Published in Cancer Discov on July 03, 2012
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miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol (2013) 1.79
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Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance. Blood (2014) 1.29
Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition. Onco Targets Ther (2013) 1.23
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. J Exp Med (2013) 1.21
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Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain. EMBO Mol Med (2013) 1.10
LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs. Carcinogenesis (2013) 1.06
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Altered features and increased chemosensitivity of human breast cancer cells mediated by adipose tissue-derived mesenchymal stromal cells. BMC Cancer (2013) 0.98
MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs. Proc Natl Acad Sci U S A (2014) 0.95
Disequilibrium of BMP2 levels in the breast stem cell niche launches epithelial transformation by overamplifying BMPR1B cell response. Stem Cell Reports (2015) 0.93
Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment. Cell Res (2015) 0.93
Ovarian cancer stem cells: a new target for cancer therapy. Biomed Res Int (2013) 0.92
Unique Versus Redundant Functions of IL-1α and IL-1β in the Tumor Microenvironment. Front Immunol (2013) 0.92
Bone marrow fat: linking adipocyte-induced inflammation with skeletal metastases. Cancer Metastasis Rev (2014) 0.92
Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression. Oncotarget (2015) 0.90
Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway. Stem Cell Res Ther (2015) 0.90
Roles of the cyclooxygenase 2 matrix metalloproteinase 1 pathway in brain metastasis of breast cancer. J Biol Chem (2015) 0.90
The role of PGE2-associated inflammatory responses in gastric cancer development. Semin Immunopathol (2012) 0.90
Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression. Int J Mol Sci (2015) 0.89
Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-β. Int J Cancer (2014) 0.88
Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties. Breast Cancer Res Treat (2013) 0.88
Altered tissue metabolites correlate with microbial dysbiosis in colorectal adenomas. J Proteome Res (2014) 0.87
Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer. Prostaglandins Other Lipid Mediat (2014) 0.86
Gastric stem cells and gastric cancer stem cells. Anat Cell Biol (2013) 0.86
Mesenchymal stem cells in the tumor microenvironment. Biomed Rep (2013) 0.85
Human mesenchymal stroma/stem cells exchange membrane proteins and alter functionality during interaction with different tumor cell lines. Stem Cells Dev (2015) 0.85
Bone marrow-derived mesenchymal stem cell-secreted IL-8 promotes the angiogenesis and growth of colorectal cancer. Oncotarget (2015) 0.83
Concise review: breast cancer stem cells: regulatory networks, stem cell niches, and disease relevance. Stem Cells Transl Med (2014) 0.83
COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset. Proc Natl Acad Sci U S A (2015) 0.83
Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies. Mediators Inflamm (2016) 0.83
Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN. Oncotarget (2014) 0.82
Active Component of Antrodia cinnamomea Mycelia Targeting Head and Neck Cancer Initiating Cells through Exaggerated Autophagic Cell Death. Evid Based Complement Alternat Med (2013) 0.82
Differentiation and transdifferentiation potentials of cancer stem cells. Oncotarget (2015) 0.82
Microenvironment, oncoantigens, and antitumor vaccination: lessons learned from BALB-neuT mice. Biomed Res Int (2014) 0.81
Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. Oncotarget (2016) 0.81
The potential role of COX-2 in cancer stem cell-mediated canine mammary tumor initiation: an immunohistochemical study. J Vet Sci (2015) 0.81
Determinants of metastatic competency in colorectal cancer. Mol Oncol (2017) 0.80
Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death. Mol Cancer (2015) 0.80
Paracrine signaling between carcinoma cells and mesenchymal stem cells generates cancer stem cell niche via epithelial-mesenchymal transition. Cancer Discov (2012) 0.80
A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties. BMC Cancer (2015) 0.79
Mesenchymal stem cells promote osteosarcoma cell survival and drug resistance through activation of STAT3. Oncotarget (2016) 0.79
Interaction of MSC with tumor cells. Cell Commun Signal (2016) 0.78
Upregulation of Cyclooxygenase-2/Prostaglandin E2 (COX-2/PGE2) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative Breast Cancer. Breast Cancer (Auckl) (2016) 0.78
Cytosolic phospholipaseA2 inhibition with PLA-695 radiosensitizes tumors in lung cancer animal models. PLoS One (2013) 0.78
Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells. Mol Cancer (2017) 0.78
The uncertain role of unmodified mesenchymal stem cells in tumor progression: what master switch? Stem Cell Res Ther (2013) 0.78
IL-1β produced by aggressive breast cancer cells is one of the factors that dictate their interactions with mesenchymal stem cells through chemokine production. Oncotarget (2015) 0.77
Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth. Cell Rep (2017) 0.77
