| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial.
|
JAMA
|
2002
|
80.37
|
|
2
|
Outcomes ascertainment and adjudication methods in the Women's Health Initiative.
|
Ann Epidemiol
|
2003
|
8.64
|
|
3
|
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
|
Nat Genet
|
2009
|
8.39
|
|
4
|
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote.
|
Genes Dev
|
2004
|
7.57
|
|
5
|
Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials.
|
JAMA
|
2013
|
7.19
|
|
6
|
Performance of common genetic variants in breast-cancer risk models.
|
N Engl J Med
|
2010
|
5.79
|
|
7
|
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
|
Nat Genet
|
2012
|
5.48
|
|
8
|
Loss-of-function mutations in APOC3, triglycerides, and coronary disease.
|
N Engl J Med
|
2014
|
5.47
|
|
9
|
Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial.
|
JAMA
|
2003
|
5.26
|
|
10
|
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
|
Nat Genet
|
2009
|
5.14
|
|
11
|
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
|
Nat Genet
|
2010
|
4.89
|
|
12
|
Recreational physical activity and the risk of breast cancer in postmenopausal women: the Women's Health Initiative Cohort Study.
|
JAMA
|
2003
|
4.72
|
|
13
|
Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing.
|
Nat Genet
|
2002
|
4.68
|
|
14
|
Regional and cellular gene expression changes in human Huntington's disease brain.
|
Hum Mol Genet
|
2006
|
3.91
|
|
15
|
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.
|
N Engl J Med
|
2016
|
3.88
|
|
16
|
Detectable clonal mosaicism and its relationship to aging and cancer.
|
Nat Genet
|
2012
|
3.69
|
|
17
|
Calcium plus vitamin D supplementation and the risk of breast cancer.
|
J Natl Cancer Inst
|
2008
|
3.60
|
|
18
|
Comparison of self-report, hospital discharge codes, and adjudication of cardiovascular events in the Women's Health Initiative.
|
Am J Epidemiol
|
2004
|
3.53
|
|
19
|
Validity of self-report for fractures among a multiethnic cohort of postmenopausal women: results from the Women's Health Initiative observational study and clinical trials.
|
Menopause
|
2004
|
3.33
|
|
20
|
Conjugated equine estrogens and breast cancer risk in the Women's Health Initiative clinical trial and observational study.
|
Am J Epidemiol
|
2008
|
3.05
|
|
21
|
The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study.
|
Am J Epidemiol
|
2011
|
2.98
|
|
22
|
Factors associated with 5-year risk of hip fracture in postmenopausal women.
|
JAMA
|
2007
|
2.81
|
|
23
|
Estrogen plus progestin therapy and breast cancer in recently postmenopausal women.
|
Am J Epidemiol
|
2008
|
2.79
|
|
24
|
Electrocardiographic abnormalities that predict coronary heart disease events and mortality in postmenopausal women: the Women's Health Initiative.
|
Circulation
|
2006
|
2.64
|
|
25
|
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
Gastroenterology
|
2012
|
2.57
|
|
26
|
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
|
Hum Mol Genet
|
2007
|
2.54
|
|
27
|
Low-fat dietary pattern and change in body-composition traits in the Women's Health Initiative Dietary Modification Trial.
|
Am J Clin Nutr
|
2010
|
2.43
|
|
28
|
Imputation methods to improve inference in SNP association studies.
|
Genet Epidemiol
|
2006
|
2.41
|
|
29
|
Effects of conjugated equine estrogen on stroke in the Women's Health Initiative.
|
Circulation
|
2006
|
2.40
|
|
30
|
Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters.
|
EMBO J
|
2006
|
2.38
|
|
31
|
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
Hum Genet
|
2011
|
2.35
|
|
32
|
Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain.
|
Hum Mol Genet
|
2002
|
2.17
|
|
33
|
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.
|
Am J Hum Genet
|
2010
|
2.15
|
|
34
|
Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.
|
PLoS Genet
|
2011
|
2.13
|
|
35
|
Electrocardiographic predictors of incident congestive heart failure and all-cause mortality in postmenopausal women: the Women's Health Initiative.
|
Circulation
|
2006
|
2.13
|
|
36
|
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
Am J Hum Genet
|
2012
|
1.96
|
|
37
|
Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
|
Arch Intern Med
|
2010
|
1.88
|
|
38
|
Cigarette smoking and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium.
