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Pannexin-1 as a potentiator of ligand-gated receptor signaling. Channels (Austin) (2014) 0.80

Regulation of PP2AC carboxylmethylation and cellular localisation by inhibitory class G-protein coupled receptors in cardiomyocytes. PLoS One (2014) 0.78

Classic studies of cultured cardiac myocyte hypertrophy: interview with a transformer. Circ Res (2013) 0.77

Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864. Br J Pharmacol (2015) 0.76

Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89

Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study. Lancet (2012) 8.42

Exome sequencing reveals de novo WDR45 mutations causing a phenotypically distinct, X-linked dominant form of NBIA. Am J Hum Genet (2012) 3.80

Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet (2013) 2.83

Calmodulin mutations associated with recurrent cardiac arrest in infants. Circulation (2013) 2.66

Crossover comparison of the laryngeal mask supreme and the i-gel in simulated difficult airway scenario in anesthetized patients. Anesthesiology (2009) 2.65

Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation (2012) 2.58

Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium. Circ Res (2010) 2.38

How reliable are G-protein-coupled receptor antibodies? Naunyn Schmiedebergs Arch Pharmacol (2009) 2.16

Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice. Circ Res (2007) 2.07

Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans. Genes Dev (2007) 1.94

Lack of the mitochondrial protein acylglycerol kinase causes Sengers syndrome. Am J Hum Genet (2012) 1.93

Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. N Engl J Med (2014) 1.89

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science (2007) 1.89

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nat Chem Biol (2009) 1.88

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest (2012) 1.85

Impaired riboflavin transport due to missense mutations in SLC52A2 causes Brown-Vialetto-Van Laere syndrome. J Inherit Metab Dis (2012) 1.77

Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing. J Med Genet (2012) 1.77

Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. Am J Physiol Heart Circ Physiol (2009) 1.71

Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. J Am Coll Cardiol (2013) 1.68

Survivin is a therapeutic target in Merkel cell carcinoma. Sci Transl Med (2012) 1.61

Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm. Circulation (2011) 1.58

Regulation of cardiac cAMP synthesis and contractility by nucleoside diphosphate kinase B/G protein beta gamma dimer complexes. Circ Res (2007) 1.58

Beta-adrenergic stimulation induces cardiac ankyrin repeat protein expression: involvement of protein kinase A and calmodulin-dependent kinase. Cardiovasc Res (2003) 1.56

Cardiac myosin-binding protein C is required for complete relaxation in intact myocytes. Circ Res (2007) 1.50

The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. J Biol Chem (2005) 1.49

Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy. Hum Mol Genet (2012) 1.48

Protein kinase D selectively targets cardiac troponin I and regulates myofilament Ca2+ sensitivity in ventricular myocytes. Circ Res (2007) 1.43

Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells. Mol Cancer Ther (2009) 1.42

Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res (2012) 1.41

Emergency skill training--a randomized controlled study on the effectiveness of the 4-stage approach compared to traditional clinical teaching. Resuscitation (2010) 1.40

Anterior screw fixation of odontoid fractures comparing younger and elderly patients. Spine (Phila Pa 1976) (2007) 1.38

Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity. J Biol Chem (2013) 1.35

Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice. J Clin Invest (2011) 1.31

Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease. Nat Genet (2013) 1.30

Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. J Clin Invest (2010) 1.29

Dual role of protein kinase C on BK channel regulation. Proc Natl Acad Sci U S A (2010) 1.29

ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy. Am J Hum Genet (2013) 1.27

DYT16 revisited: exome sequencing identifies PRKRA mutations in a European dystonia family. Mov Disord (2014) 1.27

Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol Med (2013) 1.23

Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. FASEB J (2008) 1.21

Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure. Cardiovasc Res (2002) 1.21

Assessment of the genomic variation in a cattle population by re-sequencing of key animals at low to medium coverage. BMC Genomics (2013) 1.19

Mutations in FBXL4, encoding a mitochondrial protein, cause early-onset mitochondrial encephalomyopathy. Am J Hum Genet (2013) 1.18

Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease. Annu Rev Pharmacol Toxicol (2005) 1.18

