Published in Genes Dev on March 01, 2012
Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov (2013) 4.72
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nat Rev Mol Cell Biol (2012) 3.45
Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metab (2014) 1.72
Therapeutic applications of PARP inhibitors: anticancer therapy and beyond. Mol Aspects Med (2013) 1.62
Protein poly(ADP-ribosyl)ation regulates arabidopsis immune gene expression and defense responses. PLoS Genet (2015) 1.53
Genetic factors associated with naevus count and dermoscopic patterns: preliminary results from the Study of Nevi in Children (SONIC). Br J Dermatol (2015) 1.47
Poly (ADP-ribose) polymerase inhibitors: recent advances and future development. J Clin Oncol (2015) 1.41
PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR. Nat Commun (2017) 1.38
DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res (2013) 1.33
CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells. Genes Dev (2012) 1.24
Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma. Front Oncol (2012) 1.14
Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal. Nature (2014) 1.12
Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function. Mol Cell (2015) 1.12
NAD⁺ metabolism: a therapeutic target for age-related metabolic disease. Crit Rev Biochem Mol Biol (2013) 1.11
PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage. Nucleic Acids Res (2014) 1.11
The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells. Front Oncol (2013) 1.10
The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response. Genes Dev (2013) 1.09
Beyond DNA repair, the immunological role of PARP-1 and its siblings. Immunology (2013) 1.08
The intersection between DNA damage response and cell death pathways. Exp Oncol (2012) 1.06
Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nat Rev Endocrinol (2015) 1.06
PARP1 represses PAP and inhibits polyadenylation during heat shock. Mol Cell (2012) 1.05
A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol. Nature (2014) 1.01
Mitonuclear communication in homeostasis and stress. Nat Rev Mol Cell Biol (2016) 1.01
The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy. Oncogene (2014) 0.98
Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response. Chromosoma (2013) 0.98
PARPs and ADP-Ribosylation: 50 Years … and Counting. Mol Cell (2015) 0.95
Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis. Genes Dev (2013) 0.95
Autophagy in DNA damage response. Int J Mol Sci (2015) 0.93
Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation. Cell Death Differ (2014) 0.92
Paternal poly (ADP-ribose) metabolism modulates retention of inheritable sperm histones and early embryonic gene expression. PLoS Genet (2014) 0.91
Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney. Proc Natl Acad Sci U S A (2014) 0.91
Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1. Mol Cell (2015) 0.91
Functional Aspects of PARP1 in DNA Repair and Transcription. Biomolecules (2012) 0.91
New PARP targets for cancer therapy. Nat Rev Cancer (2014) 0.91
DNA damage and repair in atherosclerosis: current insights and future perspectives. Int J Mol Sci (2012) 0.90
Depletion of the central metabolite NAD leads to oncosis-mediated cell death. J Biol Chem (2014) 0.90
PARP2 Is the Predominant Poly(ADP-Ribose) Polymerase in Arabidopsis DNA Damage and Immune Responses. PLoS Genet (2015) 0.90
The oligonucleotide/oligosaccharide-binding fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage response. Proc Natl Acad Sci U S A (2014) 0.89
Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks. J Mol Biol (2015) 0.88
Ginsenoside Rd blocks AIF mitochondrio-nuclear translocation and NF-κB nuclear accumulation by inhibiting poly(ADP-ribose) polymerase-1 after focal cerebral ischemia in rats. Neurol Sci (2013) 0.88
New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases. Chem Rev (2015) 0.88
Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells. Proc Natl Acad Sci U S A (2015) 0.87
Differential responses of pancreatic β-cells to ROS and RNS. Am J Physiol Endocrinol Metab (2013) 0.87
Readers of poly(ADP-ribose): designed to be fit for purpose. Nucleic Acids Res (2015) 0.87
Oxidative stress-mediated HMGB1 biology. Front Physiol (2015) 0.87
Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation. Genes Dev (2013) 0.86
Post-transcriptional regulation by poly(ADP-ribosyl)ation of the RNA-binding proteins. Int J Mol Sci (2013) 0.85
PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress. Nucleic Acids Res (2014) 0.85
Chromatin proteins: key responders to stress. PLoS Biol (2012) 0.85
AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6. Proc Natl Acad Sci U S A (2013) 0.85
Coordination of DNA repair by NEIL1 and PARP-1: a possible link to aging. Aging (Albany NY) (2012) 0.85
Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking. Front Pharmacol (2012) 0.85
RECQL4 in genomic instability and aging. Trends Genet (2012) 0.84
Cancer drug resistance: redox resetting renders a way. Oncotarget (2016) 0.84
Virotherapy targeting cyclin E overexpression in tumors with adenovirus-enhanced cancer-selective promoter. J Mol Med (Berl) (2014) 0.84
B cell-intrinsic and -extrinsic regulation of antibody responses by PARP14, an intracellular (ADP-ribosyl)transferase. J Immunol (2013) 0.84
Alteration of poly(ADP-ribose) metabolism affects murine sperm nuclear architecture by impairing pericentric heterochromatin condensation. Chromosoma (2013) 0.84
Poly(ADP-ribose)polymerase activity controls plant growth by promoting leaf cell number. PLoS One (2014) 0.83
Induction of mitochondrial dysfunction by poly(ADP-ribose) polymer: implication for neuronal cell death. Mol Cells (2013) 0.83
ARTD2 activity is stimulated by RNA. Nucleic Acids Res (2014) 0.82
Functions of PARylation in DNA Damage Repair Pathways. Genomics Proteomics Bioinformatics (2016) 0.82
DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1. Nucleic Acids Res (2013) 0.82
SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism. Genome Integr (2013) 0.82
The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair. PLoS One (2013) 0.82
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. J Cell Biol (2016) 0.82
Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response. Cell Rep (2015) 0.81
Binding to WGR domain by salidroside activates PARP1 and protects hematopoietic stem cells from oxidative stress. Antioxid Redox Signal (2014) 0.81
Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses. J Virol (2012) 0.81
PARP inhibitors. Hered Cancer Clin Pract (2015) 0.81
PARylation of the forkhead-associated domain protein DAWDLE regulates plant immunity. EMBO Rep (2016) 0.81
The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage. PLoS One (2013) 0.81
AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana. PLoS One (2012) 0.80
PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells. Biochem Pharmacol (2012) 0.80
The PIN domain of EXO1 recognizes poly(ADP-ribose) in DNA damage response. Nucleic Acids Res (2015) 0.80
PARP Inhibitors in Cancer Therapy: Magic Bullets but Moving Targets. Front Oncol (2013) 0.80
PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation. Nucleic Acids Res (2016) 0.80
Regulation of HFE expression by poly(ADP-ribose) polymerase-1 (PARP1) through an inverted repeat DNA sequence in the distal promoter. Biochim Biophys Acta (2013) 0.80
Poly(ADP-Ribosyl)ation Affects Histone Acetylation and Transcription. PLoS One (2015) 0.79
The Streptococcus pyogenes NAD(+) glycohydrolase modulates epithelial cell PARylation and HMGB1 release. Cell Microbiol (2015) 0.79
Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Mol Cell Biol (2015) 0.79
Epigenetics of autoantigens: new opportunities for therapy of autoimmune diseases. Genet Epigenet (2013) 0.79
Arabidopsis PARG1 is the key factor promoting cell survival among the enzymes regulating post-translational poly(ADP-ribosyl)ation. Sci Rep (2015) 0.79
DNA transcription and repair: a confluence. J Biol Chem (2012) 0.79
SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress. Open Biol (2013) 0.79
The RNA Splicing Response to DNA Damage. Biomolecules (2015) 0.79
Consequence of the tumor-associated conversion to cyclin D1b. EMBO Mol Med (2015) 0.79
Trial watch - inhibiting PARP enzymes for anticancer therapy. Mol Cell Oncol (2015) 0.79
The tale of a tail: histone H4 acetylation and the repair of DNA breaks. Philos Trans R Soc Lond B Biol Sci (2017) 0.79
PARP Inhibitors in Clinical Use Induce Genomic Instability in Normal Human Cells. PLoS One (2016) 0.79
Role of PARP-1 in prostate cancer. Am J Clin Exp Urol (2015) 0.78
Reactive intermediates: molecular and MS-based approaches to assess the functional significance of chemical-protein adducts. Toxicol Pathol (2012) 0.78
Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis. Cell Cycle (2014) 0.78
Lifelong endurance training attenuates age-related genotoxic stress in human skeletal muscle. Longev Healthspan (2013) 0.78
FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration. Cell Death Differ (2016) 0.77
Poly (ADP-ribose) in the pathogenesis of Parkinson's disease. BMB Rep (2014) 0.77
Therapeutic evaluation of monoclonal antibody-maytansinoid conjugate as a model of RON-targeted drug delivery for pancreatic cancer treatment. Am J Cancer Res (2016) 0.77
Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation. PLoS Biol (2016) 0.77
Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase. PLoS One (2014) 0.77
Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism. Oncotarget (2016) 0.77
Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression. J Cell Sci (2016) 0.76
