Published in Oncogene on May 21, 2012
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Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer (2014) 2.70
Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer. PLoS One (2013) 2.26
The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer. BMC Cancer (2013) 2.11
Targeted disruption of Hotair leads to homeotic transformation and gene derepression. Cell Rep (2013) 1.89
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Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis. Carcinogenesis (2014) 1.72
Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer. BMC Cancer (2014) 1.69
Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer. Int J Biol Sci (2013) 1.62
Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression. BMC Cancer (2013) 1.62
The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21(WAF1/CIP1) expression. PLoS One (2013) 1.55
HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma. Neuro Oncol (2013) 1.47
Long noncoding RNA HOTAIR is a prognostic marker for esophageal squamous cell carcinoma progression and survival. PLoS One (2013) 1.44
Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. J Mol Biol (2013) 1.41
Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma. Br J Cancer (2013) 1.40
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Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer. Mol Cancer (2014) 1.36
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Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner. Oncotarget (2015) 1.29
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Long non-coding RNA HOTAIR is associated with human cervical cancer progression. Int J Oncol (2014) 1.26
The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells. Oncotarget (2014) 1.26
Long non-coding RNA HOTAIR in carcinogenesis and metastasis. Acta Biochim Biophys Sin (Shanghai) (2013) 1.23
Functions of lncRNA HOTAIR in lung cancer. J Hematol Oncol (2014) 1.23
Junk DNA and the long non-coding RNA twist in cancer genetics. Oncogene (2015) 1.22
A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma. Cell Death Dis (2014) 1.22
LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer. Biochim Biophys Acta (2015) 1.21
Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells. J Biol Chem (2014) 1.21
Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma. Biomed Res Int (2013) 1.21
Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR. PLoS One (2013) 1.19
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Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen. J Hematol Oncol (2013) 1.15
Physiological roles of long noncoding RNAs: insight from knockout mice. Trends Cell Biol (2014) 1.12
The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget (2015) 1.12
Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells. Int J Mol Sci (2014) 1.09
Overexpression of Long Non-Coding RNA HOTAIR Promotes Tumor Growth and Metastasis in Human Osteosarcoma. Mol Cells (2015) 1.09
HOTAIR forms an intricate and modular secondary structure. Mol Cell (2015) 1.08
The association analysis of lncRNA HOTAIR genetic variants and gastric cancer risk in a Chinese population. Oncotarget (2015) 1.07
An emerging understanding of long noncoding RNAs in kidney cancer. J Cancer Res Clin Oncol (2014) 1.07
High expression of AFAP1-AS1 is associated with poor survival and short-term recurrence in pancreatic ductal adenocarcinoma. J Transl Med (2015) 1.05
The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation. Proc Natl Acad Sci U S A (2015) 1.05
LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer. Cell Death Dis (2015) 1.04
Long noncoding RNA HOTAIR as an independent prognostic marker in cancer: a meta-analysis. PLoS One (2014) 1.04
Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Mol Cell Biol (2014) 1.04
Diverse involvement of EZH2 in cancer epigenetics. Am J Transl Res (2015) 1.04
LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2. Oncotarget (2015) 1.03
Noncoding RNA in oncogenesis: a new era of identifying key players. Int J Mol Sci (2013) 1.03
Circulating RNAs as new biomarkers for detecting pancreatic cancer. World J Gastroenterol (2015) 1.01
Epigenetics: an emerging player in gastric cancer. World J Gastroenterol (2014) 1.01
Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo. J Steroid Biochem Mol Biol (2014) 1.01
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Prediction of long noncoding RNA functions with co-expression network in esophageal squamous cell carcinoma. BMC Cancer (2015) 0.98
Epigenetic regulation in human melanoma: past and future. Epigenetics (2015) 0.98
Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326. Oncotarget (2015) 0.98
HOTAIR is a predictive and prognostic biomarker for patients with advanced gastric adenocarcinoma receiving fluorouracil and platinum combination chemotherapy. Am J Transl Res (2015) 0.97
Upregulation of long noncoding RNA SPRY4-IT1 modulates proliferation, migration, apoptosis, and network formation in trophoblast cells HTR-8SV/neo. PLoS One (2013) 0.97
ILNCSIM: improved lncRNA functional similarity calculation model. Oncotarget (2016) 0.96
Novel therapeutic targets for pancreatic cancer. World J Gastroenterol (2014) 0.96
Large intervening non-coding RNA HOTAIR is an indicator of poor prognosis and a therapeutic target in human cancers. Int J Mol Sci (2014) 0.96
Expression profile of long non-coding RNAs in pancreatic cancer and their clinical significance as biomarkers. Oncotarget (2015) 0.96
LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer. Cell Rep (2015) 0.96
Long non-coding RNAs and their implications in cancer epigenetics. Biosci Rep (2013) 0.95
Integrated analysis of long noncoding RNA and coding RNA expression in esophageal squamous cell carcinoma. Int J Genomics (2013) 0.95
PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis. Clin Exp Med (2014) 0.95
HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells. J Cell Biochem (2013) 0.94
Low expression of novel lncRNA RP11-462C24.1 suggests a biomarker of poor prognosis in colorectal cancer. Med Oncol (2014) 0.93
Neoadjuvant therapy for pancreas cancer: past lessons and future therapies. World J Gastroenterol (2014) 0.93
Long non-coding RNAs as regulators of the endocrine system. Nat Rev Endocrinol (2015) 0.93
The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells. Mol Cancer (2015) 0.92
Prognostic value of long non-coding RNA HOTAIR in various cancers. PLoS One (2014) 0.92
The long non-coding HOTAIR is modulated by cyclic stretch and WNT/β-CATENIN in human aortic valve cells and is a novel repressor of calcification genes. PLoS One (2014) 0.92
High expression of CAI2, a 9p21-embedded long noncoding RNA, contributes to advanced-stage neuroblastoma. Cancer Res (2014) 0.91
Epigenomics of clear cell renal cell carcinoma: mechanisms and potential use in molecular pathology. Chin J Cancer Res (2016) 0.91
Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer. Genomics Proteomics Bioinformatics (2016) 0.91
The landscape of antisense gene expression in human cancers. Genome Res (2015) 0.91
Estradiol induces HOTAIR levels via GPER-mediated miR-148a inhibition in breast cancer. J Transl Med (2015) 0.91
ncRDeathDB: A comprehensive bioinformatics resource for deciphering network organization of the ncRNA-mediated cell death system. Autophagy (2015) 0.90
Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer. Oncotarget (2015) 0.90
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Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells. Oncotarget (2016) 0.89
Long noncoding RNA MIR31HG exhibits oncogenic property in pancreatic ductal adenocarcinoma and is negatively regulated by miR-193b. Oncogene (2015) 0.88
Association of HOTAIR expression in gastric carcinoma with invasion and distant metastasis. Adv Biomed Res (2014) 0.88
Critical role for the long non-coding RNA AFAP1-AS1 in the proliferation and metastasis of hepatocellular carcinoma. Tumour Biol (2016) 0.88
Decreasing lncRNA HOTAIR expression inhibits human colorectal cancer stem cells. Am J Transl Res (2016) 0.87
The prognostic significance of HOTAIR for predicting clinical outcome in patients with digestive system tumors. J Cancer Res Clin Oncol (2015) 0.87
Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence. Oncol Lett (2016) 0.87
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Long noncoding RNA Hotair mediated angiogenesis in nasopharyngeal carcinoma by direct and indirect signaling pathways. Oncotarget (2016) 0.85
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Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value. Biomed Res Int (2015) 0.84
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