Published in N Engl J Med on May 17, 1990
CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure. Exp Neurol (2007) 4.00
Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PLoS One (2012) 3.90
Computerized classification of neurologic injury based on the international standards for classification of spinal cord injury. J Spinal Cord Med (2009) 2.45
Donald Munro Lecture. Spinal cord injury--past, present, and future. J Spinal Cord Med (2007) 2.32
Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx (2004) 1.98
Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury. J Clin Invest (2007) 1.84
Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury. Proc Natl Acad Sci U S A (2004) 1.63
Timing of decompressive surgery of spinal cord after traumatic spinal cord injury: an evidence-based examination of pre-clinical and clinical studies. J Neurotrauma (2010) 1.54
Early acute management in adults with spinal cord injury: a clinical practice guideline for health-care professionals. J Spinal Cord Med (2008) 1.54
Antioxidant therapies in traumatic brain and spinal cord injury. Biochim Biophys Acta (2011) 1.48
Validity of the walking scale for spinal cord injury and other domains of function in a multicenter clinical trial. Neurorehabil Neural Repair (2007) 1.41
Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J Clin Invest (2002) 1.40
Biomaterial design strategies for the treatment of spinal cord injuries. J Neurotrauma (2010) 1.40
Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial design. Spinal Cord (2006) 1.39
National athletic trainers' association position statement: acute management of the cervical spine-injured athlete. J Athl Train (2009) 1.38
Pediatric thoracic SCIWORA after back bend during dance practice: a retrospective case series and analysis of trauma mechanisms. Childs Nerv Syst (2017) 1.38
The two-edged sword of large-dose steroids for spinal cord trauma. Ann Surg (1993) 1.36
International standards for neurological classification of spinal cord injury: training effect on accurate classification. J Spinal Cord Med (2008) 1.31
Bone marrow stem cells and polymer hydrogels--two strategies for spinal cord injury repair. Cell Mol Neurobiol (2006) 1.30
Antioxidant therapies for acute spinal cord injury. Neurotherapeutics (2011) 1.26
Naloxone in opioid poisoning: walking the tightrope. Emerg Med J (2005) 1.21
Progress of mesenchymal stem cell therapy for neural and retinal diseases. World J Stem Cells (2014) 1.20
Corticosteroids in head injury--the CRASH trial. J Accid Emerg Med (1999) 1.19
Delivery of neurotrophin-3 from fibrin enhances neuronal fiber sprouting after spinal cord injury. J Control Release (2006) 1.19
Hypertonic saline: a clinical review. Neurosurg Rev (2007) 1.13
Clinical Outcomes of Spontaneous Spinal Epidural Hematoma : A Comparative Study between Conservative and Surgical Treatment. J Korean Neurosurg Soc (2012) 1.13
An expert consensus on the evaluation and treatment of acute thoracolumbar spine and spinal cord injury in China. Neural Regen Res (2013) 1.11
Spatial distribution and acute anti-inflammatory effects of Methylprednisolone after sustained local delivery to the contused spinal cord. Biomaterials (2008) 1.09
Spinal cord injury: a review of current therapy, future treatments, and basic science frontiers. Neurochem Res (2013) 1.08
Biomaterials for the central nervous system. J R Soc Interface (2008) 1.08
Efficacy of surgical decompression in the setting of complete thoracic spinal cord injury. J Spinal Cord Med (2005) 1.06
Hypothermic treatment for acute spinal cord injury. Neurotherapeutics (2011) 1.05
The impact of age on mortality, impairment, and disability among adults with acute traumatic spinal cord injury. J Neurotrauma (2009) 1.04
Nanoparticle-mediated local delivery of Methylprednisolone after spinal cord injury. Biomaterials (2009) 1.03
The international standards for neurological classification of spinal cord injury: intra-rater agreement of total motor and sensory scores in the pediatric population. J Spinal Cord Med (2009) 1.03
Comparison of the effects of complete and incomplete spinal cord injury on lower urinary tract function as evaluated in unanesthetized rats. Exp Neurol (2007) 1.01
Cervical spondylosis. An update. West J Med (1996) 1.01
