Published in Nucleic Acids Res on October 25, 1979
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob Agents Chemother (1990) 11.71
Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1. Proc Natl Acad Sci U S A (1981) 10.04
Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones. J Bacteriol (1990) 7.61
Cloning of reiterated and nonreiterated herpes simplex virus 1 sequences as BamHI fragments. Proc Natl Acad Sci U S A (1980) 6.66
Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli. Antimicrob Agents Chemother (1991) 6.19
Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells. Proc Natl Acad Sci U S A (1982) 5.73
Cloning of herpes simplex virus type 1 sequences representing the whole genome. J Virol (1981) 5.66
DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus. Proc Natl Acad Sci U S A (1981) 5.26
Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1. J Virol (1981) 4.54
Hormone-responsive expression of an endogenous proviral gene of mouse mammary tumor virus after molecular cloning and gene transfer into cultured cells. Proc Natl Acad Sci U S A (1981) 4.30
Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus. Antimicrob Agents Chemother (1994) 3.96
gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli. Antimicrob Agents Chemother (1989) 3.67
Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene. Proc Natl Acad Sci U S A (1983) 3.42
Analysis of DNA sequences which regulate the transcription of a herpes simplex virus immediate early gene. J Virol (1984) 3.03
Alterations in the DNA topoisomerase IV grlA gene responsible for quinolone resistance in Staphylococcus aureus. Antimicrob Agents Chemother (1996) 2.84
Recombination in mouse L cells between DNA introduced into cells and homologous chromosomal sequences. Proc Natl Acad Sci U S A (1985) 2.79
Functional analysis of a herpes simplex virus type 1 promoter: identification of far-upstream regulatory sequences. Nucleic Acids Res (1983) 2.78
Polypeptide chain elongation factor 1 alpha (EF-1 alpha) from yeast: nucleotide sequence of one of the two genes for EF-1 alpha from Saccharomyces cerevisiae. EMBO J (1984) 2.77
The region of mouse mammary tumor virus DNA containing the long terminal repeat includes a long coding sequence and signals for hormonally regulated transcription. EMBO J (1982) 2.76
Fine-structure mapping of herpes simplex virus type 1 temperature-sensitive mutations within the short repeat region of the genome. J Virol (1981) 2.56
Hormonal response region in the mouse mammary tumor virus long terminal repeat can be dissociated from the proviral promoter and has enhancer properties. Proc Natl Acad Sci U S A (1985) 2.47
Molecular cloning and sequence determination of the nuclear gene coding for mitochondrial elongation factor Tu of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1983) 2.33
Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis. Nucleic Acids Res (1991) 2.33
Mapping functional domains in the promoter region of the herpes thymidine kinase gene. Proc Natl Acad Sci U S A (1981) 2.29
Transcriptional regulation of a herpes simplex virus immediate early gene is mediated through an enhancer-type sequence. EMBO J (1984) 2.29
Limited transcription of the herpes simplex virus genome when latent in human sensory ganglia. J Virol (1982) 2.12
Glucocorticoid regulation of mouse mammary tumor virus: identification of a short essential DNA region. EMBO J (1983) 2.12
Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes. Mol Cell Biol (1985) 2.09
Quantitative analysis of gene suppression in integrated retrovirus vectors. Mol Cell Biol (1986) 2.08
Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor. Nucleic Acids Res (1985) 2.06
The nucleotide sequence of the chicken thymidine kinase gene and the relationship of its predicted polypeptide to that of the vaccinia virus thymidine kinase. Nucleic Acids Res (1984) 1.96
DNA sequences outside the receptor-binding sites differently modulate the responsiveness of the mouse mammary tumour virus promoter to various steroid hormones. EMBO J (1988) 1.93
Target cell specificity of two species of human interferon-alpha produced in Escherichia coli and of hybrid molecules derived from them. Proc Natl Acad Sci U S A (1981) 1.89
Gene shuttling: moving of cloned DNA into and out of eukaryotic cells. Nucleic Acids Res (1982) 1.85
Identification and mapping of two polypeptides encoded within the herpes simplex virus type 1 thymidine kinase gene sequences. J Virol (1981) 1.83
Nucleotide sequence of the herpes simplex virus type 2 thymidine kinase gene. J Virol (1983) 1.70
The E1b promoter of Ad12 in mouse L tk- cells is activated by adenovirus region E1a. EMBO J (1983) 1.64
Positive control of the herpes simplex virus thymidine kinase gene requires upstream DNA sequences. J Virol (1983) 1.50
Transfer of human globin genes to erythroleukemic mouse cells. EMBO J (1982) 1.41
