Published in J Am Geriatr Soc on May 29, 2012
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA (2016) 17.49
Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis*. Crit Care Med (2014) 3.82
Association between hospitalization for pneumonia and subsequent risk of cardiovascular disease. JAMA (2015) 2.53
Frequency, cost, and risk factors of readmissions among severe sepsis survivors. Crit Care Med (2015) 2.50
Epidemiology of severe sepsis. Virulence (2013) 2.26
Long-term outcomes following development of new-onset atrial fibrillation during sepsis. Chest (2014) 2.26
Obesity and 1-year outcomes in older Americans with severe sepsis. Crit Care Med (2014) 2.10
Increased 1-year healthcare use in survivors of severe sepsis. Am J Respir Crit Care Med (2014) 1.95
Using existing data to address important clinical questions in critical care. Crit Care Med (2013) 1.47
Temporal Changes in the Influence of Hospitals and Regional Healthcare Networks on Severe Sepsis Mortality. Crit Care Med (2015) 1.45
Volume Overload: Prevalence, Risk Factors, and Functional Outcome in Survivors of Septic Shock. Ann Am Thorac Soc (2015) 1.41
Hospital-based acute care use in survivors of septic shock. Crit Care Med (2015) 1.34
Hospital case volume and outcomes among patients hospitalized with severe sepsis. Am J Respir Crit Care Med (2014) 1.23
Role of biomarkers in sepsis care. Shock (2013) 1.19
Late mortality after sepsis: propensity matched cohort study. BMJ (2016) 1.09
The epidemiology of acute organ system dysfunction from severe sepsis outside of the intensive care unit. J Hosp Med (2013) 1.06
Hospital readmission and healthcare utilization following sepsis in community settings. J Hosp Med (2014) 1.06
Death certificates underestimate infections as proximal causes of death in the U.S. PLoS One (2014) 0.98
Post-Acute Care Use and Hospital Readmission after Sepsis. Ann Am Thorac Soc (2015) 0.97
Systemic inflammation and the brain: novel roles of genetic, molecular, and environmental cues as drivers of neurodegeneration. Front Cell Neurosci (2015) 0.96
Understanding and reducing disability in older adults following critical illness. Crit Care Med (2015) 0.96
Patient and Hospitalization Characteristics Associated With Increased Postacute Care Facility Discharges From US Hospitals. Med Care (2015) 0.96
The role of the liver in sepsis. Int Rev Immunol (2014) 0.95
Position paper: management of perforated sigmoid diverticulitis. World J Emerg Surg (2013) 0.94
Interplay between sepsis and chronic health. Trends Mol Med (2014) 0.92
High-mobility group box 1 mediates persistent splenocyte priming in sepsis survivors: evidence from a murine model. Shock (2013) 0.91
Quantifying the improvement in sepsis diagnosis, documentation, and coding: the marginal causal effect of year of hospitalization on sepsis diagnosis. Ann Epidemiol (2015) 0.90
Evidence for a causal link between sepsis and long-term mortality: a systematic review of epidemiologic studies. Crit Care (2016) 0.89
Risk of cardiovascular events in survivors of severe sepsis. Am J Respir Crit Care Med (2014) 0.89
HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors. J Intern Med (2013) 0.89
Long-Term Quality of Life Among Survivors of Severe Sepsis: Analyses of Two International Trials. Crit Care Med (2016) 0.88
Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome. Crit Care Med (2016) 0.86
Longitudinal Changes in ICU Admissions Among Elderly Patients in the United States. Crit Care Med (2016) 0.86
Could Biomarkers Direct Therapy for the Septic Patient? J Pharmacol Exp Ther (2016) 0.84
Functional outcomes of general medical patients with severe sepsis. BMC Infect Dis (2013) 0.83
Impact of older age and nursing home residence on clinical outcomes of US emergency department visits for severe sepsis. J Crit Care (2013) 0.83
Presepsis depressive symptoms are associated with incident cognitive impairment in survivors of severe sepsis: a prospective cohort study of older Americans. J Am Geriatr Soc (2012) 0.83
Transforming PICU Culture to Facilitate Early Rehabilitation. J Pediatr Intensive Care (2015) 0.82
Combined treatment with a CXCL12 analogue and antibiotics improves survival and neutrophil recruitment and function in murine sepsis. Immunology (2014) 0.82
Current challenges in understanding immune cell functions during septic syndromes. BMC Immunol (2015) 0.80
Intermediate and long-term risk of new-onset heart failure after hospitalization for pneumonia in elderly adults. Am Heart J (2015) 0.79
