A seven-gene signature aggregates a subgroup of stage II colon cancers with stage III.

PubWeight™: 0.96‹?› | Rank: Top 15%

🔗 View Article (PMID 22917480)

Published in OMICS on August 23, 2012

Authors

Sophy Laibe1, Arnaud Lagarde, Anthony Ferrari, Geneviève Monges, Daniel Birnbaum, Sylviane Olschwang, COL2 Project

Author Affiliations

1: Tumor Biology Department, Institut Paoli-Calmettes, Marseille, France.

Articles by these authors

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 22.89

International network of cancer genome projects. Nature (2010) 20.35

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet (2007) 9.88

Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res (2009) 7.98

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet (2011) 6.77

Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome. JAMA (2011) 4.84

Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer. Clin Cancer Res (2009) 4.47

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest (2010) 4.22

Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia. Br J Haematol (2009) 4.18

Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res (2006) 3.81

Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N Engl J Med (2008) 3.76

Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA (2007) 3.62

How basal are triple-negative breast cancers? Int J Cancer (2008) 3.18

Prognostic score including gene mutations in chronic myelomonocytic leukemia. J Clin Oncol (2013) 3.10

Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value. PLoS Med (2013) 2.96

Integrated profiling of basal and luminal breast cancers. Cancer Res (2007) 2.86

Gene expression profiling shows medullary breast cancer is a subgroup of basal breast cancers. Cancer Res (2006) 2.52

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity. J Clin Invest (2011) 2.44

Gene expression profiling identifies molecular subtypes of inflammatory breast cancer. Cancer Res (2005) 2.26

TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). Blood (2009) 2.18

Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters. Oncogene (2004) 2.09

Protein expression profiling identifies subclasses of breast cancer and predicts prognosis. Cancer Res (2005) 2.05

A gene expression signature identifies two prognostic subgroups of basal breast cancer. Breast Cancer Res Treat (2010) 2.03

Comprehensive profiling of 8p11-12 amplification in breast cancer. Mol Cancer Res (2005) 1.96

TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia. Haematologica (2009) 1.95

Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias. BMC Cancer (2010) 1.93

CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction. Proc Natl Acad Sci U S A (2011) 1.91

Distinct and complementary information provided by use of tissue and DNA microarrays in the study of breast tumor markers. Am J Pathol (2002) 1.89

Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Blood (2012) 1.88

Poly(ADP-ribose) polymerase-1 mRNA expression in human breast cancer: a meta-analysis. Breast Cancer Res Treat (2010) 1.81

Cancer stem cells in breast: current opinion and future challenges. Pathobiology (2008) 1.77

Prognosis and gene expression profiling of 20q13-amplified breast cancers. Clin Cancer Res (2006) 1.75

Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome. Blood (2008) 1.74

Junctional recruitment of mammalian Scribble relies on E-cadherin engagement. Oncogene (2005) 1.73

ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia. Br J Haematol (2010) 1.71

Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. BMC Cancer (2008) 1.66

Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. Hum Mol Genet (2005) 1.64

Relative frequency and morphology of cancers in STK11 mutation carriers. Gastroenterology (2004) 1.62

Gene expression profiling for molecular characterization of inflammatory breast cancer and prediction of response to chemotherapy. Cancer Res (2004) 1.61

Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers. BMC Cancer (2006) 1.58

Retinoid signaling regulates breast cancer stem cell differentiation. Cell Cycle (2009) 1.56

Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases. J Hematol Oncol (2012) 1.56

Genome profiling of pancreatic adenocarcinoma. Genes Chromosomes Cancer (2011) 1.54

Immunophenotypic analysis of inflammatory breast cancers: identification of an 'inflammatory signature'. J Pathol (2004) 1.53

Genome profiling of ERBB2-amplified breast cancers. BMC Cancer (2010) 1.53

Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms. Genes Chromosomes Cancer (2012) 1.47

ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. EMBO Mol Med (2011) 1.47

Gene expression profiling defines molecular subtypes of classical Hodgkin's disease. Oncogene (2002) 1.44

Colonoscopic screening of first-degree relatives of patients with large adenomas: increased risk of colorectal tumors. Gastroenterology (2007) 1.44

