Major taste loss in carnivorous mammals.

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The bamboo-eating giant panda (Ailuropoda melanoleuca) has a sweet tooth: behavioral and molecular responses to compounds that taste sweet to humans. PLoS One (2014) 1.44

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An evolutionary perspective on food and human taste. Curr Biol (2013) 1.11

Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire. Mol Biol Evol (2013) 1.08

Baiji genomes reveal low genetic variability and new insights into secondary aquatic adaptations. Nat Commun (2013) 1.01

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Mismatches between feeding ecology and taste receptor evolution: an inconvenient truth. Proc Natl Acad Sci U S A (2012) 0.85

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A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs. BMC Neurosci (2015) 0.84

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Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans. J Biol Chem (2016) 0.80

Frequent loss and alteration of the MOXD2 gene in catarrhines and whales: a possible connection with the evolution of olfaction. PLoS One (2014) 0.80

Vampire bats exhibit evolutionary reduction of bitter taste receptor genes common to other bats. Proc Biol Sci (2014) 0.80

Non-classical amine recognition evolved in a large clade of olfactory receptors. Elife (2015) 0.79

The loss of taste genes in cetaceans. BMC Evol Biol (2014) 0.79

Do polymorphisms in the TAS1R1 gene contribute to broader differences in human taste intensity? Chem Senses (2013) 0.79

Sequence Analysis of Bitter Taste Receptor Gene Repertoires in Different Ruminant Species. PLoS One (2015) 0.79

Molecular pathways associated with the nutritional programming of plant-based diet acceptance in rainbow trout following an early feeding exposure. BMC Genomics (2016) 0.78

Multiple loss-of-function variants of taste receptors in modern humans. Sci Rep (2015) 0.78

Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus). PLoS One (2015) 0.78

Dietary specialization drives multiple independent losses and gains in the bitter taste gene repertoire of Laurasiatherian Mammals. Front Zool (2016) 0.77

Why do we like sweet taste: A bitter tale? Physiol Behav (2016) 0.77

Natural Selection at the Brush-Border: Adaptations to Carbohydrate Diets in Humans and Other Mammals. Genome Biol Evol (2015) 0.76

Evolutionary biology: the lost appetites. Nature (2012) 0.76

Similarities and differences between "proactive" and "passive" stress-coping rats in responses to sucrose, NaCl, citric acid, and quinine. Chem Senses (2014) 0.75

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A role for airway taste receptor modulation in the treatment of upper respiratory infections. Expert Rev Respir Med (2016) 0.75

Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foraging behavior. Elife (2016) 0.75

Somatosensory brainstem, thalamus, and cortex of the California sea lion (Zalophus californianus). J Comp Neurol (2016) 0.75

Genetic variation in bitter taste receptor genes influences the foraging behavior of plateau zokor (Eospalax baileyi). Ecol Evol (2016) 0.75

MOXD2, a Gene Possibly Associated with Olfaction, Is Frequently Inactivated in Birds. PLoS One (2016) 0.75

Loss of gene function and evolution of human phenotypes. BMB Rep (2015) 0.75

The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket. Sci Rep (2017) 0.75

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The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76

Mammalian sweet taste receptors. Cell (2001) 8.04

An amino-acid taste receptor. Nature (2002) 6.71

T2Rs function as bitter taste receptors. Cell (2000) 6.57

Initial sequence and comparative analysis of the cat genome. Genome Res (2007) 4.67

A family of candidate taste receptors in human and mouse. Nature (2000) 4.18

Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat Genet (2001) 3.65

A candidate taste receptor gene near a sweet taste locus. Nat Neurosci (2001) 3.03

Positional cloning of the mouse saccharin preference (Sac) locus. Chem Senses (2001) 2.75

Taste receptor genes. Annu Rev Nutr (2007) 2.29

Molecular phylogeny of the carnivora (mammalia): assessing the impact of increased sampling on resolving enigmatic relationships. Syst Biol (2005) 2.25

Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes. Mol Biol Evol (2005) 1.77

Independent evolution of bitter-taste sensitivity in humans and chimpanzees. Nature (2006) 1.59

Gustatory and extragustatory functions of mammalian taste receptors. Physiol Behav (2011) 1.57

Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar. PLoS Genet (2005) 1.49

Evolution of the sweet taste receptor gene Tas1r2 in bats. Mol Biol Evol (2010) 1.36

