PubRank

Paul A Insel

Author PubWeight™ 138.74‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science 2006 6.00
2 A single amino acid mutation contributes to adaptive beach mouse color pattern. Science 2006 3.99
3 Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature 2011 3.51
4 The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. Br J Pharmacol 2004 2.70
5 Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol 2008 2.57
6 Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J Biol Chem 2006 2.31
7 Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J 2007 2.04
8 Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase. Proc Natl Acad Sci U S A 2004 2.02
9 Basal release of ATP: an autocrine-paracrine mechanism for cell regulation. Sci Signal 2010 1.91
10 G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J Biol Chem 2005 1.82
11 Autonomic nervous system pharmacogenomics: a progress report. Pharmacol Rev 2004 1.73
12 Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone. J Biol Chem 2008 1.67
13 Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Hypertension 2006 1.64
14 Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. Hypertension 2006 1.61
15 Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J 2009 1.61
16 The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells. J Biol Chem 2004 1.57
17 Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse. Blood 2010 1.56
18 Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation 2008 1.56
19 beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease. Pharmacogenetics 2002 1.54
20 Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci U S A 2005 1.52
21 Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. Am J Physiol Heart Circ Physiol 2006 1.52
22 Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. Hypertension 2005 1.52
23 Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone. FASEB J 2010 1.50
24 Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A 2010 1.49
25 The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proc Natl Acad Sci U S A 2008 1.49
26 cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts. Am J Physiol Cell Physiol 2004 1.47
27 Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits. Kidney Int 2009 1.44
28 Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: expression in caveolin-rich and noncaveolin domains. Mol Pharmacol 2002 1.42
29 Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. FASEB J 2007 1.39
30 Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J 2007 1.33
31 A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. J Leukoc Biol 2004 1.32
32 Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem 2008 1.31
33 Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. Proc Natl Acad Sci U S A 2003 1.30
34 Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. J Biol Chem 2002 1.30
35 Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. J Am Soc Nephrol 2010 1.30
36 Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury. J Mol Cell Cardiol 2007 1.28
37 Do caveolins regulate cells by actions outside of caveolae? Trends Cell Biol 2006 1.23
38 Multi-tasking RGS proteins in the heart: the next therapeutic target? Circ Res 2005 1.23
39 Purinergic inhibition of ENaC produces aldosterone escape. J Am Soc Nephrol 2010 1.19
40 Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin. J Biol Chem 2006 1.18
41 Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. Am J Physiol Lung Cell Mol Physiol 2006 1.17
42 A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells. Am J Physiol Cell Physiol 2007 1.17
43 Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death. FASEB J 2007 1.16
44 P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation. Proc Natl Acad Sci U S A 2005 1.12
45 Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK. J Biol Chem 2004 1.11
46 Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. J Biol Chem 2003 1.10
47 Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism. Clin Pharmacol Ther 2004 1.09
48 Hypertonic stress regulates T-cell function by the opposing actions of extracellular adenosine triphosphate and adenosine. Shock 2007 1.08
49 Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. J Biol Chem 2007 1.08
50 Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. J Am Coll Cardiol 2011 1.08
51 Discrete intracellular signaling domains of soluble adenylyl cyclase: camps of cAMP? Sci STKE 2004 1.08
52 Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol 2006 1.07
53 Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2008 1.07
54 Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes. J Biol Chem 2004 1.07
55 Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for neuronal survival. J Neurosci 2006 1.06
56 New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors. Purinergic Signal 2012 1.04
57 Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem 2010 1.04
58 Lipid rafts and caveolae and their role in compartmentation of redox signaling. Antioxid Redox Signal 2009 1.02
59 Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J 2012 0.99
60 G-protein-coupled receptor websites. Trends Pharmacol Sci 2002 0.98
61 GPCR expression in the heart; "new" receptors in myocytes and fibroblasts. Trends Cardiovasc Med 2004 0.98
62 Vasopressin regulation of inner medullary collecting ducts and compensatory changes in mice lacking adenosine A1 receptors. Am J Physiol Renal Physiol 2008 0.98
63 ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y2 receptors. FASEB J 2012 0.98
64 Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair. FASEB J 2011 0.97
65 12-lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass spectrometric, and pharmacological analyses. Circ Res 2003 0.95
66 P2Y₂ receptor activation decreases blood pressure and increases renal Na⁺ excretion. Am J Physiol Regul Integr Comp Physiol 2011 0.95
67 Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. J Clin Invest 2012 0.95
68 Increased expression of the pro-apoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells. J Biol Chem 2011 0.93
69 Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A 2012 0.92
70 Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts. FASEB J 2012 0.92
71 Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors. J Mol Cell Cardiol 2010 0.92