|
Am J Epidemiol
|
2009
|
1.87
|
|
39
|
Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium.
|
Cancer Res
|
2010
|
1.82
|
|
40
|
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
|
Nat Genet
|
2013
|
1.82
|
|
41
|
The emergence of lineage-specific chromosomal topologies from coordinate gene regulation.
|
Proc Natl Acad Sci U S A
|
2009
|
1.78
|
|
42
|
Low-fat dietary pattern and lipoprotein risk factors: the Women's Health Initiative Dietary Modification Trial.
|
Am J Clin Nutr
|
2010
|
1.73
|
|
43
|
Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network.
|
PLoS Genet
|
2013
|
1.70
|
|
44
|
Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI Exome Sequencing Project.
|
Blood
|
2013
|
1.69
|
|
45
|
Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration.
|
J Neurosci
|
2007
|
1.66
|
|
46
|
Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
|
Gut
|
2012
|
1.66
|
|
47
|
Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study.
|
PLoS One
|
2012
|
1.65
|
|
48
|
Characterization of gene-environment interactions for colorectal cancer susceptibility loci.
|
Cancer Res
|
2012
|
1.58
|
|
49
|
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.
|
PLoS Genet
|
2013
|
1.57
|
|
50
|
Combining biomarkers to detect disease with application to prostate cancer.
|
Biostatistics
|
2003
|
1.54
|
|
51
|
Yeast Isw1p forms two separable complexes in vivo.
|
Mol Cell Biol
|
2003
|
1.53
|
|
52
|
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
|
PLoS Genet
|
2012
|
1.53
|
|
53
|
Gene expression in Huntington's disease skeletal muscle: a potential biomarker.
|
Hum Mol Genet
|
2005
|
1.51
|
|
54
|
Two-stage testing procedures with independent filtering for genome-wide gene-environment interaction.
|
Biometrika
|
2012
|
1.50
|
|
55
|
Conservation of regional gene expression in mouse and human brain.
|
PLoS Genet
|
2007
|
1.47
|
|
56
|
Powerful cocktail methods for detecting genome-wide gene-environment interaction.
|
Genet Epidemiol
|
2012
|
1.45
|
|
57
|
Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses.
|
Hum Mol Genet
|
2002
|
1.45
|
|
58
|
Walking speed and risk of incident ischemic stroke among postmenopausal women.
|
Stroke
|
2008
|
1.42
|
|
59
|
Genotype imputation of Metabochip SNPs using a study-specific reference panel of ~4,000 haplotypes in African Americans from the Women's Health Initiative.
|
Genet Epidemiol
|
2012
|
1.42
|
|
60
|
Replication of breast cancer GWAS susceptibility loci in the Women's Health Initiative African American SHARe Study.
|
Cancer Epidemiol Biomarkers Prev
|
2011
|
1.41
|
|
61
|
Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).
|
Hum Mol Genet
|
2011
|
1.37
|
|
62
|
Intrastrand annealing leads to the formation of a large DNA palindrome and determines the boundaries of genomic amplification in human cancer.
|
Mol Cell Biol
|
2007
|
1.36
|
|
63
|
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
|
PLoS Genet
|
2011
|
1.35
|
|
64
|
Inflammatory, lipid, thrombotic, and genetic markers of coronary heart disease risk in the women's health initiative trials of hormone therapy.
|
Arch Intern Med
|
2008
|
1.34
|
|
65
|
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
|
Hum Mol Genet
|
2013
|
1.34
|
|
66
|
An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.
|
PLoS One
|
2013
|
1.33
|
|
67
|
Monitoring and reporting of the Women's Health Initiative randomized hormone therapy trials.
|
Clin Trials
|
2007
|
1.33
|
|
68
|
Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects.
|
Hum Mol Genet
|
2002
|
1.33
|
|
69
|
Simultaneously testing for marginal genetic association and gene-environment interaction.
|
Am J Epidemiol
|
2012
|
1.29
|
|
70
|
Fine Mapping and Identification of BMI Loci in African Americans.
|
Am J Hum Genet
|
2013
|
1.27
|
|
71
|
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
|
Am J Hum Genet
|
2013
|
1.27
|
|
72
|
Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data.
|
BMC Bioinformatics
|
2006
|
1.24
|
|
73
|
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
|
PLoS Genet
|
2013
|
1.24
|
|
74
|
A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.
