A simple, assumption-free, and clinically interpretable approach for analysis of modified Rankin outcomes.

Long-term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis: the International Carotid Stenting Study (ICSS) randomised trial. Lancet (2014) 2.72

Acute Stroke Imaging Research Roadmap II. Stroke (2013) 1.47

Details of a prospective protocol for a collaborative meta-analysis of individual participant data from all randomized trials of intravenous rt-PA vs. control: statistical analysis plan for the Stroke Thrombolysis Trialists' Collaborative meta-analysis. Int J Stroke (2013) 1.25

Safety and Efficacy of Solitaire Stent Thrombectomy: Individual Patient Data Meta-Analysis of Randomized Trials. Stroke (2016) 0.92

Time to endovascular reperfusion and degree of disability in acute stroke. Ann Neurol (2015) 0.92

The effect of covariate adjustment for baseline severity in acute stroke clinical trials with responder analysis outcomes. Trials (2013) 0.83

Regression analysis of ordinal stroke clinical trial outcomes: an application to the NINDS t-PA trial. Int J Stroke (2013) 0.78

Stroke Treatment Academic Industry Roundtable Recommendations for Individual Data Pooling Analyses in Stroke. Stroke (2016) 0.78

Effect Size Estimates for the ESCAPE Trial: Proportional Odds Regression Versus Other Statistical Methods. Stroke (2015) 0.78

Effects of Alteplase for Acute Stroke on the Distribution of Functional Outcomes: A Pooled Analysis of 9 Trials. Stroke (2016) 0.78

Quantification of errors in ordinal outcome scales using shannon entropy: effect on sample size calculations. PLoS One (2013) 0.77

Functional Neurologic Outcomes Change Over the First 6 Months After Cardiac Arrest. Crit Care Med (2016) 0.75

Letter by Bath regarding article, "A simple, assumption-free, and clinically interpretable approach for analysis of modified Rankin outcomes". Stroke (2012) 0.75

Editorial on "A simple, assumption-free, and clinically interpretable approach for analysis of modified Rankin outcomes". Stroke (2012) 0.75

Evolution of the Modified Rankin Scale and Its Use in Future Stroke Trials. Stroke (2017) 0.75

The Randomized Controlled STRAWINSKI Trial: Procalcitonin-Guided Antibiotic Therapy after Stroke. Front Neurol (2017) 0.75

Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med (1995) 47.15

Clinically useful measures of effect in binary analyses of randomized trials. J Clin Epidemiol (1994) 8.37

NXY-059 for acute ischemic stroke. N Engl J Med (2006) 5.32

Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology (2007) 3.82

The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial. Lancet Neurol (2009) 2.78

Treatment effects for which shift or binary analyses are advantageous in acute stroke trials. Neurology (2008) 2.48

Novel end point analytic techniques and interpreting shifts across the entire range of outcome scales in acute stroke trials. Stroke (2007) 2.41

The Albumin in Acute Stroke Part 1 Trial: an exploratory efficacy analysis. Stroke (2011) 1.92

On the analysis and interpretation of outcome measures in stroke clinical trials: lessons from the SAINT I study of NXY-059 for acute ischemic stroke. Stroke (2006) 1.83

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials. Stroke (2007) 1.62

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices. Cerebrovasc Dis (2008) 1.37

Graphic reanalysis of the two NINDS-tPA trials confirms substantial treatment benefit. Stroke (2010) 1.05

Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation (2011) 31.98

Heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation (2012) 30.79

Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation (2010) 30.07

Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med (2008) 28.42

Heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation (2013) 28.02

Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation (2014) 22.74

Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med (2010) 17.57

Endovascular therapy after intravenous t-PA versus t-PA alone for stroke. N Engl J Med (2013) 14.78

Heart disease and stroke statistics--2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation (2006) 14.72

Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2013) 14.49

Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med (2003) 13.47

Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke (2007) 12.77

Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet (2007) 10.74

Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation (2015) 10.14

Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart Association. Circulation (2009) 8.11

Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA (2004) 7.35

Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2010) 6.93

Executive summary: heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation (2014) 6.55

Executive summary: heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation (2012) 6.24

Executive summary: heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation (2013) 6.13

Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation (2008) 5.97

Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: a science advisory from the American Heart Association/American Stroke Association. Stroke (2009) 5.91

2015 American Heart Association/American Stroke Association Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke (2015) 5.64

Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Circulation (2007) 5.28

Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive. BMJ (2010) 4.74

Part 1: executive summary: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation (2010) 4.59

The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke (2004) 4.39

Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study. Lancet (2008) 4.14

NXY-059 for the treatment of acute ischemic stroke. N Engl J Med (2007) 3.70

Exploring the functional landscape of gene expression: directed search of large microarray compendia. Bioinformatics (2007) 3.59

Statistical analysis of the primary outcome in acute stroke trials. Stroke (2012) 3.52

Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2014) 3.48

Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke (2002) 3.43

Exercise dose and diabetes risk in overweight and obese children: a randomized controlled trial. JAMA (2012) 3.40

Restenosis after carotid artery stenting and endarterectomy: a secondary analysis of CREST, a randomised controlled trial. Lancet Neurol (2012) 3.11

Incident cognitive impairment is elevated in the stroke belt: the REGARDS study. Ann Neurol (2011) 3.06

Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset. Stroke (2006) 3.03

Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke. Stroke (2003) 2.96

Methodology of the Interventional Management of Stroke III Trial. Int J Stroke (2008) 2.88