MSH2 in contrast to MLH1 and MSH6 is frequently inactivated by exonic and promoter rearrangements in hereditary nonpolyposis colorectal cancer. Cancer Res (2002) 1.41

A large fraction of unclassified variants of the mismatch repair genes MLH1 and MSH2 is associated with splicing defects. Hum Mutat (2008) 1.41

CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines. Breast Cancer Res (2009) 1.41

Breast cancer stem cells: tools and models to rely on. BMC Cancer (2009) 1.38

MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS Genet (2012) 1.38

Gene expression profiles of poor-prognosis primary breast cancer correlate with survival. Hum Mol Genet (2002) 1.37

Genetic variability in MCF-7 sublines: evidence of rapid genomic and RNA expression profile modifications. BMC Cancer (2003) 1.34

TACC1-chTOG-Aurora A protein complex in breast cancer. Oncogene (2003) 1.33

Identification and validation of an ERBB2 gene expression signature in breast cancers. Oncogene (2004) 1.31

Uncovering the molecular secrets of inflammatory breast cancer biology: an integrated analysis of three distinct affymetrix gene expression datasets. Clin Cancer Res (2013) 1.30

Nectin-4 is a new histological and serological tumor associated marker for breast cancer. BMC Cancer (2007) 1.30

Leiden Open Variation Database of the MUTYH gene. Hum Mutat (2010) 1.28

Typical medullary breast carcinomas have a basal/myoepithelial phenotype. J Pathol (2005) 1.27

Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer. PLoS One (2011) 1.27

Alteration of cohesin genes in myeloid diseases. Am J Hematol (2010) 1.26

Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer. Breast Cancer Res (2009) 1.26

Sixteen-kinase gene expression identifies luminal breast cancers with poor prognosis. Cancer Res (2008) 1.26

Microsatellite instability in colorectal carcinoma. The comparison of immunohistochemistry and molecular biology suggests a role for hMSH6 [correction of hMLH6] immunostaining. Arch Pathol Lab Med (2003) 1.26

Myeloid malignancies: mutations, models and management. BMC Cancer (2012) 1.24

Tissue microarray technology: validation in colorectal carcinoma and analysis of p53, hMLH1, and hMSH2 immunohistochemical expression. Virchows Arch (2003) 1.23

Kinome expression profiling and prognosis of basal breast cancers. Mol Cancer (2011) 1.22

Identification in daily practice of patients with Lynch syndrome (hereditary nonpolyposis colorectal cancer): revised Bethesda guidelines-based approach versus molecular screening. Am J Gastroenterol (2008) 1.20

Feasibility and yield of a novel 22-gauge histology EUS needle in patients with pancreatic masses: a multicenter prospective cohort study. Surg Endosc (2013) 1.19

Transcriptional profiling reveals coordinated up-regulation of oxidative metabolism genes in thyroid oncocytic tumors. J Clin Endocrinol Metab (2004) 1.19

Reasons for breast cancer heterogeneity. J Biol (2008) 1.17

BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders. Blood (2013) 1.16

How different are luminal A and basal breast cancers? Int J Cancer (2009) 1.15

High-resolution comparative genomic hybridization of inflammatory breast cancer and identification of candidate genes. PLoS One (2011) 1.14

ALDH1-positive cancer stem cells predict engraftment of primary breast tumors and are governed by a common stem cell program. Cancer Res (2013) 1.14

A polymorphism of EGFR extracellular domain is associated with progression free-survival in metastatic colorectal cancer patients receiving cetuximab-based treatment. BMC Cancer (2008) 1.13

Gene expression profiling and prediction of clinical outcome in ovarian cancer. Crit Rev Oncol Hematol (2009) 1.13

Genotype-phenotype correlation in von Hippel-Lindau families with renal lesions. Hum Mutat (2004) 1.13

Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. Stem Cells (2012) 1.13

Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. Cancer Res (2009) 1.12

An evolutionary history of the FGF superfamily. Bioessays (2005) 1.11

Acute myeloid leukemia with myelodysplasia-related changes are characterized by a specific molecular pattern with high frequency of ASXL1 mutations. Am J Hematol (2012) 1.11

The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression. Clin Cancer Res (2013) 1.10

Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. J Cell Sci (2010) 1.10