Published in FASEB J on February 23, 2012
Post-translational modifications of intermediate filament proteins: mechanisms and functions. Nat Rev Mol Cell Biol (2014) 1.50
Lamin aggregation is an early sensor of porphyria-induced liver injury. J Cell Sci (2013) 0.87
Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. J Cell Biol (2013) 0.85
A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 protein insolubility and filament organization. J Biol Chem (2013) 0.78
Keratin 8 variants are infrequent in patients with alcohol-related liver cirrhosis and do not associate with development of hepatocellular carcinoma. BMC Gastroenterol (2012) 0.77
A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress. FASEB J (2016) 0.75
Intermediate filament proteins of digestive organs: Physiology and pathophysiology. Am J Physiol Gastrointest Liver Physiol (2017) 0.75
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology (1999) 11.76
Classification of chronic viral hepatitis: a need for reassessment. J Hepatol (1991) 5.23
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature (1989) 4.27
From the globular to the fibrous state: protein structure and structural conversion in amyloid formation. Q Rev Biophys (1998) 3.04
Beta-pleated sheet fibrils. A comparison of native amyloid with synthetic protein fibrils. J Histochem Cytochem (1974) 2.69
From Mallory to Mallory-Denk bodies: what, how and why? Exp Cell Res (2007) 2.61
Transglutaminase 2 undergoes a large conformational change upon activation. PLoS Biol (2007) 2.53
Regulators of serine/threonine protein phosphatases at the dawn of a clinical era? Curr Med Chem (2002) 2.34
Toward unraveling the complexity of simple epithelial keratins in human disease. J Clin Invest (2009) 2.34
"Heads and tails" of intermediate filament phosphorylation: multiple sites and functional insights. Trends Biochem Sci (2006) 1.97
Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1. Gastroenterology (2009) 1.89
A disease- and phosphorylation-related nonmechanical function for keratin 8. J Cell Biol (2006) 1.68
Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. PLoS One (2008) 1.67
Characterization of the amyloid fibril as a cross-beta protein. Proc Soc Exp Biol Med (1969) 1.66
Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates. J Cell Biol (1998) 1.65
Intermediate filaments take the heat as stress proteins. Trends Cell Biol (2010) 1.44
Studying simple epithelial keratins in cells and tissues. Methods Cell Biol (2004) 1.43
Redox regulation of transglutaminase 2 activity. J Biol Chem (2010) 1.38
Screening for the preferred substrate sequence of transglutaminase using a phage-displayed peptide library: identification of peptide substrates for TGASE 2 and Factor XIIIA. J Biol Chem (2006) 1.37
Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation. Hepatology (2008) 1.29
Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation. J Biol Chem (2002) 1.25
The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase. J Biol Chem (2002) 1.23
Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies. Am J Pathol (2000) 1.21
Dysfunctions of neuronal and glial intermediate filaments in disease. J Clin Invest (2009) 1.21
Mallory-Denk-bodies: lessons from keratin-containing hepatic inclusion bodies. Biochim Biophys Acta (2008) 1.17
Cell type-specific activation of intracellular transglutaminase 2 by oxidative stress or ultraviolet irradiation: implications of transglutaminase 2 in age-related cataractogenesis. J Biol Chem (2004) 1.16
Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress. Gastroenterology (2010) 1.14
Hepatocyte cytokeratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in a mallory body mouse model. Am J Pathol (2000) 1.14
Type II keratins are phosphorylated on a unique motif during stress and mitosis in tissues and cultured cells. Mol Biol Cell (2002) 1.09
Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology (2007) 1.07
Keratin 8 overexpression promotes mouse Mallory body formation. J Cell Biol (2005) 1.04
N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease. J Neurochem (2001) 1.04
Nonalcoholic steatohepatitis--a long-term follow-up study: comparison with alcoholic hepatitis in ambulatory and hospitalized patients. Dig Dis Sci (2003) 1.03
High amount of epsilon-(gamma-glutamyl)lysine cross-links in Mallory bodies. Lab Invest (1992) 1.02
Hepatocellar hyalin (Mallory bodies) in long term griseofulvin-treated mice: a new experimental model for the study of hyalin formation. Lab Invest (1975) 1.01
Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation. J Biol Chem (2010) 1.00
TGFbeta mediates activation of transglutaminase 2 in response to oxidative stress that leads to protein aggregation. FASEB J (2008) 1.00
A rodent model of NASH with cirrhosis, oval cell proliferation and hepatocellular carcinoma. J Hepatol (2008) 0.98
Congenital myopathies at their molecular dawning. Muscle Nerve (2003) 0.97
Mallory body formation runs parallel to gamma-glutamyl transferase induction in hepatocytes of griseofulvin-fed mice. Hepatology (1983) 0.97
