Published in Anesth Analg on May 14, 2012
Dexmedetomidine inhibits tumor necrosis factor-alpha and interleukin 6 in lipopolysaccharide-stimulated astrocytes by suppression of c-Jun N-terminal kinases. Inflammation (2014) 0.90
Dexmedetomidine Modulates Histamine-induced Ca(2+) Signaling and Pro-inflammatory Cytokine Expression. Korean J Physiol Pharmacol (2015) 0.81
Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke (1995) 6.49
CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology (2000) 5.63
Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J (2004) 3.80
Neurological deterioration in acute ischemic stroke: potential predictors and associated factors in the European cooperative acute stroke study (ECASS) I. Stroke (1999) 1.80
The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology (1993) 1.64
Adrenergic agents modify cerebral edema and microvessel ultrastructure in porcine sepsis. Crit Care Med (2004) 1.44
Intraoperative clonidine administration to neurosurgical patients. Anesth Analg (2005) 1.44
The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. Anesth Analg (2003) 1.34
Central noradrenergic regulation of cerebral blood flow and vascular permeability. Proc Natl Acad Sci U S A (1975) 1.24
The use of dexmedetomidine infusion for awake craniotomy. Anesth Analg (2001) 1.24
Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole. Anesthesiology (1991) 1.22
Matrix metalloproteinase inhibition attenuates brain edema in an in vivo model of surgically-induced brain injury. Neurosurgery (2007) 1.22
NADPH oxidase inhibition improves neurological outcomes in surgically-induced brain injury. Neurosci Lett (2007) 1.18
Inhibition of Src tyrosine kinase and effect on outcomes in a new in vivo model of surgically induced brain injury. J Neurosurg (2007) 1.17
Dexmedetomidine attenuates the hemodynamic and neuroendocrinal responses to skull-pin head-holder application during craniotomy. J Neurosurg Anesthesiol (2008) 1.12
Clinical experience with dexmedetomidine for implantation of deep brain stimulators in Parkinson's disease. Anesth Analg (2006) 1.11
Neuroprotective effects of dexmedetomidine in the gerbil hippocampus after transient global ischemia. Anesthesiology (1997) 1.11
Neuroprotective effects of a combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats. Acta Anaesthesiol Scand (2009) 1.10
Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents. Brain Res (2008) 1.05
Surgically induced brain injury in rats: the effect of erythropoietin. J Neurosci Methods (2006) 0.99
Cyclo-oxygenase-2 mediates hyperbaric oxygen preconditioning-induced neuroprotection in the mouse model of surgical brain injury. Stroke (2009) 0.98
Effects of dexmedetomidine after transient and permanent occlusion of the middle cerebral artery in the rat. J Neural Transm (Vienna) (2001) 0.93
The influence of plasma glucose concentrations on ischemic brain damage is a threshold function. Neurosci Lett (1994) 0.92
Blood--brain barrier sodium/potassium pump: modulation by central noradrenergic innervation. Proc Natl Acad Sci U S A (1986) 0.88
Brain microvessels are innervated by locus ceruleus noradrenergic neurons. Neurosci Lett (1989) 0.84
The combined neuroprotective effects of lidocaine and dexmedetomidine after transient forebrain ischemia in rats. Acta Anaesthesiol Scand (2009) 0.82
Dynamics of experimental vasogenic brain oedema in the rat: changes induced by adrenergic drugs. J Auton Pharmacol (1999) 0.82
Adrenoceptor subtypes in the control of burn-induced plasma extravasation. Burns (2005) 0.80
Influence of electrical stimulation of locus coeruleus on the rat blood-brain barrier permeability to sodium fluorescein. Acta Neurochir (Wien) (1994) 0.79
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
The international position on laparoscopic liver surgery: The Louisville Statement, 2008. Ann Surg (2009) 5.33
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell (2007) 3.21
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science (2007) 3.13
A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods (2007) 2.64
Mechanisms of early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab (2006) 2.62
miR-301a as an NF-κB activator in pancreatic cancer cells. EMBO J (2010) 2.47
Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke (2009) 2.37
Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway. Stroke (2010) 2.30
Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution. Nat Clin Pract Neurol (2007) 2.26
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes (2011) 2.21
Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought. Neurol Res (2009) 2.09
