Low risk of thromboembolic complications with tranexamic acid after primary total hip and knee arthroplasty.

PubWeight™: 1.05‹?› | Rank: Top 15%

🔗 View Article (PMC 3528901)

Published in Clin Orthop Relat Res on January 01, 2013

Authors

Blake P Gillette1, Lori J DeSimone, Robert T Trousdale, Mark W Pagnano, Rafael J Sierra

Author Affiliations

1: Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Associated clinical trials:

Tranexamic Acid for Bleeding in Breast Surgery (TABBS) | NCT02615366

Evaluating the Use of Tranexamic Acid (TXA) in Total Joint Arthroplasty | NCT03825939

Articles citing this

Systematic review and meta-analysis of perioperative intravenous tranexamic acid use in spinal surgery. PLoS One (2013) 0.93

Which Route of Tranexamic Acid Administration is More Effective to Reduce Blood Loss Following Total Knee Arthroplasty? Arch Bone Jt Surg (2016) 0.90

Preliminary results suggest tranexamic acid is safe and effective in arthroplasty patients with severe comorbidities. Clin Orthop Relat Res (2014) 0.87

Effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients. Saudi J Anaesth (2015) 0.82

The great deception: tranexamic acid and extensive pulmonary emboli. BMJ Case Rep (2013) 0.82

Perioperative blood loss in total hip and knee arthroplasty: Outcomes associated with intravenous tranexamic acid use in an academic medical center. SAGE Open Med (2016) 0.77

Combined application versus topical and intravenous application of tranexamic acid following primary total hip arthroplasty: a meta-analysis. BMC Musculoskelet Disord (2017) 0.77

Intravenous versus topical tranexamic acid administration in primary total knee arthroplasty: a meta-analysis. Knee Surg Sports Traumatol Arthrosc (2016) 0.76

Use of tranexamic acid in total knee arthroplasty. Joints (2017) 0.75

Blood Sparing Efficacy of Oral Tranexamic Acid in Primary Total Knee Arthroplasty: A Randomized Controlled Trial. Knee Surg Relat Res (2017) 0.75

Clamping drainage is unnecessary after minimally invasive total knee arthroplasty in patients with tranexamic acid: A randomized, controlled trial. Medicine (Baltimore) (2017) 0.75

A questionnaire-based survey investigating the current use of tranexamic acid in traumatic haemorrhage and elective hip and knee arthroplasty. JRSM Open (2014) 0.75

Tranexamic acid in hip fracture patients: a protocol for a randomised, placebo controlled trial on the efficacy of tranexamic acid in reducing blood loss in hip fracture patients. BMJ Open (2016) 0.75

Articles cited by this

Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest (2008) 16.17

A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med (2008) 5.20

Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial. Lancet (2000) 4.38

Tranexamic acid: a review of its use in surgery and other indications. Drugs (1999) 3.09

American Society of Anaesthesiologists physical status classification. Indian J Anaesth (2011) 2.51

American Association of Orthopedic Surgeons and American College of Chest Physicians guidelines for venous thromboembolism prevention in hip and knee arthroplasty differ: what are the implications for clinicians and patients? Chest (2009) 2.13

Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta-analysis of randomized controlled trials. Transfusion (2005) 1.82

Use of intravenous tranexamic acid to reduce allogeneic blood transfusion in total hip and knee arthroplasty: a meta-analysis. Anaesth Intensive Care (2003) 1.81

Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth (2006) 1.75

Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev (2011) 1.74

Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials. Thromb Res (2008) 1.64

Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied. Transfusion (2007) 1.51

Antifibrinolytics in major orthopaedic surgery. J Am Acad Orthop Surg (2010) 1.50

Tranexamic acid given intraoperatively reduces blood loss after total knee replacement: a randomized, controlled study. Acta Anaesthesiol Scand (2002) 1.38

American academy of orthopaedic surgeons clinical practice guideline on. Prevention of symptomatic pulmonary embolism in patients undergoing total hip or knee arthroplasty. J Bone Joint Surg Am (2009) 1.34

