Anti-LFA-1 antibodies enhance metastasis of ocular lymphoma to the brain and contralateral eye.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 3529209)

Published in Clin Exp Metastasis on August 05, 2012

Authors

Jacob Hochman1, DeFen Shen, Michael M Gottesman, Chi-Chao Chan

Author Affiliations

1: Department of Cell and Developmental Biology, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel. hochman@vms.huji.ac.il

Articles cited by this

Integrins: bidirectional, allosteric signaling machines. Cell (2002) 36.25

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol (2002) 17.85

Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer (2004) 14.55

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature (2004) 11.14

Statins and cancer prevention. Nat Rev Cancer (2005) 4.12

JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes. Nat Immunol (2002) 3.17

The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapy. J Neurovirol (2002) 3.10

Interstitial leukocyte migration and immune function. Nat Immunol (2008) 2.99

Molecular mechanisms of lymphocyte homing to peripheral lymph nodes. J Exp Med (1998) 2.87

Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity (2009) 2.50

Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow. J Cell Biol (2003) 2.40

T-cell integrins: more than just sticking points. J Cell Sci (2003) 2.21

Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells. J Immunol (1994) 2.11

The role of immunoglobulin in the neutralization of trachoma infectivity. J Immunol (1974) 2.10

M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells. J Immunol (2011) 2.02

Integrins in immunity. J Cell Sci (2009) 2.02

LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment. J Cell Sci (2003) 1.98

CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation. J Exp Med (1993) 1.91

Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies. Eur J Immunol (1991) 1.90

The role of the integrin LFA-1 in T-lymphocyte migration. Immunol Rev (2007) 1.47

Reduced contact sensitivity reactions in mice treated with monoclonal antibodies to leukocyte function-associated molecule-1 and intercellular adhesion molecule-1. J Immunol (1993) 1.38

Cell adhesion molecules: selectins and integrins. Crit Rev Immunol (1999) 1.37

Role of CD11/CD18 in adhesion and transendothelial migration of T cells. Analysis utilizing CD18-deficient T cell clones. J Immunol (1991) 1.34

Lymph node (but not spleen) invasion by murine lymphoma is both CD44- and hyaluronate-dependent. J Immunol (1995) 1.25

A phase I/II randomized open-label multicenter trial of efalizumab, a humanized anti-CD11a, anti-LFA-1 in renal transplantation. Am J Transplant (2007) 1.23

LFA-1 (CD11a) as a therapeutic target. Am J Transplant (2006) 1.20

Monoclonal antibodies against ICAM-1 (CD54) and LFA-1 (CD11a/CD18) inhibit experimental autoimmune uveitis. Clin Immunol Immunopathol (1993) 1.16

Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development. J Immunol (2002) 1.08

Murine model of primary intraocular lymphoma. Invest Ophthalmol Vis Sci (2005) 1.01

The molecular makeup and function of regulatory and effector synapses. Immunol Rev (2007) 0.98

LFA-1 as a key regulator of immune function: approaches toward the development of LFA-1-based therapeutics. Curr Pharm Des (2006) 0.98

Primary CNS lymphoma in HIV positive and negative patients: comparison of clinical characteristics, outcome and prognostic factors. J Neurooncol (2010) 0.97

Blocking lymphoma invasiveness with a monoclonal antibody directed against the beta-chain of the leukocyte adhesion molecule (CD18). J Immunol (1993) 0.93

Therapeutic anti-integrin (alpha4 and alphaL) monoclonal antibodies: two-edged swords? Immunology (2005) 0.93

Effects of humanized monoclonal antibody to rhesus CD11a in rhesus monkey cardiac allograft recipients. Transplantation (2000) 0.92

Monoclonal antibodies against CD54 (ICAM-1) and CD11a (LFA-1) prevent and inhibit endotoxin-induced uveitis. Exp Eye Res (1995) 0.92

Entry routes of malignant lymphoma into the brain and eyes in a mouse model. Cancer Res (2001) 0.91

The role of statins in clinical medicine--LDL--cholesterol lowering and beyond. Swiss Med Wkly (2006) 0.91

Primary CNS lymphoma. Expert Rev Anticancer Ther (2007) 0.91

Involvement of integrin alphavbeta3 in cell adhesion, motility, and liver metastasis of murine RAW117 large cell lymphoma. Cancer Res (1996) 0.90

Prevention of autoimmune insulin-dependent diabetes in non-obese diabetic mice by anti-LFA-1 and anti-ICAM-1 mAb. Int Immunol (1994) 0.89

The regulation of ICAM-1 and LFA-1 interaction by autacoids and statins: a novel strategy for controlling inflammation and immune responses. J Pharmacol Sci (2003) 0.89

Anti-adhesion therapies. Curr Opin Pharmacol (2005) 0.87

Effect of an anti-CD54 (ICAM-1) monoclonal antibody (UV3) on the growth of human uveal melanoma cells transplanted heterotopically and orthotopically in SCID mice. Int J Cancer (2006) 0.87