Evaluation of the hematoma consequences, neurobehavioral profiles, and histopathology in a rat model of pontine hemorrhage. J Neurosurg (2012) 2.02
A novel neuroprotectant granulocyte-colony stimulating factor. Stroke (2006) 2.00
Signaling pathways for early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab (2004) 1.99
Mmp-9 deficiency enhances collagenase-induced intracerebral hemorrhage and brain injury in mutant mice. J Cereb Blood Flow Metab (2004) 1.97
NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage. Ann Neurol (2014) 1.95
Mechanisms of hyperbaric oxygen-induced neuroprotection in a rat model of subarachnoid hemorrhage. J Cereb Blood Flow Metab (2005) 1.84
The importance of early brain injury after subarachnoid hemorrhage. Prog Neurobiol (2012) 1.84
Simulation of robustness against lesions of cortical networks. Eur J Neurosci (2007) 1.81
Transgenic rat model of neurodegeneration caused by mutation in the TDP gene. PLoS Genet (2010) 1.81
Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke (2004) 1.79
Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice. Crit Care Med (2012) 1.78
Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats. Crit Care Med (2010) 1.78
IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest (2011) 1.77
P2X7 receptor antagonism inhibits p38 mitogen-activated protein kinase activation and ameliorates neuronal apoptosis after subarachnoid hemorrhage in rats. Crit Care Med (2013) 1.76
Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett (2008) 1.71
Metamorphosis of subarachnoid hemorrhage research: from delayed vasospasm to early brain injury. Mol Neurobiol (2010) 1.69
Molecular mechanisms of early brain injury after subarachnoid hemorrhage. Neurol Res (2006) 1.64
Application of medical gases in the field of neurobiology. Med Gas Res (2011) 1.64
Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population. Atherosclerosis (2011) 1.64
Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice. Stroke (2009) 1.63
Is in-class physical activity at risk in constructivist physical education? Res Q Exerc Sport (2007) 1.63
Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res (2008) 1.60
Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Crit Care Med (2012) 1.60
FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. PLoS Genet (2011) 1.57
Diabetes mellitus: is it protective against aortic root dilatation? Cardiology (2008) 1.54
Nonmetabolizable analogue of 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. PCC 7120. Proc Natl Acad Sci U S A (2005) 1.51
Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage. J Neurosci Res (2007) 1.50
Early brain injury, an evolving frontier in subarachnoid hemorrhage research. Transl Stroke Res (2013) 1.49
Cerebral vasospasm: looking beyond vasoconstriction. Trends Pharmacol Sci (2007) 1.49
Toric Implantable Collamer Lens for moderate to high myopic astigmatism. Ophthalmology (2007) 1.45
RIGOR guidelines: escalating STAIR and STEPS for effective translational research. Transl Stroke Res (2012) 1.45
Role of HCN channels in neuronal hyperexcitability after subarachnoid hemorrhage in rats. J Neurosci (2012) 1.42
Irreversible electroporation of the pancreas: definitive local therapy without systemic effects. J Surg Oncol (2011) 1.40
Black carbon emissions in China from 1949 to 2050. Environ Sci Technol (2012) 1.38
Role of NADPH oxidase in the brain injury of intracerebral hemorrhage. J Neurochem (2005) 1.37
Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model. J Neurosci Methods (2010) 1.37
Subarachnoid hemorrhage: is it time for a new direction? Stroke (2008) 1.35
Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress. Brain Res (2010) 1.31
Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. Free Radic Res (2009) 1.31
Dynamic changes in genome-wide histone H3 lysine 4 methylation patterns in response to dehydration stress in Arabidopsis thaliana. BMC Plant Biol (2010) 1.28
Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun (2009) 1.28
HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model. Neurobiol Dis (2008) 1.28
Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats. Exp Biol Med (Maywood) (2009) 1.26
Cathepsin and calpain inhibitor E64d attenuates matrix metalloproteinase-9 activity after focal cerebral ischemia in rats. Stroke (2006) 1.25
Neonatal hypoxia/ischemia is associated with decreased inflammatory mediators after erythropoietin administration. Stroke (2005) 1.24
Inhibition of apoptosis by hyperbaric oxygen in a rat focal cerebral ischemic model. J Cereb Blood Flow Metab (2003) 1.23