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Genetics (2005) 1.31

Evolution of marine mammals: back to the sea after 300 million years. Anat Rec (Hoboken) (2007) 1.30

Adaptations of the cetacean hyolingual apparatus for aquatic feeding and thermoregulation. Anat Rec (Hoboken) (2007) 1.12

Use it or lose it: molecular evolution of sensory signaling in primates. Pflugers Arch (2006) 1.00

Analyses of sweet receptor gene (Tas1r2) and preference for sweet stimuli in species of Carnivora. J Hered (2009) 0.98

Phylogenetic utility of nuclear introns in interfamilial relationships of Caniformia (order Carnivora). Syst Biol (2011) 0.95

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Taste rejection of nonnutritive sweeteners in cats. J Comp Physiol Psychol (1975) 0.92

Taste preferences of the common vampire bat (Desmodus rotundus). J Chem Ecol (1982) 0.91

Responses of cultured rat trigeminal ganglion neurons to bitter tastants. Chem Senses (1998) 0.89

Scanning electron microscopy study of the tongue and lingual papillae of the California sea lion (Zalophus californianus californianus). Anat Rec (2002) 0.89

Identification of non-taster Japanese macaques for a specific bitter taste. Primates (2010) 0.87

Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A (2007) 4.62

Detection of sweet and umami taste in the absence of taste receptor T1r3. Science (2003) 4.54

APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Res (2008) 4.23

Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation. Immunity (2011) 3.75

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68

The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol (2005) 3.41

A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci (2002) 3.35

Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet (2002) 3.26

A high-resolution map of segmental DNA copy number variation in the mouse genome. PLoS Genet (2006) 3.24

China: the aging giant. J Am Geriatr Soc (2007) 2.89

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest (2012) 2.66

Prediction of drug-target interactions and drug repositioning via network-based inference. PLoS Comput Biol (2012) 2.63

Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature (2005) 2.52

Afferent neurotransmission mediated by hemichannels in mammalian taste cells. EMBO J (2007) 2.51

Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25. BMC Biol (2006) 2.41

Taste receptor genes. Annu Rev Nutr (2007) 2.29

Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics (2005) 2.29

Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcohol Clin Exp Res (2004) 2.26

Trpm5 null mice respond to bitter, sweet, and umami compounds. Chem Senses (2006) 2.25

The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. J Biol Chem (2004) 2.11

admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties. J Chem Inf Model (2012) 2.04

Towards precise classification of cancers based on robust gene functional expression profiles. BMC Bioinformatics (2005) 2.01

TRPM5-expressing solitary chemosensory cells respond to odorous irritants. J Neurophysiol (2007) 2.01

Copy-number variations measured by single-nucleotide-polymorphism oligonucleotide arrays in patients with mental retardation. Am J Hum Genet (2007) 2.00

Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. J Biol Chem (2005) 1.99

Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol (2002) 1.97

MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features. Nucleic Acids Res (2010) 1.94

Transmission of MDR and XDR tuberculosis in Shanghai, China. PLoS One (2009) 1.93

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet (2011) 1.92

Brain cannabinoid CB₂ receptors modulate cocaine's actions in mice. Nat Neurosci (2011) 1.88

The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J Clin Invest (2013) 1.76

Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J Biol Chem (2005) 1.74

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Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease. J Magn Reson Imaging (2009) 1.64

Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. Mol Cell (2012) 1.63

High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic Acids Res (2013) 1.61

The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein. PLoS Biol (2012) 1.60

G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells. J Comp Neurol (2003) 1.59

The timing and duration of a sensitive period in human flavor learning: a randomized trial. Am J Clin Nutr (2011) 1.59

T1R3 taste receptor is critical for sucrose but not Polycose taste. Am J Physiol Regul Integr Comp Physiol (2008) 1.57

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Sodium in the food supply: challenges and opportunities. Nutr Rev (2013) 1.56

Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells. Free Radic Biol Med (2002) 1.54

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Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience. Cell Transplant (2013) 1.53

Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue. PLoS One (2009) 1.53

Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A (2007) 1.50

Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar. PLoS Genet (2005) 1.49

The heterodimeric sweet taste receptor has multiple potential ligand binding sites. Curr Pharm Des (2006) 1.49

Apparently low reproducibility of true differential expression discoveries in microarray studies. Bioinformatics (2008) 1.48