Alterations in chondroitin sulfate proteoglycan expression occur both at and far from the site of spinal contusion injury. Exp Neurol (2011) 1.00
An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate. Biomaterials (2010) 1.00
Efficacy of surgical decompression in regard to motor recovery in the setting of conus medullaris injury. J Spinal Cord Med (2006) 1.00
Glutamine synthetase protects against neuronal degeneration in injured retinal tissue. Proc Natl Acad Sci U S A (1997) 0.99
Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J Neurosci (2008) 0.98
Glucocorticoid receptor pathways are involved in the inhibition of astrocyte proliferation. Proc Natl Acad Sci U S A (1997) 0.96
Public health in the emergency department: overcoming barriers to implementation and dissemination. Acad Emerg Med (2009) 0.95
Acetyl-L-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery. Neuroscience (2012) 0.95
Methylprednisolone for acute spinal cord injury: not a standard of care. CMAJ (2003) 0.95
Emerging approaches to the surgical management of acute traumatic spinal cord injury. Neurotherapeutics (2011) 0.94
Post-traumatic visual loss. Rev Neurol Dis (2008) 0.94
The dark side of neuroplasticity. Exp Neurol (2011) 0.93
Effects of zileuton and montelukast in mouse experimental spinal cord injury. Br J Pharmacol (2007) 0.93
Mortality and morbidity after high-dose methylprednisolone treatment in patients with acute cervical spinal cord injury: a propensity-matched analysis using a nationwide administrative database. Emerg Med J (2013) 0.93
Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration. Neurochem Int (2013) 0.92
Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries. Drug Discov Today (2012) 0.91
Plasmid-based genetic modification of human bone marrow-derived stromal cells: analysis of cell survival and transgene expression after transplantation in rat spinal cord. BMC Biotechnol (2007) 0.90
Surgical-site infection in spinal injury: incidence and risk factors in a prospective cohort of 518 patients. Eur Spine J (2014) 0.90
Infarction of the cervical spinal cord following multilevel transforaminal epidural steroid injection: case report and review of the literature. J Spinal Cord Med (2007) 0.89
Outcome Measures for Acute/Subacute Cervical Sensorimotor Complete (AIS-A) Spinal Cord Injury During a Phase 2 Clinical Trial. Top Spinal Cord Inj Rehabil (2012) 0.89
Emerging therapies for acute traumatic spinal cord injury. CMAJ (2012) 0.88
Neuroplasticity. Key to recovery after central nervous system injury. West J Med (1993) 0.88
The influence of time from injury to surgery on motor recovery and length of hospital stay in acute traumatic spinal cord injury: an observational Canadian cohort study. J Neurotrauma (2014) 0.87
Guanosine reduces apoptosis and inflammation associated with restoration of function in rats with acute spinal cord injury. Purinergic Signal (2007) 0.87
Minimizing errors in acute traumatic spinal cord injury trials by acknowledging the heterogeneity of spinal cord anatomy and injury severity: an observational Canadian cohort analysis. J Neurotrauma (2014) 0.87
Controversies in neuro-ophthalmology: steroid therapy for traumatic optic neuropathy. Indian J Ophthalmol (2014) 0.87
Clinical and experimental advances in regeneration of spinal cord injury. J Tissue Eng (2010) 0.87
Thoracolumbar spine trauma: Evaluation and surgical decision-making. J Craniovertebr Junction Spine (2013) 0.87
Traumatic optic neuropathy: a review. Craniomaxillofac Trauma Reconstr (2014) 0.86
Cerebrospinal fluid cortisol and progesterone profiles and outcomes prognostication after severe traumatic brain injury. J Neurotrauma (2014) 0.86
Acupuncture's Effects in Treating the Sequelae of Acute and Chronic Spinal Cord Injuries: A Review of Allopathic and Traditional Chinese Medicine Literature. Evid Based Complement Alternat Med (2010) 0.86
Concise Review: Bridging the Gap: Novel Neuroregenerative and Neuroprotective Strategies in Spinal Cord Injury. Stem Cells Transl Med (2016) 0.85
Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury. J Control Release (2015) 0.85
Thoracic spine fractures: injury profile and outcomes of a surgically treated cohort. Eur Spine J (2011) 0.85
Chemokines as possible targets in modulation of the secondary damage after acute spinal cord injury: a review. Cell Mol Neurobiol (2009) 0.85