The membrane subunit NuoL(ND5) is involved in the indirect proton pumping mechanism of Escherichia coli complex I. J Biol Chem (2010) 1.23
Preservation of tropomyosin-related kinase B (TrkB) signaling by sodium orthovanadate attenuates early brain injury after subarachnoid hemorrhage in rats. Stroke (2010) 1.22
Matrix metalloproteinase inhibition attenuates brain edema in an in vivo model of surgically-induced brain injury. Neurosurgery (2007) 1.22
A comparison of pulmonary vein ostial anatomy by computerized tomography, echocardiography, and venography in patients with atrial fibrillation having radiofrequency catheter ablation. Am J Cardiol (2004) 1.22
Nucleosomes suppress spontaneous mutations base-specifically in eukaryotes. Science (2012) 1.22
Apoptotic mechanisms for neuronal cells in early brain injury after subarachnoid hemorrhage. Acta Neurochir Suppl (2011) 1.21
Mechanisms of osteopontin-induced stabilization of blood-brain barrier disruption after subarachnoid hemorrhage in rats. Stroke (2010) 1.21
Hyperbaric oxygen suppresses NADPH oxidase in a rat subarachnoid hemorrhage model. Stroke (2006) 1.21
Vascular adhesion protein-1 inhibition provides antiinflammatory protection after an intracerebral hemorrhagic stroke in mice. J Cereb Blood Flow Metab (2010) 1.21
Glibenclamide improves neurological function in neonatal hypoxia-ischemia in rats. Brain Res (2009) 1.21
Vasospasm and p53-induced apoptosis in an experimental model of subarachnoid hemorrhage. Stroke (2006) 1.20
Assessing functional outcomes following intracerebral hemorrhage in rats. Brain Res (2009) 1.19
PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage. Ann Neurol (2011) 1.19
Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab (2004) 1.19
Transition of research focus from vasospasm to early brain injury after subarachnoid hemorrhage. J Neurochem (2012) 1.18
NADPH oxidase inhibition improves neurological outcomes in surgically-induced brain injury. Neurosci Lett (2007) 1.18
Dimensions of the cervical neural foramina in resting and retracted positions using magnetic resonance imaging. J Orthop Sports Phys Ther (2002) 1.18
Protective effect of melatonin upon neuropathology, striatal function, and memory ability after intracerebral hemorrhage in rats. J Neurotrauma (2010) 1.17
P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH. Neurobiol Dis (2013) 1.17
Inhibition of Src tyrosine kinase and effect on outcomes in a new in vivo model of surgically induced brain injury. J Neurosurg (2007) 1.17
Mechanism of ischemic tolerance induced by hyperbaric oxygen preconditioning involves upregulation of hypoxia-inducible factor-1alpha and erythropoietin in rats. J Appl Physiol (1985) (2008) 1.16
Granulocyte colony-stimulating factor protects the brain against experimental stroke via inhibition of apoptosis and inflammation. Neurol Res (2009) 1.16
Cerebral microvascular responses to hypercholesterolemia: roles of NADPH oxidase and P-selectin. Circ Res (2003) 1.16
Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury. Am J Physiol Heart Circ Physiol (2004) 1.15
Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury. Crit Care Med (2010) 1.15
p53 may play an orchestrating role in apoptotic cell death after experimental subarachnoid hemorrhage. Neurosurgery (2007) 1.14
Nutritional support with endoluminal stenting during neoadjuvant therapy for esophageal malignancy. Ann Surg Oncol (2009) 1.14
Neuroprotection against surgically induced brain injury. Surg Neurol (2007) 1.13
Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion. J Cereb Blood Flow Metab (2004) 1.13
Matrix metalloproteinases inhibition provides neuroprotection against hypoxia-ischemia in the developing brain. J Neurochem (2009) 1.13
Cyclooxygenase-2 mediates hyperbaric oxygen preconditioning in the rat model of transient global cerebral ischemia. Stroke (2010) 1.12
Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage. Exp Neurol (2012) 1.11
Acute splenic irradiation reduces brain injury in the rat focal ischemic stroke model. Transl Stroke Res (2012) 1.11
Comparison of three rat models of cerebral vasospasm. Am J Physiol Heart Circ Physiol (2002) 1.11
Therapeutic application of gene silencing MMP-9 in a middle cerebral artery occlusion-induced focal ischemia rat model. Exp Neurol (2008) 1.11
Pathophysiology of an hypoxic-ischemic insult during the perinatal period. Neurol Res (2005) 1.11
Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase. J Neurosci Res (2008) 1.11
Comparative manufacture and cell-based delivery of antiretroviral nanoformulations. Int J Nanomedicine (2011) 1.11
Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol (2011) 1.11