Published in Genes Chromosomes Cancer on April 19, 2012
The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression. Oncotarget (2015) 0.87
Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer. Clin Cancer Res (2014) 0.83
Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid Neoplasia. Cancers (Basel) (2013) 0.80
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene. Genes (Basel) (2016) 0.79
Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter. Oncotarget (2017) 0.75
Telomerase Activation in Hematological Malignancies. Genes (Basel) (2016) 0.75
GATA2 regulates the erythropoietin receptor in t(12;21) ALL. Oncotarget (2017) 0.75
Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group. J Clin Oncol (2010) 4.09
Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis. Blood (2010) 2.16
Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. J Invest Dermatol (2008) 1.93
The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes Dev (2007) 1.88
The Enzyme Function Initiative. Biochemistry (2011) 1.87
Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis. J Natl Cancer Inst (2012) 1.82
Insights into enzyme structure and dynamics elucidated by amide H/D exchange mass spectrometry. Arch Biochem Biophys (2005) 1.70
TAZ expression as a prognostic indicator in colorectal cancer. PLoS One (2013) 1.55
Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage. PLoS One (2010) 1.50
Laparoendoscopic single-site radical cystectomy and urinary diversion: initial experience in China using a homemade single-port device. J Endourol (2011) 1.48
Crystal structure of a genomically encoded fosfomycin resistance protein (FosA) at 1.19 A resolution by MAD phasing off the L-III edge of Tl(+). J Am Chem Soc (2002) 1.39
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell (2013) 1.33
An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase. Br J Haematol (2008) 1.33
Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans. Hum Mol Genet (2006) 1.30
miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro. Biochem Biophys Res Commun (2010) 1.29
Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor. J Gerontol A Biol Sci Med Sci (2005) 1.24
Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging). Ann N Y Acad Sci (2007) 1.21
Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements. Nucleic Acids Res (2009) 1.19
Fosfomycin resistance proteins: a nexus of glutathione transferases and epoxide hydrolases in a metalloenzyme superfamily. Methods Enzymol (2005) 1.18
Mechanistic diversity of fosfomycin resistance in pathogenic microorganisms. J Am Chem Soc (2003) 1.13
Stress sensor triggers conformational response of the integral membrane protein microsomal glutathione transferase 1. Biochemistry (2004) 1.13
Mapping protein dynamics in catalytic intermediates of the redox-driven proton pump cytochrome c oxidase. Proc Natl Acad Sci U S A (2006) 1.11
Phosphonoformate: a minimal transition state analogue inhibitor of the fosfomycin resistance protein, FosA. Biochemistry (2004) 1.08
Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease. Br J Haematol (2014) 1.07
Short telomeres are preferentially elongated by telomerase in human cells. FEBS Lett (2009) 1.07
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC. Blood (2009) 1.06
Application of connectivity mapping in predictive toxicology based on gene-expression similarity. Toxicology (2009) 1.05
Parallel evolutionary pathways for glutathione transferases: structure and mechanism of the mitochondrial class kappa enzyme rGSTK1-1. Biochemistry (2004) 1.05
Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation. PLoS One (2010) 1.03
Analysis of the structure and function of YfcG from Escherichia coli reveals an efficient and unique disulfide bond reductase. Biochemistry (2009) 1.03
Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping. PLoS One (2011) 1.01
EPR study of substrate binding to the Mn(II) active site of the bacterial antibiotic resistance enzyme FosA: a better way to examine Mn(II). J Am Chem Soc (2002) 1.00
New initiatives pertaining to biochemistry in 2008. Biochemistry (2008) 1.00
Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes. Biochemistry (2007) 0.98
Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability. J Natl Cancer Inst (2013) 0.98
Gene expression meta-analysis identifies VDAC1 as a predictor of poor outcome in early stage non-small cell lung cancer. PLoS One (2011) 0.98
Conserved structural elements in glutathione transferase homologues encoded in the genome of Escherichia coli. Proteins (2003) 0.97
Synthesis of bacillithiol and the catalytic selectivity of FosB-type fosfomycin resistance proteins. Org Lett (2012) 0.95
Functional effector memory T cells enrich the peritoneal cavity of patients treated with peritoneal dialysis. J Am Soc Nephrol (2009) 0.94
Location of substrate binding sites within the integral membrane protein microsomal glutathione transferase-1. Biochemistry (2007) 0.94
Telomere dysfunction and its role in haematological cancer. Br J Haematol (2012) 0.93
Judge a paper on its own merits, not its journal's. Nature (2006) 0.93
Structure of fosfomycin resistance protein FosA from transposon Tn2921. Protein Sci (2004) 0.93
RanGTPase: a candidate for Myc-mediated cancer progression. J Natl Cancer Inst (2013) 0.93
Location of inhibitor binding sites in the human inducible prostaglandin E synthase, MPGES1. Biochemistry (2011) 0.92
Structural and chemical aspects of resistance to the antibiotic fosfomycin conferred by FosB from Bacillus cereus. Biochemistry (2013) 0.91