Experimental production of Mallory bodies in mice by diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Gastroenterology (1982) 0.92
The Mallory body as an aggresome: in vitro studies. Exp Mol Pathol (2002) 0.92
Transglutaminase cross-links in intranuclear inclusions in Huntington disease. J Neuropathol Exp Neurol (2003) 0.91
Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies. Exp Cell Res (2005) 0.91
Mallory-Denk bodies are associated with outcomes and histologic features in patients with chronic hepatitis C. Clin Gastroenterol Hepatol (2011) 0.90
Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions. Gastroenterology (2011) 0.90
Impaired mitochondrial function results in increased tissue transglutaminase activity in situ. J Neurochem (2000) 0.88
"Toxic memory" via chaperone modification is a potential mechanism for rapid Mallory-Denk body reinduction. Hepatology (2008) 0.87
Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation. FEBS Lett (2006) 0.84
Molecular structural changes in Mallory body proteins in human and mouse livers: an infrared spectroscopy study. Exp Mol Pathol (1993) 0.84
Topography of alpha-internexin-positive neuronal aggregates in 10 patients with neuronal intermediate filament inclusion disease. Eur J Neurol (2006) 0.83
Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease. J Biol Chem (2009) 0.83
Transglutaminase-mediated intramolecular cross-linking of membrane-bound alpha-synuclein promotes amyloid formation in Lewy bodies. J Biol Chem (2009) 0.83
Alteration in molecular structure of cytoskeleton proteins in griseofulvin-treated mouse liver: a pressure tuning infrared spectroscopy study. Exp Mol Pathol (1991) 0.83
Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation. Hepatology (2007) 0.82
Cytokeratin of apparent high molecular weight in livers from griseofulvin-fed mice. J Hepatol (1992) 0.80
Hepatocellular cytokeratins as substrates of transglutaminases. Lab Invest (1989) 0.79
Effect of griseofulvin treatment and neoplastic transformation on transglutaminase activity in mouse liver. Liver (1984) 0.76
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
New consensus nomenclature for mammalian keratins. J Cell Biol (2006) 3.27
'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments. Curr Opin Cell Biol (2002) 3.00
Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3. Am J Pathol (2004) 2.81
From Mallory to Mallory-Denk bodies: what, how and why? Exp Cell Res (2007) 2.61
Toward unraveling the complexity of simple epithelial keratins in human disease. J Clin Invest (2009) 2.34
Panhematin provides a therapeutic benefit in experimental pancreatitis. Gut (2010) 2.23
CD73 (ecto-5'-nucleotidase) hepatocyte levels differ across mouse strains and contribute to mallory-denk body formation. Hepatology (2013) 2.04
Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chem Biol (2005) 2.00
Underrepresentation of underrepresented minorities in academic medicine: the need to enhance the pipeline and the pipe. Gastroenterology (2009) 1.91
Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments. Trends Cell Biol (2005) 1.89
Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells. Nat Cell Biol (2003) 1.84
Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation. J Cell Biol (2011) 1.72
Identification of novel principles of keratin filament network turnover in living cells. Mol Biol Cell (2004) 1.68
A disease- and phosphorylation-related nonmechanical function for keratin 8. J Cell Biol (2006) 1.68
Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. PLoS One (2008) 1.67
Telomerase gene mutations are associated with cirrhosis formation. Hepatology (2011) 1.67
Epidemiology of alcohol-related liver and pancreatic disease in the United States. Arch Intern Med (2008) 1.59
Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma. Gastroenterology (2006) 1.54
Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2. Am J Gastroenterol (2007) 1.46
Iron Parameters Determine the Prognosis of Critically Ill Patients. Crit Care Med (2016) 1.43
Studying simple epithelial keratins in cells and tissues. Methods Cell Biol (2004) 1.43
Regression of follicular lymphoma of the duodenum following eradication of H. pylori infection. Intern Med (2013) 1.43
Keratin 8/18 breakdown and reorganization during apoptosis. Exp Cell Res (2004) 1.42
Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation. Hepatology (2012) 1.40
Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment. J Cell Sci (2005) 1.39
Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells. J Biol Chem (2005) 1.38
Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies. Hepatology (2007) 1.37
Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization. J Cell Sci (2007) 1.34
Hepatocyte-derived Snail1 propagates liver fibrosis progression. Mol Cell Biol (2011) 1.32
Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression. Proc Natl Acad Sci U S A (2002) 1.32
Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction. J Clin Invest (2005) 1.31
Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. Mol Biol Cell (2003) 1.29
Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation. Hepatology (2008) 1.29
Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations. Gastroenterology (2010) 1.28
Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation. J Biol Chem (2002) 1.25
Keratins as susceptibility genes for end-stage liver disease. Gastroenterology (2005) 1.24
A less radical treatment option to the fertility-sparing radical trachelectomy in patients with stage I cervical cancer. Gynecol Oncol (2008) 1.23
The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase. J Biol Chem (2002) 1.23
Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury. Hepatology (2003) 1.21
The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells. Clin Cancer Res (2002) 1.20
Acknowledging joint first authors of published work: the time has come. Gastroenterology (2012) 1.19
Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease. Hepatology (2004) 1.19
Keratins modulate colonocyte electrolyte transport via protein mistargeting. J Cell Biol (2004) 1.18
Study of lymphatic mapping and sentinel node identification in early stage cervical cancer. Gynecol Oncol (2005) 1.18
Cytoskeletal keratin glycosylation protects epithelial tissue from injury. Nat Cell Biol (2010) 1.18
Tumor necrosis factor-alpha and interferon-gamma directly impair epithelial barrier function in cultured mouse cholangiocytes. Liver Int (2003) 1.17
Keratin variants associate with progression of fibrosis during chronic hepatitis C infection. Hepatology (2006) 1.14
Epidermolysis bullosa simplex-type mutations alter the dynamics of the keratin cytoskeleton and reveal a contribution of actin to the transport of keratin subunits. Mol Biol Cell (2003) 1.14
Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress. Gastroenterology (2010) 1.14
Functional analysis of the human papillomavirus type 16 E1=E4 protein provides a mechanism for in vivo and in vitro keratin filament reorganization. J Virol (2004) 1.10
Type II keratins are phosphorylated on a unique motif during stress and mitosis in tissues and cultured cells. Mol Biol Cell (2002) 1.09
Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity. Hepatology (2009) 1.08
Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology (2007) 1.07
The genetic background modulates susceptibility to mouse liver Mallory-Denk body formation and liver injury. Hepatology (2008) 1.07
Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models. Gastroenterology (2008) 1.07
Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells. J Hepatol (2007) 1.06
Presentation, management and outcome of 32 patients with pregnancy-associated breast cancer: a matched controlled study. Breast J (2009) 1.05
Keratin 8 overexpression promotes mouse Mallory body formation. J Cell Biol (2005) 1.04
Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation. J Cell Sci (2004) 1.04
Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells. J Cell Sci (2012) 1.04
Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma. Clin Cancer Res (2002) 1.04
Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis. J Cell Sci (2009) 1.04
Switching in discoid domain receptor expressions in SLUG-induced epithelial-mesenchymal transition. Cancer (2008) 1.03
Endothelial progenitor cell transplantation improves the survival following liver injury in mice. Gastroenterology (2006) 1.02
Etiologies and outcomes of acute liver failure in Germany. Clin Gastroenterol Hepatol (2012) 1.02
Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation. J Biol Chem (2010) 1.00
Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3. J Biol Chem (2013) 1.00
Keratin mutation primes mouse liver to oxidative injury. Hepatology (2005) 1.00
Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease. Clin Gastroenterol Hepatol (2007) 1.00
Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies. Proc Natl Acad Sci U S A (2003) 1.00
Identification of cytokeratins as accessory mediators of Salmonella entry into eukaryotic cells. Life Sci (2002) 0.98
Severe hepatotoxicity associated with a N-nitrosofenfluramine-containing weight-loss supplement: report of three cases. J Gastroenterol Hepatol (2004) 0.97
Hepcidin is localised in gastric parietal cells, regulates acid secretion and is induced by Helicobacter pylori infection. Gut (2011) 0.96
A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice. Exp Cell Res (2007) 0.96
Raf-1 activation disrupts its binding to keratins during cell stress. J Cell Biol (2004) 0.95
The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein. Am J Pathol (2005) 0.95
Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon. Proc Natl Acad Sci U S A (2011) 0.94
Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker. J Biol Chem (2006) 0.94
Mouse hepatocyte overexpression of NF-κB-inducing kinase (NIK) triggers fatal macrophage-dependent liver injury and fibrosis. Hepatology (2014) 0.93