Published in BMC Cancer on May 16, 2012
EGFR Signaling in Liver Diseases. Int J Mol Sci (2015) 0.90
Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors. Mol Cancer Res (2015) 0.75
Endocytic recycling. Nat Rev Mol Cell Biol (2004) 10.87
The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Eur J Cancer (2001) 5.96
Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol (2009) 5.83
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol Cell (2006) 4.36
Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes. Proc Natl Acad Sci U S A (1998) 4.03
EGF receptor. Int J Biochem Cell Biol (1999) 3.91
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies. J Cell Biol (2002) 2.81
The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Mol Biol Cell (2004) 2.71
Grb2 regulates internalization of EGF receptors through clathrin-coated pits. Mol Biol Cell (2003) 2.58
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor. J Biol Chem (1999) 2.13
Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma. Br J Cancer (2007) 2.09
Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res (2008) 1.96
Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation. Exp Cell Res (2004) 1.96
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits. Mol Biol Cell (2004) 1.82
c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route. J Cell Sci (2001) 1.77
A structure-based model for ligand binding and dimerization of EGF receptors. Proc Natl Acad Sci U S A (2004) 1.62
Mechanisms for oncogenic activation of the epidermal growth factor receptor. Cell Signal (2007) 1.61
The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor. J Biol Chem (2000) 1.60
Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. J Pathol (2005) 1.52
Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling. Proc Natl Acad Sci U S A (2010) 1.46
Cholangiocarcinoma--current treatment options. Scand J Surg (2011) 1.45
Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events associated with mutated EGFR compared with wild type. Mol Cell Proteomics (2008) 1.44
Preliminary experience of cetuximab in the treatment of advanced-stage biliary tract cancer. Onkologie (2010) 1.44
c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes. J Biol Chem (2004) 1.36
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation. Mol Biol Cell (2008) 1.34
Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas. J Cancer Res Clin Oncol (2005) 1.30
A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes. J Cell Biol (2009) 1.30
Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity. J Biol Chem (1988) 1.26
Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation. J Biol Chem (2002) 1.21
Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII. Cancer Biol Ther (2006) 1.20
Relationship of EGFR mutations, expression, amplification, and polymorphisms to epidermal growth factor receptor inhibitors in the NCI60 cell lines. Clin Cancer Res (2007) 1.20
Stimulation of epidermal growth factor receptor threonine 654 phosphorylation by platelet-derived growth factor in protein kinase C-deficient human fibroblasts. J Biol Chem (1987) 1.13
Extended liver resection for intrahepatic cholangiocarcinoma: A comparison of the prognostic accuracy of the fifth and sixth editions of the TNM classification. Ann Surg (2009) 1.08
Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Res (2007) 1.07
Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop. Cell Signal (2008) 1.06
Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized. Cancer Res (2007) 1.05
Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src. BMC Cell Biol (2009) 1.03
Epithelial-mesenchymal-transition induced by EGFR activation interferes with cell migration and response to irradiation and cetuximab in head and neck cancer cells. Radiother Oncol (2011) 1.01
Cetuximab plus gemcitabine-oxaliplatin (GEMOX) in patients with refractory advanced intrahepatic cholangiocarcinomas. Oncology (2007) 1.01
Establishment of a highly differentiated immortalized human cholangiocyte cell line with SV40T and hTERT. Transplantation (2004) 1.00
Cbl controls EGFR fate by regulating early endosome fusion. Sci Signal (2009) 0.98
Epidermal growth factor receptor lacking C-terminal autophosphorylation sites retains signal transduction and high sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor. Cancer Sci (2009) 0.84
ZD1839 (IRESSA) stabilizes p27Kip1 and enhances radiosensitivity in cholangiocarcinoma cell lines. Anticancer Res (2009) 0.79
COP35, a cholangiocarcinoma-binding oligopeptide, interacts with the clathrin heavy chain accompanied by GRP78. Mol Cancer Res (2011) 0.78
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol (2010) 6.95
Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol (2003) 6.14
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell (2006) 6.09
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci U S A (2004) 5.54
