Published in Int J Mol Sci on June 12, 2012
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ (2014) 2.66
Necrostatin-1 attenuates ischemia injury induced cell death in rat tubular cell line NRK-52E through decreased Drp1 expression. Int J Mol Sci (2013) 0.92
The critical role of redox homeostasis in shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE pathway. Oxid Med Cell Longev (2012) 0.81
Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy. Oncotarget (2016) 0.78
Valproic acid induces neuronal cell death through a novel calpain-dependent necroptosis pathway. J Neurochem (2015) 0.78
Silencing of GATA6 suppresses SW1990 pancreatic cancer cell growth in vitro and up-regulates reactive oxygen species. Dig Dis Sci (2013) 0.78
Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species. Sci Rep (2016) 0.77
Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells. Curr Genomics (2017) 0.75
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell (2009) 11.26
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24
Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev (1999) 4.39
RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis. EMBO J (1996) 4.33
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. Sci Signal (2010) 3.20
RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ (2007) 2.96
Necrostatin: a potentially novel cardioprotective agent? Cardiovasc Drugs Ther (2007) 2.50
Tumour cell survival signalling by the ERK1/2 pathway. Cell Death Differ (2008) 2.44
cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ (2010) 2.26
NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling. Cell (2011) 2.13
Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther (2007) 1.90
Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK repels. Cell Cycle (2007) 1.68
Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo. Int J Cancer (2009) 1.55
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation. Blood (2006) 1.48
Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis. Apoptosis (2009) 1.33
RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. PLoS One (2011) 1.33
Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim. J Biol Chem (2008) 1.32
Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. Biol Pharm Bull (2010) 1.20
Topoisomerase I poisons and suppressors as anticancer drugs. Curr Med Chem (2000) 1.19
Naturally-occurring shikonin analogues--a class of necroptotic inducers that circumvent cancer drug resistance. Cancer Lett (2008) 1.06
Antitumor activities of a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33. Cancer Lett (2001) 0.98
Necroptosis contributes to the NMDA-induced excitotoxicity in rat's cultured cortical neurons. Neurosci Lett (2008) 0.96
Acylshikonin analogues: synthesis and inhibition of DNA topoisomerase-I. J Med Chem (1995) 0.92
The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal. Cell Res (2010) 0.91
A shikonin derivative, beta-hydroxyisovalerylshikonin, is an ATP-non-competitive inhibitor of protein tyrosine kinases. Anticancer Drugs (2003) 0.89
RIP1's function in NF-kappaB activation: from master actor to onlooker. Cell Death Differ (2010) 0.82
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol (2008) 23.93
Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial. Lancet Oncol (2013) 4.20
Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors. Prenat Diagn (2012) 3.54
EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One (2011) 1.73
Noninvasive Fetal Trisomy (NIFTY) test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies. BMC Med Genomics (2012) 1.45
Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: subset analyses of the phase III Sorafenib Asia-Pacific trial. Eur J Cancer (2012) 1.45
Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study). Gastric Cancer (2014) 1.41
Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis. Apoptosis (2009) 1.33
Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells. PLoS One (2011) 1.22
miR-9 regulation of BRCA1 and ovarian cancer sensitivity to cisplatin and PARP inhibition. J Natl Cancer Inst (2013) 1.18
Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc. BMC Cancer (2010) 1.08
Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death. J Pathol (2012) 1.08
Water-soluble superparamagnetic manganese ferrite nanoparticles for magnetic resonance imaging. Biomaterials (2010) 1.06
Biochemical issues in estimation of cytosolic free NAD/NADH ratio. PLoS One (2012) 1.06
A melting curve analysis--based PCR assay for one-step genotyping of β-thalassemia mutations a multicenter validation. J Mol Diagn (2011) 1.04
Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3β/Snail signaling. Carcinogenesis (2013) 1.01
Interleukin-23: immunological roles and clinical implications. Int J Biochem Cell Biol (2008) 1.00
Isorhapontigenin (ISO) inhibited cell transformation by inducing G0/G1 phase arrest via increasing MKP-1 mRNA Stability. Oncotarget (2014) 0.99
Genomic characterization of prenatally detected chromosomal structural abnormalities using oligonucleotide array comparative genomic hybridization. Am J Med Genet A (2011) 0.94
