Published in Cell on April 13, 2012
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Targeting pathological B cell receptor signalling in lymphoid malignancies. Nat Rev Drug Discov (2013) 2.31
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Where is mTOR and what is it doing there? J Cell Biol (2013) 1.91
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell (2014) 1.87
Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation. Blood (2013) 1.85
The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell (2015) 1.83
Functions of autophagy in normal and diseased liver. Autophagy (2013) 1.81
Autophagy regulation by nutrient signaling. Cell Res (2013) 1.81
Glucose-TOR signalling reprograms the transcriptome and activates meristems. Nature (2013) 1.76
Metabolism of kidney cancer: from the lab to clinical practice. Eur Urol (2012) 1.75
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Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov (2013) 1.66
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A Central role for mTOR in lipid homeostasis. Cell Metab (2013) 1.57
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Regulation of mTORC1 by PI3K signaling. Trends Cell Biol (2015) 1.54
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Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2. Cell Metab (2013) 1.54
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Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. Nat Immunol (2017) 1.52
Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep (2014) 1.51
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AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow. Cell Stem Cell (2015) 1.51
The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol (2014) 1.51
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BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY) (2014) 1.48
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Dual modulation of MCL-1 and mTOR determines the response to sunitinib. J Clin Invest (2016) 1.47
New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis. Aging (Albany NY) (2012) 1.47
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TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell (2002) 18.22
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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol (2004) 12.12
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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature (2011) 8.03
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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science (2011) 7.55
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The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol Cell Biol (2002) 7.44
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A unifying model for mTORC1-mediated regulation of mRNA translation. Nature (2012) 6.44
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell (2009) 5.97
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mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell (2011) 4.70
Genome-scale loss-of-function screening with a lentiviral RNAi library. Nat Methods (2006) 4.12
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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science (2013) 3.96
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res (2010) 3.94
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature (2010) 3.81
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell (2009) 3.78
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell (2012) 3.77
Tumours with PI3K activation are resistant to dietary restriction. Nature (2009) 3.60
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature (2012) 3.51
An emerging role of mTOR in lipid biosynthesis. Curr Biol (2009) 3.50
An expanding role for mTOR in cancer. Trends Mol Med (2005) 3.40
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