supports human mesenchymal stem cell proliferation and chromosomal stability. Cell Transplant (2010) 1.34
Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. J Clin Invest (2004) 1.33
Long-term cardiac pro-B-type natriuretic peptide gene delivery prevents the development of hypertensive heart disease in spontaneously hypertensive rats. Circulation (2011) 1.33
Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation. Am J Physiol Heart Circ Physiol (2002) 1.32
Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining body weight. Cell Metab (2010) 1.31
Clinical and translational science: from bench-bedside to global village. Clin Transl Sci (2010) 1.30
Immunization with a lentiviral vector stimulates both CD4 and CD8 T cell responses to an ovalbumin transgene. Mol Ther (2005) 1.30
Tandem function of nucleotide binding domains confers competence to sulfonylurea receptor in gating ATP-sensitive K+ channels. J Biol Chem (2002) 1.29
Gene knockout of the KCNJ8-encoded Kir6.1 K(ATP) channel imparts fatal susceptibility to endotoxemia. FASEB J (2006) 1.28
Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts. Cardiovasc Res (2008) 1.27
K(ATP) channel therapeutics at the bedside. J Mol Cell Cardiol (2005) 1.27
Intravenous injection of a lentiviral vector encoding NY-ESO-1 induces an effective CTL response. J Immunol (2004) 1.26
Nucleotide-gated KATP channels integrated with creatine and adenylate kinases: amplification, tuning and sensing of energetic signals in the compartmentalized cellular environment. Mol Cell Biochem (2004) 1.26
Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure. J Am Coll Cardiol (2007) 1.24
Laboratory evidence of sustained chronic inflammatory reaction in retinitis pigmentosa. Ophthalmology (2012) 1.24
Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K+ channel, predisposes to catecholamine-induced ventricular dysrhythmia. Diabetes (2004) 1.23
Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure. Circulation (2005) 1.23
Disease-causing mitochondrial heteroplasmy segregated within induced pluripotent stem cell clones derived from a patient with MELAS. Stem Cells (2013) 1.22
No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan. Retrovirology (2011) 1.22
Stem cells transform into a cardiac phenotype with remodeling of the nuclear transport machinery. Nat Clin Pract Cardiovasc Med (2007) 1.21
Ischemic pre-conditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase. J Am Coll Cardiol (2009) 1.20
Translating MicroRNA discovery into clinical biomarkers in cancer. JAMA (2007) 1.20
Induced pluripotent reprogramming from promiscuous human stemness related factors. Clin Transl Sci (2009) 1.20
Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa. Ophthalmology (2012) 1.20
Aging and cardioprotection. J Appl Physiol (1985) (2007) 1.20
Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration. Am J Pathol (2008) 1.20
Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther (2012) 1.19
Xenotropic murine leukemia virus-related virus is susceptible to AZT. Virology (2009) 1.19
Potassium channel openers are uncoupling protonophores: implication in cardioprotection. FEBS Lett (2004) 1.18
No evidence of XMRV in prostate cancer cohorts in the Midwestern United States. Retrovirology (2011) 1.18
Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction. Biochem Biophys Res Commun (2010) 1.16
Cardioinductive network guiding stem cell differentiation revealed by proteomic cartography of tumor necrosis factor alpha-primed endodermal secretome. Stem Cells (2007) 1.16