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature (2005) 26.32
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med (2009) 24.75
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature (2005) 19.13
Origin and physiological roles of inflammation. Nature (2008) 11.68
Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol (2006) 9.58
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
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Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science (2002) 8.41
From endoplasmic-reticulum stress to the inflammatory response. Nature (2008) 7.17
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science (2006) 6.71
PARP inhibition: PARP1 and beyond. Nat Rev Cancer (2010) 6.70
The PARP superfamily. Bioessays (2004) 6.14
Eukaryotic stress granules: the ins and outs of translation. Mol Cell (2009) 6.09
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell (2010) 5.06
Rapid, transcription-independent loss of nucleosomes over a large chromatin domain at Hsp70 loci. Cell (2008) 4.81
Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal. Genes Dev (2005) 4.61
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev (1995) 4.54
NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1. Cell (2004) 4.21
Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science (2003) 3.97
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J Biol Chem (2002) 3.92
Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci U S A (1999) 3.85
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature (2008) 3.67
The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci (2008) 3.56
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell (2011) 3.53
Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes. Science (2008) 3.45
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A (2010) 3.31
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat Struct Mol Biol (2009) 3.26
Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation. Curr Opin Cell Biol (2008) 3.18
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Proc Natl Acad Sci U S A (2009) 3.02
SIRT6 promotes DNA repair under stress by activating PARP1. Science (2011) 2.99
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J (2003) 2.94
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab (2011) 2.94
Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature (2010) 2.85
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? Mutat Res (2000) 2.81
A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation. Mol Cell (2009) 2.56
Role of oxidative stress and DNA damage in human carcinogenesis. Mutat Res (2011) 2.54
Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene (2004) 2.52
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell (2010) 2.52
Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50
DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation. Mol Cell (2007) 2.48
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell (2005) 2.44
Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism. Cell (2011) 2.34
Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Mol Cell (2011) 2.33
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. Cell Commun Signal (2010) 2.27
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Nat Cell Biol (2011) 2.25
Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites. Nucleic Acids Res (2009) 2.22
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PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway. Mol Cell (2010) 2.06
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Parthanatos, a messenger of death. Front Biosci (Landmark Ed) (2009) 1.84
Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase. J Biol Chem (2005) 1.83
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell (2011) 1.83
Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1. J Biol Chem (2003) 1.79
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol (2009) 1.79
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation. Nat Cell Biol (2007) 1.73
Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal (2011) 1.73
Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters. J Biol Chem (2009) 1.70
Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates. Int J Cancer (2011) 1.70
Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc Natl Acad Sci U S A (2006) 1.68
Cellular stress response pathways and ageing: intricate molecular relationships. EMBO J (2011) 1.66
Mediation of cell death by poly(ADP-ribose) polymerase-1. Pharmacol Res (2005) 1.57
Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones. Proc Natl Acad Sci U S A (1999) 1.56
PARP-2 regulates SIRT1 expression and whole-body energy expenditure. Cell Metab (2011) 1.55
Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS). Genes Dev (2011) 1.52
Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus. J Biol Chem (2007) 1.51
Recruitment timing and dynamics of transcription factors at the Hsp70 loci in living cells. Mol Cell (2010) 1.50
Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity. J Biol Chem (2007) 1.50
Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation. J Immunol (2010) 1.46
Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. PLoS One (2011) 1.46
Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. Proc Natl Acad Sci U S A (2011) 1.42
APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells. Mol Cell Biol (2008) 1.41
A review of PARP inhibitors: from bench to bedside. Ann Oncol (2010) 1.41
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Activator-induced spread of poly(ADP-ribose) polymerase promotes nucleosome loss at Hsp70. Mol Cell (2011) 1.37
Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death. Nat Med (2011) 1.36
c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation. Cell Death Differ (2007) 1.36
The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives. Curr Opin Cell Biol (2006) 1.35
PARP-1 transcriptional activity is regulated by sumoylation upon heat shock. EMBO J (2009) 1.33
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA. J Biol Chem (2010) 1.32
PARP-1 attenuates Smad-mediated transcription. Mol Cell (2010) 1.32
Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells. J Biol Chem (2009) 1.32
Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing. Nucleic Acids Res (2009) 1.30
Chromatin regulation and genome maintenance by mammalian SIRT6. Trends Biochem Sci (2010) 1.28
Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1. Proc Natl Acad Sci U S A (2007) 1.23
Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. Mol Biol Cell (2009) 1.20
Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin. Proc Natl Acad Sci U S A (2011) 1.17
The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation. PLoS Biol (2008) 1.17
PARP1 deficiency exacerbates diet-induced obesity in mice. J Endocrinol (2010) 1.17
DNA repair factor APLF is a histone chaperone. Mol Cell (2011) 1.17
Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation. Int J Biochem Cell Biol (2008) 1.16
Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. PLoS Genet (2009) 1.15
Proteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase. J Proteome Res (2009) 1.14
New functions for an ancient domain. Nat Struct Mol Biol (2009) 1.12
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell (2010) 5.06
Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal. Genes Dev (2005) 4.61
A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells. Cell (2011) 4.42
NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1. Cell (2004) 4.21
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nat Rev Mol Cell Biol (2012) 3.45
Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes. Science (2008) 3.45
Enhancer transcripts mark active estrogen receptor binding sites. Genome Res (2013) 2.82
Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. Proc Natl Acad Sci U S A (2005) 2.40
Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters. Mol Cell Biol (2007) 2.33
Signaling pathways differentially affect RNA polymerase II initiation, pausing, and elongation rate in cells. Mol Cell (2013) 2.13
PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway. Mol Cell (2010) 2.06
Specific contributions of histone tails and their acetylation to the mechanical stability of nucleosomes. J Mol Biol (2004) 1.87
The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing. Genes Dev (2009) 1.82
The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription. Mol Cell Biol (2007) 1.82
Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation. Mol Cell Biol (2010) 1.75
Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. Mol Endocrinol (2006) 1.73
Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters. J Biol Chem (2009) 1.70
A global view of transcriptional regulation by nuclear receptors: gene expression, factor localization, and DNA sequence analysis. Nucl Recept Signal (2008) 1.62
Postrecruitment regulation of RNA polymerase II directs rapid signaling responses at the promoters of estrogen target genes. Mol Cell Biol (2008) 1.60
Estrogen-regulated gene networks in human breast cancer cells: involvement of E2F1 in the regulation of cell proliferation. Mol Endocrinol (2007) 1.55
Poly(ADP-ribose) polymerase 1 is inhibited by a histone H2A variant, MacroH2A, and contributes to silencing of the inactive X chromosome. J Biol Chem (2007) 1.53
The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction. J Biol Chem (2010) 1.47
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochim Biophys Acta (2009) 1.41