A negative regulatory sequence near the mouse beta-maj globin gene associated with a region of potential Z-DNA. EMBO J (1984) 1.40
Host-specificities of papillomavirus, Moloney murine sarcoma virus and simian virus 40 enhancer sequences. EMBO J (1983) 1.38
Nucleotide sequence of bean golden mosaic virus and a model for gene regulation in geminiviruses. Proc Natl Acad Sci U S A (1985) 1.35
Identification of an Epstein-Barr virus-coded thymidine kinase. EMBO J (1986) 1.31
In vitro transcription of the thymidine kinase gene of herpes simplex virus. Proc Natl Acad Sci U S A (1982) 1.31
Cloning an expressed gene shared by the human sex chromosomes. Proc Natl Acad Sci U S A (1986) 1.20
Genetic determinants of growth phase-dependent and adenovirus 5-responsive expression of the Chinese hamster thymidine kinase gene are contained within thymidine kinase mRNA sequences. Mol Cell Biol (1986) 1.19
A Mup promoter-thymidine kinase reporter gene shows relaxed tissue-specific expression and confers male sterility upon transgenic mice. Mol Cell Biol (1988) 1.18
Comparison of promoter suppression in avian and murine retrovirus vectors. Nucleic Acids Res (1986) 1.17
Expression and amplification of engineered mouse dihydrofolate reductase minigenes. Mol Cell Biol (1983) 1.15
Regulation of the expression of the tufB operon: DNA sequences directly involved in the stringent control. EMBO J (1985) 1.14
The 5'-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of transcription. Nucleic Acids Res (1983) 1.08
Biochemical and genetic analysis of the OKa blood group antigen. Immunogenetics (1988) 1.07
Biochemical transformation of thymidine kinase (TK)-deficient mouse cells by herpes simplex virus type 1 DNA fragments purified from hybrid plasmids. Nucleic Acids Res (1980) 1.00
Dexamethasone increases the number of RNA polymerase II molecules transcribing integrated mouse mammary tumor virus DNA and flanking mouse sequences. Mol Cell Biol (1984) 0.99
Nonselective expression of simian virus 40 large tumor antigen fragments in mouse cells. Proc Natl Acad Sci U S A (1982) 0.99
Cis-acting sequences from mouse rDNA promote plasmid DNA amplification and persistence in mouse cells: implication of HMG-I in their function. Nucleic Acids Res (1989) 0.97
The herpes simplex virus type 1 thymidine kinase is expressed in the testes of transgenic mice under the control of a cryptic promoter. Mol Cell Biol (1991) 0.91
DNA sequences required for transcription in vivo of the human corticotropin-beta-lipotropin precursor gene. EMBO J (1982) 0.88
Identification of an amplification promoting DNA sequence from the hypotrichous ciliate Stylonychia lemnae. Nucleic Acids Res (1989) 0.84
Initiation of herpes simplex virus thymidine kinase polypeptides. Nucleic Acids Res (1996) 0.75
DNA-mediated gene transfer in Friend leukemia cells by cotransfection of simian virus 40 DNA with herpes simplex virus thymidine kinase DNA. J Virol (1983) 0.75
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J Mol Biol (1977) 205.11
A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36
Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. Proc Natl Acad Sci U S A (1975) 77.46
A membrane-filter technique for the detection of complementary DNA. Biochem Biophys Res Commun (1966) 71.25
General method for the isolation of plasmid deoxyribonucleic acid. J Bacteriol (1973) 31.68
A colony bank containing synthetic Col El hybrid plasmids representative of the entire E. coli genome. Cell (1976) 26.20
Isolation of covalently closed circular DNA of high molecular weight from bacteria. Anal Biochem (1976) 25.02
Polyoma transformation of hamster cell clones--an investigation of genetic factors affecting cell competence. Virology (1962) 24.93
Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell (1978) 19.44
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell (1977) 18.95
A simple method for the preparation of large quantities of pure plasmid DNA. Biochim Biophys Acta (1975) 15.28
Inverted repetitions in the chromosome of herpes simplex virus. Cold Spring Harb Symp Quant Biol (1975) 11.86
Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild-type virus or the temperature-sensitive mutant tsK. J Virol (1979) 11.34
DELETION OF THYMIDINE KINASE ACTIVITY FROM L CELLS RESISTANT TO BROMODEOXYURIDINE. Exp Cell Res (1963) 11.23
Temporal regulation of herpes simplex virus type 1 transcription: location of transcripts on the viral genome. Cell (1977) 7.60
The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell (1978) 6.38
Transfer of thymidine kinase to thymidine kinaseless L cells by infection with ultraviolet-irradiated herpes simplex virus. J Virol (1971) 5.13
Induction of both thymidine and deoxycytidine kinase activity by herpes viruses. J Gen Virol (1974) 4.50
Herpes simplex virus gene expression in transformed cells. I. Regulation of the viral thymidine kinase gene in transformed L cells by products of superinfecting virus. J Virol (1976) 3.94
