Hydroxychloroquine improves insulin sensitivity in obese non-diabetic individuals.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMC 3446518)

Published in Arthritis Res Ther on June 07, 2012

Authors

Emileigh Mercer1, Laura Rekedal, Rajesh Garg, Bing Lu, Elena M Massarotti, Daniel H Solomon

Author Affiliations

1: Division of Rheumatology, Brigham and Women's Hospital/Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

Associated clinical trials:

Efficacy Study of Hydroxychloroquine to Treat High-risk Coronary Artery Disease. (CHANGAN) | NCT02874287

Articles cited by this

Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia (1985) 109.13

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care (1999) 26.39

The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA (2002) 18.43

Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med (2007) 11.62

Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab (2007) 6.91

Pathophysiology of coronary artery disease. Circulation (2005) 6.65

Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation (2003) 6.62

High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors. Arthritis Rheum (2001) 5.87

NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes (2003) 5.11

Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis. JAMA (2011) 3.02

Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis. Clin Rheumatol (2007) 2.18

Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis. JAMA (2007) 2.17

Cardiovascular admissions and mortality in an inception cohort of patients with rheumatoid arthritis with onset in the 1980s and 1990s. Ann Rheum Dis (2005) 2.11

Psoriasis and the risk of diabetes and hypertension: a prospective study of US female nurses. Arch Dermatol (2009) 1.91

Pioglitazone improves insulin sensitivity among nondiabetic patients with a recent transient ischemic attack or ischemic stroke. Stroke (2003) 1.77

Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis. Atherosclerosis (2007) 1.73

Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis. Ann Rheum Dis (2004) 1.73

Insulin resistance in patients with rheumatoid arthritis: effect of anti-TNFalpha therapy. Scand J Rheumatol (2007) 1.36

Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes. Diabetes Care (2002) 1.26

Risk of diabetes among patients with rheumatoid arthritis, psoriatic arthritis and psoriasis. Ann Rheum Dis (2010) 1.21

The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas--a randomized trial. Diabetes Res Clin Pract (2002) 1.17

Hyperinsulinemia, insulin resistance, and circulating oxidized low density lipoprotein in women with systemic lupus erythematosus. J Rheumatol (2006) 1.16

Hydroxychloroquine in decompensated, treatment-refractory noninsulin-dependent diabetes mellitus. A new job for an old drug? Ann Intern Med (1990) 1.14

Insulin-sparing effect of hydroxychloroquine in diabetic rats is concentration dependent. Can J Physiol Pharmacol (1999) 0.98

Hydroxychloroquine and glycemia in women with rheumatoid arthritis and systemic lupus erythematosus. J Rheumatol (2010) 0.97

Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea. Diabetes Care (2006) 0.93

Silent myocardial ischemia in prediabetics in relation to insulin resistance. J Cardiovasc Dis Res (2010) 0.90

Moxonidine improves glycaemic control in mildly hypertensive, overweight patients: a comparison with metformin. Diabetes Obes Metab (2006) 0.89

Insulin binding and degradation in isolated hepatocytes from streptozotocin injected rats. Biochem Biophys Res Commun (1985) 0.87

Association of osteoporosis and cardiovascular disease in women with systemic lupus erythematosus. Arthritis Rheum (2001) 0.82

Pioglitazone improvement of fasting and postprandial hyperglycaemia in Mexican-American patients with Type 2 diabetes: a double tracer OGTT study. Clin Endocrinol (Oxf) (2010) 0.80

Articles by these authors

Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res (2007) 14.84

Risk of death in elderly users of conventional vs. atypical antipsychotic medications. N Engl J Med (2005) 8.44

Accuracy of Medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records. Am Heart J (2004) 6.57

Surgery versus physical therapy for a meniscal tear and osteoarthritis. N Engl J Med (2013) 6.08

Self-management education programs in chronic disease: a systematic review and methodological critique of the literature. Arch Intern Med (2004) 4.68

Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science (2010) 4.22

Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. BMJ (2013) 4.17

Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation (2005) 4.17

Cost-effectiveness of total knee arthroplasty in the United States: patient risk and hospital volume. Arch Intern Med (2009) 3.84

Adherence to lipid-lowering therapy and the use of preventive health services: an investigation of the healthy user effect. Am J Epidemiol (2007) 3.82

Initiation of tumor necrosis factor-α antagonists and the risk of hospitalization for infection in patients with autoimmune diseases. JAMA (2011) 3.58

Evaluating short-term drug effects using a physician-specific prescribing preference as an instrumental variable. Epidemiology (2006) 3.54

Incentives for drug development--the curious case of colchicine. N Engl J Med (2010) 3.06

Tumor necrosis factor alpha antagonist use and cancer in patients with rheumatoid arthritis. Arthritis Rheum (2006) 3.04

Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis. JAMA (2011) 3.02

Development of classification and response criteria for rheumatic diseases. Arthritis Rheum (2006) 2.88