A clinical prediction model for long-term functional outcome after traumatic spinal cord injury based on acute clinical and imaging factors. J Neurotrauma (2012) 0.85
Effect of combined treatment with melatonin and methylprednisolone on neurological recovery after experimental spinal cord injury. Eur Spine J (2004) 0.85
The dual cyclooxygenase/5-lipoxygenase inhibitor licofelone attenuates p-glycoprotein-mediated drug resistance in the injured spinal cord. J Neurotrauma (2013) 0.85
Granulocyte colony-stimulating factor (G-CSF) protects oligodendrocyte and promotes hindlimb functional recovery after spinal cord injury in rats. PLoS One (2012) 0.85
Recent advances in managing a spinal cord injury secondary to trauma. F1000Res (2016) 0.84
Post-traumatic optic neuropathy: our surgical and medical protocol. Eur Arch Otorhinolaryngol (2014) 0.84
ATLS(R) and damage control in spine trauma. World J Emerg Surg (2009) 0.84
A review: the role of high dose methylprednisolone in spinal cord trauma in children. Pediatr Surg Int (2011) 0.84
Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone. BMC Neurosci (2013) 0.84
Prognostic factors for surgical outcome in spinal cord injury associated with ossification of the posterior longitudinal ligament (OPLL). J Orthop Surg Res (2015) 0.84
Antioxidant and anti-inflammatory effects of intravenously injected adipose derived mesenchymal stem cells in dogs with acute spinal cord injury. Stem Cell Res Ther (2015) 0.83
Neuroprotective ferulic acid (FA)-glycol chitosan (GC) nanoparticles for functional restoration of traumatically injured spinal cord. Biomaterials (2013) 0.83
Neuroprotective therapy using granulocyte colony-stimulating factor for acute spinal cord injury: a phase I/IIa clinical trial. Eur Spine J (2012) 0.83
The CRASH trial protocol (Corticosteroid randomisation after significant head injury) [ISRCTN74459797]. BMC Emerg Med (2001) 0.83
Methylprednisolone for the Treatment of Patients with Acute Spinal Cord Injuries: A Systematic Review and Meta-Analysis. J Neurotrauma (2015) 0.83
Rapid non-genomic inhibition of ATP-induced Cl- secretion by dexamethasone in human bronchial epithelium. J Physiol (2002) 0.83
Therapeutic strategy for acute spinal cord contusion injury: cell elimination combined with microsurgical intervention. PLoS One (2007) 0.82
Central cord syndrome in Ireland: the effect of age on clinical outcome. Eur Spine J (2009) 0.82
Patients with Spinal Cord Injuries Favor Administration of Methylprednisolone. PLoS One (2016) 0.82
Intramedullary lesion expansion on magnetic resonance imaging in patients with motor complete cervical spinal cord injury. J Neurosurg Spine (2012) 0.82
A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. N Engl J Med (1990) 0.82
Combined Transplantation of Human Neuronal and Mesenchymal Stem Cells following Spinal Cord Injury. Global Spine J (2013) 0.82
Unstable vertebral fractures in the lower third of the spine treated with closed reduction and transpedicular posterior fixation: a retrospective analysis of 82 fractures in 78 patients. Eur Spine J (1997) 0.82
Spinal cord birth injury--diagnostic difficulties. Arch Dis Child (1993) 0.81
Spinal cord injury: how can we improve the classification and quantification of its severity and prognosis? J Neurotrauma (2014) 0.81
Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats. Surg Neurol Int (2016) 0.81
Spinal cord injury: is monitoring from the injury site the future? Crit Care (2016) 0.81
A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol (1996) 20.25
A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med (1999) 11.80
Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J Clin Epidemiol (1995) 6.94
The risk of determining risk with multivariable models. Ann Intern Med (1993) 6.45
Unintended changes in cognition, mood, and behavior arising from cell-based interventions for neurological conditions: ethical challenges. Am J Bioeth (2009) 6.13
International Standards for Neurological and Functional Classification of Spinal Cord Injury. American Spinal Injury Association. Spinal Cord (1997) 5.91
Restricted activity among community-living older persons: incidence, precipitants, and health care utilization. Ann Intern Med (2001) 4.25
The role of secondary brain injury in determining outcome from severe head injury. J Trauma (1993) 4.25