Venous thromboembolic disease after total hip and knee arthroplasty. J Bone Joint Surg Am (2008) 1.30

Blood conservation with tranexamic acid in total hip arthroplasty: a randomized, double-blind study in 40 primary operations. Acta Orthop Scand (2001) 1.21

Multimodal thromboprophylaxis for total hip and knee arthroplasty based on risk assessment. J Bone Joint Surg Am (2007) 1.13

The use of tranexamic acid to reduce blood loss during total knee arthroplasty. Knee (2003) 1.08

The use of antifibrinolytic agents in total hip arthroplasty: a meta-analysis. J Arthroplasty (2006) 1.02

Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement. Can J Anaesth (2004) 1.00

Regional hemostatic status and blood requirements after total knee arthroplasty with and without tranexamic acid or aprotinin. Anesth Analg (2001) 1.00

Tranexamic acid reduces postoperative blood loss in cementless total hip arthroplasty. J Bone Joint Surg Am (2005) 0.98

Current trends in blood conservation in total knee arthroplasty. Clin Orthop Relat Res (2005) 0.94

Aprotinin decreases exposure to allogeneic blood during primary unilateral total hip replacement. J Bone Joint Surg Am (2000) 0.92

Aprotinin in major orthopedic surgery: a systematic review of randomized controlled trials. Anesth Analg (2005) 0.86

What is the state of the art in orthopaedic thromboprophylaxis in lower extremity reconstruction? Instr Course Lect (2011) 0.83

A prospective comparison of warfarin to aspirin for thromboprophylaxis in total hip and total knee arthroplasty. J Arthroplasty (2011) 0.83

A comparative study of the postoperative allogeneic blood-sparing effects of tranexamic acid and of desmopressin after total knee replacement. Transfusion (2001) 0.81

Articles by these authors

Effect of postoperative mechanical axis alignment on the fifteen-year survival of modern, cemented total knee replacements. J Bone Joint Surg Am (2010) 4.53

Factors affecting the durability of primary total knee prostheses. J Bone Joint Surg Am (2003) 3.44

A systematic approach to the plain radiographic evaluation of the young adult hip. J Bone Joint Surg Am (2008) 3.43

A pre-emptive multimodal pathway featuring peripheral nerve block improves perioperative outcomes after major orthopedic surgery. Reg Anesth Pain Med (2009) 3.27

Acetabular labral tears rarely occur in the absence of bony abnormalities. Clin Orthop Relat Res (2004) 2.94

Ischial spine projection into the pelvis : a new sign for acetabular retroversion. Clin Orthop Relat Res (2008) 2.49

Orthopaedic surgeon workforce and volume assessment for total hip and knee replacement in the United States: preparing for an epidemic. J Bone Joint Surg Am (2008) 2.09

The reliability of arthroscopic classification of acetabular rim labrochondral disease. Am J Sports Med (2012) 2.04

Acetabular retroversion is associated with osteoarthritis of the hip. Clin Orthop Relat Res (2003) 2.01

A comparison of psoas compartment block and spinal and general anesthesia for outpatient knee arthroscopy. Anesth Analg (2003) 1.84

Thrombosis prevention after total hip arthroplasty: a prospective, randomized trial comparing a mobile compression device with low-molecular-weight heparin. J Bone Joint Surg Am (2010) 1.79

The effectiveness of isolated tibial insert exchange in revision total knee arthroplasty. J Bone Joint Surg Am (2002) 1.72

Muscle damage during MIS total hip arthroplasty: Smith-Petersen versus posterior approach. Clin Orthop Relat Res (2006) 1.69

Primary and revision total hip arthroplasty for patients 90 years of age and older. Mayo Clin Proc (2003) 1.67

Surgical treatment of femoroacetabular impingement: evaluation of the effect of the size of the resection. J Bone Joint Surg Am (2005) 1.63

Decreased range of motion is associated with structural hip deformity in asymptomatic adolescent athletes. Am J Sports Med (2013) 1.58

Multicenter study of complications following surgical dislocation of the hip. J Bone Joint Surg Am (2011) 1.55