A comparison of patient characteristics and outcomes in selected European and U.S. rheumatoid arthritis registries. Semin Arthritis Rheum (2010) 2.88

Identification of individuals with CKD from Medicare claims data: a validation study. Am J Kidney Dis (2005) 2.65

A new stage of the nutrition transition in China. Public Health Nutr (2002) 2.52

Medicaid prior-authorization programs and the use of cyclooxygenase-2 inhibitors. N Engl J Med (2004) 2.52

Veteran's affairs hospital discharge databases coded serious bacterial infections accurately. J Clin Epidemiol (2006) 2.51

Biologic discontinuation studies: a systematic review of methods. Ann Rheum Dis (2013) 2.42

Classification criteria in rheumatic diseases: a review of methodologic properties. Arthritis Rheum (2007) 2.41

Relative effectiveness of osteoporosis drugs for preventing nonvertebral fracture. Ann Intern Med (2008) 2.40

Tumour necrosis factor antagonist use and associated risk reduction of cardiovascular events among patients with rheumatoid arthritis. Ann Rheum Dis (2010) 2.39

Adjusting for unmeasured confounders in pharmacoepidemiologic claims data using external information: the example of COX2 inhibitors and myocardial infarction. Epidemiology (2005) 2.38

Anti-tumor necrosis factor alpha therapy and the risk of serious bacterial infections in elderly patients with rheumatoid arthritis. Arthritis Rheum (2007) 2.37

Impact of obesity and knee osteoarthritis on morbidity and mortality in older Americans. Ann Intern Med (2011) 2.35

Arthritis self-management education programs: a meta-analysis of the effect on pain and disability. Arthritis Rheum (2003) 2.30

Validation of rheumatoid arthritis diagnoses in health care utilization data. Arthritis Res Ther (2011) 2.24

Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease. Am J Cardiol (2011) 2.20

Treatment of older adult patients diagnosed with rheumatoid arthritis: improved but not optimal. Arthritis Rheum (2007) 2.18

Receipt of disease-modifying antirheumatic drugs among patients with rheumatoid arthritis in Medicare managed care plans. JAMA (2011) 2.17

Rates of malignancy associated with juvenile idiopathic arthritis and its treatment. Arthritis Rheum (2012) 2.15

Preoperative A1C and clinical outcomes in patients with diabetes undergoing major noncardiac surgical procedures. Diabetes Care (2013) 2.14

Initiation of anti-TNF therapy and the risk of optic neuritis: from the safety assessment of biologic ThERapy (SABER) Study. Am J Ophthalmol (2012) 2.14

Osteoporosis telephonic intervention to improve medication regimen adherence: a large, pragmatic, randomized controlled trial. Arch Intern Med (2012) 1.94

Understanding the nutrition transition: measuring rapid dietary changes in transitional countries. Public Health Nutr (2002) 1.93

Measuring concurrent adherence to multiple related medications. Am J Manag Care (2009) 1.88

A Medicare database review found that physician preferences increasingly outweighed patient characteristics as determinants of first-time prescriptions for COX-2 inhibitors. J Clin Epidemiol (2005) 1.83

Trends in drug prescribing for osteoporosis after hip fracture, 1995-2004. J Rheumatol (2007) 1.80

Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among US adults with Medicaid coverage, 2000-2004. Arthritis Rheum (2013) 1.80

Body mass index predicts aldosterone production in normotensive adults on a high-salt diet. J Clin Endocrinol Metab (2007) 1.78

Measuring quality in arthritis care: methods for developing the Arthritis Foundation's quality indicator set. Arthritis Rheum (2004) 1.76

Opioid analgesics and the risk of fractures in older adults with arthritis. J Am Geriatr Soc (2011) 1.76

The patient's perspective on the recall of Vioxx. J Rheumatol (2006) 1.71

Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US. Arthritis Care Res (Hoboken) (2013) 1.70

Physician preference motivates the use of anti-tumor necrosis factor therapy independent of clinical disease activity. Arthritis Care Res (Hoboken) (2010) 1.68

Trends in the incidence, demographics, and outcomes of end-stage renal disease due to lupus nephritis in the US from 1995 to 2006. Arthritis Rheum (2011) 1.68

Effectiveness of clinical pathways for total knee and total hip arthroplasty: literature review. J Arthroplasty (2003) 1.68

Agreement of diagnosis and its date for hematologic malignancies and solid tumors between medicare claims and cancer registry data. Cancer Causes Control (2007) 1.66

Bisphosphonates and risk of subtrochanteric, femoral shaft, and atypical femur fracture: a systematic review and meta-analysis. J Bone Miner Res (2013) 1.66

Physician follow-up and provider continuity are associated with long-term medication adherence: a study of the dynamics of statin use. Arch Intern Med (2007) 1.62