Anaphylactic shock depends on endothelial Gq/G11. J Exp Med (2009) 1.16

Exome sequencing identifies a REEP1 mutation involved in distal hereditary motor neuropathy type V. Am J Hum Genet (2012) 1.16

Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin. EMBO J (2007) 1.14

The natriuretic peptide/guanylyl cyclase--a system functions as a stress-responsive regulator of angiogenesis in mice. J Clin Invest (2009) 1.13

Terminal differentiation, advanced organotypic maturation, and modeling of hypertrophic growth in engineered heart tissue. Circ Res (2011) 1.12

Parthenogenetic stem cells for tissue-engineered heart repair. J Clin Invest (2013) 1.11

Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation. Proc Natl Acad Sci U S A (2008) 1.10

Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation. J Mol Cell Cardiol (2008) 1.09

Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells. J Biol Chem (2002) 1.08

Regulators of G protein signalling: a spotlight on emerging functions in the cardiovascular system. Curr Opin Pharmacol (2007) 1.07

Total synthesis and biological evaluation of C16 analogs of (-)-dictyostatin. J Med Chem (2007) 1.06

Diabetes-related knowledge among medical and nursing house staff. Swiss Med Wkly (2010) 1.06

Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling. Circ Heart Fail (2009) 1.06

The beta-subunit of G proteins is a substrate of protein histidine phosphatase. Biochem Biophys Res Commun (2005) 1.06

Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. J Biol Chem (2002) 1.05

Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product. Chem Biol Drug Des (2006) 1.05

The Sec translocon mediated protein transport in prokaryotes and eukaryotes. Mol Membr Biol (2014) 1.05

Atorvastatin desensitizes beta-adrenergic signaling in cardiac myocytes via reduced isoprenylation of G-protein gamma-subunits. FASEB J (2006) 1.04

p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. Naunyn Schmiedebergs Arch Pharmacol (2004) 1.03

Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. Biochemistry (2005) 1.03

The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Proc Natl Acad Sci U S A (2009) 1.03

Comparison of splicing factor 3b inhibitors in human cells. Chembiochem (2012) 1.02

Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatin. J Am Chem Soc (2010) 1.02

Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors. Cell Signal (2005) 1.01

Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload. Cardiovasc Res (2008) 1.01

M2 muscarinic receptors induce airway smooth muscle activation via a dual, Gbetagamma-mediated inhibition of large conductance Ca2+-activated K+ channel activity. J Biol Chem (2008) 1.01

Function and regulation of serine/threonine phosphatases in the healthy and diseased heart. J Mol Cell Cardiol (2013) 1.01

Phosphatase-1 inhibitor-1 in physiological and pathological β-adrenoceptor signalling. Cardiovasc Res (2011) 1.01

Protein translocation across the inner membrane of Gram-negative bacteria: the Sec and Tat dependent protein transport pathways. Res Microbiol (2013) 1.00

Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells. Circ Res (2003) 0.99

Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells. Carcinogenesis (2012) 0.99

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Structure-activity and high-content imaging analyses of novel tubulysins. Chem Biol Drug Des (2007) 0.98

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation. Proteomics (2011) 0.98

Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase. Mol Pharmacol (2004) 0.96

De novo mutations in beta-catenin (CTNNB1) appear to be a frequent cause of intellectual disability: expanding the mutational and clinical spectrum. Hum Genet (2014) 0.96

Structural and functional protein network analyses predict novel signaling functions for rhodopsin. Mol Syst Biol (2011) 0.95

NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors. J Pharmacol Exp Ther (2013) 0.95

p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. FASEB J (2010) 0.95

A high-throughput FRET-based assay for determination of Atg4 activity. Autophagy (2012) 0.94

A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain. Biochem J (2002) 0.94

Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF. Cell Signal (2010) 0.94

Evaluation of spontaneous propulsive movement as a screening tool to detect rescue of Parkinsonism phenotypes in zebrafish models. Neurobiol Dis (2011) 0.94

Exome sequencing unravels unexpected differential diagnoses in individuals with the tentative diagnosis of Coffin-Siris and Nicolaides-Baraitser syndromes. Hum Genet (2015) 0.94