Measuring and predicting long-term outcomes in older survivors of critical illness. Minerva Anestesiol (2014) 0.79
Sepsis-induced selective parvalbumin interneuron phenotype loss and cognitive impairments may be mediated by NADPH oxidase 2 activation in mice. J Neuroinflammation (2015) 0.78
Short- and Long-Term Mortality Rates of Elderly Acute Kidney Injury Patients Who Underwent Continuous Renal Replacement Therapy. PLoS One (2016) 0.78
Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation. PLoS One (2016) 0.77
Bloodstream infections in older patients. Virulence (2015) 0.77
Issues of survivorship are rarely addressed during intensive care unit stays. Baseline results from a statewide quality improvement collaborative. Ann Am Thorac Soc (2014) 0.77
Sepsis after Scotland: enough with the averages, show us the effect modifiers. Crit Care (2013) 0.77
Mobilization in severe sepsis: an integrative review. J Hosp Med (2015) 0.77
Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy. Inflammation (2016) 0.76
Milk fat globule-epidermal growth factor-factor VIII-derived peptide MSP68 is a cytoskeletal immunomodulator of neutrophils that inhibits Rac1. J Surg Res (2016) 0.75
Toward a Nuanced Understanding of the Role of Infection in Readmissions After Sepsis. Crit Care Med (2016) 0.75
Expanding the dimensions of effectiveness research in sepsis. Am J Respir Crit Care Med (2014) 0.75
TAT-HSP70 Attenuates Experimental Lung Injury. Shock (2015) 0.75
From self-awareness to self-actualization: empowering sepsis survivors to a meaningful and enduring recovery. J Thorac Dis (2016) 0.75
The impact of post-operative sepsis on mortality after hospital discharge among elective surgical patients: a population-based cohort study. Crit Care (2017) 0.75
Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism. Sci Rep (2017) 0.75
Preoperative assessment of the risk for multiple complications after surgery. Surgery (2016) 0.75
Nephroprotective strategies in septic shock: the VANISH trial. J Thorac Dis (2016) 0.75
Sepsis and Other Infectious Disease Emergencies in the Elderly. Emerg Med Clin North Am (2016) 0.75
Untangling Health Trajectories among Patients with Sepsis. Ann Am Thorac Soc (2015) 0.75
Employment Outcomes After Critical Illness: An Analysis of the Bringing to Light the Risk Factors and Incidence of Neuropsychological Dysfunction in ICU Survivors Cohort. Crit Care Med (2016) 0.75
Diagnostic and Predictive Levels of Calcium-binding Protein A8 and Tumor Necrosis Factor Receptor-associated Factor 6 in Sepsis-associated Encephalopathy: A Prospective Observational Study. Chin Med J (Engl) (2016) 0.75
Hemoadsorption corrects hyperresistinemia and restores anti-bacterial neutrophil function. Intensive Care Med Exp (2017) 0.75
Readmissions for Recurrent Sepsis: New or Relapsed Infection? Crit Care Med (2017) 0.75
Characteristics of postintensive care syndrome in survivors of pediatric critical illness: A systematic review. World J Crit Care Med (2017) 0.75
Improving Long-Term Outcomes After Sepsis. Crit Care Clin (2017) 0.75
Sepsis-Associated Encephalopathy: The Blood-Brain Barrier and the Sphingolipid Rheostat. Front Immunol (2017) 0.75
Endothelial protein C receptor polymorphisms and risk of sepsis in a Chinese population. J Int Med Res (2017) 0.75
Evidence of High Mortality and Increasing Burden of Sepsis in a Regional Sample of the New Zealand Population. Open Forum Infect Dis (2017) 0.75
A patient cohort on long-term sequelae of sepsis survivors: study protocol of the Mid-German Sepsis Cohort. BMJ Open (2017) 0.75
Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med (2001) 51.99
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med (2000) 48.03
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58
The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med (2003) 32.30
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med (2004) 24.47
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med (2006) 23.62
Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet (2009) 11.72
Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA (2010) 10.82
Regional variations in diagnostic practices. N Engl J Med (2010) 7.44
Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA (2008) 6.29
An administrative claims model suitable for profiling hospital performance based on 30-day mortality rates among patients with an acute myocardial infarction. Circulation (2006) 5.35
Epidemiology of sepsis: an update. Crit Care Med (2001) 5.16
