Published in Curr Oncol on June 01, 2012
Tarceva Italian Lung Optimization tRial (TAILOR) | NCT00637910
A Phase 1/2 Study of the Oral ALK/EGFR Inhibitor AP26113 | NCT01449461
Hydroxychloroquine + Vorinostat in Advanced Solid Tumors | NCT01023737
Sirolimus or Vorinostat and Hydroxychloroquine in Advanced Cancer | NCT01266057
Selumetinib in Cancers With BRAF Mutations | NCT00888134
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Pemetrexed and LBH589 in Patients With Advanced Non-Small Cell Lung Cancer | NCT00907179
Phase I Study of LBH589 & Erlotinib for Advanced Aerodigestive Tract Cancers | NCT00738751
Sirolimus or Everolimus or Temsirolimus and Vorinostat in Advanced Cancer | NCT01087554
Phase I Study of Pazopanib and Vorinostat | NCT01339871
BIBW 2992 (Afatinib) in Combination With Pemetrexed in Advanced Solid Tumours | NCT01169675
Dysregulation of the Met pathway in non-small cell lung cancer: implications for drug targeting and resistance. Transl Lung Cancer Res (2015) 0.80
Personalized oncology in interventional radiology. J Vasc Interv Radiol (2013) 0.78
In Vitro and In Vivo Anti-tumoral Effects of the Flavonoid Apigenin in Malignant Mesothelioma. Front Pharmacol (2017) 0.76
Inhibition of rhotekin exhibits antitumor effects in lung cancer cells. Oncol Rep (2016) 0.75
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells. Oncotarget (2016) 0.75
Global cancer statistics. CA Cancer J Clin (2011) 185.92
Mutations of the BRAF gene in human cancer. Nature (2002) 65.42
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med (2009) 46.35
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature (2007) 37.09
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med (2010) 36.78
Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med (2005) 25.93
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol (2012) 22.04
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol (2009) 15.23
Lung cancer. N Engl J Med (2008) 13.49
Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet (2008) 10.74
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol (2008) 9.43
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol (2010) 8.56
Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol (2003) 8.17
The RAF proteins take centre stage. Nat Rev Mol Cell Biol (2004) 8.04
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res (2008) 6.71
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. Lancet Oncol (2011) 6.69
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res (2007) 5.45
Regulation, substrates and functions of src. Biochim Biophys Acta (1996) 5.45
Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev (2003) 4.62
Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol (2009) 4.07
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Res (2009) 3.59
Role of Src expression and activation in human cancer. Oncogene (2000) 3.41
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets (2008) 3.36
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res (2006) 3.21
Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data from 16 randomized controlled trials. J Clin Oncol (2008) 3.03
Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis. Lung Cancer (2006) 2.52
Bromodomains as therapeutic targets. Expert Rev Mol Med (2011) 2.52
Missense mutations of the BRAF gene in human lung adenocarcinoma. Cancer Res (2002) 2.48
Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling. Mol Cancer Ther (2004) 2.25
Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. Proc Natl Acad Sci U S A (2007) 2.10
Cyclophosphamide facilitates antitumor efficacy against subcutaneous tumors following intravenous delivery of reovirus. Clin Cancer Res (2008) 1.91
A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors. Clin Cancer Res (2008) 1.89
Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res (2001) 1.87
Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors. Ann Oncol (2009) 1.68
The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance. Cancer Res (2006) 1.67
Systemic reovirus therapy of metastatic cancer in immune-competent mice. Cancer Res (2003) 1.59