Kidney function and use of recommended medications after myocardial infarction in elderly patients. Clin J Am Soc Nephrol (2006) 1.60

Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective cyclooxygenase 2 inhibitors and nonselective nonsteroidal antiinflammatory drugs: an instrumental variable analysis. Arthritis Rheum (2006) 1.60

Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis. Am Heart J (2013) 1.60

Flares in rheumatoid arthritis: frequency and management. A report from the BRASS registry. J Rheumatol (2013) 1.59

At Pitney Bowes, value-based insurance design cut copayments and increased drug adherence. Health Aff (Millwood) (2010) 1.59

The impact of reducing cardiovascular medication copayments on health spending and resource utilization. J Am Coll Cardiol (2012) 1.58

Relationship of sedentary behavior and physical activity to incident cardiovascular disease: results from the Women's Health Initiative. J Am Coll Cardiol (2013) 1.57

Variation in initial kidney replacement therapy for end-stage renal disease due to lupus nephritis in the United States. Arthritis Care Res (Hoboken) (2011) 1.57

Sleep duration, insomnia, and coronary heart disease among postmenopausal women in the Women's Health Initiative. J Womens Health (Larchmt) (2013) 1.57

Should patients with rheumatoid arthritis receive statin therapy? Arthritis Rheum (2009) 1.56

Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone. Hypertension (2013) 1.55

Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study. Arthritis Res Ther (2011) 1.55

Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study. Rheumatology (Oxford) (2010) 1.53

Remission and radiographic outcome in rheumatoid arthritis: application of the 2011 ACR/EULAR remission criteria in an observational cohort. Ann Rheum Dis (2011) 1.51

Patterns of bone mineral density testing: current guidelines, testing rates, and interventions. J Gen Intern Med (2004) 1.50

Risk of osteoporotic fracture in a large population-based cohort of patients with rheumatoid arthritis. Arthritis Res Ther (2010) 1.48

Design of cluster-randomized trials of quality improvement interventions aimed at medical care providers. Med Care (2007) 1.47

Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction. Circulation (2004) 1.46

The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther (2009) 1.45

Association between the initiation of anti-tumor necrosis factor therapy and the risk of herpes zoster. JAMA (2013) 1.45

Comparison of cardiovascular outcomes in elderly patients with diabetes who initiated rosiglitazone vs pioglitazone therapy. Arch Intern Med (2008) 1.45

Identification and validation of vertebral compression fractures using administrative claims data. Med Care (2009) 1.45

Variation in the risk of suicide attempts and completed suicides by antidepressant agent in adults: a propensity score-adjusted analysis of 9 years' data. Arch Gen Psychiatry (2010) 1.43

Effect of the Women's Health Initiative on osteoporosis therapy and expenditure in Medicaid. J Bone Miner Res (2006) 1.43

Coxibs, science, and the public trust. Arch Intern Med (2005) 1.43

The validity of a rheumatoid arthritis medical records-based index of severity compared with the DAS28. Arthritis Res Ther (2006) 1.43

Comparative safety of antidepressant agents for children and adolescents regarding suicidal acts. Pediatrics (2010) 1.40

Vaginal estrogen use and effects on quality of life and urogenital morbidity in postmenopausal women after publication of the Women's Health Initiative in New York City. Menopause (2016) 1.40

The end of rheumatoid factor as we know it? Arthritis Rheum (2011) 1.39

Complete genome sequences of Mycobacterium tuberculosis strains CCDC5079 and CCDC5080, which belong to the Beijing family. J Bacteriol (2011) 1.38

Cancer and the risk of suicide in older Americans. J Clin Oncol (2008) 1.33

More on reports of esophageal cancer with oral bisphosphonate use. N Engl J Med (2009) 1.31

Confounder summary scores when comparing the effects of multiple drug exposures. Pharmacoepidemiol Drug Saf (2010) 1.31

Conversion from intravenous to oral medications: assessment of a computerized intervention for hospitalized patients. Arch Intern Med (2003) 1.31

Efficacy and safety of certolizumab pegol in a broad population of patients with active rheumatoid arthritis: results from the REALISTIC phase IIIb study. Rheumatology (Oxford) (2012) 1.31

Study design for a comprehensive assessment of biologic safety using multiple healthcare data systems. Pharmacoepidemiol Drug Saf (2011) 1.30

Impact of Janani Suraksha Yojana on institutional delivery rate and maternal morbidity and mortality: an observational study in India. J Health Popul Nutr (2012) 1.29

Association of knee injuries with accelerated knee osteoarthritis progression: data from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken) (2014) 1.27

Medical device innovation--is "better" good enough? N Engl J Med (2011) 1.26

Guidelines for immunologic laboratory testing in the rheumatic diseases: anti-DNA antibody tests. Arthritis Rheum (2002) 1.26

Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis Rheum (2010) 1.25

Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action. J Clin Endocrinol Metab (2003) 1.25