Zebrafish screen identifies novel compound with selective toxicity against leukemia.

PubWeight™: 1.81‹?› | Rank: Top 3%

🔗 View Article (PMC 3382926)

Published in Blood on April 09, 2012

Authors

Suzanne Ridges1, Will L Heaton, Deepa Joshi, Henry Choi, Anna Eiring, Lance Batchelor, Priya Choudhry, Elizabeth J Manos, Hossein Sofla, Ali Sanati, Seth Welborn, Archana Agarwal, Gerald J Spangrude, Rodney R Miles, James E Cox, J Kimble Frazer, Michael Deininger, Kaveri Balan, Matthew Sigman, Markus Müschen, Tatiana Perova, Radia Johnson, Bertrand Montpellier, Cynthia J Guidos, David A Jones, Nikolaus S Trede

Author Affiliations

1: Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

Articles citing this

Zebrafish cancer: the state of the art and the path forward. Nat Rev Cancer (2013) 1.87

Zebrafish as tools for drug discovery. Nat Rev Drug Discov (2015) 1.28

Phenotypic screens as a renewed approach for drug discovery. Drug Discov Today (2013) 1.18

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era. Dis Model Mech (2014) 1.14

15 years of zebrafish chemical screening. Curr Opin Chem Biol (2014) 1.13

Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune encephalomyelitis mice. NMR Biomed (2014) 0.96

Zebrafish models of cancer: progress and future challenges. Curr Opin Genet Dev (2013) 0.94

Orthotopic models of pediatric brain tumors in zebrafish. Oncogene (2014) 0.92

Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway. Oncogenesis (2014) 0.91

Zebrafish as a model to assess cancer heterogeneity, progression and relapse. Dis Model Mech (2014) 0.90

Oceans of opportunity: exploring vertebrate hematopoiesis in zebrafish. Exp Hematol (2014) 0.89

Cannabinoid receptor 2 suppresses leukocyte inflammatory migration by modulating the JNK/c-Jun/Alox5 pathway. J Biol Chem (2013) 0.89

UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol Cancer Ther (2013) 0.86

Advances in zebrafish chemical screening technologies. Future Med Chem (2012) 0.86

Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish. J Exp Med (2016) 0.85

Anti-cancer drug discovery: update and comparisons in yeast, Drosophila, and zebrafish. Curr Mol Pharmacol (2014) 0.82

Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia. Haematologica (2014) 0.80

Oncogenic KRAS promotes malignant brain tumors in zebrafish. Mol Cancer (2015) 0.80

Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer. Cancer Res (2015) 0.79

A fresh look at zebrafish from the perspective of cancer research. J Exp Clin Cancer Res (2015) 0.78

The Zebrafish as a Tool to Cancer Drug Discovery. Austin J Pharmacol Ther (2015) 0.78

High-Throughput Method for Automated Colony and Cell Counting by Digital Image Analysis Based on Edge Detection. PLoS One (2016) 0.78

Zebrafish embryonic stromal trunk (ZEST) cells support hematopoietic stem and progenitor cell (HSPC) proliferation, survival, and differentiation. Exp Hematol (2015) 0.78

Targeting insulin-like growth factor 1 leads to amelioration of inflammatory demyelinating disease. PLoS One (2014) 0.77

In vivo chemical screening for modulators of hematopoiesis and hematological diseases. Adv Hematol (2012) 0.76

Fish pharming: zebrafish antileukemia screening. Blood (2012) 0.76

Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol (2016) 0.76

c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia (2016) 0.75

A novel TGFβ modulator that uncouples R-Smad/I-Smad-mediated negative feedback from R-Smad/ligand-driven positive feedback. PLoS Biol (2015) 0.75

Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights. Adv Exp Med Biol (2016) 0.75

Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish. Blood Cancer J (2016) 0.75

Zebrafish Models of Prader-Willi Syndrome: Fast Track to Pharmacotherapeutics. Diseases (2016) 0.75

Danio rerio: Small Fish Making a Big Splash in Leukemia. Curr Pathobiol Rep (2014) 0.75

A small molecule screen identifies in vivo modulators of peripheral nerve regeneration in zebrafish. PLoS One (2017) 0.75

Zebrafish in Translational Cancer Research: Insight into Leukemia, Melanoma, Glioma and Endocrine Tumor Biology. Genes (Basel) (2017) 0.75

Zebrafish phenotypic screen identifies novel notch antagonists. Invest New Drugs (2017) 0.75

Articles cited by this

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99

Causal protein-signaling networks derived from multiparameter single-cell data. Science (2005) 34.28

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med (1996) 13.49

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell (2002) 11.83

Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell (1996) 10.40

Acute lymphoblastic leukemia. N Engl J Med (2004) 7.83

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med (2007) 6.55

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell (2006) 6.15

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res (2008) 5.82

PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol (2004) 5.10

Multiple molecular mechanisms for multidrug resistance transporters. Nature (2007) 3.96

Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Curr Opin Pharmacol (2008) 3.41

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med (2010) 3.26

Myc-induced T cell leukemia in transgenic zebrafish. Science (2003) 3.15

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood (2009) 3.02

Childhood T-cell acute lymphoblastic leukemia: the Dana-Farber Cancer Institute acute lymphoblastic leukemia consortium experience. J Clin Oncol (2003) 2.88

Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol (2005) 2.74

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J Exp Med (2000) 2.51

Targeting the Notch1 and mTOR pathways in a mouse T-ALL model. Blood (2009) 2.29

DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature (2011) 2.23

Regulating the licensing of DNA replication origins in metazoa. Curr Opin Cell Biol (2006) 2.08

Immunology and zebrafish: spawning new models of human disease. Dev Comp Immunol (2008) 2.04

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem (2005) 1.92

Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nat Chem Biol (2005) 1.87

In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci U S A (2004) 1.85

The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia. Cell Cycle (2008) 1.83

Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines. Proc Natl Acad Sci U S A (1979) 1.72

Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation. Nat Chem Biol (2009) 1.58

A chemical genetic screen for cell cycle inhibitors in zebrafish embryos. Chem Biol Drug Des (2006) 1.50

AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development (2008) 1.44

Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia. Semin Hematol (2000) 1.40

Critical roles of the PI3K/Akt signaling pathway in T cell development. Immunol Lett (2008) 1.37

Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia. Cancer Res (2009) 1.29

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J Exp Med (2011) 1.27

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. Blood (2009) 1.23

DNA damage-induced cell-cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway. Blood (2001) 1.17

A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells. Leukemia (2003) 1.12

Heritable T-cell malignancy models established in a zebrafish phenotypic screen. Leukemia (2009) 1.09

Screening for drug discovery: the leading question. Nature (2002) 0.99

The relationship between histone H3 phosphorylation and acetylation throughout the mammalian cell cycle. Biochem Cell Biol (2006) 0.99

Human myeloid and lymphoid malignancies in the non-obese diabetic/severe combined immunodeficiency mouse model: frequency of apoptotic cells in solid tumors and efficiency and speed of engraftment correlate with vascular endothelial growth factor production. Cancer Res (2000) 0.98

Notch3-mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cells. Leukemia (2011) 0.92

Notch cleavage: Nicastrin helps Presenilin make the final cut. Curr Biol (2002) 0.88

Fas apoptosis inhibitory molecule regulates T cell receptor-mediated apoptosis of thymocytes by modulating Akt activation and Nur77 expression. J Biol Chem (2010) 0.82

Articles by these authors

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med (2012) 9.69

Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol (2009) 9.40

DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell (2008) 8.62

Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood (2006) 7.30

Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood (2006) 6.89

Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia. J Clin Oncol (2008) 4.53

A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med (2004) 4.37

Widespread reward-system activation in obese women in response to pictures of high-calorie foods. Neuroimage (2008) 3.65

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature (2011) 3.63

Multicenter independent assessment of outcomes in chronic myeloid leukemia patients treated with imatinib. J Natl Cancer Inst (2011) 3.51

A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science (2012) 3.39

Myc-induced T cell leukemia in transgenic zebrafish. Science (2003) 3.15

The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood (2007) 2.99

Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99

A two-step model for colon adenoma initiation and progression caused by APC loss. Cell (2009) 2.80

Obese women show greater delay discounting than healthy-weight women. Appetite (2008) 2.78

Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia. Cancer Discov (2013) 2.74

Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors. Nucleic Acids Res (2004) 2.55

Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remissions in patients with hematological diseases. Blood (2002) 2.49

The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell (2009) 2.42

Method for isolation of PCR-ready genomic DNA from zebrafish tissues. Biotechniques (2007) 2.34

Requirement for Notch1 signals at sequential early stages of intrathymic T cell development. Nat Immunol (2005) 2.19

The Gulf: a young sea in decline. Mar Pollut Bull (2009) 2.13

Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II. Nat Genet (2009) 2.12

A randomized trial of dasatinib 100 mg versus imatinib 400 mg in newly diagnosed chronic-phase chronic myeloid leukemia. Blood (2012) 2.11

Immunology and zebrafish: spawning new models of human disease. Dev Comp Immunol (2008) 2.04

Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches. Immunity (2009) 2.03

The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem (2003) 1.97

Major age-related changes of mouse hematopoietic stem/progenitor cells. Ann N Y Acad Sci (2003) 1.96

The zebrafish as a model organism to study development of the immune system. Adv Immunol (2003) 1.96

The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell (2003) 1.90

DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell (2010) 1.89

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol (2013) 1.87

In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci U S A (2004) 1.85

Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function. J Exp Med (2009) 1.80

BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nat Med (2013) 1.79

Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures. DNA Repair (Amst) (2006) 1.76