Enhanced in vitro and in vivo cytotoxicity of combined reovirus and radiotherapy. Clin Cancer Res (2008) 1.56
Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells. Mol Cancer (2009) 1.32
Differential sensitivity of normal and transformed human cells to reovirus infection. J Virol (1978) 1.32
Biomarkers for predicting clinical responses to HDAC inhibitors. Cancer Lett (2009) 1.31
Vorinostat increases carboplatin and paclitaxel activity in non-small-cell lung cancer cells. Int J Cancer (2010) 1.13
The status of KRAS mutations in patients with non-small cell lung cancers from mainland China. Oncol Rep (2009) 0.91
Low concentrations of the histone deacetylase inhibitor, depsipeptide, enhance the effects of gemcitabine and docetaxel in hormone refractory prostate cancer cells. Oncol Rep (2007) 0.88
Using oligonucleotide probe arrays to access genetic diversity. Biotechniques (1995) 12.18
Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy. Nat Genet (1996) 5.77
Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays. Nat Med (1996) 5.35
Early discharge after hernia repair. Lancet (1968) 5.29
Fish consumption and the 30-year risk of fatal myocardial infarction. N Engl J Med (1997) 4.27
Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc Natl Acad Sci U S A (2000) 3.47
Language discrimination by human newborns and by cotton-top tamarin monkeys. Science (2000) 2.89
Quantification of adipose tissue by MRI: relationship with anthropometric variables. J Appl Physiol (1985) (1992) 2.85
Discrepant legacies: premature mortality in two industrial towns. Soc Sci Med (1991) 2.62
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Mol Psychiatry (2010) 2.59
Link between the angiographic substudy and mortality outcomes in a large randomized trial of myocardial reperfusion. Importance of early and complete infarct artery reperfusion. GUSTO-I Investigators. Circulation (1995) 2.53
Once-daily intravenous busulfan given with fludarabine as conditioning for allogeneic stem cell transplantation: study of pharmacokinetics and early clinical outcomes. Biol Blood Marrow Transplant (2002) 2.37
Surgical operation rates: a twelve year experience in Stockton on Tees. Ann R Coll Surg Engl (1983) 2.35
The Motor Activity Log-28: assessing daily use of the hemiparetic arm after stroke. Neurology (2006) 2.29
The declining specificity of exercise radionuclide ventriculography. N Engl J Med (1983) 2.22
Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Mol Psychiatry (2012) 2.20
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology. Ann Surg Oncol (2006) 2.13
Scleroderma and silicone gel breast prostheses--the Sydney study revisited. Aust N Z J Med (1996) 2.04
Admissions from surgical waiting lists. Br J Prev Soc Med (1969) 1.95
Effects of methods of admitting emergencies on use of hospital beds. Br J Prev Soc Med (1971) 1.86
Identification and characterization of polymorphisms in the promoter region of the human Apo-1/Fas (CD95) gene. Mol Immunol (1997) 1.71
Depression during mania. Treatment response to lithium or divalproex. Arch Gen Psychiatry (1997) 1.63
Mycobacterium bovis as an occupational hazard in abattoir workers. Aust N Z J Med (1988) 1.62
Evaluation of diagnosis-related groups in the National Health Service. Community Med (1989) 1.60
Increased viral titer through concentration of viral harvests from retroviral packaging lines. Hum Gene Ther (1993) 1.58
A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice. Nat Genet (1995) 1.49
Improved infarct-related arterial patency after high dose, weight-adjusted, rapid infusion of tissue-type plasminogen activator in myocardial infarction: results of a multicenter randomized trial of two dosage regimens. J Am Coll Cardiol (1990) 1.48
Pathologists' views on consent for autopsy. J R Soc Med (2002) 1.45
Routine hospital admission in twin pregnancy between 26 and 30 weeks' gestation. Lancet (1990) 1.42
MRI-guided, open trial of abciximab for ischemic stroke within a 3- to 24-hour window. Neurology (2005) 1.40
Obstetric and perinatal outcomes in pregnancies complicated by Type 1 and Type 2 diabetes: influences of glycaemic control, obesity and social disadvantage. Diabet Med (2011) 1.26
Surgical waiting lists. Br Med J (Clin Res Ed) (1984) 1.26
