Published in Nature on September 13, 2012
The hallmarks of aging. Cell (2013) 14.29
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol Cell (2012) 2.54
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab (2014) 2.48
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun (2014) 1.96
A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. J Gerontol A Biol Sci Med Sci (2015) 1.96
Promoting health and longevity through diet: from model organisms to humans. Cell (2015) 1.80
Mechanisms that regulate stem cell aging and life span. Cell Stem Cell (2013) 1.73
The GH/IGF-1 axis in ageing and longevity. Nat Rev Endocrinol (2013) 1.68
Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov (2013) 1.66
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature (2014) 1.63
The search for antiaging interventions: from elixirs to fasting regimens. Cell (2014) 1.63
Death by transposition - the enemy within? Bioessays (2013) 1.53
Current concepts in age-related hearing loss: epidemiology and mechanistic pathways. Hear Res (2013) 1.51
AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow. Cell Stem Cell (2015) 1.51
Interventions to Slow Aging in Humans: Are We Ready? Aging Cell (2015) 1.46
Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial. JAMA Intern Med (2016) 1.45
The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol (2013) 1.41
Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1. Eur J Cancer Prev (2016) 1.39
Antibody persistence and T-cell balance: two key factors confronting HIV vaccine development. Proc Natl Acad Sci U S A (2014) 1.39
Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell (2013) 1.31
SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol Med (2013) 1.30
Metabolic and nutritional support of critically ill patients: consensus and controversies. Crit Care (2015) 1.28
AMPK at the nexus of energetics and aging. Cell Metab (2014) 1.28
Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues. Aging (Albany NY) (2013) 1.26
Essential role for autophagy in life span extension. J Clin Invest (2015) 1.25
Coming of age: molecular drivers of aging and therapeutic opportunities. J Clin Invest (2013) 1.22
Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts. Antioxid Redox Signal (2013) 1.20
Longevity and aging. F1000Prime Rep (2013) 1.18
Optimal body weight for health and longevity: bridging basic, clinical, and population research. Aging Cell (2014) 1.16
Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society. J Gerontol A Biol Sci Med Sci (2015) 1.16
The sirtuin family's role in aging and age-associated pathologies. J Clin Invest (2013) 1.12
A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci (2013) 1.12
NAD⁺ metabolism: a therapeutic target for age-related metabolic disease. Crit Rev Biochem Mol Biol (2013) 1.11
Will calorie restriction work in humans? Aging (Albany NY) (2013) 1.11
Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions. Oncotarget (2012) 1.11
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell (2015) 1.10
Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance. Aging (Albany NY) (2013) 1.07
Skeletal muscle, autophagy, and physical activity: the ménage à trois of metabolic regulation in health and disease. J Mol Med (Berl) (2013) 1.07
Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol (2015) 1.03
Calorie restriction and cancer prevention: a mechanistic perspective. Cancer Metab (2013) 1.01
Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. PLoS Genet (2013) 1.01
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). Dose Response (2014) 1.00
Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction. Aging (Albany NY) (2013) 1.00
Autophagy in blood cancers: biological role and therapeutic implications. Haematologica (2013) 0.99
Development and characterization of a chemically defined food for Drosophila. PLoS One (2013) 0.99
Aging and energetics' 'Top 40' future research opportunities 2010-2013. F1000Res (2014) 0.98
Metformin: do we finally have an anti-aging drug? Cell Cycle (2013) 0.98
Protein and amino acid restriction, aging and disease: from yeast to humans. Trends Endocrinol Metab (2014) 0.97
Caloric restriction and the aging process: a critique. Free Radic Biol Med (2014) 0.97
Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast. Exp Gerontol (2013) 0.97
Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8. Age (Dordr) (2012) 0.96
Newer antidiabetic drugs and calorie restriction mimicry. Indian J Endocrinol Metab (2016) 0.96
Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice. Cell Rep (2015) 0.94
Macronutrients and caloric intake in health and longevity. J Endocrinol (2015) 0.94
Independent and additive effects of glutamic acid and methionine on yeast longevity. PLoS One (2013) 0.94
Reductions in serum IGF-1 during aging impair health span. Aging Cell (2013) 0.93
Nutrition and healthy ageing: calorie restriction or polyphenol-rich "MediterrAsian" diet? Oxid Med Cell Longev (2013) 0.93
Major urinary protein 5, a scent communication protein, is regulated by dietary restriction and subsequent re-feeding in mice. Proc Biol Sci (2013) 0.92