Tumor-driven Molecular Changes in Human Mesenchymal Stromal Cells. Cancer Microenviron (2014) 0.77
Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis. J Biol Chem (2015) 0.77
Pancreatic cancer stem cell markers and exosomes - the incentive push. World J Gastroenterol (2016) 0.76
Exogenous marker-engineered mesenchymal stem cells detect cancer and metastases in a simple blood assay. Stem Cell Res Ther (2015) 0.76
TWIST1 and BMI1 in Cancer Metastasis and Chemoresistance. J Cancer (2016) 0.76
Physical Intimacy of Breast Cancer Cells with Mesenchymal Stem Cells Elicits Trastuzumab Resistance through Src Activation. Sci Rep (2015) 0.76
Cooperation among heterogeneous prostate cancer cells in the bone metastatic niche. Oncogene (2016) 0.75
Regulation of inflammation by lipid mediators in oral diseases. Oral Dis (2016) 0.75
Stromal Myofibroblasts Are Associated with Poor Prognosis in Solid Cancers: A Meta-Analysis of Published Studies. PLoS One (2016) 0.75
Snail/Slug-YAP/TAZ Complexes Cooperatively Regulate Mesenchymal Stem Cell Function and Bone Formation. Cell Cycle (2017) 0.75
Host knockout of E-prostanoid 2 receptors reduces tumor growth and causes major alterations of gene expression in prostaglandin E2-producing tumors. Oncol Lett (2016) 0.75
Nuclear transport of cancer extracellular vesicle-derived biomaterials through nuclear envelope invagination-associated late endosomes. Oncotarget (2017) 0.75
Cancer stem cell phenotype is supported by secretory phospholipase A2 in human lung cancer cells. Ann Thorac Surg (2014) 0.75
Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment. Stem Cells Int (2017) 0.75
Breast Carcinoma: From Initial Tumor Cell Detachment to Settlement at Secondary Sites. Biomed Res Int (2017) 0.75
The role of dendritic cells in cancer. Semin Immunopathol (2016) 0.75
Biologically Relevant Heterogeneity: Metrics and Practical Insights. SLAS Discov (2017) 0.75
Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells. J Vis Exp (2017) 0.75
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Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
Wnt signalling in stem cells and cancer. Nature (2005) 19.26
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20
ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J Immunol Methods (2009) 9.00
Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One (2008) 8.97
Cells of origin in cancer. Nature (2011) 6.85
G-protein-coupled receptors and cancer. Nat Rev Cancer (2007) 6.80
Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res (2009) 6.43
Gastric cancer originating from bone marrow-derived cells. Science (2004) 6.04
Eicosanoids and cancer. Nat Rev Cancer (2010) 5.96
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science (2005) 5.68
Mesenchymal stromal cells: current understanding and clinical status. Stem Cells (2010) 4.79
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell (2011) 4.79
Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet (2007) 4.09
Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells. Cancer Res (2008) 3.97
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell (2011) 3.83
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Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer Res (2011) 3.18
Tumor-stroma interactions. Curr Opin Genet Dev (2005) 2.89
Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Mol Cancer Res (2008) 2.82
Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival. Cancer Res (2011) 2.50
Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem (2001) 2.31
ALDH1 as a functional marker of cancer stem and progenitor cells. Stem Cells Dev (2010) 2.07
Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. Int J Cancer (2011) 2.05
Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth. Proc Natl Acad Sci U S A (2003) 2.01
Why not treat human cancer with interleukin-1 blockade? Cancer Metastasis Rev (2010) 1.96
Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway. Curr Top Microbiol Immunol (2010) 1.85
Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward. Clin Cancer Res (2010) 1.44
Understanding the cancer stem cell. Br J Cancer (2010) 1.42
CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis. Cancer Sci (2009) 1.32
Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells. PLoS One (2011) 1.16
Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression. Carcinogenesis (2010) 1.15
Tumor-host interactions: the role of inflammation. Histochem Cell Biol (2008) 1.11
Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030. Br J Cancer (2011) 1.09
Interleukin-1 family expression in human breast cancer: interleukin-1 receptor antagonist. Cancer Invest (2000) 1.04
Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2. J Lipid Res (2012) 1.01
Cyclooxygenase-2 inhibitors decrease interleukin-1beta-stimulated prostaglandin E2 and IL-6 production by human gingival fibroblasts. J Periodontol (2003) 0.91
Enteric bacteria and cancer stem cells. Cancers (Basel) (2010) 0.87
Hallmarks of cancer: the next generation. Cell (2011) 140.01
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The basics of epithelial-mesenchymal transition. J Clin Invest (2009) 32.82
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature (2007) 21.53
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 18.53
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet (2008) 17.67