Genomic analyses of hormone signaling and gene regulation. Annu Rev Physiol (2010) 1.38
Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells. PLoS Genet (2011) 1.33
Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells. J Biol Chem (2009) 1.32
Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J (2006) 1.30
Multiple facets of the unique histone variant macroH2A: from genomics to cell biology. Cell Cycle (2010) 1.25
Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases. J Am Chem Soc (2010) 1.18
p300-mediated tax transactivation from recombinant chromatin: histone tail deletion mimics coactivator function. Mol Cell Biol (2002) 1.12
Mediator and p300/CBP-steroid receptor coactivator complexes have distinct roles, but function synergistically, during estrogen receptor alpha-dependent transcription with chromatin templates. Mol Cell Biol (2003) 1.12
New functions for an ancient domain. Nat Struct Mol Biol (2009) 1.12
Transcriptional activation by nuclear receptors. Essays Biochem (2004) 1.10
Selective recognition of distinct classes of coactivators by a ligand-inducible activation domain. Mol Cell (2004) 1.08
Histone H1 represses estrogen receptor alpha transcriptional activity by selectively inhibiting receptor-mediated transcription initiation. Mol Cell Biol (2002) 1.06
Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1. Proc Natl Acad Sci U S A (2005) 1.05
Chromatin exposes intrinsic differences in the transcriptional activities of estrogen receptors alpha and beta. EMBO J (2003) 1.04
Isoflavones stimulate estrogen receptor-mediated core histone acetylation. Biochem Biophys Res Commun (2004) 1.03
Hormone-regulated transcriptomes: lessons learned from estrogen signaling pathways in breast cancer cells. Mol Cell Endocrinol (2013) 0.99
MYBBP1a is a novel repressor of NF-kappaB. J Mol Biol (2006) 0.99
The role of the C-terminal extension (CTE) of the estrogen receptor alpha and beta DNA binding domain in DNA binding and interaction with HMGB. J Biol Chem (2004) 0.99
From discovery to function: the expanding roles of long noncoding RNAs in physiology and disease. Endocr Rev (2014) 0.98
PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2? Breast Cancer Res (2009) 0.95
Multiple sequence-specific DNA-binding proteins mediate estrogen receptor signaling through a tethering pathway. Mol Endocrinol (2011) 0.95
A role for BAF57 in cell cycle-dependent transcriptional regulation by the SWI/SNF chromatin remodeling complex. Cancer Res (2010) 0.95
Regulation of chromatin structure and chromatin-dependent transcription by poly(ADP-ribose) polymerase-1: possible targets for drug-based therapies. Subcell Biochem (2007) 0.94
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A novel Arabidopsis acetyltransferase interacts with the geminivirus movement protein NSP. Plant Cell (2003) 0.92
Promoter cleavage: a topoIIbeta and PARP-1 collaboration. Cell (2006) 0.89
Small molecules, big effects: a role for chromatin-localized metabolite biosynthesis in gene regulation. Mol Cell (2011) 0.89
Transcriptional activation by thyroid hormone receptor-beta involves chromatin remodeling, histone acetylation, and synergistic stimulation by p300 and steroid receptor coactivators. Mol Endocrinol (2003) 0.87
Biochemical analyses of nuclear receptor-dependent transcription with chromatin templates. Prog Mol Biol Transl Sci (2009) 0.86
A one and a two … expanding roles for poly(ADP-ribose) polymerases in metabolism. Cell Metab (2011) 0.85
Evolution of ligand specificity in vertebrate corticosteroid receptors. BMC Evol Biol (2011) 0.84
Minireview: Long noncoding RNAs: new "links" between gene expression and cellular outcomes in endocrinology. Mol Endocrinol (2013) 0.83
Development of a stable dual cell-line GFP expression system to study estrogenic endocrine disruptors. Biotechnol Bioeng (2008) 0.82
Visualizing the histone code on LSD1. Cell (2007) 0.81
Estrogen regulates JNK1 genomic localization to control gene expression and cell growth in breast cancer cells. Mol Endocrinol (2012) 0.80
Mapping ERβ genomic binding sites reveals unique genomic features and identifies EBF1 as an ERβ interactor. PLoS One (2013) 0.80
From Discovery to Function: The Expanding Roles of Long Non-Coding RNAs in Physiology and Disease. Endocr Rev (2015) 0.78
Activation of estrogen receptor α by raloxifene through an activating protein-1-dependent tethering mechanism in human cervical epithelial cancer cells: a role for c-Jun N-terminal kinase. Mol Cell Endocrinol (2011) 0.77
A PreSTIGEous use of LncRNAs to predict enhancers. Cell Cycle (2015) 0.75
Editorial: Centennial Celebration - A Focus on Endocrine Disrupting Chemicals… One Hundred Years in the Making. Mol Endocrinol (2016) 0.75
Generation and Characterization of Recombinant Antibody-Like ADP-Ribose Binding Proteins. Biochemistry (2017) 0.75