72 Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction. Am J Physiol Heart Circ Physiol 2007 0.92
73 Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons. J Biol Chem 2011 0.91
74 Human response to alpha2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype. Clin Pharmacol Ther 2005 0.90
75 P2Y receptors mediate Ca2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol 2008 0.89
76 The Gln27Glu beta2-adrenoceptor polymorphism slows the onset of desensitization of cardiac functional responses in vivo. Pharmacogenetics 2003 0.88
77 P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx. Pharmacogenet Genomics 2006 0.88
78 Nerve growth factor-stimulated neuronal differentiation induces changes in P2 receptor expression and nucleotide-stimulated catecholamine release. J Neurochem 2007 0.88
79 Methods for the study of signaling molecules in membrane lipid rafts and caveolae. Methods Mol Biol 2006 0.87
80 P2Y11 receptors activate adenylyl cyclase and contribute to nucleotide-promoted cAMP formation in MDCK-D(1) cells. A mechanism for nucleotide-mediated autocrine-paracrine regulation. J Biol Chem 2002 0.87
81 Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function. Mol Pharmacol 2006 0.87
82 Quantification of adenylyl cyclase messenger RNA by real-time polymerase chain reaction. Anal Biochem 2003 0.86
83 P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation. Biochem Biophys Res Commun 2006 0.86
84 Caveolin-3 undergoes SUMOylation by the SUMO E3 ligase PIASy: sumoylation affects G-protein-coupled receptor desensitization. J Biol Chem 2011 0.85
85 Role of O(2)-sensitive K(+) and Ca(2+) channels in the regulation of the pulmonary circulation: potential role of caveolae and implications for high altitude pulmonary edema. Respir Physiol Neurobiol 2005 0.85
86 Transient activation and delayed inhibition of Na+,K+,Cl- cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms. J Biol Chem 2006 0.84
87 Can you blame cold feet on Epac (and Rap1A)? Focus on "cyclic AMP-Rap1A signaling activates RhoA to induce α(2C)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells". Am J Physiol Cell Physiol 2012 0.84
88 Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Mol Pharmacol 2013 0.83
89 Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis. Am J Physiol Cell Physiol 2013 0.83
90 Purinergic-induced signaling in C11-MDCK cells inhibits the secretory Na-K-Cl cotransporter. Am J Physiol Cell Physiol 2003 0.82
91 Genetic variation in G-protein-coupled receptors--consequences for G-protein-coupled receptors as drug targets. Expert Opin Ther Targets 2005 0.82
92 Beta-2-adrenergic receptor polymorphisms in cystic fibrosis. Pharmacogenet Genomics 2007 0.82
93 Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts. J Biol Chem 2013 0.81
94 Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA. Cell Signal 2011 0.81
95 Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training. Acad Med 2013 0.80
96 Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry 2012 0.80
97 Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma. Expert Opin Ther Targets 2013 0.80
98 Genetic variation in phosphodiesterase (PDE) 7B in chronic lymphocytic leukemia: overview of genetic variants of cyclic nucleotide PDEs in human disease. J Hum Genet 2011 0.79
99 Coordinate down-regulation of adenylyl cyclase isoforms and the stimulatory G protein (G(s)) in intestinal epithelial cell differentiation. J Biol Chem 2010 0.79
100 Human adenosine 2B receptor: SNP discovery and evaluation of expression in patients with cystic fibrosis. Pharmacogenet Genomics 2005 0.79
101 Regulation of pulmonary vasoconstriction by agonists and caveolae. Exp Lung Res 2008 0.79
102 Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: structure-function implications for Epac activation and inhibition. J Biol Chem 2014 0.79
103 Pharmacogenetics of hypertension treatment: a structured review. Pharmacogenetics 2003 0.78
104 Cyclic nucleotide phosphodiesterase 7B mRNA: an unfavorable characteristic in chronic lymphocytic leukemia. Int J Cancer 2011 0.78
105 Identification of proteins and phosphoproteins using pulsed Q collision induced dissociation (PQD). J Am Soc Mass Spectrom 2011 0.78
106 Blasts from the past. J Clin Invest 2004 0.78
107 Cl- secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P 2Y1 receptors, phospholipase A2 and protein kinase A. J Physiol 2005 0.78
108 Discovery- and target-based protein quantification using iTRAQ and pulsed Q collision induced dissociation (PQD). J Proteomics 2012 0.77
109 The best "model system" for human (coronary arteries) is human. J Am Coll Cardiol 2009 0.77
110 Receptor databases and computational websites for ligand binding. Methods Mol Biol 2012 0.76
111 Receptor databases and computational websites for ligand binding. Methods Mol Biol 2005 0.76
112 I don't know the question, but sex is definitely the answer! Focus on "In pursuit of scientific excellence: sex matters" and "Do you know the sex of your cells?". Am J Physiol Cell Physiol 2013 0.76
113 AJP-Cell Physiology begins a Theme series on Evolution and Cell Physiology. Am J Physiol Cell Physiol 2013 0.75
114 Receptor gene polymorphisms: lessons on functional relevance from the beta 1-adrenoceptor. Br J Pharmacol 2003 0.75
115 Clarifying the effects of adrenergic receptor polymorphisms by measuring synaptic parameters. J Am Coll Cardiol 2004 0.75
116 Historical perspectives in cell physiology: looking back to help the discipline move forward. Am J Physiol Cell Physiol 2010 0.75
117 Editor's Note: AJP-Cell and AJP-Renal article series to honor the work of Dale Benos. Am J Physiol Cell Physiol 2011 0.75
118 AJP-Cell Physiology initiates publication of the Hans H. Ussing Lecture. Am J Physiol Cell Physiol 2010 0.75
119 A theme series on physical biology in cancer in AJP-Cell. Am J Physiol Cell Physiol 2013 0.75
120 Special issue on cell and molecular biology of purinergic signalling: an introduction. Purinergic Signal 2012 0.75
121 American Journal of Physiology-Cell Physiology initiates a series of articles around a theme: autophagy is the first theme. Am J Physiol Cell Physiol 2010 0.75
122 AJP-Cell begins a theme series on tissue fibrosis. Am J Physiol Cell Physiol 2012 0.75