Characterization of transcription-deficient temperature-sensitive mutants of herpes simplex virus type 1. Virology (1978) 3.87
Physical maps for Herpes simplex virus type 1 DNA for restriction endonucleases Hind III, Hpa-1, and X. bad. J Virol (1976) 3.56
The synthesis and substructure of herpesvirus DNA: the distribution of alkali-labile single strand interruptions in HSV-1 DNA. J Gen Virol (1973) 3.15
Biochemical studies on the herpes simplex virus-specified deoxypyrimidine kinase activity. J Gen Virol (1974) 3.06
Electrophoresis of thymidine kinase activity synthesized by cells transformed by herpes simplex virus. Virology (1972) 3.05
Physical mapping of herpes simplex virus type 1 mutations by marker rescue. J Virol (1978) 2.86
THE INOSINIC ACID PYROPHOSPHORYLASE ACTIVITY OF MOUSE FIBROBLASTS PARTIALLY RESISTANT TO 8-AZAGUANINE. Proc Natl Acad Sci U S A (1963) 2.75
Characterization of the mRNA for herpes simplex virus thymidine kinase by cell-free synthesis of active enzyme. Nucleic Acids Res (1978) 2.40
Expression of the viral thymidine kinase gene in herpes simplex virus-transformed L cells. J Virol (1974) 2.15
Restriction and modification enzymes and their recognition sequences. Gene (1978) 2.02
Regulation of herpesvirus thymidine kinase activity in LM(TK) cells transformed by ultraviolet light-irradiated herpes simplex virus. Virology (1977) 1.96
Reduction of possible hazards in the preparation of recombinant plasmid DNA. Nature (1976) 1.21
A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal Biochem (1973) 31.32
Mapping of RNA by a modification of the Berk-Sharp procedure: the 5' termini of 15 S beta-globin mRNA precursor and mature 10 s beta-globin mRNA have identical map coordinates. Nucleic Acids Res (1979) 31.23
Mice devoid of PrP are resistant to scrapie. Cell (1993) 11.46
Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit beta-globin gene in mouse 3T6 cells. Cell (1983) 9.51
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature (1992) 9.01
A herpes simplex virus type 1 function continuously required for early and late virus RNA synthesis. Nature (1980) 8.47
An improved technique for obtaining enhanced infectivity with herpes simplex virus type 1 DNA. J Gen Virol (1976) 8.07
Temporal regulation of herpes simplex virus type 1 transcription: location of transcripts on the viral genome. Cell (1977) 7.60
The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3' termini. Nucleic Acids Res (1985) 7.18
Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence. Science (1979) 6.94
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J (1996) 6.66
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A (1978) 6.20
Physical mapping of herpes simplex virus-induced polypeptides. J Virol (1978) 6.08
Nucleotide sequence heterogeneity of an RNA phage population. Cell (1978) 5.55
A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron. Cell (1984) 5.37
DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus. Proc Natl Acad Sci U S A (1981) 5.26
Separation and characterization of herpes simplex virus type 1 immediate-early mRNA's. J Virol (1979) 5.21
Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell (1986) 4.92
Recombinants between herpes simplex virus types 1 and 2: analyses of genome structures and expression of immediate early polypeptides. J Virol (1978) 4.87
The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha. Nature (1980) 4.82
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell (1986) 4.82
A partial denaturation map of herpes simplex virus type 1 DNA: evidence for inversions of the unique DNA regions. J Gen Virol (1976) 4.45
Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA. Cell (1986) 4.40
Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene. Nature (1983) 4.38
Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature (1996) 4.25
Mapping of biological functions on RNA of avian tumor viruses: location of regions required for transformation and determination of host range. Proc Natl Acad Sci U S A (1975) 4.01
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc Natl Acad Sci U S A (1997) 3.88
Rabbit beta-globin mRNA production in mouse L cells transformed with cloned rabbit beta-globin chromosomal DNA. Nature (1979) 3.88
Characterization of transcription-deficient temperature-sensitive mutants of herpes simplex virus type 1. Virology (1978) 3.87
Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns. Nature (1978) 3.86
Specific excision of the inserted DNA segment from hybrid plasmids constructed by the poly(dA). poly (dT) method. Biochim Biophys Acta (1976) 3.79
Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes. J Immunol (1987) 3.78
Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature (1980) 3.78
Nucleotide sequences of the joint between the L and S segments of herpes simplex virus types 1 and 2. J Gen Virol (1981) 3.70
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell (1998) 3.59
Human leukocyte and fibroblast interferons are structurally related. Nature (1980) 3.57