Executive Summary: Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation (2016) 2.87

Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial. Circulation (2005) 2.83

Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation (2017) 2.76

A review of the evidence for the use of telemedicine within stroke systems of care: a scientific statement from the American Heart Association/American Stroke Association. Stroke (2009) 2.74

Estimated 10-year stroke risk by region and race in the United States: geographic and racial differences in stroke risk. Ann Neurol (2008) 2.68

Forecasting the future of stroke in the United States: a policy statement from the American Heart Association and American Stroke Association. Stroke (2013) 2.66

Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke. Resuscitation (2008) 2.63

Racial differences in the impact of elevated systolic blood pressure on stroke risk. JAMA Intern Med (2013) 2.55

Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2014) 2.50

Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke (2012) 2.46

Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke. Stroke (2003) 2.42

NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials. Stroke (2008) 2.39

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. Lancet (2014) 2.31

Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST). Stroke (2008) 2.24

Comparison of stratification and adaptive methods for treatment allocation in an acute stroke clinical trial. Stat Med (2003) 2.21

Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J Cereb Blood Flow Metab (2006) 2.20

Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial. Lancet Neurol (2012) 2.19

Remote evaluation of acute ischemic stroke: reliability of National Institutes of Health Stroke Scale via telestroke. Stroke (2003) 2.17

Influence of sex on outcomes of stenting versus endarterectomy: a subgroup analysis of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). Lancet Neurol (2011) 2.15

Effect of area-based deprivation on the severity, subtype, and outcome of ischemic stroke. Stroke (2003) 2.13

Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR. Lancet Neurol (2010) 2.12

Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy. J Neurotrauma (2005) 2.06

Implications of increased C-reactive protein for cardiovascular risk stratification in black and white men and women in the US. Clin Chem (2009) 2.03

A multicentre observational study of presentation and early assessment of acute stroke. BMJ (2002) 2.01

SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury. J Neuropathol Exp Neurol (2004) 1.94

Implementation strategies for emergency medical services within stroke systems of care: a policy statement from the American Heart Association/American Stroke Association Expert Panel on Emergency Medical Services Systems and the Stroke Council. Stroke (2007) 1.94

Stroke Treatment Academic Industry Roundtable (STAIR) recommendations for maximizing the use of intravenous thrombolytics and expanding treatment options with intra-arterial and neuroprotective therapies. Stroke (2011) 1.92

Life's Simple 7 and risk of incident stroke: the reasons for geographic and racial differences in stroke study. Stroke (2013) 1.89

Targets for vascular protection after acute ischemic stroke. Stroke (2004) 1.88

Traditional risk factors as the underlying cause of racial disparities in stroke: lessons from the half-full (empty?) glass. Stroke (2011) 1.86

Metrics for measuring quality of care in comprehensive stroke centers: detailed follow-up to Brain Attack Coalition comprehensive stroke center recommendations: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2011) 1.85

ABCD2 scores and prediction of noncerebrovascular diagnoses in an outpatient population: a case-control study. Stroke (2009) 1.84

Relative edema volume is a predictor of outcome in patients with hyperacute spontaneous intracerebral hemorrhage. Stroke (2002) 1.82

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82

Advancing the hypothesis that geographic variations in risk factors contribute relatively little to observed geographic variations in heart disease and stroke mortality. Prev Med (2009) 1.81

Matrix metalloproteinase-9 in an exploratory trial of intravenous minocycline for acute ischemic stroke. Stroke (2011) 1.80

Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem (2004) 1.79

Predicting gene function in a hierarchical context with an ensemble of classifiers. Genome Biol (2008) 1.78

Myocardial infarction after carotid stenting and endarterectomy: results from the carotid revascularization endarterectomy versus stenting trial. Circulation (2011) 1.78

Detection of atrial fibrillation after ischemic stroke or transient ischemic attack: a systematic review and meta-analysis. Stroke (2014) 1.77

Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT Trial. Stroke (2007) 1.75

Self-report of stroke, transient ischemic attack, or stroke symptoms and risk of future stroke in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Stroke (2012) 1.74

Effects of aerobic exercise on overweight children's cognitive functioning: a randomized controlled trial. Res Q Exerc Sport (2007) 1.74

Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score. Stroke (2012) 1.73

Carotid artery stenting is associated with increased complications in octogenarians: 30-day stroke and death rates in the CREST lead-in phase. J Vasc Surg (2004) 1.71

Cognitive status, stroke symptom reports, and modifiable risk factors among individuals with no diagnosis of stroke or transient ischemic attack in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Stroke (2007) 1.69

Minocycline to improve neurologic outcome in stroke (MINOS): a dose-finding study. Stroke (2010) 1.69

Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke. BMC Neurosci (2006) 1.69

Acute stroke imaging research roadmap. Stroke (2008) 1.66

Stroke and conversion to high risk in children screened with transcranial Doppler ultrasound during the STOP study. Blood (2004) 1.66

Noninvasive cardiac event monitoring to detect atrial fibrillation after ischemic stroke: a randomized, controlled trial. Stroke (2013) 1.66

Prevention of recurrent urinary tract infections with immuno-active E. coli fractions: a meta-analysis of five placebo-controlled double-blind studies. Int J Antimicrob Agents (2002) 1.63

Randomized trial testing a worksite sun protection program in an outdoor recreation industry. Health Educ Behav (2005) 1.63

Self-reported atrial fibrillation and risk of stroke in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. Stroke (2011) 1.63

Part 11: adult stroke: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation (2010) 1.62