Removal of nasogastric tube fragments from three horses. J Am Vet Med Assoc (1992) 1.14
Simulation of emergency bed occupancy. Health Serv Res (1967) 1.13
Migration and differentiation of adult rat subventricular zone progenitor cells transplanted into the adult rat striatum. Neuroscience (2003) 1.11
Extended spectrum beta-lactamase production and fluorquinolone resistance in pathogens associated with community acquired urinary tract infection. Diagn Microbiol Infect Dis (1998) 1.10
The kinetic properties of human placental choline acetyltransferase. Biochem J (1971) 1.10
Expression of biologically active recombinant keratinocyte growth factor. Structure/function analysis of amino-terminal truncation mutants. J Biol Chem (1993) 1.08
Gastrin: growth enhancing effects on human gastric and colonic tumour cells. Br J Cancer (1989) 1.08
Opiate addiction and plasma beta-endorphin-like immunoreactivity: methadone maintained, recently detoxified and early naltrexone treated ex-addicts. Alcohol Drug Res (1987) 1.07
Performance indicators in health service management--a clinical analogy. Hosp Health Serv Rev (1986) 1.07
Intragastric N-nitrosation is unlikely to be responsible for gastric carcinoma developing after operations for duodenal ulcer. Gut (1984) 1.05
Comparison of two methods of preparing enzyme-antibody conjugates: application of these conjugates for enzyme immunoassay. Anal Biochem (1979) 1.04
Neurological functional recovery after thymosin beta4 treatment in mice with experimental auto encephalomyelitis. Neuroscience (2009) 1.03
Cerebral microvascular obstruction by fibrin is associated with upregulation of PAI-1 acutely after onset of focal embolic ischemia in rats. J Neurosci (1999) 1.03
Marked inhibition of tumor growth in a malignant glioma tumor model by a novel synthetic matrix metalloproteinase inhibitor AG3340. Clin Cancer Res (1999) 1.03
Unrelated donor BMT recipients given pretransplant low-dose antithymocyte globulin have outcomes equivalent to matched sibling BMT: a matched pair analysis. Bone Marrow Transplant (2002) 1.02
A longitudinal study of bronchodilator responsiveness in cystic fibrosis. Am Rev Respir Dis (1985) 1.02
Phylogenetics of social behavior in Australian gall-forming thrips: evidence from mitochondrial DNA sequence, adult morphology and behavior, and gall morphology. Mol Phylogenet Evol (1998) 1.02
ED length-of-stay and illness severity in dizzy and chest-pain patients. Am J Emerg Med (1994) 0.99
Montreal prognostic score: estimating survival of patients with non-small cell lung cancer using clinical biomarkers. Br J Cancer (2013) 0.99
Quantitative analysis of the tomographic thallium-201 myocardial bullseye display: critical role of correcting for patient motion. J Nucl Med (1988) 0.99
The choline acetyltransferase of human placenta. Biochem J (1966) 0.99
Embolization of pulmonary pseudoaneurysms secondary to metastatic synovial sarcoma of the right atrium. J Vasc Interv Radiol (1999) 0.99
The effect of sulphydryl and other disulphide reducing agents on choline acetyltransferase activity estimated with synthetic acetyl-CoA. J Neurochem (1967) 0.99
Changing use of coronary angioplasty and coronary bypass surgery in the treatment of chronic coronary artery disease. Am J Cardiol (1990) 0.98
National clinical guidelines for management of the palatally ectopic maxillary canine. Br Dent J (2012) 0.98
mdm-2 gene amplification in 3T3-L1 preadipocytes. Differentiation (1999) 0.97
Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease. Aliment Pharmacol Ther (2008) 0.97
Control of Mycobacterium tuberculosis growth by activated natural killer cells. Clin Exp Immunol (2012) 0.97
Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype. Am J Med Genet B Neuropsychiatr Genet (2012) 0.97
Association between prenatal exposure to methylmercury and developmental outcomes in Seychellois children: effect modification by social and environmental factors. Neurotoxicology (1999) 0.97
Acrogeria. Proc R Soc Med (1957) 0.96
A randomized trial of photocoagulation or injection sclerotherapy for the treatment of first- and second-degree hemorrhoids. Dis Colon Rectum (1985) 0.96
