Published in J Biol Chem on May 03, 2012
Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia. J Clin Oncol (2015) 1.84
A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia. Nat Genet (2014) 1.38
Deoxyribonucleotide metabolism, mutagenesis and cancer. Nat Rev Cancer (2015) 0.96
NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. Nat Genet (2016) 0.93
NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD. Pharmacogenomics J (2015) 0.90
NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia. Pharmacogenomics J (2015) 0.87
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2. Nat Commun (2015) 0.87
NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease. J Gastroenterol (2015) 0.84
Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age. J Hum Genet (2016) 0.83
Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance. J Biol Chem (2013) 0.83
Elimination and utilization of oxidized guanine nucleotides in the synthesis of RNA and its precursors. J Biol Chem (2013) 0.80
Search for proteins required for accurate gene expression under oxidative stress: roles of guanylate kinase and RNA polymerase. J Biol Chem (2013) 0.79
Battle against RNA oxidation: molecular mechanisms for reducing oxidized RNA to protect cells. Wiley Interdiscip Rev RNA (2013) 0.78
Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.77
Birth of MTH1 as a therapeutic target for glioblastoma: MTH1 is indispensable for gliomatumorigenesis. Am J Transl Res (2016) 0.77
An increase of oxidised nucleotides activates DNA damage checkpoint pathway that regulates post-embryonic development in Caenorhabditis elegans. Mutagenesis (2014) 0.76
The Evolution of Function within the Nudix homology Clan. Proteins (2016) 0.75
NUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases. Intest Res (2017) 0.75
Pathways of oxidative damage. Annu Rev Microbiol (2003) 7.08
MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature (1992) 5.54
The MutT proteins or "Nudix" hydrolases, a family of versatile, widely distributed, "housecleaning" enzymes. J Biol Chem (1996) 5.08
Mutagenesis by 8-oxoguanine: an enemy within. Trends Genet (1993) 3.96
The Nudix hydrolase superfamily. Cell Mol Life Sci (2006) 3.60
Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Nature (1987) 3.55
Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science (1997) 2.67
Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J Biol Chem (1993) 2.52
Structures and mechanisms of Nudix hydrolases. Arch Biochem Biophys (2005) 2.33
Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli. Mutat Res (1995) 2.28
Mutagenicity, toxicity and repair of DNA base damage induced by oxidation. Mutat Res (2003) 2.18
Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool. Proc Natl Acad Sci U S A (1992) 2.04
The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein. J Biol Chem (1999) 1.92
Factors contributing to the outcome of oxidative damage to nucleic acids. Bioessays (2004) 1.55
Oxidative nucleotide damage: consequences and prevention. Oncogene (2002) 1.50
Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Proc Natl Acad Sci U S A (2001) 1.48
Multiple enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools. Biochemistry (2005) 1.31
Metabolic fate of oxidized guanine ribonucleotides in mammalian cells. Biochemistry (1999) 1.30
Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion. Genomics (1994) 1.21
Mammalian enzymes for preventing transcriptional errors caused by oxidative damage. Nucleic Acids Res (2005) 1.18
A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides. EMBO Rep (2003) 1.14
Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides. Biochem Biophys Res Commun (2003) 1.13
Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis. Cancer Sci (2007) 1.11
Crystal structure of human MTH1 and the 8-oxo-dGMP product complex. FEBS Lett (2011) 1.09
MutT-related error avoidance mechanism for DNA synthesis. Genes Cells (1996) 1.05
Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif. Biochem J (1999) 1.05
Cloning and characterization of a new member of the Nudix hydrolases from human and mouse. J Biol Chem (2000) 1.03
Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases. J Biol Chem (2002) 1.00
Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base. J Biol Chem (2009) 0.93
Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity. J Mol Biol (2006) 0.93
Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies. J Mol Biol (2008) 0.91
A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae. Nucleic Acids Res (2004) 0.85
Diverse substrate recognition and hydrolysis mechanisms of human NUDT5. Nucleic Acids Res (2011) 0.85
Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.82
Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein. J Biochem (2011) 0.81
NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity. DNA Repair (Amst) (2009) 0.80
NDX-1 protein hydrolyzes 8-oxo-7, 8-dihydrodeoxyguanosine-5'-diphosphate to sanitize oxidized nucleotides and prevent oxidative stress in Caenorhabditis elegans. J Biochem (2011) 0.79
Watching DNA polymerase η make a phosphodiester bond. Nature (2012) 1.92
Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. Cancer Res (2003) 1.75
Effect of clopidogrel on perioperative blood loss and transfusion in coronary artery bypass graft surgery. Interact Cardiovasc Thorac Surg (2009) 1.51
Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer. Oncogene (2003) 1.47
Myocardial tissue engineering: the extracellular matrix. Eur J Cardiothorac Surg (2008) 1.43
Hybrid surgical angiogenesis: omentopexy can enhance myocardial angiogenesis induced by cell therapy. Ann Thorac Surg (2006) 1.39
Hypothermic circulatory arrest with selective antegrade cerebral perfusion in ascending aortic and aortic arch surgery: a risk factor analysis for adverse outcome in 501 patients. J Thorac Cardiovasc Surg (2008) 1.35
Multiple enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools. Biochemistry (2005) 1.31
Crystallographic investigation of the inhibition mode of a VIM-2 metallo-beta-lactamase from Pseudomonas aeruginosa by a mercaptocarboxylate inhibitor. J Med Chem (2007) 1.27
Solution of the structure of the TNF-TNFR2 complex. Sci Signal (2010) 1.25
Mammalian enzymes for preventing transcriptional errors caused by oxidative damage. Nucleic Acids Res (2005) 1.18
A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides. EMBO Rep (2003) 1.14
Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans. Nat Immunol (2007) 1.14
Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides. Biochem Biophys Res Commun (2003) 1.13
Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. Genes Cells (2008) 1.11
Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. J Biol Chem (2003) 1.11
Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine. Biochemistry (2002) 1.10
Buried water molecules contribute to the conformational stability of a protein. Protein Eng (2003) 1.10
Progress of the treatment for extended aortic aneurysms; is the frozen elephant trunk technique the next standard in the treatment of complex aortic disease including the arch? Eur J Cardiothorac Surg (2008) 1.08
Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases. EMBO Rep (2003) 1.06
Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist. J Biol Chem (2007) 1.06
Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant. J Mol Biol (2008) 1.03
Probing the role of Asp-120(81) of metallo-beta-lactamase (IMP-1) by site-directed mutagenesis, kinetic studies, and X-ray crystallography. J Biol Chem (2005) 1.02
Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system. Biochemistry (2004) 1.02
Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates. J Biol Chem (2004) 1.01
No enhancement of nuclear entry by direct conjugation of a nuclear localization signal peptide to linearized DNA. Bioconjug Chem (2003) 1.01
Aortic valve-sparing operation in Marfan syndrome: what do we know after a decade? Ann Thorac Surg (2007) 1.01
Human polynucleotide phosphorylase protein in response to oxidative stress. Biochemistry (2006) 1.00
New NTP analogs: the synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX. Nucleic Acids Res (2005) 1.00
Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria. Mitochondrion (2006) 0.99
Involvement of Y-family DNA polymerases in mutagenesis caused by oxidized nucleotides in Escherichia coli. J Bacteriol (2006) 0.99
RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells. FEBS Lett (2005) 0.99
The crystal structure of the green tea polyphenol (-)-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site. Biochemistry (2010) 0.97
MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. Biochim Biophys Acta (2007) 0.97
PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells. Nucleic Acids Res (2005) 0.97
Identification of single Mn(2+) binding sites required for activation of the mutant proteins of E.coli RNase HI at Glu48 and/or Asp134 by X-ray crystallography. J Mol Biol (2004) 0.97
Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. DNA Repair (Amst) (2003) 0.97
Structure and binding mode of a ribosome recycling factor (RRF) from mesophilic bacterium. J Biol Chem (2002) 0.95
Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes. DNA Repair (Amst) (2002) 0.95
Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability. Nucleic Acids Res (2005) 0.95
Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5. Free Radic Biol Med (2010) 0.94
Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base. J Biol Chem (2009) 0.93
Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol (2002) 0.93
Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. J Biol Chem (2009) 0.92
Mutagenicity of secondary oxidation products of 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-hydroxy-2'- deoxyguanosine 5'-triphosphate). Mutat Res (2011) 0.92
Irreversible inhibition of metallo-beta-lactamase (IMP-1) by 3-(3-mercaptopropionylsulfanyl)propionic acid pentafluorophenyl ester. Angew Chem Int Ed Engl (2005) 0.91
Mixed-type multicentric Castleman's disease developing during a 17-year follow-up of sarcoidosis. Intern Med (2012) 0.90
Dual hydrolysis of diphosphate and triphosphate derivatives of oxidized deoxyadenosine by Orf17 (NtpA), a MutT-type enzyme. DNA Repair (Amst) (2005) 0.90
Acceleration of autologous in vivo recellularization of decellularized aortic conduits by fibronectin surface coating. Biomaterials (2013) 0.90
Mutagenic effects of 8-hydroxy-dGTP in live mammalian cells. Free Radic Biol Med (2007) 0.89