Anticancer agent shikonin is an incompetent inducer of cancer drug resistance. PLoS One (2013) 0.94
Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblasts. Int J Dermatol (2004) 0.93
Upregulated expression of C-X-C chemokine receptor 4 is an independent prognostic predictor for patients with gastric cancer. PLoS One (2013) 0.92
Regulation of Vinca alkaloid-induced apoptosis by NF-kappaB/IkappaB pathway in human tumor cells. Mol Cancer Ther (2004) 0.92
Assessment of surface water quality using multivariate statistical techniques in red soil hilly region: a case study of Xiangjiang watershed, China. Environ Monit Assess (2008) 0.92
Viral deletions among healthy young Chinese adults with occult hepatitis B virus infection. Virus Res (2011) 0.91
Virus infection of a weed increases vector attraction to and vector fitness on the weed. Sci Rep (2013) 0.91
Aprepitant triple therapy for the prevention of chemotherapy-induced nausea and vomiting following high-dose cisplatin in Chinese patients: a randomized, double-blind, placebo-controlled phase III trial. Support Care Cancer (2013) 0.89
Tumor metastasis and the reciprocal regulation of heparanase gene expression by nuclear factor kappa B in human gastric carcinoma tissue. World J Gastroenterol (2005) 0.89
Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer. BMC Cancer (2011) 0.88
Transcriptomic and proteomic responses of sweetpotato whitefly, Bemisia tabaci, to thiamethoxam. PLoS One (2013) 0.88
The role of STAT3 in autophagy. Autophagy (2015) 0.88
Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α. Cancer Lett (2011) 0.87
Mesenchymal stem cells as carriers and amplifiers in CRAd delivery to tumors. Mol Cancer (2011) 0.87
AIB1 cooperates with ERα to promote epithelial mesenchymal transition in breast cancer through SNAI1 activation. PLoS One (2013) 0.86
A Non-invasive detection of lung cancer combined virtual gas sensors array with imaging recognition technique. Conf Proc IEEE Eng Med Biol Soc (2005) 0.86
Construction of a star-shaped copolymer as a vector for FGF receptor-mediated gene delivery in vitro and in vivo. Biomacromolecules (2010) 0.86
SUMOylation of AhR modulates its activity and stability through inhibiting its ubiquitination. J Cell Physiol (2012) 0.86
Screening and identification of novel B cell epitopes in human heparanase and their anti-invasion property for hepatocellular carcinoma. Cancer Immunol Immunother (2009) 0.85
The possible correlation between activation of NF-kappaB/IkappaB pathway and the susceptibility of tumor cells to paclitaxel-induced apoptosis. Oncol Res (2002) 0.84
Aptamer-conjugated Mn3O4@SiO2 core-shell nanoprobes for targeted magnetic resonance imaging. Nanoscale (2013) 0.84
The inhibition of human bladder cancer growth by calcium carbonate/CaIP6 nanocomposite particles delivering AIB1 siRNA. Biomaterials (2012) 0.84
Three-way interactions between the tomato plant, tomato yellow leaf curl virus, and Bemisia tabaci (Hemiptera: Aleyrodidae) facilitate virus spread. J Econ Entomol (2014) 0.84
A novel oncolytic adenovirus selectively silences the expression of tumor-associated STAT3 and exhibits potent antitumoral activity. Carcinogenesis (2009) 0.83
Human papillomavirus type 16 variant analysis of E6, E7, and L1 [corrected] genes and long control region in [corrected] cervical carcinomas in patients in northeast China. J Clin Microbiol (2011) 0.82
Active autophagy in the tumor microenvironment: A novel mechanism for cancer metastasis. Oncol Lett (2012) 0.82
Bleeding and hyperpyrexia in an adult with gastric inflammatory fibroid polyp. Chin Med J (Engl) (2013) 0.82
Next-generation sequencing identifies a novel compound heterozygous mutation in MYO7A in a Chinese patient with Usher Syndrome 1B. Clin Chim Acta (2012) 0.82
Antimicrobial photodynamic therapy for methicillin-resistant Staphylococcus aureus infection. Biomed Res Int (2013) 0.82
Hemoglobin H disease due to a de novo mutation at the α2-globin gene and an inherited common α-thalassemia deletion found in a Chinese boy. Blood Cells Mol Dis (2010) 0.81
Clinical and prognostic implications of β1, 6-N-acetylglucosaminyltransferase V in patients with gastric cancer. Cancer Sci (2012) 0.81
Inhibition of Hec1 expression enhances the sensitivity of human ovarian cancer cells to paclitaxel. Acta Pharmacol Sin (2013) 0.81
Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP. Apoptosis (2011) 0.81
Autophagy activated by Toxoplasma gondii infection in turn facilitates Toxoplasma gondii proliferation. Parasitol Res (2014) 0.79
[Genetic analysis and prenatal diagnosis of two Chinese families with split hand foot malformation]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2014) 0.79
MiR-320a downregulation is associated with imatinib resistance in gastrointestinal stromal tumors. Acta Biochim Biophys Sin (Shanghai) (2013) 0.79
Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response. Crit Care (2013) 0.79
Overcoming 5-Fu resistance of colon cells through inhibition of Glut1 by the specific inhibitor WZB117. Asian Pac J Cancer Prev (2014) 0.79
Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 cervical cancer model in vivo. J Immunol (2009) 0.79