Measures of cognitive functioning in the AHEAD Study. J Gerontol B Psychol Sci Soc Sci (1997) 4.97
National estimates of the quantity and cost of informal caregiving for the elderly with dementia. J Gen Intern Med (2001) 4.69
Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med (2010) 4.69
Comparisons of patient and physician expectations for cancer survivorship care. J Clin Oncol (2009) 4.39
Medicare's common denominator: the covered population. Health Care Financ Rev (1980) 4.37
The Informant Questionnaire on cognitive decline in the elderly (IQCODE): a review. Int Psychogeriatr (2004) 4.05
Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristics. Am J Respir Crit Care Med (2007) 3.17
Magnitude and duration of the effect of sepsis on survival. Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group. JAMA (1997) 3.11
Three-year outcomes for Medicare beneficiaries who survive intensive care. JAMA (2010) 2.87
Seasons of survival: reflections of a physician with cancer. N Engl J Med (1985) 2.86
Long-term mortality and quality of life in sepsis: a systematic review. Crit Care Med (2010) 2.86
Long-term outcome and quality-adjusted life years after severe sepsis. Crit Care Med (2009) 2.41
Long-term mortality and medical care charges in patients with severe sepsis. Crit Care Med (2003) 2.39
Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. JAMA (2010) 2.27
The Surviving Sepsis Campaign: raising awareness to reduce mortality. Crit Care (2003) 2.07
The role of primary care physicians in cancer care. J Gen Intern Med (2009) 1.87
Survivorship will be the defining challenge of critical care in the 21st century. Ann Intern Med (2010) 1.84
The lingering consequences of sepsis: a hidden public health disaster? JAMA (2010) 1.67
Volume-based referral for cardiovascular procedures in the United States: a cross-sectional regression analysis. BMC Health Serv Res (2005) 1.58
Assessment of incidence of severe sepsis in Sweden using different ways of abstracting International Classification of Diseases codes: difficulties with methods and interpretation of results. Crit Care Med (2010) 1.33
Interhospital transfers among Medicare beneficiaries admitted for acute myocardial infarction at nonrevascularization hospitals. Circ Cardiovasc Qual Outcomes (2010) 1.31
Detailed cost analysis of care for survivors of severe sepsis. Crit Care Med (2004) 1.19
Toward an integrated research agenda for critical illness in aging. Am J Respir Crit Care Med (2010) 1.10
Marital status and the epidemiology and outcomes of sepsis. Chest (2010) 1.09
Quality of life after septic illness. J Crit Care (2009) 0.98
Duration of resuscitation efforts and survival after in-hospital cardiac arrest: an observational study. Lancet (2012) 6.60
Nighttime intensivist staffing and mortality among critically ill patients. N Engl J Med (2012) 5.22
Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med (2012) 4.68
The effect of multidisciplinary care teams on intensive care unit mortality. Arch Intern Med (2010) 4.41
Nighttime intensivist staffing, mortality, and limits on life support: a retrospective cohort study. Chest (2015) 3.77
Severe sepsis in pre-hospital emergency care: analysis of incidence, care, and outcome. Am J Respir Crit Care Med (2012) 3.36
The epidemiology of mechanical ventilation use in the United States. Crit Care Med (2010) 3.28
One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study. Ann Intern Med (2010) 3.23
Estimates of the need for palliative care consultation across united states intensive care units using a trigger-based model. Am J Respir Crit Care Med (2014) 2.95
Organizational characteristics, outcomes, and resource use in 78 Brazilian intensive care units: the ORCHESTRA study. Intensive Care Med (2015) 2.92
The burden of influenza-associated critical illness hospitalizations. Crit Care Med (2014) 2.84
The costs of critical care telemedicine programs: a systematic review and analysis. Chest (2013) 2.75
Hospital factors associated with discharge bias in ICU performance measurement. Crit Care Med (2014) 2.74
The Association Between Daytime Intensivist Physician Staffing and Mortality in the Context of Other ICU Organizational Practices: A Multicenter Cohort Study. Crit Care Med (2015) 2.71
Do intensivist staffing patterns influence hospital mortality following ICU admission? A systematic review and meta-analyses. Crit Care Med (2013) 2.64
Prediction of critical illness during out-of-hospital emergency care. JAMA (2010) 2.60
