Published in PLoS Genet on July 26, 2012
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KSRP promotes post-transcriptional destabilization of Spry4 transcripts in non-small cell lung cancer. J Biol Chem (2017) 0.75
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Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell (2006) 12.73
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miRNAs in human cancer. J Pathol (2010) 6.02
Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87
The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature (2009) 4.61
HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev (2009) 4.41
Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover. Nat Struct Mol Biol (2005) 4.01
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Essential role for Dicer during skeletal muscle development. Dev Biol (2007) 2.76
The ATM kinase induces microRNA biogenesis in the DNA damage response. Mol Cell (2011) 2.50
Retracted The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling. PLoS Biol (2006) 2.42
Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell (2006) 2.40
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A (2008) 2.32
Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. Nat Struct Mol Biol (2010) 2.30
miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. Proc Natl Acad Sci U S A (2008) 2.29
Molecular physiology of pituitary development: signaling and transcriptional networks. Physiol Rev (2007) 2.10
LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J (2009) 1.99
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The Wnt/beta-catenin-->Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs. Mol Cell (2003) 1.91
MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation. J Immunol (2010) 1.74
Pituitary development: regulatory codes in mammalian organogenesis. Science (2002) 1.72
Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes Dev (2006) 1.60
Targeted disruption of the pituitary glycoprotein hormone alpha-subunit produces hypogonadal and hypothyroid mice. Genes Dev (1995) 1.58
MicroRNA-125a represses cell growth by targeting HuR in breast cancer. RNA Biol (2009) 1.45
Turnover of AU-rich-containing mRNAs during stress: a matter of survival. Wiley Interdiscip Rev RNA (2010) 1.27
Posttranscriptional control of type I interferon genes by KSRP in the innate immune response against viral infection. Mol Cell Biol (2011) 1.13
KSRP, many functions for a single protein. Front Biosci (Landmark Ed) (2011) 1.13
The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets. Nucleic Acids Res (2008) 1.04
Gonadotrope and thyrotrope development in the human and mouse anterior pituitary gland. Dev Biol (2006) 0.89
Gonadotropin-releasing hormone stimulates glycoprotein hormone alpha-subunit messenger ribonucleic acid (mRNA) levels in alpha T3 cells by increasing transcription and mRNA stability. Endocrinology (1994) 0.85
Expression of FOXL2 in human normal pituitaries and pituitary adenomas. Mod Pathol (2011) 0.82
Molecular determinants of resistance to antiandrogen therapy. Nat Med (2003) 18.90
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell (2007) 12.72
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet (2003) 12.16
Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model. Proc Natl Acad Sci U S A (2008) 11.86
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature (2008) 7.18
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature (2005) 6.83
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science (2006) 6.71
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature (2011) 6.25
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature (2011) 6.10
Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell (2009) 5.74
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron (2004) 5.40
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell (2002) 5.15
Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med (2008) 4.68
The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature (2009) 4.61
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell (2009) 4.60
A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell (2004) 4.39
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell (2007) 4.33
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature (2007) 4.33
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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell (2005) 4.30
ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell (2011) 4.26
Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science (2002) 4.19
Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature (2009) 4.13
Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature (2007) 4.12
Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell (2005) 3.98
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell (2005) 3.96
Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature (2013) 3.93
BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet (2006) 3.79
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature (2005) 3.78
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature (2003) 3.72
A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Mol Cell (2004) 3.71
Direct isolation and identification of promoters in the human genome. Genome Res (2005) 3.68
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell (2013) 3.53
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci U S A (2003) 3.48
Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell (2002) 3.37
Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron (2010) 3.37
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature (2009) 3.36
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature (2013) 3.33
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33
Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet (2010) 3.29
Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase. Mol Cell (2002) 3.28
Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet (2006) 3.27
Controlling nuclear receptors: the circular logic of cofactor cycles. Nat Rev Mol Cell Biol (2005) 3.25
Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol Cell (2008) 3.18
Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell (2006) 3.12
Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal. Cell Cycle (2011) 3.11
Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J Physiol (2009) 3.02
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature (2010) 2.91
Biological roles and mechanistic actions of co-repressor complexes. J Cell Sci (2002) 2.86
Epidermal stem cells arise from the hair follicle after wounding. FASEB J (2007) 2.81
MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes (2007) 2.80
Essential role for Dicer during skeletal muscle development. Dev Biol (2007) 2.76
SR proteins in vertical integration of gene expression from transcription to RNA processing to translation. Mol Cell (2009) 2.73
Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis. Science (2007) 2.70
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol (2008) 2.69
The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol (2008) 2.61
Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways. J Biol Chem (2009) 2.59
A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc Natl Acad Sci U S A (2004) 2.56
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci (2008) 2.50
Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev (2009) 2.47
Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet (2013) 2.46
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature (2005) 2.43
Retracted The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling. PLoS Biol (2006) 2.42
Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell (2006) 2.40
p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Mol Cell (2005) 2.38
N-CoR controls differentiation of neural stem cells into astrocytes. Nature (2002) 2.36
Nuclear receptor coregulators: multiple modes of modification. Trends Endocrinol Metab (2002) 2.33
Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A (2009) 2.33
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A (2008) 2.32
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science (2012) 2.25
Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters. Proc Natl Acad Sci U S A (2007) 2.17
Molecular physiology of pituitary development: signaling and transcriptional networks. Physiol Rev (2007) 2.10
Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Mol Cell Biol (2003) 2.10
Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem (2009) 2.07
Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis. Mol Cell Biol (2007) 2.04
LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J (2009) 1.99
TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res (2012) 1.98
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Mol Cell (2007) 1.98