|
PLoS Genet
|
2013
|
1.21
|
|
75
|
Semiparametric estimation exploiting covariate independence in two-phase randomized trials.
|
Biometrics
|
2008
|
1.21
|
|
76
|
Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.
|
Carcinogenesis
|
2012
|
1.20
|
|
77
|
Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium.
|
Cancer Causes Control
|
2012
|
1.17
|
|
78
|
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
|
Am J Hum Genet
|
2012
|
1.16
|
|
79
|
Prior oral contraception and postmenopausal fracture: a Women's Health Initiative observational cohort study.
|
Fertil Steril
|
2005
|
1.13
|
|
80
|
Inflammation and hemostasis biomarkers for predicting stroke in postmenopausal women: the Women's Health Initiative Observational Study.
|
J Stroke Cerebrovasc Dis
|
2008
|
1.13
|
|
81
|
Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium.
|
Cancer Epidemiol Biomarkers Prev
|
2010
|
1.11
|
|
82
|
A genome-wide association study of breast cancer in women of African ancestry.
|
Hum Genet
|
2012
|
1.11
|
|
83
|
Lipoprotein-associated phospholipase A2, hormone use, and the risk of ischemic stroke in postmenopausal women.
|
Hypertension
|
2008
|
1.09
|
|
84
|
Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
|
Hum Mol Genet
|
2002
|
1.09
|
|
85
|
Associations of serum sex hormone-binding globulin and sex hormone concentrations with hip fracture risk in postmenopausal women.
|
J Clin Endocrinol Metab
|
2008
|
1.08
|
|
86
|
Distributions of beta sheets in proteins with application to structure prediction.
|
Proteins
|
2002
|
1.08
|
|
87
|
Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.
|
Hum Mol Genet
|
2011
|
1.07
|
|
88
|
Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
|
Int J Cancer
|
2010
|
1.07
|
|
89
|
Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan).
|
Cancer Causes Control
|
2010
|
1.07
|
|
90
|
Postmenopausal estrogen and progestin effects on the serum proteome.
|
Genome Med
|
2009
|
1.07
|
|
91
|
Imputation of coding variants in African Americans: better performance using data from the exome sequencing project.
|
Bioinformatics
|
2013
|
1.05
|
|
92
|
Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.
|
Circ Cardiovasc Genet
|
2011
|
1.05
|
|
93
|
Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia.
|
Arterioscler Thromb Vasc Biol
|
2013
|
1.03
|
|
94
|
The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the Women's Health Initiative.
|
J Am Geriatr Soc
|
2010
|
1.01
|
|
95
|
Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.
|
Exp Gerontol
|
2009
|
1.00
|
|
96
|
Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.
|
PLoS One
|
2012
|
0.99
|
|
97
|
Homocysteine levels and risk of hip fracture in postmenopausal women.
|
J Clin Endocrinol Metab
|
2009
|
0.98
|
|
98
|
Multivariate detection of gene-gene interactions.
|
Genet Epidemiol
|
2012
|
0.98
|
|
99
|
HNF1B and endometrial cancer risk: results from the PAGE study.
|
PLoS One
|
2012
|
0.97
|
|
100
|
Identifying target populations for screening or not screening using logic regression.
|
Stat Med
|
2005
|
0.97
|
|
101
|
Statins, angiotensin-converting enzyme inhibitors, and physical performance in older women.
|
J Am Geriatr Soc
|
2012
|
0.97
|
|
102
|
Extreme regression.
|
Biostatistics
|
2005
|
0.93
|
|
103
|
Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia.
|
Gut
|
2013
|
0.92
|
|
104
|
A variational Bayes discrete mixture test for rare variant association.
|
Genet Epidemiol
|
2014
|
0.92
|
|
105
|
A novel variational Bayes multiple locus Z-statistic for genome-wide association studies with Bayesian model averaging.
|
Bioinformatics
|
2012
|
0.91
|
|
106
|
Caution in reinterpreting the Women's Health Initiative (WHI) Calcium and Vitamin D Trial breast cancer results.
|
Am J Clin Nutr
|
2012
|
0.87
|
|
107
|
Renin-angiotensin system haplotypes and the risk of myocardial infarction and stroke in pharmacologically treated hypertensive patients.
|
Am J Epidemiol
|
2007
|
0.86
|
|
108
|
Fine-mapping and initial characterization of QT interval loci in African Americans.