Successful brain aging: plasticity, environmental enrichment, and lifestyle. Dialogues Clin Neurosci (2013) 0.91
Enhanced phase II detoxification contributes to beneficial effects of dietary restriction as revealed by multi-platform metabolomics studies. Mol Cell Proteomics (2012) 0.91
The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects. Vet Pathol (2015) 0.91
Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury. Autophagy (2015) 0.91
Restriction on an energy-dense diet improves markers of metabolic health and cellular aging in mice through decreasing hepatic mTOR activity. Rejuvenation Res (2015) 0.90
Aging signaling pathways and circadian clock-dependent metabolic derangements. Trends Endocrinol Metab (2013) 0.90
Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Aging Cell (2015) 0.90
Patterns of intraspecific variability in the response to caloric restriction. Exp Gerontol (2013) 0.90
Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis. Aging (Albany NY) (2013) 0.90
Caloric restriction improves health and survival of rhesus monkeys. Nat Commun (2017) 0.90
The Role of INDY in Metabolic Regulation. Comput Struct Biotechnol J (2013) 0.89
Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation. Diabetes Metab J (2014) 0.89
Molecular pathology endpoints useful for aging studies. Ageing Res Rev (2016) 0.89
Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster. Aging (Albany NY) (2014) 0.89
Impact of moderate calorie restriction on testicular morphology and endocrine function in adult rhesus macaques (Macaca mulatta). Age (Dordr) (2013) 0.89
Linking the metabolic state and mitochondrial DNA in chronic disease, health, and aging. Diabetes (2013) 0.89
Regulation of Liver Metabolism by Autophagy. Gastroenterology (2015) 0.89
Immune correlates of aging in outdoor-housed captive rhesus macaques (Macaca mulatta). Immun Ageing (2012) 0.88
Genetic variation in responses to dietary restriction--an unbiased tool for hypothesis testing. Exp Gerontol (2013) 0.88
Food Restriction Ameliorates the Development of Polycystic Kidney Disease. J Am Soc Nephrol (2015) 0.88
Plants do not count… or do they? New perspectives on the universality of senescence. J Ecol (2013) 0.88
Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance. Cell Metab (2015) 0.88
A mitochondrial ATP synthase subunit interacts with TOR signaling to modulate protein homeostasis and lifespan in Drosophila. Cell Rep (2014) 0.87
Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity. PLoS One (2013) 0.87
The scientific quest for lasting youth: prospects for curing aging. Rejuvenation Res (2014) 0.87
Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research. Cell Cycle (2014) 0.87
Cranberry interacts with dietary macronutrients to promote healthy aging in Drosophila. J Gerontol A Biol Sci Med Sci (2013) 0.87
Long-term calorie restriction decreases metabolic cost of movement and prevents decrease of physical activity during aging in rhesus monkeys. Exp Gerontol (2013) 0.86
Muscle heat shock protein 70 predicts insulin resistance with aging. J Gerontol A Biol Sci Med Sci (2014) 0.86
Autophagy in ageing and ageing-associated diseases. Acta Pharmacol Sin (2013) 0.86
Molecular and metabolomic effects of voluntary running wheel activity on skeletal muscle in late middle-aged rats. Physiol Rep (2015) 0.86
Calorie restriction in humans: An update. Ageing Res Rev (2016) 0.85
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab (2016) 0.85
Caloric restriction and its mimetics. BMB Rep (2013) 0.85
Dietary restriction with and without caloric restriction for healthy aging. F1000Res (2016) 0.85
Maintaining good hearing: calorie restriction, Sirt3, and glutathione. Exp Gerontol (2013) 0.85
Calorie restriction does not elicit a robust extension of replicative lifespan in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2014) 0.85
Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency. Cell Stem Cell (2015) 0.85
Preoperative dietary restriction reduces intimal hyperplasia and protects from ischemia-reperfusion injury. J Vasc Surg (2014) 0.85
Metabolism, longevity and epigenetics. Cell Mol Life Sci (2013) 0.85
Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans. Free Radic Biol Med (2014) 0.85
The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse. Oncotarget (2015) 0.84
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA (2007) 11.87
Caloric restriction delays disease onset and mortality in rhesus monkeys. Science (2009) 9.84
Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell (2009) 3.78
Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction. J Gerontol A Biol Sci Med Sci (2003) 3.77
Genotype and age influence the effect of caloric intake on mortality in mice. FASEB J (2003) 2.51
"Control" laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci U S A (2010) 2.50
Aging in rhesus monkeys: relevance to human health interventions. Science (2004) 2.37
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc Natl Acad Sci U S A (2006) 2.03
Attenuation of sarcopenia by dietary restriction in rhesus monkeys. J Gerontol A Biol Sci Med Sci (2008) 2.00
Does caloric restriction extend life in wild mice? Aging Cell (2006) 1.99
