Published in World J Diabetes on March 15, 2012
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Insulin resistance in patients with chronic kidney disease. J Biomed Biotechnol (2012) 1.15
Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis. Diabetes (2012) 1.07
Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth. Nutr J (2013) 0.95
Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice. Cancer Metab (2014) 0.89
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The pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitus. Curr Diabetes Rev (2015) 0.80
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Metabolic effects of milk protein intake strongly depend on pre-existing metabolic and exercise status. Nutr Metab (Lond) (2013) 0.79
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Milk consumption during pregnancy increases birth weight, a risk factor for the development of diseases of civilization. J Transl Med (2015) 0.77
MPINet: metabolite pathway identification via coupling of global metabolite network structure and metabolomic profile. Biomed Res Int (2014) 0.77
Mitochondrial health, the epigenome and healthspan. Clin Sci (Lond) (2016) 0.76
Dietary Interventions for Type 2 Diabetes: How Millet Comes to Help. Front Plant Sci (2016) 0.76
Branched-Chain Amino Acids as New Biomarkers of Major Depression - A Novel Neurobiology of Mood Disorder. PLoS One (2016) 0.75
Molecular Characterization and Expression Analysis of S6K1 in Cashmere Goats (Capra hircus). Asian-Australas J Anim Sci (2013) 0.75
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08
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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24
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mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell (2011) 4.70
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An accurate risk score based on anthropometric, dietary, and lifestyle factors to predict the development of type 2 diabetes. Diabetes Care (2007) 4.14
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab (2010) 4.08
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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol (2006) 3.67
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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One (2010) 3.62
p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Mol Cell (2011) 3.46
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2007) 3.32
Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab (2007) 3.30
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Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J Biol Chem (2005) 2.70
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A prospective study of red meat consumption and type 2 diabetes in middle-aged and elderly women: the women's health study. Diabetes Care (2004) 2.57
Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev (2005) 2.56
Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes (2005) 2.55
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Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. Am J Physiol Endocrinol Metab (2007) 2.46
Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab (2008) 2.27
Lower protein in infant formula is associated with lower weight up to age 2 y: a randomized clinical trial. Am J Clin Nutr (2009) 2.23
Processed meat intake and incidence of Type 2 diabetes in younger and middle-aged women. Diabetologia (2003) 2.19
Prospective study on nutrition transition in China. Nutr Rev (2009) 2.18
Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease. FEBS Lett (2007) 2.15
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FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. Dev Cell (2010) 2.11
The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man. Diabetes (2007) 2.09
Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci STKE (2005) 2.04
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Nutrient control of TORC1, a cell-cycle regulator. Trends Cell Biol (2009) 1.88
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Increased incidence of non-insulin dependent diabetes mellitus among Japanese schoolchildren correlates with an increased intake of animal protein and fat. Clin Pediatr (Phila) (1998) 1.82
Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy (2011) 1.81
Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem (2010) 1.80
S6K1 plays a critical role in early adipocyte differentiation. Dev Cell (2010) 1.74
The role of FOXO in the regulation of metabolism. Curr Diab Rep (2009) 1.73
Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab (2007) 1.71
Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem (2004) 1.69
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Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle. Cell Metab (2011) 1.67
Cow's milk and linear growth in industrialized and developing countries. Annu Rev Nutr (2006) 1.65
Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes (2010) 1.64
Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p. J Biol Chem (2006) 1.63
Meats, processed meats, obesity, weight gain and occurrence of diabetes among adults: findings from Adventist Health Studies. Ann Nutr Metab (2008) 1.61
Can infant feeding choices modulate later obesity risk? Am J Clin Nutr (2009) 1.61
Regulation of mTORC1 by the Rab and Arf GTPases. J Biol Chem (2010) 1.60
Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem Biophys Res Commun (2004) 1.59
Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells. Cancer Res (2008) 1.59
Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells. Int J Cancer (2006) 1.57
Dietary patterns and diabetes incidence in the Melbourne Collaborative Cohort Study. Am J Epidemiol (2007) 1.53
Size at birth as a predictor of mortality in adulthood: a follow-up of 350 000 person-years. Int J Epidemiol (2005) 1.47
Interplay between FOXO, TOR, and Akt. Biochim Biophys Acta (2011) 1.47
Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice. Mol Cell Biol (2008) 1.46
Dietary iron intake and Type 2 diabetes incidence in postmenopausal women: the Iowa Women's Health Study. Diabetologia (2004) 1.44
Coffee and its consumption: benefits and risks. Crit Rev Food Sci Nutr (2011) 1.43
Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. Proc Natl Acad Sci U S A (2006) 1.43
Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells. Diabetes (2001) 1.42