Retracted: This article has been retracted.

Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype.

PubWeight™: 2.39‹?› | Rank: Top 2%

🔗 View Article (PMC 3443798)

Published in Am J Respir Crit Care Med on July 05, 2012

Authors

Njira L Lugogo1, John W Hollingsworth, Druhan L Howell, Loretta G Que, Dave Francisco, Tony D Church, Erin N Potts-Kant, Jennifer L Ingram, Ying Wang, Sin-Ho Jung, Monica Kraft

Author Affiliations

1: Duke University Medical Center, P.O. Box 2629, Durham, NC 27710, USA. njira.lugogo@duke.edu

Associated clinical trials:

Adiposity and Airway Inflammation in HIV-Associated Airway Disease (SHOP) | NCT02975258

Articles citing this

Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med (2013) 4.95

Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases. Pulm Pharmacol Ther (2013) 1.54

Inflammation, metabolic dysregulation, and pulmonary function among obese urban adolescents with asthma. Am J Respir Crit Care Med (2015) 1.52

Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med (2012) 1.28

Expression of concern: Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype. Am J Respir Crit Care Med (2015) 1.08

Is there a link between obesity and asthma? Allergy Asthma Immunol Res (2014) 1.04

The impact of diet on asthma and allergic diseases. Nat Rev Immunol (2015) 1.00

Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma. Sci Rep (2013) 0.91

Immunometabolism in obese asthmatics: are we there yet? Nutrients (2013) 0.86

Emerging molecular phenotypes of asthma. Am J Physiol Lung Cell Mol Physiol (2014) 0.85

Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population Studies. J Allergy (Cairo) (2013) 0.85

Nutrition and respiratory health--feature review. Nutrients (2015) 0.84

Role of obesity in asthma control, the obesity-asthma phenotype. J Allergy (Cairo) (2013) 0.84

Obesity in asthma: approaches to treatment. Curr Allergy Asthma Rep (2013) 0.84

Influence of distinct asthma phenotypes on lung function following weight loss in the obese. Respirology (2014) 0.83

Data-driven asthma endotypes defined from blood biomarker and gene expression data. PLoS One (2015) 0.82

Obesity and asthma in children: current and future therapeutic options. Paediatr Drugs (2014) 0.81

Obesity: changing asthma in the 21st century. Am J Respir Crit Care Med (2012) 0.81

Obesity and weight gain in relation to incidence of sarcoidosis in US black women: data from the Black Women's Health Study. Chest (2015) 0.80

Arginine and nitric oxide pathways in obesity-associated asthma. J Allergy (Cairo) (2013) 0.78

Weight gain and lung disease: the vagary of body mass index and the dilemma of the obese smoker. Am J Respir Crit Care Med (2014) 0.77

Immunological characteristics and management considerations in obese patients with asthma. Expert Rev Clin Immunol (2015) 0.76

Asthma and obesity: mechanisms and clinical implications. Asthma Res Pract (2015) 0.75

Retraction: Alveolar Macrophages from Overweight/Obese Subjects with Asthma Demonstrate a Proinflammatory Phenotype. Am J Respir Crit Care Med (2015) 0.75

Adipokines and Cysteinyl Leukotrienes in the Pathogenesis of Asthma. J Allergy (Cairo) (2015) 0.75

Inflammatory and Oxidative Stress Markers in Experimental Allergic Asthma. Inflammation (2017) 0.75

Articles cited by this

Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature (1997) 10.53

Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol (2006) 10.05

Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol (2005) 8.39

Obesity-induced inflammatory changes in adipose tissue. J Clin Invest (2003) 7.50

Mechanisms of leptin action and leptin resistance. Annu Rev Physiol (2008) 4.72

Leptin regulates proinflammatory immune responses. FASEB J (1998) 4.31

Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol (2006) 4.07

Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med (2007) 3.95

Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab (2010) 2.79

Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation. J Allergy Clin Immunol (2011) 2.53

Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol (2005) 2.08

The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol (2008) 1.96

Body mass index in relation to adult asthma among 135,000 Norwegian men and women. Am J Epidemiol (2004) 1.88

Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: effect of clarithromycin. Chest (2002) 1.84

Secretory factors from human adipose tissue and their functional role. Proc Nutr Soc (2005) 1.78

Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med (2008) 1.68

Asthma control, adiposity, and adipokines among inner-city adolescents. J Allergy Clin Immunol (2010) 1.63

Association between leptin and asthma in adults. Thorax (2006) 1.59

The association between obesity and asthma is stronger in nonallergic than allergic adults. Chest (2006) 1.54

Mechanisms for the anti-inflammatory effects of statins. Curr Opin Lipidol (2011) 1.47

Is obesity a risk factor for childhood asthma? Allergy (2001) 1.45

Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-alpha system. J Clin Endocrinol Metab (2002) 1.43

Anti-inflammatory effects of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein: the PIOSTAT Study. J Am Coll Cardiol (2007) 1.38

The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes (2002) 1.37

Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. Respir Res (2007) 1.33

The relationship between asthma and obesity in children: is it real or a case of over diagnosis? J Asthma (2004) 1.33

Obesity and the lung: 4. Obesity and asthma. Thorax (2008) 1.28

Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase. J Allergy Clin Immunol (2010) 1.17

Obesity and adult asthma: potential effect modification by gender, but not by hay fever. Ann Epidemiol (2008) 1.02

Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls. J Asthma (2011) 0.96

Obesity and poor asthma control in patients with severe asthma. J Asthma (2011) 0.91

Leptin and adiponectin in obese and non-obese subjects with asthma. Biomarkers (2011) 0.84

[Secretory activity of the adipocytes and comorbidities of obesity]. MMW Fortschr Med (2005) 0.81

Articles by these authors

(truncated to the top 100)

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Genomewide association study of leprosy. N Engl J Med (2009) 8.17

Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med (2005) 7.61

Mapping human genetic diversity in Asia. Science (2009) 7.40

In vivo genome editing using a high-efficiency TALEN system. Nature (2012) 7.11

Updated National Birth Prevalence estimates for selected birth defects in the United States, 2004-2006. Birth Defects Res A Clin Mol Teratol (2010) 7.00

Management of lung nodules detected by volume CT scanning. N Engl J Med (2009) 6.79

KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science (2003) 6.60

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42

Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med (2010) 6.19

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet (2009) 5.62

Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol (2010) 5.55

Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01

Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med (2009) 4.83

Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol (2010) 4.38

Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA (2012) 4.30

Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A (2009) 4.25

Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis (2002) 4.23

Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell (2004) 3.98

Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol (2002) 3.66

The SOL Genomics Network: a comparative resource for Solanaceae biology and beyond. Plant Physiol (2005) 3.65

Fluoxetine versus placebo in advanced cancer outpatients: a double-blinded trial of the Hoosier Oncology Group. J Clin Oncol (2003) 3.58

Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol (2003) 3.54

Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography. Genome Res (2006) 3.53

Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke (2004) 3.53

Asthma and chronic obstructive pulmonary disease exhibit common origins in any country! Am J Respir Crit Care Med (2006) 3.47

Draft genome sequence of chickpea (Cicer arietinum) provides a resource for trait improvement. Nat Biotechnol (2013) 3.41

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A (2004) 3.40

Gene expression profiling of familial and sporadic interstitial pneumonia. Am J Respir Crit Care Med (2006) 3.32

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One (2008) 3.25

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell (2005) 3.15

Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. J Allergy Clin Immunol (2010) 2.98

Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Am J Psychiatry (2007) 2.84

Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet (2009) 2.82

Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: sustained regression before and after allogeneic stem cell transplantation. Blood (2009) 2.82

Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med (2004) 2.81

Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med (2007) 2.81

Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration. Proc Natl Acad Sci U S A (2008) 2.65

Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell (2007) 2.65

Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. Nat Med (2006) 2.57

Experimental evidence for epitaxial silicene on diboride thin films. Phys Rev Lett (2012) 2.56

Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med (2014) 2.53

Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202). J Clin Oncol (2013) 2.50

Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab (2012) 2.48

Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects. Am J Physiol Lung Cell Mol Physiol (2002) 2.46

beta-Adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med (2005) 2.45

Exploration of gene-gene interaction effects using entropy-based methods. Eur J Hum Genet (2007) 2.42

Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats. J Cereb Blood Flow Metab (2004) 2.41

A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res (2008) 2.38

MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-β1 pathway. Circulation (2012) 2.36

P25-graphene composite as a high performance photocatalyst. ACS Nano (2010) 2.34

Murine B7-H3 is a negative regulator of T cells. J Immunol (2004) 2.33

Vitellogenin, juvenile hormone, insulin signaling, and queen honey bee longevity. Proc Natl Acad Sci U S A (2007) 2.31

Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes. Clin Cancer Res (2013) 2.30

Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors. Cell Res (2008) 2.29

Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate. Am J Respir Crit Care Med (2009) 2.27

Self-assembly of CdTe nanocrystals into free-floating sheets. Science (2006) 2.25

Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med (2002) 2.24

Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke (2002) 2.24

Long-acting β2-agonist step-off in patients with controlled asthma. Arch Intern Med (2012) 2.24

The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer. J Clin Invest (2006) 2.18

Endobronchial ultrasound versus mediastinoscopy for mediastinal nodal staging of non-small-cell lung cancer. J Thorac Oncol (2015) 2.17

Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction. Am J Epidemiol (2012) 2.16

Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol (2007) 2.16

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity (2009) 2.13

Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. J Biol Chem (2003) 2.12

Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J Clin Invest (2005) 2.08

Elafin is a biomarker of graft-versus-host disease of the skin. Sci Transl Med (2010) 2.08

Concern TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation. Am J Respir Crit Care Med (2009) 2.07

Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia. J Cereb Blood Flow Metab (2006) 2.06

Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration. J Neurosci (2006) 2.06

PD-L1 expression in triple-negative breast cancer. Cancer Immunol Res (2014) 2.06

Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient mice. J Immunol (2009) 2.03

Development of a EST dataset and characterization of EST-SSRs in a traditional Chinese medicinal plant, Epimedium sagittatum (Sieb. Et Zucc.) Maxim. BMC Genomics (2010) 2.01

Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis. Cancer Res (2011) 2.00

Impact of visual field loss on health-related quality of life in glaucoma: the Los Angeles Latino Eye Study. Ophthalmology (2007) 2.00

Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature (2004) 1.99

Features of resolving and nonresolving indeterminate pulmonary nodules at follow-up CT: the NELSON study. Radiology (2013) 1.98

A distribution-free test of constant mean in linear mixed effects models. Stat Med (2008) 1.97

A prospective multicenter study of competency metrics and educational interventions in the learning of bronchoscopy among new pulmonary fellows. Chest (2009) 1.97

CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell (2012) 1.97

Regulatory divergence modifies limb length between mammals. Genes Dev (2008) 1.96

The 21-nucleotide, but not 22-nucleotide, viral secondary small interfering RNAs direct potent antiviral defense by two cooperative argonautes in Arabidopsis thaliana. Plant Cell (2011) 1.95

T-cell tolerance or function is determined by combinatorial costimulatory signals. EMBO J (2006) 1.92

Concern c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice. Am J Respir Crit Care Med (2011) 1.91

Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study. Leuk Lymphoma (2008) 1.91

Nonparametric inference on median residual life function. Biometrics (2007) 1.90

Distribution and speciation of heavy metals in sediments from the mainstream, tributaries, and lakes of the Yangtze River catchment of Wuhan, China. J Hazard Mater (2008) 1.89

Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. J Allergy Clin Immunol (2005) 1.88

The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial. J Allergy Clin Immunol (2007) 1.87

Chemical characteristics of PM2.5 and PM10 in haze-fog episodes in Beijing. Environ Sci Technol (2006) 1.86

Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol (2004) 1.82

Accuracy of ROPtool vs individual examiners in assessing retinal vascular tortuosity. Arch Ophthalmol (2007) 1.81

Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor. Proc Natl Acad Sci U S A (2008) 1.81

IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration. J Immunol (2012) 1.81

MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A (2010) 1.80

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80

Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice. J Orthop Res (2009) 1.76