Structural elements involved in proton translocation by cytochrome c oxidase as revealed by backbone amide hydrogen-deuterium exchange of the E286H mutant. Biochemistry (2007) 0.90
Microarray analysis of tumour antigen expression in presentation acute myeloid leukaemia. Biochem Biophys Res Commun (2005) 0.90
HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy. Haematologica (2013) 0.89
Telomere length maintenance in stem cell populations. Biochim Biophys Acta (2009) 0.89
Structure and function of YghU, a nu-class glutathione transferase related to YfcG from Escherichia coli. Biochemistry (2011) 0.89
Connectivity Mapping for Candidate Therapeutics Identification Using Next Generation Sequencing RNA-Seq Data. PLoS One (2013) 0.88
DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase. Mutat Res (2010) 0.88
Enzyme control of small-molecule coordination in FosA as revealed by 31P pulsed ENDOR and ESE-EPR. J Am Chem Soc (2005) 0.88
Strain-specific telomere length revealed by single telomere length analysis in Caenorhabditis elegans. Nucleic Acids Res (2004) 0.88
cudaMap: a GPU accelerated program for gene expression connectivity mapping. BMC Bioinformatics (2013) 0.88
Molecular recognition at the dimer interface of a class mu glutathione transferase: role of a hydrophobic interaction motif in dimer stability and protein function. Biochemistry (2002) 0.87
Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia. Br J Haematol (2012) 0.87
Exploring the evolutionary differences of SBP-box genes targeted by miR156 and miR529 in plants. Genetica (2012) 0.87
Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution. Biochemistry (2012) 0.86
Influence of the dimer interface on glutathione transferase structure and dynamics revealed by amide H/D exchange mass spectrometry. Biochemistry (2005) 0.86
Local protein dynamics and catalysis: detection of segmental motion associated with rate-limiting product release by a glutathione transferase. Biochemistry (2002) 0.86
Molecular similarity between myelodysplastic form of chronic myelomonocytic leukemia and refractory anemia with ring sideroblasts. Haematologica (2012) 0.86
Mre11 modulates the fidelity of fusion between short telomeres in human cells. Nucleic Acids Res (2011) 0.86
Impact of domain interchange on conformational stability and equilibrium folding of chimeric class micro glutathione transferases. Protein Sci (2002) 0.85
Entinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia. Stem Cells (2013) 0.84
Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione. Arch Biochem Biophys (2009) 0.84
No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis. Ageing Res Rev (2010) 0.84
A model for glutathione binding and activation in the fosfomycin resistance protein, FosA. Arch Biochem Biophys (2007) 0.84
Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression. Cancer Sci (2012) 0.84
Catalytic mechanism of dichloromethane dehalogenase from Methylophilus sp. strain DM11. Biochemistry (2003) 0.84
Immunotherapy of myeloid leukaemia. Cancer Immunol Immunother (2006) 0.83
Structure and function of the genomically encoded fosfomycin resistance enzyme, FosB, from Staphylococcus aureus. Biochemistry (2014) 0.83
SSX2IP expression in acute myeloid leukaemia: an association with mitotic spindle failure in t(8;21), and cell cycle in t(15;17) patients. Br J Haematol (2007) 0.83
Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes. J Clin Oncol (2013) 0.83
In pursuit of effective toxicogenomics. Mutat Res (2005) 0.82
Double mutation at the subunit interface of glutathione transferase rGSTM1-1 results in a stable, folded monomer. Biochemistry (2006) 0.82
Novel genomic methods for drug discovery and mechanism-based toxicological assessment. Curr Opin Drug Discov Devel (2009) 0.81
2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida. Biochemistry (2007) 0.81
Leukemia associated antigens: their dual role as biomarkers and immunotherapeutic targets for acute myeloid leukemia. Biomark Insights (2007) 0.81
Elevated expression of the leukemia-associated antigen SSX2IP predicts survival in acute myeloid leukemia patients who lack detectable cytogenetic rearrangements. Blood (2009) 0.81
Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies. BMC Syst Biol (2015) 0.81
Hoxa6 potentiates short-term hemopoietic cell proliferation and extended self-renewal. Exp Hematol (2009) 0.81
Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence. Mech Ageing Dev (2010) 0.80
Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin. Carcinogenesis (2006) 0.80
Regarding "Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients". Breast Cancer Res Treat (2011) 0.80
Prediction of substrates for glutathione transferases by covalent docking. J Chem Inf Model (2014) 0.79
Kinetic characterization of thiolate anion formation and chemical catalysis of activated microsomal glutathione transferase 1. Biochemistry (2004) 0.79
Microarray for epigenetic changes: gene expression arrays. Methods Mol Biol (2012) 0.78
The tumour antigens RAGE-1 and MGEA6 are expressed more frequently in the less lineage restricted subgroups of presentation acute myeloid leukaemia. Br J Haematol (2006) 0.78
Comparison of the survival implications of tumour-associated versus cancer-testis antigen expression in acute myeloid leukaemia. Br J Haematol (2007) 0.78
Néstor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation. BMC Mol Biol (2014) 0.78
Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative. Biogerontology (2015) 0.77