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell (2008) 14.80
A perspective on cancer cell metastasis. Science (2011) 13.31
Retracted A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell (2009) 10.51
Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34
A progression puzzle. Nature (2002) 9.56
Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07
Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A (2004) 7.96
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res (2008) 7.91
Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol (2010) 6.67
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53
Modelling the molecular circuitry of cancer. Nat Rev Cancer (2002) 5.43
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24
Cancer stem cells: mirage or reality? Nat Med (2009) 5.20
The signals and pathways activating cellular senescence. Int J Biochem Cell Biol (2004) 5.00
Rules for making human tumor cells. N Engl J Med (2002) 4.84
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol (2010) 4.80
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell (2011) 4.79
Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol (2002) 4.77
Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet (2005) 4.70
Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle (2006) 4.67
Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell (2007) 4.30
Species- and cell type-specific requirements for cellular transformation. Cancer Cell (2004) 4.25
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol (2012) 3.98
The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96
Exploring a new twist on tumor metastasis. Cancer Res (2006) 3.96
Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell (2008) 3.95
Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene (2002) 3.80
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell (2008) 3.75
The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Proc Natl Acad Sci U S A (2006) 3.64
Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell (2013) 3.61
Retracted Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell (2003) 3.56
Telomerase maintains telomere structure in normal human cells. Cell (2003) 3.29
Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer (2003) 3.23
Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res (2007) 3.04
Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci U S A (2010) 3.03
Telomeres: cancer to human aging. Annu Rev Cell Dev Biol (2006) 2.88
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci U S A (2002) 2.82
Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A (2009) 2.75
Tumor-host interactions: a far-reaching relationship. J Clin Oncol (2010) 2.48
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res (2009) 2.44
Target identification using drug affinity responsive target stability (DARTS). Proc Natl Acad Sci U S A (2009) 2.40
Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia (2010) 2.38
When cells get stressed: an integrative view of cellular senescence. J Clin Invest (2004) 2.37
A mouse model of human breast cancer metastasis to human bone. Cancer Res (2005) 2.24
Adaptation versus selection: the origins of metastatic behavior. Cancer Res (2007) 2.08
Micromanagers of malignancy: role of microRNAs in regulating metastasis. Trends Genet (2008) 2.03
Taking the study of cancer cell survival to a new dimension. Cell (2002) 2.03
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest (2011) 1.96
Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell (2013) 1.86
IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell (2002) 1.79
Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer (2011) 1.79
Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet (2003) 1.78
Cell plasticity and heterogeneity in cancer. Clin Chem (2012) 1.74
Retracted Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis. Genes Dev (2009) 1.74
MicroRNAs in malignant progression. Cell Cycle (2007) 1.74
Retracted Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis. Cancer Res (2010) 1.73
Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers. Cancer Res (2007) 1.66
MicroRNAs: Crucial multi-tasking components in the complex circuitry of tumor metastasis. Cell Cycle (2009) 1.63
Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol (2003) 1.59
miR-31: a crucial overseer of tumor metastasis and other emerging roles. Cell Cycle (2010) 1.51
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J Exp Med (2014) 1.49
The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions. Cancer Discov (2012) 1.45
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A (2008) 1.41
Retracted Activation of miR-31 function in already-established metastases elicits metastatic regression. Genes Dev (2011) 1.40
Adiponectin promotes revascularization of ischemic muscle through a cyclooxygenase 2-dependent mechanism. Mol Cell Biol (2009) 1.40
An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell (2013) 1.36
Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Semin Cancer Biol (2010) 1.36
Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells. PLoS One (2010) 1.28
TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. J Biol Chem (2005) 1.28
Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography. Proc Natl Acad Sci U S A (2009) 1.26