Properties of a fetal multipotent neural stem cell (NEP cell). Dev Biol (2002) 1.75

Reactivating the expression of methylation silenced genes in human cancer. Oncogene (2002) 1.73

Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development. Mol Cell Biol (2006) 1.71

Internalization of flax rust avirulence proteins into flax and tobacco cells can occur in the absence of the pathogen. Plant Cell (2010) 1.70

Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish. Genes Dev (2007) 1.69

Functions of notch signaling in the immune system: consensus and controversies. Annu Rev Immunol (2010) 1.68

The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol (2004) 1.64

GFP-tagging of cell components reveals the dynamics of subcellular re-organization in response to infection of Arabidopsis by oomycete pathogens. Plant J (2003) 1.64

fMRI reactivity to high-calorie food pictures predicts short- and long-term outcome in a weight-loss program. Neuroimage (2012) 1.63

Control of B cell development by the histone H2A deubiquitinase MYSM1. Immunity (2011) 1.63

Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome. Blood (2007) 1.59

A model 450 million years in the making: zebrafish and vertebrate immunity. Dis Model Mech (2012) 1.59

Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches. Nat Immunol (2006) 1.57

Cytoskeleton and cell wall function in penetration resistance. Curr Opin Plant Biol (2007) 1.57

BCL6 is critical for the development of a diverse primary B cell repertoire. J Exp Med (2010) 1.56

Drink temperature influences fluid intake and endurance capacity in men during exercise in a hot, dry environment. Exp Physiol (2006) 1.54

Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol (2009) 1.52

Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine. Mol Pharmacol (2004) 1.50

Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells. J Exp Med (2007) 1.47

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med (2011) 1.45

Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer. Cancer Cell (2012) 1.44

Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis. J Exp Med (2006) 1.43

An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles. Vaccine (2008) 1.42

Dnmt3 and G9a cooperate for tissue-specific development in zebrafish. J Biol Chem (2009) 1.42

Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet (2003) 1.40

L-selectin defines a bone marrow analog to the thymic early T-lineage progenitor. Blood (2003) 1.39

Chronic exertional compartment syndrome: muscle changes with isometric exercise. Med Sci Sports Exerc (2002) 1.38

Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma. Blood (2003) 1.36

UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants. Curr Biol (2007) 1.36

Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J (2003) 1.36

Network distribution of mitochondria and lipid droplets in human muscle fibres. Histochem Cell Biol (2007) 1.35

Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation. J Clin Oncol (2005) 1.35

Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. Cancer Discov (2012) 1.33

EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression. Blood (2007) 1.33

The effect of carbohydrate mouth rinse on 1-h cycle time trial performance. Med Sci Sports Exerc (2004) 1.33

Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation. J Biol Chem (2004) 1.31

Transcriptional profiles predict disease outcome in patients with cutaneous T-cell lymphoma. Clin Cancer Res (2010) 1.31

Resolution of the novel immune-type receptor gene cluster in zebrafish. Proc Natl Acad Sci U S A (2004) 1.30

Effectors of biotrophic fungi and oomycetes: pathogenicity factors and triggers of host resistance. New Phytol (2009) 1.30

The role of cyclooxygenase-2 and prostaglandins in colon cancer. Prostaglandins Other Lipid Mediat (2006) 1.29

Fish immunology. Curr Biol (2009) 1.28

DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling. Exp Cell Res (2004) 1.28

The zebrafish as a model for cancer. Dis Model Mech (2010) 1.25

Applicant attraction to organizations and job choice: a meta-analytic review of the correlates of recruiting outcomes. J Appl Psychol (2005) 1.24

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. Blood (2011) 1.24

Effective connectivity of a reward network in obese women. Brain Res Bull (2009) 1.23

New perspectives on APC control of cell fate and proliferation in colorectal cancer. Cell Cycle (2009) 1.21

Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia. Blood (2011) 1.20

Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions. Immunol Rev (2006) 1.20

Comparison of serum and heparinized plasma samples for measurement of chemistry analytes. Clin Chem (2004) 1.17

Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor. Immunity (2007) 1.17

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood (2013) 1.16

Congenital erythropoietic porphyria due to a mutation in GATA1: the first trans-acting mutation causative for a human porphyria. Blood (2006) 1.16

Low-level expression of proapoptotic Bcl-2-interacting mediator in leukemic cells in patients with chronic myeloid leukemia: role of BCR/ABL, characterization of underlying signaling pathways, and reexpression by novel pharmacologic compounds. Cancer Res (2005) 1.16

Transcription factor Oct1 is a somatic and cancer stem cell determinant. PLoS Genet (2012) 1.15

Adaptive response of human tendon to paralysis. Muscle Nerve (2006) 1.15

Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib. Leuk Lymphoma (2004) 1.15

ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection. Immunol Rev (2006) 1.15

IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia. PLoS One (2012) 1.15

Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish. Development (2002) 1.14