Published in Trends Biochem Sci on May 23, 2012
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Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem (2016) 0.84
Metformin inhibits gastric cancer via the inhibition of HIF1α/PKM2 signaling. Am J Cancer Res (2015) 0.84
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KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma. Angiogenesis (2015) 0.84
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Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner. J Biol Chem (2014) 0.83
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An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing Glycolysis. PLoS Pathog (2016) 0.78
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Structures of pyruvate kinases display evolutionarily divergent allosteric strategies. R Soc Open Sci (2014) 0.77
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SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth. Cancer Res (2016) 0.76
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ERK2-Pyruvate Kinase Axis Permits Phorbol 12-Myristate 13-Acetate-induced Megakaryocyte Differentiation in K562 Cells. J Biol Chem (2015) 0.76
Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity. Drug Des Devel Ther (2014) 0.75
Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells. World J Gastroenterol (2015) 0.75
MiR-338-3p targets pyruvate kinase M2 and affects cell proliferation and metabolism of ovarian cancer. Am J Transl Res (2016) 0.75
AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth. Oncotarget (2016) 0.75
EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression. Mol Cancer (2017) 0.75
A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia. Mol Cells (2015) 0.75
Linking apoptosis to cancer metabolism: Another missing piece of JuNK. Mol Cell Oncol (2016) 0.75
Exploring targeted therapy of osteosarcoma using proteomics data. Onco Targets Ther (2017) 0.75
Identification of potential serum biomarkers for breast cancer using a functional proteomics technology. Biomark Res (2017) 0.75
The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2. BMC Biochem (2015) 0.75
Pyruvate kinase M knockdown induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival. J Biol Chem (2017) 0.75
CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma. Oncogene (2017) 0.75
Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect. Mol Cell Oncol (2017) 0.75
Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity. J Clin Invest (2017) 0.75
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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature (2012) 3.77
Predicting selective drug targets in cancer through metabolic networks. Mol Syst Biol (2011) 3.65
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature (2013) 3.46
Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol Cell Biol (2007) 3.33
Glutaminolysis activates Rag-mTORC1 signaling. Mol Cell (2012) 2.82
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Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis. Biochim Biophys Acta (2009) 1.66
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect. PLoS Comput Biol (2011) 1.66
Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53. Mol Cell (2013) 1.65
Mitochondria-derived reactive oxygen species mediate blue light-induced death of retinal pigment epithelial cells. Photochem Photobiol (2004) 1.50
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HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression. J Mol Med (Berl) (2010) 1.06
Prolyl hydroxylases as regulators of cell metabolism. Biochem Soc Trans (2009) 1.05
Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas. Acta Neuropathol (2014) 1.04
The music of lipids: how lipid composition orchestrates cellular behaviour. Acta Oncol (2012) 0.93
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p53 guards the metabolic pathway less travelled. Nat Cell Biol (2011) 0.85
Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid. PLoS One (2013) 0.78
Corrigendum: Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. Nature (2016) 0.77
Cancer metabolism: Friendly neighbours feed tumour cells. Nature (2016) 0.76
PGAMgnam style: a glycolytic switch controls biosynthesis. Cancer Cell (2012) 0.75