Prioritizing the organization and management of intensive care services in the United States: the PrOMIS Conference. Crit Care Med (2007) 2.42
Intensive care unit outcomes among patients with lung cancer in the surveillance, epidemiology, and end results-medicare registry. J Clin Oncol (2012) 2.30
Variation in use of intensive care for adults with diabetic ketoacidosis*. Crit Care Med (2012) 2.24
The epidemiology of intensive care unit readmissions in the United States. Am J Respir Crit Care Med (2012) 2.23
Predictors of hospital mortality in a population-based cohort of patients with acute lung injury. Crit Care Med (2008) 2.09
Family satisfaction in the ICU: differences between families of survivors and nonsurvivors. Chest (2007) 2.08
A comparison of critical care research funding and the financial burden of critical illness in the United States. Crit Care Med (2012) 2.07
Relationship Between ICU Length of Stay and Long-Term Mortality for Elderly ICU Survivors. Crit Care Med (2016) 2.03
The effect of insurance status on mortality and procedural use in critically ill patients. Am J Respir Crit Care Med (2011) 2.03
Critical care bed growth in the United States. A comparison of regional and national trends. Am J Respir Crit Care Med (2015) 1.93
A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation. Crit Care Med (2012) 1.92
Use of intravenous infusion sedation among mechanically ventilated patients in the United States. Crit Care Med (2009) 1.90
Intensive care unit occupancy and patient outcomes. Crit Care Med (2009) 1.87
Understanding changes in established practice: pulmonary artery catheter use in critically ill patients. Crit Care Med (2013) 1.82
Hospital-level variation in the use of intensive care. Health Serv Res (2012) 1.79
Aggressiveness of intensive care use among patients with lung cancer in the Surveillance, Epidemiology, and End Results-Medicare registry. Chest (2014) 1.78
Development and pilot testing of a decision aid for surrogates of patients with prolonged mechanical ventilation. Crit Care Med (2012) 1.76
The role of stepdown beds in hospital care. Am J Respir Crit Care Med (2014) 1.74
Critical illness outcomes in specialty versus general intensive care units. Am J Respir Crit Care Med (2009) 1.73
The structure of critical care transfer networks. Med Care (2009) 1.72
Effect of work-hours regulations on intensive care unit mortality in United States teaching hospitals. Crit Care Med (2009) 1.72
Perceived effects of attending physician workload in academic medical intensive care units: a national survey of training program directors. Crit Care Med (2012) 1.71
Access to urban acute care services in high- vs. middle-income countries: an analysis of seven cities. Intensive Care Med (2013) 1.64
Insurance and racial differences in long-term acute care utilization after critical illness. Crit Care Med (2012) 1.63
Acute respiratory distress syndrome after trauma: development and validation of a predictive model. Crit Care Med (2012) 1.62
Accuracy of prehospital transport time estimation. Acad Emerg Med (2014) 1.56
Intravenous access during out-of-hospital emergency care of noninjured patients: a population-based outcome study. Ann Emerg Med (2011) 1.55
Inter-hospital variability in post-cardiac arrest mortality. Resuscitation (2008) 1.54
Hospitals with the highest intensive care utilization provide lower quality pneumonia care to the elderly. Crit Care Med (2015) 1.53
Potential value of regionalized intensive care for mechanically ventilated medical patients. Am J Respir Crit Care Med (2007) 1.47
Use of Intensive Care Services for Medicare Beneficiaries Undergoing Major Surgical Procedures. Anesthesiology (2016) 1.47
Reorganizing adult critical care delivery: the role of regionalization, telemedicine, and community outreach. Am J Respir Crit Care Med (2010) 1.46
Use of intensive care services and associated hospital mortality after Massachusetts healthcare reform*. Crit Care Med (2014) 1.43
Early and late unplanned rehospitalizations for survivors of critical illness*. Crit Care Med (2015) 1.43
Intensive care unit renal support therapy volume is not associated with patient outcome. Crit Care Med (2011) 1.42
Effect of a mass casualty incident: clinical outcomes and hospital charges for casualty patients versus concurrent inpatients. Acad Emerg Med (2012) 1.41
Variations in Case-Mix-Adjusted Duration of Mechanical Ventilation Among ICUs. Crit Care Med (2016) 1.39
