Published in PLoS One on April 27, 2012
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Leptin induces cyclin D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT, PI3K/Akt and MEK/ERK pathways. PLoS One (2012) 1.03
Foxa1 and Foxa2 are required for formation of the intervertebral discs. PLoS One (2013) 0.92
A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse. PLoS One (2013) 0.90
Notochord Cells in Intervertebral Disc Development and Degeneration. J Dev Biol (2016) 0.84
Genetic and functional studies of the intervertebral disc: a novel murine intervertebral disc model. PLoS One (2014) 0.82
Wnt signaling activates Shh signaling in early postnatal intervertebral discs, and re-activates Shh signaling in old discs in the mouse. PLoS One (2014) 0.81
Notochordal cell-derived therapeutic strategies for discogenic back pain. Global Spine J (2013) 0.81
Increased caveolin-1 in intervertebral disc degeneration facilitates repair. Arthritis Res Ther (2016) 0.78
Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development. Arthritis Res Ther (2013) 0.78
HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells. FASEB J (2014) 0.78
The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice. J Appl Physiol (1985) (2014) 0.77
Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration. Curr Stem Cell Res Ther (2015) 0.77
Cell signaling pathways related to pain receptors in the degenerated disk. Global Spine J (2013) 0.75
Syndecan-4 in intervertebral disc and cartilage: Saint or synner? Matrix Biol (2016) 0.75
A Controlled Release Codelivery System of MSCs Encapsulated in Dextran/Gelatin Hydrogel with TGF-β3-Loaded Nanoparticles for Nucleus Pulposus Regeneration. Stem Cells Int (2016) 0.75
Ageing in the musculoskeletal system. Acta Orthop (2016) 0.75
Differentiation of Human Ligamentum Flavum Stem Cells Toward Nucleus Pulposus-Like Cells Induced by Coculture System and Hypoxia. Spine (Phila Pa 1976) (2015) 0.75
Biological challenges for regeneration of the degenerated disc using cellular therapies. Acta Orthop (2016) 0.75
Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis. Bone Res (2017) 0.75
Signaling networks in joint development. Dev Dyn (2016) 0.75
Research on the function and related mechanism of P27 gene in the intervertebral disc degeneration of mice. Exp Ther Med (2017) 0.75
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev (2002) 8.56
Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (2002) 6.53
SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol (1997) 5.72
Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A (2002) 5.54
The Hedgehog response network: sensors, switches, and routers. Science (2004) 5.20
SOX9 directly regulates the type-II collagen gene. Nat Genet (1997) 4.88
Sonic hedgehog regulates growth and morphogenesis of the tooth. Development (2000) 4.71
Degeneration of the intervertebral disc. Arthritis Res Ther (2003) 4.30
Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res (2005) 4.08
Descriptive epidemiology of low-back pain and its related medical care in the United States. Spine (Phila Pa 1976) (1987) 3.80
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell (2001) 2.84
Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation. Dev Dyn (2008) 1.91
Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proc Natl Acad Sci U S A (2007) 1.85
The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J (1994) 1.63
More surprises in the Hedgehog signaling pathway. Cell (2000) 1.43
Endogenous patterns of BMP signaling during early chick development. Dev Biol (2002) 1.19
Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning. Development (1997) 1.18
A BMP-Shh negative-feedback loop restricts Shh expression during limb development. Development (2009) 1.16
Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs. Proc Natl Acad Sci U S A (2011) 1.15
Hedgehog signaling regulates segment formation in the annelid Platynereis. Science (2010) 1.12
Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development. Development (2000) 1.12
Molecular signaling in intervertebral disk development. J Orthop Res (2005) 1.06
Postnatal growth, differentiation, and aging of the mouse intervertebral disc. Spine (Phila Pa 1976) (2009) 1.03
Comparison of the structure of human intervertebral discs in the cervical, thoracic and lumbar regions of the spine. Surg Radiol Anat (1986) 0.99
Inhibition of ocular neovascularization by hedgehog blockade. Mol Ther (2005) 0.94
Intercellular signaling pathways active during intervertebral disc growth, differentiation, and aging. Spine (Phila Pa 1976) (2009) 0.93
SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription. Biochem J (2008) 0.92
Differential expression of TGF-beta isoforms during postlactational mammary gland involution. Cell Tissue Res (2000) 0.91
Intercellular signaling pathways active during and after growth and differentiation of the lumbar vertebral growth plate. Spine (Phila Pa 1976) (2011) 0.88
Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration. Development (2006) 1.54
Primordial germ cell migration. Int J Dev Biol (2004) 1.42
N- and E-cadherins in Xenopus are specifically required in the neural and non-neural ectoderm, respectively, for F-actin assembly and morphogenetic movements. Development (2009) 1.39
Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation. Development (2008) 1.29
The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo. Development (2003) 1.25
Repression of organizer genes in dorsal and ventral Xenopus cells mediated by maternal XTcf3. Development (2002) 1.24
Wnt11/beta-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin. Development (2007) 1.24
Wnt11/5a complex formation caused by tyrosine sulfation increases canonical signaling activity. Curr Biol (2009) 1.16
The roles of three signaling pathways in the formation and function of the Spemann Organizer. Development (2002) 1.15
Nectin-2 and N-cadherin interact through extracellular domains and induce apical accumulation of F-actin in apical constriction of Xenopus neural tube morphogenesis. Development (2010) 1.09
G-protein-coupled signals control cortical actin assembly by controlling cadherin expression in the early Xenopus embryo. Development (2007) 1.07
The relationships among spatiotemporal collagen gene expression, histology, and biomechanics following full-length injury in the murine patellar tendon. J Orthop Res (2011) 1.04
Postnatal growth, differentiation, and aging of the mouse intervertebral disc. Spine (Phila Pa 1976) (2009) 1.03
Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon. Tissue Eng Part A (2011) 1.01
GP130, the shared receptor for the LIF/IL6 cytokine family in the mouse, is not required for early germ cell differentiation, but is required cell-autonomously in oocytes for ovulation. Development (2003) 0.98
What we should know before using tissue engineering techniques to repair injured tendons: a developmental biology perspective. Tissue Eng Part B Rev (2011) 0.97
The paratenon contributes to scleraxis-expressing cells during patellar tendon healing. PLoS One (2013) 0.96
The distribution and behavior of extragonadal primordial germ cells in Bax mutant mice suggest a novel origin for sacrococcygeal germ cell tumors. Int J Dev Biol (2008) 0.94
Intercellular signaling pathways active during intervertebral disc growth, differentiation, and aging. Spine (Phila Pa 1976) (2009) 0.93
Impaired growth of denervated muscle contributes to contracture formation following neonatal brachial plexus injury. J Bone Joint Surg Am (2011) 0.91
The roles of maternal Vangl2 and aPKC in Xenopus oocyte and embryo patterning. Development (2011) 0.91
A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse. PLoS One (2013) 0.90
Maternal Xenopus Zic2 negatively regulates Nodal-related gene expression during anteroposterior patterning. Development (2005) 0.90
Intercellular signaling pathways active during and after growth and differentiation of the lumbar vertebral growth plate. Spine (Phila Pa 1976) (2011) 0.88
Membrane-bound steel factor maintains a high local concentration for mouse primordial germ cell motility, and defines the region of their migration. PLoS One (2011) 0.85
The effects of denervation, reinnervation, and muscle imbalance on functional muscle length and elbow flexion contracture following neonatal brachial plexus injury. J Orthop Res (2012) 0.84
The Xenopus LIM-homeodomain protein Xlim5 regulates the differential adhesion properties of early ectoderm cells. Development (2003) 0.84
The Xenopus laevis isoform of G protein-coupled receptor 3 (GPR3) is a constitutively active cell surface receptor that participates in maintaining meiotic arrest in X. laevis oocytes. Mol Endocrinol (2008) 0.83
The functions of maternal Dishevelled 2 and 3 in the early Xenopus embryo. Dev Dyn (2011) 0.82
Surface contraction waves (SCWs) in the Xenopus egg are required for the localization of the germ plasm and are dependent upon maternal stores of the kinesin-like protein Xklp1. Dev Biol (2002) 0.81
Regulation of classical cadherin membrane expression and F-actin assembly by alpha-catenins, during Xenopus embryogenesis. PLoS One (2012) 0.81
Whole transcriptome expression profiling of mouse limb tendon development by using RNA-seq. J Orthop Res (2015) 0.80
Minimally invasive tension-free inguinal hernia repair. Surg Technol Int (2005) 0.79
Par6b regulates the dynamics of apicobasal polarity during development of the stratified Xenopus epidermis. PLoS One (2013) 0.79
Foxi2 is an animally localized maternal mRNA in Xenopus, and an activator of the zygotic ectoderm activator Foxi1e. PLoS One (2012) 0.78
Evolving strategies in mechanobiology to more effectively treat damaged musculoskeletal tissues. J Biomech Eng (2013) 0.77
A lifetime of migration. Int J Dev Biol (2013) 0.75
In the beginning. Development (2012) 0.75
An interview with Christopher Wylie and Janet Heasman. Development (2014) 0.75
The genome and the germ cell. Genome Biol (2002) 0.75