Can oxidative damage be treated nutritionally? Clin Nutr (2005) 1.96
The effects of different levels of dietary restriction on aging and survival in the Sprague-Dawley rat: implications for chronic studies. Aging (Milano) (2001) 1.93
Dietary restriction and aging: the initiation of a primate study. J Gerontol (1990) 1.84
Calorie restriction and prevention of age-associated chronic disease. FEBS Lett (2011) 1.69
Mice and flies and monkeys too: caloric restriction rejuvenates the aging immune system of non-human primates. Exp Gerontol (2005) 1.43
Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan. Ageing Res Rev (2011) 1.42
Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes. Antioxid Redox Signal (2010) 1.42
Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J Gerontol A Biol Sci Med Sci (2005) 1.41
Starving for life: what animal studies can and cannot tell us about the use of caloric restriction to prolong human lifespan. J Nutr (2007) 1.37
Effects of food restriction on aging: separation of food intake and adiposity. Proc Natl Acad Sci U S A (1984) 1.31
Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake. Metabolism (2011) 1.27
Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates. Exp Gerontol (2009) 1.26
Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture in young C57BL/6 mice. Clin Diagn Lab Immunol (2001) 1.23
Exploiting the rodent model for studies on the pharmacology of lifespan extension. Aging Cell (2006) 1.19
Short-term calorie restriction improves disease-related markers in older male rhesus monkeys (Macaca mulatta). Mech Ageing Dev (2000) 1.19
Are mice calorically restricted in nature? Aging Cell (2003) 1.19
Age-related decline in caloric intake and motivation for food in rhesus monkeys. Neurobiol Aging (2004) 1.10
Chronic calorie restriction increases susceptibility of laboratory mice (Mus musculus) to a primary intestinal parasite infection. Aging Cell (2007) 1.09
Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates. Aging Cell (2008) 1.09
Aging and food restriction alter some indices of bone metabolism in male rhesus monkeys (Macaca mulatta). J Nutr (1995) 1.07
Caloric restriction and body weight independently affect longevity in Wistar rats. Int J Obes Relat Metab Disord (2004) 1.02
A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys. J Neurosci (2010) 1.02
Influences of calorie restriction and age on energy expenditure in the rhesus monkey. Am J Physiol Endocrinol Metab (2006) 0.99
An isoflavone metabolite reduces arterial stiffness and blood pressure in overweight men and postmenopausal women. Atherosclerosis (2006) 0.99
Fish oil supplementation improves large arterial elasticity in overweight hypertensive patients. Eur J Clin Nutr (2007) 0.98
Energy intake and response to infection with influenza. Annu Rev Nutr (2011) 0.96
A high-sucrose isocaloric pair-fed model induces obesity and impairs NDUFB6 gene function in rat adipose tissue. J Nutrigenet Nutrigenomics (2010) 0.92
The effects of a calorie-reduced diet on periodontal inflammation and disease in a non-human primate model. J Periodontol (2008) 0.92
Source of dietary carbohydrate affects life span of Fischer 344 rats independent of caloric restriction. J Gerontol A Biol Sci Med Sci (1995) 0.89
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med (2002) 24.07
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
A potential decline in life expectancy in the United States in the 21st century. N Engl J Med (2005) 19.63
Years of life lost due to obesity. JAMA (2003) 12.18
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Caloric restriction delays disease onset and mortality in rhesus monkeys. Science (2009) 9.84
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74
Repeatability of published microarray gene expression analyses. Nat Genet (2008) 8.24
Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents. J Pediatr (2004) 7.08
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles. Am J Hum Genet (2008) 5.53
Myths, presumptions, and facts about obesity. N Engl J Med (2013) 5.39
Data Sharing. N Engl J Med (2016) 5.12
Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239. J Virol (2006) 4.68
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
The origins of age-related proinflammatory state. Blood (2004) 4.15
Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA (2011) 4.09
Zonisamide for weight reduction in obese adults: a 1-year randomized controlled trial. Arch Intern Med (2012) 3.95
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
Primary care physicians' attitudes about obesity and its treatment. Obes Res (2003) 3.80
Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med (2009) 3.71
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Belief beyond the evidence: using the proposed effect of breakfast on obesity to show 2 practices that distort scientific evidence. Am J Clin Nutr (2013) 3.67
Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication. J Virol (2003) 3.64
Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J Exp Med (2004) 3.62
Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression. J Immunol (2007) 3.59