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res (2008) 3.56
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proc Natl Acad Sci U S A (2004) 2.94
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun (2005) 2.85
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. Biol Chem (2006) 2.61
Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. Mol Cell Biol (2007) 2.38
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity. Mol Cell Biol (2008) 2.15
Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients. Kidney Int (2009) 2.10
Results of surgical resection for patients with hilar bile duct cancer: application of extended hepatectomy after biliary drainage and hemihepatic portal vein embolization. Ann Surg (2003) 2.04
Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate. Nat Chem Biol (2007) 1.93
Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem (2007) 1.90
Immunoglobulin G4-related lymphoplasmacytic sclerosing cholangitis that mimics infiltrating hilar cholangiocarcinoma: part of a spectrum of autoimmune pancreatitis? Gastrointest Endosc (2005) 1.81
Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J Biol Chem (2008) 1.73
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. Arch Biochem Biophys (2005) 1.71
Subcellular localization and cytoplasmic complex status of endogenous Keap1. Genes Cells (2007) 1.67
Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery. J Gastroenterol (2006) 1.65
Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. Development (2007) 1.65
Mathematical projection model of visual loss due to fuchs corneal dystrophy. Invest Ophthalmol Vis Sci (2011) 1.53
Surgical treatment for anorectal malignant melanoma: report of five cases and review of 79 Japanese cases. Int J Colorectal Dis (2008) 1.50
Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2. Proc Natl Acad Sci U S A (2004) 1.47
Primary pulmonary synovial sarcoma confirmed by molecular detection of SYT-SSX1 fusion gene transcripts: a case report and review of the literature. Jpn J Clin Oncol (2005) 1.47
Prognosis of adult patients transplanted with liver grafts < 35% of their standard liver volume. Liver Transpl (2009) 1.45
Reassessment of the classification of the severity in idiopathic pulmonary fibrosis using SF-36 questionnaire. Intern Med (2005) 1.45
Successful delivery derived from vitrified-warmed spermatozoa from a patient with nonobstructive azoospermia. Fertil Steril (2012) 1.41
Identification of polymorphisms in the promoter region of the human NRF2 gene. Biochem Biophys Res Commun (2004) 1.40
Temporary auxiliary liver transplantation from a living donor to an adult recipient with familial amyloid polyneuropathy. Transplantation (2002) 1.40
Ebselen, a seleno-organic antioxidant, as an electrophile. Chem Res Toxicol (2006) 1.25
Silencing of the tapetum-specific zinc finger gene TAZ1 causes premature degeneration of tapetum and pollen abortion in petunia. Plant Cell (2002) 1.23
Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization. Cancer Res (2010) 1.19
Transabdominal preperitoneal repair for obturator hernia. World J Surg (2011) 1.19
Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog. Endocrinology (2010) 1.19
A new method for aromatic difluoromethylation: copper-catalyzed cross-coupling and decarboxylation sequence from aryl iodides. Org Lett (2011) 1.18
Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment. Am J Pathol (2007) 1.17
A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans. Nat Commun (2013) 1.11
Functional analysis of basic transcription element binding protein by gene targeting technology. Mol Cell Biol (2003) 1.10
Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms. Mol Cell Biol (2011) 1.09
Clinical and pathological features of primary carcinoma of the cystic duct. J Hepatobiliary Pancreat Surg (2008) 1.08
Methylation of ASC/TMS1, a proapoptotic gene responsible for activating procaspase-1, in human colorectal cancer. Cancer Lett (2003) 1.08
Rewiring mitogen-activated protein kinase cascade by positive feedback confers potato blight resistance. Plant Physiol (2006) 1.04
Gastric schwannoma exhibiting increased fluorodeoxyglucose uptake. Gastric Cancer (2010) 1.03
Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function. Exp Eye Res (2006) 1.02
Endoillumination-assisted cataract surgery in a patient with corneal opacity. J Cataract Refract Surg (2003) 1.02
Essential role of gastric gland mucin in preventing gastric cancer in mice. J Clin Invest (2012) 1.01
Crucial role of nrf3 in smooth muscle cell differentiation from stem cells. Circ Res (2010) 0.99
Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer. Hum Pathol (2007) 0.98
Surgical treatment of 144 cases of hilar cholangiocarcinoma without liver-related mortality. World J Surg (2014) 0.98
The petunia ortholog of Arabidopsis SUPERMAN plays a distinct role in floral organ morphogenesis. Plant Cell (2004) 0.98
Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78. Int J Cancer (2010) 0.98
Killian-Jamieson diverticulitis with cervical cellulitis: report of a case. Surg Today (2010) 0.97
Nox4-derived ROS signaling contributes to TGF-β-induced epithelial-mesenchymal transition in pancreatic cancer cells. Anticancer Res (2013) 0.97
Downregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma. Cancer Sci (2013) 0.97
Clinicopathologic features and histochemical analyses of proliferative activity and angiogenesis in small cell carcinoma of the esophagus. J Gastroenterol (2007) 0.97
Impact of tumor spread to the cystic duct on the prognosis of patients with gallbladder carcinoma. World J Surg (2007) 0.96
Effects of storage temperature on the contents of sugars and free amino acids in tubers from different potato cultivars and acrylamide in chips. Biosci Biotechnol Biochem (2006) 0.96
Is major hepatectomy with pancreatoduodenectomy justified for advanced biliary malignancy? J Hepatobiliary Pancreat Surg (2007) 0.95
The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence. J Biol Chem (2008) 0.95
Identification of oligopeptide binding to colon cancer cells separated from patients using laser capture microdissection. J Drug Target (2008) 0.94
Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2004) 0.93
Isolating triamcinolone acetonide particles for intravitreal use with a porous membrane filter. Retina (2003) 0.93
Gastric small cell carcinoma successfully treated by surgery and postoperative chemotherapy consisting of cisplatin and S-1: report of a case. Surg Today (2007) 0.92
The hedgehog signal induced modulation of bone morphogenetic protein signaling: an essential signaling relay for urinary tract morphogenesis. PLoS One (2012) 0.92
Decrease in vitamin D receptor and calcium-sensing receptor in highly proliferative parathyroid adenomas. Eur J Endocrinol (2003) 0.92
Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation. Endocrinology (2011) 0.92
Enhanced baroreflex sensitivity in free-moving calponin knockout mice. Am J Physiol Heart Circ Physiol (2002) 0.91
Molecular cloning of the estrogen and progesterone receptors of the American alligator. Gen Comp Endocrinol (2004) 0.91
Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation. PLoS One (2011) 0.91
A splice variant of ASC regulates IL-1beta release and aggregates differently from intact ASC. Mediators Inflamm (2009) 0.91
Pseudo-Meigs syndrome caused by sigmoid colon cancer metastasis to the ovary. Am J Surg (2011) 0.91
NMDA receptor activation upstream of methyl farnesoate signaling for short day-induced male offspring production in the water flea, Daphnia pulex. BMC Genomics (2015) 0.91
In vivo confocal microscopy and ultrasound biomicroscopy study of filtering blebs after trabeculectomy: limbus-based versus fornix-based conjunctival flaps. J Glaucoma (2012) 0.91
Efficacy of S-1 for patients with peritoneal metastasis of gastric cancer. Chemotherapy (2006) 0.91
Identification of genes associated with multiple nodules in hepatocellular carcinoma using cDNA microarray: multicentric occurrence or intrahepatic metastasis? Hepatogastroenterology (2008) 0.90
Potentials of regenerative medicine for liver disease. Surg Today (2009) 0.90
Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments. Tohoku J Exp Med (2008) 0.90
Mapping of normal corneal K-structures by in vivo laser confocal microscopy. Cornea (2008) 0.90
Prognostic impact of anatomical resection on early and late intrahepatic recurrence in patients with hepatocellular carcinoma. J Hepatobiliary Pancreat Surg (2008) 0.89
Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system. Stem Cells (2005) 0.89
Change in content of sugars and free amino acids in potato tubers under short-term storage at low temperature and the effect on acrylamide level after frying. Biosci Biotechnol Biochem (2005) 0.89
Gene transduction by sonoporation. Dev Growth Differ (2008) 0.88
Molecular cloning of doublesex genes of four cladocera (water flea) species. BMC Genomics (2013) 0.88
Bmp7 and Lef1 are the downstream effectors of androgen signaling in androgen-induced sex characteristics development in medaka. Endocrinology (2013) 0.88
A new self-sealing cannula system for 20-gauge vitrectomy: outcomes of 247 consecutive cases. Retina (2008) 0.87
Endophthalmitis caused by Enterococcus mundtii. J Clin Microbiol (2005) 0.87
Morphometric analysis of liver macrophages in patients with colorectal liver metastasis. Clin Exp Metastasis (2002) 0.87
Marked and sustained increase in bone mineral density after parathyroidectomy in patients with primary hyperparathyroidism; a six-year longitudinal study with or without parathyroidectomy in a Japanese population. Clin Endocrinol (Oxf) (2004) 0.87
Dendritic cells, T-cell infiltration, and Grp94 expression in cholangiocellular carcinoma. Hum Pathol (2004) 0.87
A novel ultralow-illumination endoscope system. Surg Endosc (2010) 0.86