Circulating soluble advanced glycation end product is inversely associated with the significant risk of developing cancer: evidence from a meta-analysis. Tumour Biol (2014) 0.78
Borealin/Dasra B is overexpressed in colorectal cancers and contributes to proliferation of cancer cells. Med Oncol (2014) 0.78
Primer-introduced restriction analysis polymerase chain reaction method for non-invasive prenatal testing of β-thalassemia. Hemoglobin (2014) 0.78
A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition. Biochem J (2014) 0.78
[Clinical values of extended lymph node dissection for gastric cancer:a meta-analysis for D1 versus D2 gastrectomy]. Zhonghua Wei Chang Wai Ke Za Zhi (2007) 0.78
Size effect of se-enriched green tea particles on in vitro antioxidant and antitumor activities. J Agric Food Chem (2008) 0.78
Molecular mechanism of sustained inflation in acute respiratory distress syndrome. J Trauma Acute Care Surg (2012) 0.78
Ubiquitin released in the plasma of whole blood during storage promotes mRNA expression of Th2 cytokines and Th2-inducing transcription factors. Transfus Apher Sci (2012) 0.77
[Clinicopathological features of small gastrointestinal stromal tumors]. Zhonghua Wei Chang Wai Ke Za Zhi (2015) 0.77
A novel missense mutation of FGFR3 in a Chinese female and her fetus with Hypochondroplasia by next-generation sequencing. Clin Chim Acta (2013) 0.77
Synthesis, characterization and cytotoxicity studies of chitosan-coated tea polyphenols nanoparticles. Colloids Surf B Biointerfaces (2010) 0.76
Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo. Cancer Cell Int (2013) 0.76
Quercetin suppresses HeLa cells by blocking PI3K/Akt pathway. J Huazhong Univ Sci Technolog Med Sci (2014) 0.76
Inhibition of cyclophoshamide-induced mutagenicity by microsized powder of selenium-enriched green tea in mice. J Agric Food Chem (2008) 0.76
Complete genome sequence and transcription profiles of the rock bream iridovirus RBIV-C1. Dis Aquat Organ (2013) 0.76
PP242 synergizes with suberoylanilide hydroxamic acid to inhibit growth of ovarian cancer cells. Int J Gynecol Cancer (2014) 0.76
[Establishment of the retrovirus-mediated murine model with MLL-AF9 leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2013) 0.75
Construction and expression of eukaryotic plasmids containing lamivudine-resistant or wild-type strains of Hepatitis B Virus genotype C. World J Gastroenterol (2008) 0.75
Correction: Ubiquitin B in Cervical Cancer: Critical for the Maintenance of Cancer Stem-Like Cell Characters. PLoS One (2016) 0.75
Epigenetic regulation of the human telomerase reverse transciptase gene: A potential therapeutic target for the treatment of leukemia (Review). Oncol Lett (2013) 0.75
Impact of age on the cancer-specific survival of patients with localized renal cell carcinoma: martingale residual and competing risks analysis. PLoS One (2012) 0.75
[A novel mutation of cartilage oligomeric matrix protein gene underlies multiple epiphyseal dysplasia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2013) 0.75
Differential inhibition of lamivudine-resistant hepatitis B virus by allele-specific RNAi. J Virol Methods (2010) 0.75
[Advancement in the research of effect of low level laser therapy on wound healing]. Zhonghua Shao Shang Za Zhi (2012) 0.75
[Comparative study of laparoscopic and open surgery for gastric gastrointestinal stromal tumors]. Zhonghua Wei Chang Wai Ke Za Zhi (2015) 0.75
[Impact of radiofrequency on splenocyte immunity of mice bearing H22 liver cancer]. Ai Zheng (2006) 0.75
[Application of array-CGH and MLPA for detection of 4 cryptic unbalanced translocations]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2013) 0.75
[Reflection on tuberculosis infection]. Zhonghua Jie He He Hu Xi Za Zhi (2016) 0.75
[Mutation analysis of the androgen receptor gene in a complete androgen insensitivity syndrome family]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2009) 0.75
[Therapeutic effects of B and T lymphocyte attenuator extracellular domain and heat shock protein 70 antigen peptide on cervical cancer in mouse model]. Zhonghua Fu Chan Ke Za Zhi (2010) 0.75
Isolable Borane-Based Diradical and Triradical Fused by a Diamagnetic Transition Metal Ion. J Am Chem Soc (2017) 0.75
[Surgical correction of buried penis in children by solution and fixation of the penile venter]. Zhonghua Nan Ke Xue (2008) 0.75
Magnetic Bistability in a Discrete Organic Radical. J Am Chem Soc (2016) 0.75
[Establishment of "in-hospital critical illness management system" in general hospital: establishment of "general critical medicine" mode]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue (2016) 0.75
Thermal Radiofrequency Ablation as an Adjuvant Therapy for Patients With Colorectal Liver Metastasis. Oncol Res (2016) 0.75
[Advancement in the research of fractional carbon dioxide laser in treating burn scars]. Zhonghua Shao Shang Za Zhi (2012) 0.75
[Prevention and treatment of anastomosis complications after radical gastrectomy]. Zhonghua Wei Chang Wai Ke Za Zhi (2017) 0.75
Synthesis and antitumor activity of new shikonin glycosides. Eur J Med Chem (2010) 0.75