The estimation of age, period and cohort effects for vital rates. Biometrics (1983) 3.86
The Hospital Elder Life Program: a model of care to prevent cognitive and functional decline in older hospitalized patients. Hospital Elder Life Program. J Am Geriatr Soc (2000) 3.58
Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. J Neurosurg (1992) 3.52
Has laparoscopic cholecystectomy changed patterns of practice and patient outcome in Ontario? CMAJ (1996) 3.51
The analysis of rates and of survivorship using log-linear models. Biometrics (1980) 2.98
Neurobehavioral outcome following minor head injury: a three-center study. J Neurosurg (1987) 2.92
A randomized controlled trial of auricular acupuncture for cocaine dependence. Arch Intern Med (2000) 2.87
A new route of transmission for Escherichia coli: infection from dry fermented salami. Am J Public Health (1996) 2.78
Overproduction of Escherichia coli integration host factor, a protein with nonidentical subunits. J Bacteriol (1987) 2.67
Emotional support and survival after myocardial infarction. A prospective, population-based study of the elderly. Ann Intern Med (1992) 2.62
The international standards booklet for neurological and functional classification of spinal cord injury. American Spinal Injury Association. Paraplegia (1994) 2.59
Multivariate analysis for matched case-control studies. Am J Epidemiol (1978) 2.40
Importance of events per independent variable in proportional hazards analysis. I. Background, goals, and general strategy. J Clin Epidemiol (1995) 2.32
Mild head injury classification. Neurosurgery (1990) 2.30
MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study. J Neurotrauma (1996) 2.23
Turtle-associated salmonellosis. I. An estimation of the magnitude of the problem in the United States, 1970-1971. Am J Epidemiol (1972) 2.15
Ventriculostomy infections: the effect of monitoring duration and catheter exchange in 584 patients. J Neurosurg (1996) 2.07
1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five U.S. studies. J Natl Cancer Inst (2001) 2.05
Stereotactic, automated, large-core needle biopsy of nonpalpable breast lesions: false-negative and histologic underestimation rates after long-term follow-up. Radiology (1999) 2.04
Brush cytology for the diagnosis of rectal carcinoma. Br J Surg (1996) 2.03
Vegetative state after closed-head injury. A Traumatic Coma Data Bank Report. Arch Neurol (1991) 2.03
Ischemic heart disease, atherosclerosis, and longevity. Circulation (1966) 2.03
Efficacy of methylprednisolone in acute spinal cord injury. JAMA (1984) 1.99
Determinants of head injury mortality: importance of the low risk patient. Neurosurgery (1989) 1.97
Androgen receptor: an overview. Crit Rev Eukaryot Gene Expr (1995) 1.81
An epidemiologic study of epithelial carcinoma of the ovary. Am J Epidemiol (1981) 1.80
Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices. J Neurosci (1999) 1.80
The neurobehavioural rating scale: assessment of the behavioural sequelae of head injury by the clinician. J Neurol Neurosurg Psychiatry (1987) 1.79
Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2. J Neurosurg (1993) 1.75
An Escherichia coli mutant unable to support site-specific recombination of bacteriophage lambda. J Mol Biol (1985) 1.68
Octreotide as primary therapy for acromegaly. J Clin Endocrinol Metab (1998) 1.68
Life tables with concomitant information. Biometrics (1976) 1.65
Malignant melanoma incidence in Connecticut (United States): time trends and age-period-cohort modeling by anatomic site. Cancer Causes Control (1994) 1.64
Asthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors. Am J Respir Crit Care Med (1996) 1.63
Behavioral changes after closed head injury in children. J Consult Clin Psychol (1990) 1.61
An epidemiologic study of hip fracture in postmenopausal women. Am J Epidemiol (1982) 1.60
Change points in the series of T4 counts prior to AIDS. Biometrics (1995) 1.58
Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. J Neurosurg (1998) 1.58
Cell-based interventions for neurologic conditions: ethical challenges for early human trials. Neurology (2008) 1.57
Acute prolapsed lumbar intervertebral disc. An epidemiologic study with special reference to driving automobiles and cigarette smoking. Spine (Phila Pa 1976) (1984) 1.56