Uveal melanoma: the inflammatory microenvironment. J Innate Immun (2012) 0.87

Monoclonal antibody against CD11b/CD18 inhibits endotoxin-induced uveitis. Invest Ophthalmol Vis Sci (1993) 0.86

An experimental model for infiltration of malignant lymphoma to the eye and brain. Virchows Arch (1997) 0.85

Reduction of graft failure by a monoclonal antibody (anti-LFA-1 CD11a) after HLA nonidentical bone marrow transplantation in children with immunodeficiencies, osteopetrosis, and Fanconi's anemia: a European Group for Immunodeficiency/European Group for Bone Marrow Transplantation report. Blood (1991) 0.84

A phase II trial of partially incompatible bone marrow transplantation for high-risk acute lymphoblastic leukaemia in children: prevention of graft rejection with anti-LFA-1 and anti-CD2 antibodies. Société Française de Greffe de Moelle Osseuse. Br J Haematol (1996) 0.82

Efalizumab. Nat Rev Drug Discov (2004) 0.81

Cranberry juice constituents impair lymphoma growth and augment the generation of antilymphoma antibodies in syngeneic mice. Nutr Cancer (2008) 0.80

CD8 and antigen-specific T cell adhesion cascades. Semin Immunol (1993) 0.80

Anti-idiotype x anti-LFA-1 bispecific antibodies inhibit metastasis of B cell lymphoma. J Immunol (2003) 0.80

Differential Th1 and Th2 cell regulation of murine cardiac allograft acceptance by blocking cell adhesion of ICAM-1/LFA-1 and VCAM-1/VLA-4. Transpl Immunol (1999) 0.79

Increase in axonal transport in demyelinating optic nerve fibres in the mouse infected with Semliki Forest virus. Brain (1984) 0.76

Anti-LFA-1 alpha reduces the dose of cyclosporin A needed to produce immunosuppression in heterotopic cardiac transplanted rats. J Heart Lung Transplant (1999) 0.76

Articles by these authors

(truncated to the top 100)

A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science (2006) 15.18

Targeting multidrug resistance in cancer. Nat Rev Drug Discov (2006) 10.55

CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol (2005) 6.95

Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood (2008) 6.81

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med (2008) 5.25

The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci (2012) 4.11

Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81

Rapamycin slows aging in mice. Aging Cell (2012) 3.76

Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell (2004) 3.72

P-glycoprotein: from genomics to mechanism. Oncogene (2003) 3.66

Molecular pathology of age-related macular degeneration. Prog Retin Eye Res (2008) 3.35

Age-related macular degeneration. Lancet (2008) 3.34

Th17 cells are long lived and retain a stem cell-like molecular signature. Immunity (2011) 2.64

Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells. Genome Biol (2003) 2.52

Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci (2007) 2.36

Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes. Pharmacol Rev (2012) 2.31

The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy. Annu Rev Pharmacol Toxicol (2008) 2.26

Mechanisms of multidrug resistance in cancer. Methods Mol Biol (2010) 2.25

Conjunctival T-cell subpopulations in Sjögren's and non-Sjögren's patients with dry eye. Invest Ophthalmol Vis Sci (2002) 2.19

Genetic factors of age-related macular degeneration. Prog Retin Eye Res (2004) 2.17

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity. Proc Natl Acad Sci U S A (2008) 2.07

The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. FASEB J (2004) 2.04

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance. Proc Natl Acad Sci U S A (2011) 1.97

Serum inflammatory markers in diabetic retinopathy. Invest Ophthalmol Vis Sci (2005) 1.92

Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer. Cancer Res (2007) 1.91

Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics. J Natl Cancer Inst (2010) 1.89

Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database. Mol Cancer Ther (2009) 1.83

Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima. J Mol Biol (2008) 1.80

A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function. Biochim Biophys Acta (2009) 1.79

Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis. J Immunother (2004) 1.77

Noncanonical autophagy promotes the visual cycle. Cell (2013) 1.74

Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype. J Immunol (2007) 1.65

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer. Cancer Res (2006) 1.64

Immunopathological aspects of age-related macular degeneration. Semin Immunopathol (2008) 1.63

Macrophage polarization in the maculae of age-related macular degeneration: a pilot study. Pathol Int (2011) 1.62

Silent (synonymous) SNPs: should we care about them? Methods Mol Biol (2009) 1.61

Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol (2009) 1.57

The role of infectious agents in the etiology of ocular adnexal neoplasia. Surv Ophthalmol (2008) 1.57

The clinical relevance of cancer cell lines. J Natl Cancer Inst (2013) 1.54

Collateral sensitivity as a strategy against cancer multidrug resistance. Drug Resist Updat (2012) 1.53

A double-masked, randomized study to investigate the safety and efficacy of daclizumab to treat the ocular complications related to Behçet's disease. Ocul Immunol Inflamm (2007) 1.53

Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition. Proc Natl Acad Sci U S A (2006) 1.52

Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity. J Immunol (2005) 1.50

Vitreous cytokine levels. Ophthalmology (2003) 1.48

Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines. Cancer Res (2003) 1.48

Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. J Transl Med (2011) 1.47

The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). ACS Chem Neurosci (2010) 1.46

An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms. J Exp Med (2003) 1.44

Resolution of autoimmune polyglandular syndrome-associated keratopathy with keratolimbal stem cell transplantation: case report and historical literature review. Cornea (2007) 1.42

Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. Blood (2011) 1.41

Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Retin Eye Res (2010) 1.39

Pathological findings in eyes with the ganciclovir implant. Ophthalmology (2005) 1.38

Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. Pigment Cell Melanoma Res (2009) 1.38

Is resistance useless? Multidrug resistance and collateral sensitivity. Trends Pharmacol Sci (2009) 1.37

Both Th1 and Th17 are immunopathogenic but differ in other key biological activities. J Immunol (2008) 1.36

Drug resistance: still a daunting challenge to the successful treatment of AML. Drug Resist Updat (2012) 1.35

Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity. J Exp Med (2006) 1.34

Choroideremia: new findings from ocular pathology and review of recent literature. Surv Ophthalmol (2009) 1.34

Inflammatory mediators in uveitis: differential induction of cytokines and chemokines in Th1- versus Th2-mediated ocular inflammation. J Immunol (2002) 1.33

Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane. Biochemistry (2007) 1.33

A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice. J Clin Invest (2003) 1.32

Biopsy techniques and yields in diagnosing primary intraocular lymphoma. Int Ophthalmol (2007) 1.31

SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Mol Cancer Res (2008) 1.30

Aging is not a disease: distinguishing age-related macular degeneration from aging. Prog Retin Eye Res (2013) 1.29

Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. Cell Rep (2012) 1.28

Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology. Invest Ophthalmol Vis Sci (2004) 1.27

Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses. J Immunol (2008) 1.26

Waldenström's macroglobulinemia-associated retinopathy. Ophthalmology (2004) 1.26

Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis. Proc Natl Acad Sci U S A (2010) 1.25

Sympathetic ophthalmia: to the twenty-first century and beyond. J Ophthalmic Inflamm Infect (2013) 1.25

Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy. Mol Cancer Ther (2004) 1.24

Ophthalmic manifestations, cytology, immunohistochemistry, and molecular analysis of intraocular metastatic T-cell lymphoma: report of a case and review of the literature. Surv Ophthalmol (2008) 1.24

Ophthalmic manifestations and histopathology of xeroderma pigmentosum: two clinicopathological cases and a review of the literature. Surv Ophthalmol (2011) 1.23

A dual-fluorescence high-throughput cell line system for probing multidrug resistance. Assay Drug Dev Technol (2009) 1.22

Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters. Mol Cancer Ther (2008) 1.19

Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration. Exp Eye Res (2008) 1.19

Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance. Mol Pharmacol (2004) 1.18

Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas. Proc Natl Acad Sci U S A (2006) 1.18

Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma. Ophthalmology (2003) 1.17

The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples. Invest Ophthalmol Vis Sci (2007) 1.17

Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells. J Med Chem (2009) 1.17

Endocytic recycling compartments altered in cisplatin-resistant cancer cells. Cancer Res (2006) 1.16

Genetic markers and biomarkers for age-related macular degeneration. Expert Rev Ophthalmol (2007) 1.15

The sounds of silence: synonymous mutations affect function. Pharmacogenomics (2007) 1.14

Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter. Mol Cancer Ther (2007) 1.13

Primary intraocular lymphoma. Arch Pathol Lab Med (2009) 1.13

Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system. Mol Pharmacol (2002) 1.13

Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes. Pigment Cell Res (2005) 1.12

The dynamics of drug resistance: a mathematical perspective. Drug Resist Updat (2012) 1.12

Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family. Cancer Res (2012) 1.11

Histopathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels. Ophthalmology (2003) 1.11

Induction of ocular inflammation by T-helper lymphocytes type 2. Invest Ophthalmol Vis Sci (2002) 1.09

Autoreactive memory CD4+ T lymphocytes that mediate chronic uveitis reside in the bone marrow through STAT3-dependent mechanisms. J Immunol (2011) 1.09

Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice. Invest Ophthalmol Vis Sci (2008) 1.09

A unique pattern of up- and down-regulation of chemokine receptor CXCR3 on inflammation-inducing Th1 cells. Eur J Immunol (2004) 1.08

MCP-1 expression in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci (2002) 1.08

Diagnosis and management of primary intraocular lymphoma. Hematol Oncol Clin North Am (2005) 1.08

P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential. Cancer Res (2003) 1.08

Studies with novel Pdr5p substrates demonstrate a strong size dependence for xenobiotic efflux. J Biol Chem (2002) 1.08

Differences in scrapie-induced pathology of the retina and brain in transgenic mice that express hamster prion protein in neurons, astrocytes, or multiple cell types. Am J Pathol (2004) 1.07