Physical maps for Herpes simplex virus type 1 DNA for restriction endonucleases Hind III, Hpa-1, and X. bad. J Virol (1976) 3.56
Orientation of herpes simplex virus type 1 immediate early mRNA's. Nucleic Acids Res (1979) 3.54
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J (1997) 3.34
Identification and characterization of an inhibitor of haemopoietic stem cell proliferation. Nature (1990) 3.29
Malignant transformation of early passage rodent cells by a single mutated human oncogene. Nature (1984) 3.24
Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter. Mol Cell Biol (1988) 3.19
Analysis of herpesvirus DNA substructure by means of restriction endonucleases. J Gen Virol (1976) 3.19
The synthesis and substructure of herpesvirus DNA: the distribution of alkali-labile single strand interruptions in HSV-1 DNA. J Gen Virol (1973) 3.15
QB DNA-containing hybrid plasmids giving rise to QB phage formation in the bacterial host. Nature (1978) 3.11
The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei. Gene (1980) 2.99
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions. Proc Natl Acad Sci U S A (2003) 2.94
Infectivity in mouse fibroblasts of polyoma DNA integrated into plasmid pBR322 or lambdoid phage DNA. Nature (1979) 2.92
Localization of Q-beta maturation cistron ribosome binding site. Nat New Biol (1971) 2.91
Physical mapping of herpes simplex virus type 1 mutations by marker rescue. J Virol (1978) 2.86
The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate. Gene (1976) 2.77
5' cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved 5' GU. Cell (1987) 2.69
A 46-nucleotide promoter segment from an IFN-alpha gene renders an unrelated promoter inducible by virus. Cell (1985) 2.65
Avian myeloblastosis virus RNA is terminally redundant: implications for the mechanism of retrovirus replication. Cell (1977) 2.55
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc Natl Acad Sci U S A (2001) 2.53
The nucleotide sequence of a cloned human leukocyte interferon cDNA. Gene (1980) 2.51
Structure and function of phage RNA. Annu Rev Biochem (1973) 2.50
Replication of viral ribonucleic acid. IX. Properties of double-stranded RNA from Escherichia coli infected with bacteriophage MS2. J Mol Biol (1966) 2.45
Quantitative determination and location of newly synthesized virus-specific ribonucleic acid in chicken cells infected with Rous sarcoma virus. J Virol (1973) 2.45
Physical mapping of paar mutations of herpes simplex virus type 1 and type 2 by intertypic marker rescue. J Virol (1979) 2.41
PrP expression in B lymphocytes is not required for prion neuroinvasion. Nat Med (1998) 2.40
At least three human type alpha interferons: structure of alpha 2. Science (1980) 2.38
Rapid construction of large synthetic genes: total chemical synthesis of two different versions of the bovine prochymosin gene. Gene (1987) 2.36
Replication origins and a sequence involved in coordinate induction of the immediate-early gene family are conserved in an intergenic region of herpes simplex virus. Nucleic Acids Res (1984) 2.35
Structure and expression of cloned murine IFN-alpha genes. Nucleic Acids Res (1983) 2.35
A herpes simplex virus type 1 immediate-early gene product, IE63, regulates small nuclear ribonucleoprotein distribution. Proc Natl Acad Sci U S A (1993) 2.31
Subunit structure of Q-beta replicase. Nature (1970) 2.30
Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3' processing. J Virol (1992) 2.29
Transcriptional regulation of a herpes simplex virus immediate early gene is mediated through an enhancer-type sequence. EMBO J (1984) 2.29
Location and orientation of homologous sequences in the genomes of five herpesviruses. J Gen Virol (1983) 2.29
Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes. EMBO J (1994) 2.27
Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro. Mol Biol Cell (1996) 2.27
Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme. EMBO J (1988) 2.21
Corrected splicing of a chicken ovalbumin gene transcript in mouse L cells. Proc Natl Acad Sci U S A (1980) 2.19
Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes. EMBO J (1997) 2.19
High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene. Mol Med (1994) 2.18
Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. EMBO J (2001) 2.17
Site-directed mutagenesis in DNA: generation of point mutations in cloned beta globin complementary dna at the positions corresponding to amino acids 121 to 123. J Mol Biol (1978) 2.17
Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science (2000) 2.15
Transduction and rearrangement of the myc gene by feline leukaemia virus in naturally occurring T-cell leukaemias. Nature (1984) 2.14
Disruption of the mouse L1 gene leads to malformations of the nervous system. Nat Genet (1997) 2.14
Prion research: the next frontiers. Nature (1997) 2.13
Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice. Neuron (2000) 2.13