Multicomponent targeted intervention to prevent delirium in hospitalized older patients: what is the economic value? Med Care (2001) 1.52
Endogenous repair after spinal cord contusion injuries in the rat. Exp Neurol (1997) 1.52
A case-control study of cancer of the endometrium. Am J Epidemiol (1982) 1.50
Additive, multiplicative, and other models for disease risks. Am J Epidemiol (1978) 1.49
Physical activity and the risk of spontaneous preterm delivery. J Reprod Med (1983) 1.46
Sex differences in survival after myocardial infarction in older adults: a community-based approach. J Am Geriatr Soc (1996) 1.46
Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks. J Neurosci (2000) 1.45
Epidemiology of non-Hodgkin lymphoma in Connecticut. 1935-1988. Cancer (1992) 1.44
Devolution of hip and knee replacement surgery? Can J Surg (1996) 1.44
Magnetic resonance imaging and computerized tomography in relation to the neurobehavioral sequelae of mild and moderate head injuries. J Neurosurg (1987) 1.44
Pulse pressure and risk for myocardial infarction and heart failure in the elderly. J Am Coll Cardiol (2000) 1.43
Predictors of outcome following severe head trauma: follow-up data from the Traumatic Coma Data Bank. Brain Inj (1993) 1.43
Time trend and the age-period-cohort effect on the incidence of histologic types of lung cancer in Connecticut, 1960-1989. Cancer (1994) 1.43
Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function. J Pharmacol Exp Ther (1997) 1.42
Risk factors predicting the incidence of second primary breast cancer among women diagnosed with a first primary breast cancer. Am J Epidemiol (1992) 1.42
Maternal smoking and congenital malformations: an epidemiological study. J Epidemiol Community Health (1978) 1.42
Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients. Mol Psychiatry (2007) 1.41
Transvascular treatment of giant aneurysms of the cavernous carotid and vertebral arteries. Functional investigation and embolization. Surg Neurol (1984) 1.40
Serial MRI and neurobehavioural findings after mild to moderate closed head injury. J Neurol Neurosurg Psychiatry (1992) 1.40
Trends in clinical and economic outcomes of coronary angioplasty from 1992 to 1995: a population-based analysis. Am Heart J (1999) 1.39
The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats. J Neurosurg (1994) 1.39
Predictors of mortality and institutionalization after hip fracture: the New Haven EPESE cohort. Established Populations for Epidemiologic Studies of the Elderly. Am J Public Health (1994) 1.38
Identification of simian virus 40 T-antigen residues important for specific and nonspecific binding to DNA and for helicase activity. J Virol (1990) 1.35
Cross-cultural association between dietary animal protein and hip fracture: a hypothesis. Calcif Tissue Int (1992) 1.34
Stereotaxic large-core needle biopsy of 450 nonpalpable breast lesions with surgical correlation in lesions with cancer or atypical hyperplasia. Radiology (1994) 1.33
Gene expression profiling of acute spinal cord injury reveals spreading inflammatory signals and neuron loss. Physiol Genomics (2001) 1.32
Time-frequency analysis using the matching pursuit algorithm applied to seizures originating from the mesial temporal lobe. Electroencephalogr Clin Neurophysiol (1998) 1.31
An evaluation of two equations for predicting fetal weight by ultrasound. Am J Obstet Gynecol (1982) 1.30
Human monoclonal antibody against Forssman antigen. Science (1980) 1.30
Indoor, outdoor, and regional summer and winter concentrations of PM10, PM2.5, SO4(2)-, H+, NH4+, NO3-, NH3, and nitrous acid in homes with and without kerosene space heaters. Environ Health Perspect (1999) 1.29
Extracranial complications of severe head injury. J Neurosurg (1992) 1.25
Neurobehavioral outcome 1 year after severe head injury. Experience of the Traumatic Coma Data Bank. J Neurosurg (1990) 1.25
Memory and intellectual ability after head injury in children and adolescents. Neurosurgery (1982) 1.25
An epidemiologic study of lifting and twisting on the job and risk for acute prolapsed lumbar intervertebral disc. J Orthop Res (1984) 1.24
Transmission, from man to hamster, of Creutzfeldt-Jakob disease with clinical recovery. Lancet (1978) 1.24
Risk of female breast cancer associated with serum polychlorinated biphenyls and 1,1-dichloro-2,2'-bis(p-chlorophenyl)ethylene. Cancer Epidemiol Biomarkers Prev (2000) 1.24