The impact of development of acute lung injury on hospital mortality in critically ill trauma patients. Crit Care Med (2008) 1.38
Uncharted paths: hospital networks in critical care. Chest (2009) 1.37
An official American Thoracic Society systematic review: the association between health insurance status and access, care delivery, and outcomes for patients who are critically ill. Am J Respir Crit Care Med (2010) 1.32
Variation in critical care beds per capita in the United States: implications for pandemic and disaster planning. JAMA (2010) 1.32
Interhospital transfers among Medicare beneficiaries admitted for acute myocardial infarction at nonrevascularization hospitals. Circ Cardiovasc Qual Outcomes (2010) 1.31
An official American Thoracic Society policy statement: pay-for-performance in pulmonary, critical care, and sleep medicine. Am J Respir Crit Care Med (2010) 1.20
More doctors to the rescue in the intensive care unit: a cautionary note. Am J Respir Crit Care Med (2010) 1.20
Cost-effectiveness of implementing low-tidal volume ventilation in patients with acute lung injury. Chest (2009) 1.17
Clinical review: International comparisons in critical care - lessons learned. Crit Care (2012) 1.16
Out-of-hospital fluid in severe sepsis: effect on early resuscitation in the emergency department. Prehosp Emerg Care (2010) 1.16
An official American Thoracic Society/American Association of Critical-Care Nurses/American College of Chest Physicians/Society of Critical Care Medicine policy statement: the Choosing Wisely® Top 5 list in Critical Care Medicine. Am J Respir Crit Care Med (2014) 1.15
Nighttime intensivist staffing and the timing of death among ICU decedents: a retrospective cohort study. Crit Care (2013) 1.15
Gaming hospital-level pneumonia 30-day mortality and readmission measures by legitimate changes to diagnostic coding. Crit Care Med (2015) 1.15
Exploring the scope of post-intensive care syndrome therapy and care: engagement of non-critical care providers and survivors in a second stakeholders meeting. Crit Care Med (2014) 1.14
Adverse events during rotary-wing transport of mechanically ventilated patients: a retrospective cohort study. Crit Care (2008) 1.13
The availability of clinical protocols in US teaching intensive care units. J Crit Care (2010) 1.10
Marital status and the epidemiology and outcomes of sepsis. Chest (2010) 1.09
Association Between Noninvasive Ventilation and Mortality Among Older Patients With Pneumonia. Crit Care Med (2016) 1.09
Risk factors for group B streptococcal genitourinary tract colonization in pregnant women. Obstet Gynecol (2005) 1.09
Dexmedetomidine in the care of critically ill patients from 2001 to 2007: an observational cohort study. Anesthesiology (2010) 1.08
The burdens of survivorship: an approach to thinking about long-term outcomes after critical illness. Semin Respir Crit Care Med (2012) 1.07
Risk factors for dementia after critical illness in elderly Medicare beneficiaries. Crit Care (2012) 1.07
The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury. Crit Care (2008) 1.06
The evolving role of dedicated weaning facilities in critical care. Intensive Care Med (2009) 1.05
Automated Classification of Radiology Reports for Acute Lung Injury: Comparison of Keyword and Machine Learning Based Natural Language Processing Approaches. Proceedings (IEEE Int Conf Bioinformatics Biomed) (2009) 1.04
Critical care: the impact of organization and management on outcomes. Curr Opin Crit Care (2010) 1.02
Out-of-hospital characteristics and care of patients with severe sepsis: a cohort study. J Crit Care (2010) 1.02
An alternative method of acute lung injury classification for use in observational studies. Chest (2010) 1.02
Prehospital systolic blood pressure thresholds: a community-based outcomes study. Acad Emerg Med (2013) 1.02
Red blood cell transfusion and outcomes in patients with acute lung injury, sepsis and shock. Crit Care (2011) 1.00
Nurse practitioner/physician assistant staffing and critical care mortality. Chest (2014) 1.00
A prognostic model for 6-month mortality in elderly survivors of critical illness. Chest (2013) 1.00
Hospital-level variation in ICU admission and critical care procedures for patients hospitalized for pulmonary embolism. Chest (2014) 0.99
Prehospital intravenous access and fluid resuscitation in severe sepsis: an observational cohort study. Crit Care (2014) 0.98
Limiting the spread of highly resistant hospital-acquired microorganisms via critical care transfers: a simulation study. Intensive Care Med (2011) 0.98