Pathological differentiation of chronic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis/usual interstitial pneumonia. Histopathology (2012) 0.88
Loss of expression of DNA repair enzymes MGMT, hMLH1, and hMSH2 during tumor progression in gastric cancer. Gastric Cancer (2003) 0.87
Intranuclear disposition of exogenous DNA in vivo: silencing, methylation and fragmentation. FEBS Lett (2006) 0.87
Age-dependent increases in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LC-MS/MS: urinary 8-oxoguanosine as a novel biomarker of aging. Free Radic Biol Med (2012) 0.87
Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine. DNA Repair (Amst) (2010) 0.87
Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma. Ann Surg Oncol (2002) 0.86
Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta. Biochemistry (2007) 0.86
Completely buried, non-ion-paired glutamic acid contributes favorably to the conformational stability of pyrrolidone carboxyl peptidases from hyperthermophiles. Biochemistry (2006) 0.86
A novel customizable modular bioreactor system for whole-heart cultivation under controlled 3D biomechanical stimulation. J Artif Organs (2013) 0.86
Structure of metallo-beta-lactamase IND-7 from a Chryseobacterium indologenes clinical isolate at 1.65-A resolution. J Biochem (2010) 0.86
Probing, inhibition, and crystallographic characterization of metallo-beta-lactamase (IMP-1) with fluorescent agents containing dansyl and thiol groups. ChemMedChem (2006) 0.86
DNA microarray analysis of whole blood cells and insulin-sensitive tissues reveals the usefulness of blood RNA profiling as a source of markers for predicting type 2 diabetes. Biol Pharm Bull (2010) 0.86
Characterization of a nudix hydrolase from Deinococcus radiodurans with a marked specificity for (deoxy)ribonucleoside 5'-diphosphates. BMC Biochem (2004) 0.85
Cell cycle dependent transcription, a determinant factor of heterogeneity in cationic lipid-mediated transgene expression. J Gene Med (2007) 0.85
Diverse substrate recognition and hydrolysis mechanisms of human NUDT5. Nucleic Acids Res (2011) 0.85
Effects of overexpression and antisense RNA expression of Orf17, a MutT-type enzyme. Biol Pharm Bull (2006) 0.85
Different initial steps of apoptosis induced by two types of antineoplastic drugs. Biochem Pharmacol (2008) 0.85
Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA. DNA Repair (Amst) (2011) 0.85
Crystallization and preliminary X-ray crystallographic studies of a mutant of ribosome recycling factor from Escherichia coli, Arg132Gly. Acta Crystallogr D Biol Crystallogr (2001) 0.85
Correction of frameshift mutations with single-stranded and double-stranded DNA fragments prepared from phagemid/plasmid DNAs. Biol Pharm Bull (2005) 0.84
Creatine kinase isoenzyme MB relative index as predictor of mortality on extracorporeal membrane oxygenation support for postcardiotomy cardiogenic shock in adult patients. Eur J Cardiothorac Surg (2006) 0.84
Involvement of specialized DNA polymerases in mutagenesis by 8-hydroxy-dGTP in human cells. DNA Repair (Amst) (2009) 0.84
In vivo functional performance and structural maturation of decellularised allogenic aortic valves in the subcoronary position. Eur J Cardiothorac Surg (2010) 0.84
Chromium(III) ion and thyroxine cooperate to stabilize the transthyretin tetramer and suppress in vitro amyloid fibril formation. FEBS Lett (2005) 0.84
Molecular actions of Escherichia coli MutT for control of spontaneous mutagenesis. Mutat Res (2010) 0.84
Comparison of different surgical techniques in 112 consecutive patients with aortic root operations: when should the valve be spared? J Heart Valve Dis (2014) 0.84
Upper gastrointestinal sarcoidosis: report of three cases. Intern Med (2012) 0.84
Aortic dissection type A after supra-aortic debranching and implantation of an endovascular stent-graft for type B dissection: A word of caution. J Thorac Cardiovasc Surg (2009) 0.84
Off-pump CABG with synchronized arterial flow ensuring system. Ann Thorac Surg (2005) 0.83
An autopsy study of combined pulmonary fibrosis and emphysema: correlations among clinical, radiological, and pathological features. BMC Pulm Med (2014) 0.83
Age-related alterations in the expression of MTH2 in the hippocampus of the SAMP8 mouse with learning and memory deterioration. J Neurol Sci (2009) 0.83
The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine. PLoS One (2012) 0.83
Femoro-femoral versus atrio-aortic extracorporeal membrane oxygenation: selecting the ideal cannulation technique. Artif Organs (2014) 0.83
In vivo mutagenicities of damaged nucleotides produced by nitric oxide and ionizing radiation. Biol Pharm Bull (2005) 0.83
Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.82
Crystallization and preliminary X-ray analysis of Escherichia coli MutT in binary and ternary complex forms. Acta Crystallogr D Biol Crystallogr (2004) 0.82
Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent, on human and mouse cells: effects of Mgmt and Mlh1 mutations. DNA Repair (Amst) (2004) 0.82
Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window. Clin Cancer Res (2004) 0.82
Optimal site-specific PEGylation of mutant TNF-alpha improves its antitumor potency. Biochem Biophys Res Commun (2004) 0.82
Age-dependent accumulation of 8-oxoguanine in the DNA and RNA in various rat tissues. Oxid Med Cell Longev (2013) 0.82