|
PLoS Genet
|
2012
|
0.86
|
|
109
|
Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study.
|
BMC Genet
|
2013
|
0.86
|
|
110
|
Genome-wide association study of age at menarche in African-American women.
|
Hum Mol Genet
|
2013
|
0.85
|
|
111
|
Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia.
|
J Natl Cancer Inst
|
2014
|
0.85
|
|
112
|
Estrogen receptor polymorphisms and the vascular effects of hormone therapy.
|
Arterioscler Thromb Vasc Biol
|
2010
|
0.85
|
|
113
|
Associations between incident ischemic stroke events and stroke and cardiovascular disease-related genome-wide association studies single nucleotide polymorphisms in the Population Architecture Using Genomics and Epidemiology study.
|
Circ Cardiovasc Genet
|
2012
|
0.84
|
|
114
|
SHARE: an adaptive algorithm to select the most informative set of SNPs for candidate genetic association.
|
Biostatistics
|
2009
|
0.83
|
|
115
|
Robust estimation for secondary trait association in case-control genetic studies.
|
Am J Epidemiol
|
2014
|
0.83
|
|
116
|
Association of DXA-derived bone mineral density and fat mass with African ancestry.
|
J Clin Endocrinol Metab
|
2013
|
0.82
|
|
117
|
Validity of Self-Reported Medication Use Compared With Pharmacy Records in a Cohort of Older Women: Findings From the Women's Health Initiative.
|
Am J Epidemiol
|
2016
|
0.81
|
|
118
|
Evidence of heterogeneity by race/ethnicity in genetic determinants of QT interval.
|
Epidemiology
|
2014
|
0.81
|
|
119
|
African American race but not genome-wide ancestry is negatively associated with atrial fibrillation among postmenopausal women in the Women's Health Initiative.
|
Am Heart J
|
2013
|
0.81
|
|
120
|
Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study.
|
Circ Cardiovasc Genet
|
2014
|
0.81
|
|
121
|
Functional redundancy in the nuclear compartmentalization of the late-replicating genome.
|
Nucleus
|
2014
|
0.80
|
|
122
|
Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study.
|
Ann Hum Genet
|
2013
|
0.80
|
|
123
|
OPG and sRANKL serum levels and incident hip fracture in postmenopausal Caucasian women in the Women's Health Initiative Observational Study.
|
Bone
|
2013
|
0.79
|
|
124
|
Hormone Use, Reproductive History, and Risk of Lung Cancer: The Women's Health Initiative Studies.
|
J Thorac Oncol
|
2015
|
0.78
|
|
125
|
Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4.
|
Cancer Causes Control
|
2013
|
0.78
|
|
126
|
No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.
|
Hum Genet
|
2013
|
0.78
|
|
127
|
Adaptively weighted association statistics.
|
Genet Epidemiol
|
2009
|
0.77
|
|
128
|
Directed indices for exploring gene expression data.
|
Bioinformatics
|
2003
|
0.77
|
|
129
|
Estimating the statistical significance of gene expression changes observed with oligonucleotide arrays.
|
Hum Mol Genet
|
2002
|
0.76
|
|
130
|
Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses.
|
Hum Mol Genet
|
2014
|
0.76
|
|
131
|
Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses.
|
Hum Mol Genet
|
2015
|
0.76
|
|
132
|
Corrigendum: Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
|
Nat Commun
|
2015
|
0.76
|
|
133
|
Long-term oral bisphosphonate use in relation to fracture risk in postmenopausal women with breast cancer: findings from the Women's Health Initiative.
|
Menopause
|
2016
|
0.75
|
|
134
|
Fine mapping of 14q24.1 breast cancer susceptibility locus.
|
Hum Genet
|
2011
|
0.75
|
|
135
|
Boosting predictions of treatment success.
|
Proc Natl Acad Sci U S A
|
2010
|
0.75
|
|
136
|
Associations of Accelerometer-Measured and Self-Reported Sedentary Time With Leukocyte Telomere Length in Older Women.
|
Am J Epidemiol
|
2017
|
0.75
|
|
137
|
Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk.
|
Nat Commun
|
2017
|
0.75
|
|
138
|
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals.
|
Circ Cardiovasc Genet
|
2017
|
0.75
|
|
139
|
Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
|
PLoS Genet
|
2017
|
0.75
|
|
140
|
Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
|
Nat Genet
|
2017
|
0.75
|