Predicting genetic predisposition in humans: the promise of whole-genome markers. Nat Rev Genet (2010) 3.59
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
Stochastic search variable selection for identifying multiple quantitative trait loci. Genetics (2003) 3.48
Beyond missing heritability: prediction of complex traits. PLoS Genet (2011) 3.39
Body mass index and waist circumference independently contribute to the prediction of nonabdominal, abdominal subcutaneous, and visceral fat. Am J Clin Nutr (2002) 3.33
Statistical methods for testing effects on "maximum lifespan". Mech Ageing Dev (2004) 3.26
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One (2008) 3.25
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
Evaluation of a portable device to measure daily energy expenditure in free-living adults. Am J Clin Nutr (2007) 3.18
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene (2005) 3.17
Bayesian model selection for genome-wide epistatic quantitative trait loci analysis. Genetics (2005) 3.10
Detection of gene x gene interactions in genome-wide association studies of human population data. Hum Hered (2007) 2.97
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology (2007) 2.95
PGC-1alpha: a key regulator of energy metabolism. Adv Physiol Educ (2006) 2.88
Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci (2006) 2.85
Calorie restriction mimetics: an emerging research field. Aging Cell (2006) 2.82
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82
Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz. Nature (2009) 2.78
Towards sound epistemological foundations of statistical methods for high-dimensional biology. Nat Genet (2004) 2.72
Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science (2005) 2.72
Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr (2009) 2.71
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Precision medicine--personalized, problematic, and promising. N Engl J Med (2015) 2.67
Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol (2009) 2.65
Tumor heterogeneity and personalized medicine. N Engl J Med (2012) 2.63
Distinct DNA methylation changes highly correlated with chronological age in the human brain. Hum Mol Genet (2011) 2.62
Drug-Induced Megaloblastic Anemia. N Engl J Med (2015) 2.62
Macaques vaccinated with live-attenuated SIV control replication of heterologous virus. J Exp Med (2008) 2.59
Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med (2012) 2.58
Insights into thymic aging and regeneration. Immunol Rev (2005) 2.55
Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54
Calorie restriction in rhesus monkeys. Exp Gerontol (2003) 2.52
Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection. J Virol (2002) 2.50
Mortality, health outcomes, and body mass index in the overweight range: a science advisory from the American Heart Association. Circulation (2009) 2.49
Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge. J Virol (2009) 2.38
Aging in rhesus monkeys: relevance to human health interventions. Science (2004) 2.37
New therapies for castration-resistant prostate cancer. N Engl J Med (2010) 2.37
Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents: a frequently sampled intravenous glucose tolerance test and minimal model analysis. Arch Gen Psychiatry (2005) 2.35
Talking with patients about dying. N Engl J Med (2012) 2.34
Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol A Biol Sci Med Sci (2009) 2.32
Biomarkers of caloric restriction may predict longevity in humans. Science (2002) 2.32
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell (2009) 2.32
High oxidative damage levels in the longest-living rodent, the naked mole-rat. Aging Cell (2006) 2.31
Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway. J Biol Chem (2005) 2.30
Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy. Blood (2002) 2.28
Linking beta-catenin to androgen-signaling pathway. J Biol Chem (2002) 2.27
Bias in estimates of quantitative-trait-locus effect in genome scans: demonstration of the phenomenon and a method-of-moments procedure for reducing bias. Am J Hum Genet (2002) 2.25
Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci (2010) 2.24
IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat Med (2007) 2.23
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
Missing data in randomized clinical trials for weight loss: scope of the problem, state of the field, and performance of statistical methods. PLoS One (2009) 2.21
Proinflammatory state, hepcidin, and anemia in older persons. Blood (2010) 2.19
Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy. J Exp Med (2013) 2.18
A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr (2007) 2.16
Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239. J Virol (2003) 2.14
Kidney function influences warfarin responsiveness and hemorrhagic complications. J Am Soc Nephrol (2009) 2.13
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One (2009) 2.07
Bayesian model choice and search strategies for mapping interacting quantitative trait Loci. Genetics (2003) 2.05
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc Natl Acad Sci U S A (2006) 2.03