Cross-priming amplification for rapid detection of Mycobacterium tuberculosis in sputum specimens. J Clin Microbiol (2008) 1.47

Electrophysiological characterization of voltage-gated currents in defined taste cell types of mice. J Neurosci (2003) 1.47

Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. J Neurosci (2006) 1.46

Prioritizing risk pathways: a novel association approach to searching for disease pathways fusing SNPs and pathways. Bioinformatics (2008) 1.46

Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci U S A (2010) 1.46

Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells. Proc Natl Acad Sci U S A (2011) 1.46

SubpathwayMiner: a software package for flexible identification of pathways. Nucleic Acids Res (2009) 1.45

Voluntary consumption of NaCl, KCl, CaCl2, and NH4Cl solutions by 28 mouse strains. Behav Genet (2002) 1.44

Allelic variation of the Tas1r3 taste receptor gene selectively affects behavioral and neural taste responses to sweeteners in the F2 hybrids between C57BL/6ByJ and 129P3/J mice. J Neurosci (2004) 1.43

Optimizing oral medications for children. Clin Ther (2008) 1.42

Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J Clin Invest (2014) 1.42

Sem1, the yeast ortholog of a human BRCA2-binding protein, is a component of the proteasome regulatory particle that enhances proteasome stability. J Cell Sci (2004) 1.42

Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice. Am J Physiol Regul Integr Comp Physiol (2010) 1.41

Flavor experiences during formula feeding are related to preferences during childhood. Early Hum Dev (2002) 1.40

Olfactory fingerprints for major histocompatibility complex-determined body odors II: relationship among odor maps, genetics, odor composition, and behavior. J Neurosci (2002) 1.39

QDMR: a quantitative method for identification of differentially methylated regions by entropy. Nucleic Acids Res (2011) 1.37

Umami taste responses are mediated by alpha-transducin and alpha-gustducin. J Neurosci (2004) 1.36

Evaluation of the Monell forced-choice, paired-comparison tracking procedure for determining sweet taste preferences across the lifespan. Chem Senses (2011) 1.35

Plasticity in eucaryotic 20S proteasome ring assembly revealed by a subunit deletion in yeast. EMBO J (2004) 1.34

Disruption of the cellulose synthase gene, AtCesA8/IRX1, enhances drought and osmotic stress tolerance in Arabidopsis. Plant J (2005) 1.34

Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones. Am J Clin Nutr (2009) 1.34

Flavor programming during infancy. Pediatrics (2004) 1.34

Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. Cell Res (2010) 1.33

The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions. Br J Pharmacol (2003) 1.33

Umami responses in mouse taste cells indicate more than one receptor. J Neurosci (2006) 1.33

The relationship between body mass index and hip osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine (2010) 1.33

Early milk feeding influences taste acceptance and liking during infancy. Am J Clin Nutr (2009) 1.33

Female oxytocin-deficient mice display enhanced anxiety-related behavior. Endocrinology (2003) 1.32

Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38. BMC Genet (2010) 1.31

MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer. J Pathol (2014) 1.31

Urinary volatile compounds as biomarkers for lung cancer: a proof of principle study using odor signatures in mouse models of lung cancer. PLoS One (2010) 1.31

Discrimination of taste qualities among mouse fungiform taste bud cells. J Physiol (2009) 1.30

Identification and expression analysis of miRNAs from nitrogen-fixing soybean nodules. Biochem Biophys Res Commun (2008) 1.30

Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor. J Biol Chem (2004) 1.30

A robust hybrid between genetic algorithm and support vector machine for extracting an optimal feature gene subset. Genomics (2005) 1.30

A review of localization systems for robotic endoscopic capsules. IEEE Trans Biomed Eng (2012) 1.29

Heavy metal sources identification and sampling uncertainty analysis in a field-scale vegetable soil of Hangzhou, China. Environ Pollut (2008) 1.29

The Salt Overly Sensitive (SOS) pathway: established and emerging roles. Mol Plant (2013) 1.28

Allelic variation of the Tas1r3 taste receptor gene selectively affects taste responses to sweeteners: evidence from 129.B6-Tas1r3 congenic mice. Physiol Genomics (2007) 1.28

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NDRG2 expression and mutation in human liver and pancreatic cancers. World J Gastroenterol (2004) 1.27

Contribution of alpha-gustducin to taste-guided licking responses of mice. Chem Senses (2005) 1.26