Factors predicting engraftment of autologous blood stem cells: CD34+ subsets inferior to the total CD34+ cell dose. Bone Marrow Transplant (1999) 0.95
Halogen substituted derivatives of acetylcholine as inhibitors of choline acetyltransferase. Life Sci (1969) 0.95
Causes of higher in-hospital mortality in women than in men after acute myocardial infarction. Am J Cardiol (1994) 0.95
MacFee incision: a safe approach to the neck. South Med J (1993) 0.94
Immunoglobulin produced by guinea-pig leukaemic B lymphocytes: its source and use as a monitor of tumour load. Immunology (1980) 0.94
Inhibitory effects of the gastrin receptor antagonist (L-365,260) on gastrointestinal tumor cells. Cancer (1991) 0.94
Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry (2011) 0.93
Chymotryptic conversion of bacterial membrane ATPase to an active form with modified alpha chains and defective membrane binding properties. Biochemistry (1976) 0.92
Gastrointestinal bleeding in patients on bromocriptine. Lancet (1976) 0.92
Critical research needs for managing coral reef marine protected areas: perspectives of academics and managers. J Environ Manage (2012) 0.92
Isotopic exchange between acetylcholine and [Me-14C] choline catalysed by human placental choline acetyltransferase. Biochem J (1969) 0.90
Electrical treatment of Lewis lung carcinoma in mice. J Surg Res (1986) 0.90
Temperature acclimatization and protein synthesis in the goldfish mucosa. Experientia (1966) 0.89
Methanol poisoning complicated by myoglobinuric renal failure. Am J Emerg Med (1985) 0.89
Maintenance clinical trials in bipolar disorder: design implications of the divalproex-lithium-placebo study. Psychopharmacol Bull (1997) 0.89
Antimicrobial resistance and phage types of human and non-human Salmonella enterica isolates in Ireland, 1998-2003. Commun Dis Public Health (2004) 0.89
Parental reactions to perinatal death. Proc R Soc Med (1976) 0.89
Clonal expansion may account for high levels of quinolone resistance in Salmonella enterica serovar enteritidis. Appl Environ Microbiol (2005) 0.88
Alphagan allergy may increase the propensity for multiple eye-drop allergy. Eye (Lond) (2005) 0.88
Epilepsy and pregnancy--a review of 98 pregnancies. Aust N Z J Obstet Gynaecol (1990) 0.87
Antibiotic resistance amongst Salmonella enterica species isolated in the Republic of Ireland. J Antimicrob Chemother (1998) 0.87
Congenital disorder of glycosylation type 1a: three siblings with a mild neurological phenotype. J Clin Neurosci (2007) 0.87
Commonly used disinfectants fail to eradicate Salmonella enterica biofilms from food contact surface materials. Appl Environ Microbiol (2013) 0.87
High-dose thiotepa, busulfan, cyclophosphamide and ASCT without whole-brain radiotherapy for poor prognosis primary CNS lymphoma. Bone Marrow Transplant (2003) 0.86
PrP genotype progression in flocks participating in the National Scrapie Plan for Great Britain. Vet Rec (2006) 0.86
Evaluation of the safety and pharmacokinetics of the multi-targeted receptor tyrosine kinase inhibitor sunitinib during embryo-fetal development in rats and rabbits. Birth Defects Res B Dev Reprod Toxicol (2009) 0.86
Osteoporosis associated with mastocytosis confined to bone: report of two cases. Bone (1989) 0.86
A personalized approach to treatment: use of EGFR tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer in Canada. Curr Oncol (2012) 0.86
Effects of laparoscopic ovarian drilling on serum vascular endothelial growth factor and on insulin responses to the oral glucose tolerance test in women with polycystic ovary syndrome. Fertil Steril (2000) 0.85
Disposal arrangements for second trimester fetuses. Br J Obstet Gynaecol (1988) 0.85
A prospective study of proneness to acute respiratory illness in the first two years of life. Int J Epidemiol (1994) 0.85
The association between body mass index and health-related quality of life: influence of ethnicity on this relationship. Diabetes Obes Metab (2012) 0.85
Autologous transplantation for primary systemic AL amyloidosis is feasible outside a major amyloidosis referral centre: the Calgary BMT Program experience. Bone Marrow Transplant (2005) 0.84