Intraneural ganglia in the hip and pelvic region. Clinical article. J Neurosurg (2009) 1.54

Femoral head resurfacing for the treatment of osteonecrosis in the young patient. Clin Orthop Relat Res (2003) 1.54

Restoration of the hip center during THA performed for protrusio acetabuli is associated with better implant survival. Clin Orthop Relat Res (2013) 1.49

Tranexamic Acid in Hip and Knee Arthroplasty. J Am Acad Orthop Surg (2015) 1.47

Computer-assisted surgery: a wine before its time. Orthopedics (2008) 1.43

Labral reconstruction using the ligamentum teres capitis: report of a new technique. Clin Orthop Relat Res (2008) 1.41

Hip and knee arthroplasty in hypophosphatemic rickets. J Arthroplasty (2009) 1.39

Total hip arthroplasty with shortening subtrochanteric osteotomy in Crowe type-IV developmental dysplasia. J Bone Joint Surg Am (2009) 1.36

Descriptive epidemiology of femoroacetabular impingement: a North American cohort of patients undergoing surgery. Am J Sports Med (2013) 1.36

A comprehensive anesthesia protocol that emphasizes peripheral nerve blockade for total knee and total hip arthroplasty. J Bone Joint Surg Am (2005) 1.34

The Frank Stinchfield Award: muscle damage after total hip arthroplasty done with the two-incision and mini-posterior techniques. Clin Orthop Relat Res (2005) 1.33

The Mark Coventry Award: Trabecular metal tibial components were durable and reliable in primary total knee arthroplasty: a randomized clinical trial. Clin Orthop Relat Res (2015) 1.32

Surgical treatment of developmental dysplasia of the hip in adults: II. Arthroplasty options. J Am Acad Orthop Surg (2002) 1.30

The 2008 Frank Stinchfield award: variation in postoperative pelvic tilt may confound the accuracy of hip navigation systems. Clin Orthop Relat Res (2008) 1.29

Total hip arthroplasty with shortening subtrochanteric osteotomy in Crowe type-IV developmental dysplasia: surgical technique. J Bone Joint Surg Am (2010) 1.29

The 2009 Frank Stinchfield Award: "Hip squeaking": a biomechanical study of ceramic-on-ceramic bearing surfaces. Clin Orthop Relat Res (2009) 1.28

High rate of infection after aseptic revision of failed metal-on-metal total hip arthroplasty. Clin Orthop Relat Res (2014) 1.26

Rotating platform knees did not improve patellar tracking: a prospective, randomized study of 240 primary total knee arthroplasties. Clin Orthop Relat Res (2004) 1.25

Cemented long-stem revision total knee arthroplasty. J Arthroplasty (2003) 1.17

Total hip arthroplasty using highly cross-linked polyethylene in patients younger than 50 years with minimum 10-year follow-up. J Arthroplasty (2013) 1.17

Surgical treatment of femoroacetabular impingement: evaluation of the effect of the size of the resection. Surgical technique. J Bone Joint Surg Am (2006) 1.16

Quadriceps tendon rupture after total knee arthroplasty. Prevalence, complications, and outcomes. J Bone Joint Surg Am (2005) 1.16

Total knee arthroplasty in young patients with juvenile rheumatoid arthritis. J Bone Joint Surg Am (2003) 1.15

Failure of metal-on-metal total hip arthroplasty mimicking hip infection. A report of two cases. J Bone Joint Surg Am (2009) 1.15

Analgesia for total hip and knee arthroplasty: a multimodal pathway featuring peripheral nerve block. J Am Acad Orthop Surg (2006) 1.14

Slower recovery after two-incision than mini-posterior-incision total hip arthroplasty. A randomized clinical trial. J Bone Joint Surg Am (2008) 1.13

Patients preferred a mini-posterior THA to a contralateral two-incision THA. Clin Orthop Relat Res (2006) 1.12

Total joint arthroplasty in human immunodeficiency virus-positive patients: an alarming rate of early failure. J Arthroplasty (2003) 1.11

Preliminary pain and function after labral reconstruction during femoroacetabular impingement surgery. Clin Orthop Relat Res (2012) 1.11

Extended femoral osteotomy for revision of hip arthroplasty: results and complications. J Arthroplasty (2005) 1.10

Postoperative patient falls on an orthopedic inpatient unit. J Arthroplasty (2008) 1.10

Solitary bony metastasis from renal cell carcinoma: significance of surgical treatment. Clin Orthop Relat Res (2005) 1.10

Race, ethnicity, insurance coverage, and preoperative status of hip and knee surgical patients. J Arthroplasty (2004) 1.09

Instability after total knee arthroplasty. J Bone Joint Surg Am (2008) 1.09

Direct anterior versus miniposterior THA with the same advanced perioperative protocols: surprising early clinical results. Clin Orthop Relat Res (2015) 1.09

Revision total knee arthroplasty with cemented components and uncemented intramedullary stems. J Arthroplasty (2003) 1.07

Outcomes of slipped capital femoral epiphysis treated with in situ pinning. J Pediatr Orthop (2012) 1.06

Surgical technique: a simple soft-tissue-only repair of the capsule and external rotators in posterior-approach THA. Clin Orthop Relat Res (2012) 1.06

A comprehensive five-phase rehabilitation programme after hip arthroscopy for femoroacetabular impingement. Knee Surg Sports Traumatol Arthrosc (2014) 1.06

Comparative survival of uncemented acetabular components following primary total hip arthroplasty. J Bone Joint Surg Am (2011) 1.06

The prevalence of groin pain after metal-on-metal total hip arthroplasty and total hip resurfacing. Clin Orthop Relat Res (2010) 1.06

Hip disease in the young, active patient: evaluation and nonarthroplasty surgical options. J Am Acad Orthop Surg (2008) 1.05

Randomized clinical trial of rotating-platform and fixed-bearing total knee arthroplasty: no clinically detectable differences at five years. J Bone Joint Surg Am (2012) 1.03

Reoperations after 3200 revision TKAs: rates, etiology, and lessons learned. Clin Orthop Relat Res (2004) 1.03

Total knee arthroplasty in post-traumatic arthrosis of the knee. J Arthroplasty (2003) 1.02

Prevention of wound contamination using DuraPrep solution plus Ioban 2 drapes. Clin Orthop Relat Res (2005) 1.02

Above-the-knee amputation after a total knee replacement: prevalence, etiology, and functional outcome. J Bone Joint Surg Am (2003) 1.02

Intraoperative fracture during primary total knee arthroplasty. Clin Orthop Relat Res (2009) 1.01

Rate and risk factors for blood transfusion in patients undergoing periacetabular osteotomy. J Surg Orthop Adv (2008) 1.00

Modified complete synovectomy prevents recurrence in synovial chondromatosis of the hip. Clin Orthop Relat Res (2006) 1.00

Preoperative hip to ankle radiographs in total knee arthroplasty. Clin Orthop Relat Res (2002) 0.99

Flexion instability without dislocation after posterior stabilized total knees. Clin Orthop Relat Res (2005) 0.99

Clinical diagnosis of femoroacetabular impingement. J Am Acad Orthop Surg (2013) 0.98

Dislocation of primary THA done through a posterolateral approach in the elderly. Clin Orthop Relat Res (2005) 0.98

Economic impact of tranexamic acid in healthy patients undergoing primary total hip and knee arthroplasty. J Arthroplasty (2013) 0.97

Total knee arthroplasty for patients 90 years of age and older. Clin Orthop Relat Res (2004) 0.97

Ceramic-on-ceramic total hip arthroplasty in patients younger than 20 years. J Arthroplasty (2011) 0.95

Thirty-year follow-up of patient with Gorham disease (massive osteolysis) treated with hip arthroplasty. J Arthroplasty (2010) 0.95

Total knee arthroplasty in patients with a prior fracture of the tibial plateau. J Bone Joint Surg Am (2003) 0.95

Prevention of nerve injury after periacetabular osteotomy. Clin Orthop Relat Res (2012) 0.95