Published in Nat Med on September 01, 2012
Epigenetics in liver disease. Hepatology (2014) 1.77
Pathobiology of liver fibrosis: a translational success story. Gut (2015) 1.72
Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis. J Am Soc Nephrol (2014) 1.71
Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. Am J Physiol Cell Physiol (2012) 1.70
Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. PLoS One (2015) 1.68
DNA methylation contributes to natural human variation. Genome Res (2013) 1.66
The genetics of NAFLD. Nat Rev Gastroenterol Hepatol (2013) 1.55
Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa. Nat Struct Mol Biol (2013) 1.54
Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research. J Med Genet (2014) 1.34
Transgenerational epigenetic inheritance: how important is it? Nat Rev Genet (2013) 1.32
Postnatal stability, tissue, and time specific effects of AHRR methylation change in response to maternal smoking in pregnancy. Epigenetics (2013) 1.17
Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences. Sci Rep (2016) 1.08
Perinatal nicotine-induced transgenerational asthma. Am J Physiol Lung Cell Mol Physiol (2013) 1.06
Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease. Clin Epigenetics (2015) 1.05
Differentiation of progenitors in the liver: a matter of local choice. J Clin Invest (2013) 1.00
Epigenetic memory: the Lamarckian brain. EMBO J (2014) 0.99
Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update. World J Gastroenterol (2014) 0.97
Molecular mechanism and treatment of viral hepatitis-related liver fibrosis. Int J Mol Sci (2014) 0.95
Is the growth of the fetus of a non-smoking mother influenced by the smoking of either grandmother while pregnant? PLoS One (2014) 0.93
Epigenetic marking of sperm by post-translational modification of histones and protamines. Epigenetics Chromatin (2014) 0.92
Epigenetics and phenotypic variability: some interesting insights from birds. Genet Sel Evol (2013) 0.91
Liver Injury and the Activation of the Hepatic Myofibroblasts. Curr Pathobiol Rep (2013) 0.89
Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease. Gut (2016) 0.86
Choline's role in maintaining liver function: new evidence for epigenetic mechanisms. Curr Opin Clin Nutr Metab Care (2013) 0.85
Dietary alleviation of maternal obesity and diabetes: increased resistance to diet-induced obesity transcriptional and epigenetic signatures. PLoS One (2013) 0.85
Genome-wide chromatin analysis in mature mouse and human spermatozoa. Nat Protoc (2013) 0.85
Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis. Nat Commun (2016) 0.82
Defining the interorgan communication network: systemic coordination of organismal cellular processes under homeostasis and localized stress. Front Cell Infect Microbiol (2013) 0.82
Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications. Nat Rev Genet (2016) 0.81
Emerging role of epigenetics in systemic sclerosis pathogenesis. Genes Immun (2014) 0.81
Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p. Stem Cells (2015) 0.81
Epigenetics and the overhealing wound: the role of DNA methylation in fibrosis. Fibrogenesis Tissue Repair (2015) 0.81
Epigenetics in the perioperative period. Br J Pharmacol (2015) 0.81
Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring. Elife (2017) 0.81
Extracellular matrix and liver disease. Antioxid Redox Signal (2014) 0.80
Is the growth of the child of a smoking mother influenced by the father's prenatal exposure to tobacco? A hypothesis generating longitudinal study. BMJ Open (2014) 0.79
Multigenerational exposure to dietary zearalenone (ZEA), an estrogenic mycotoxin, affects puberty and reproduction in female mice. Reprod Toxicol (2014) 0.79
Zinc supplementation suppresses the progression of bile duct ligation-induced liver fibrosis in mice. Exp Biol Med (Maywood) (2014) 0.78
Reversibility and heritability of liver fibrosis: Implications for research and therapy. World J Gastroenterol (2015) 0.78
Epigenetics in liver disease: from biology to therapeutics. Gut (2016) 0.78
Adaptation or malignant transformation: the two faces of epigenetically mediated response to stress. Biomed Res Int (2013) 0.77
Expansion of hepatic stem cell compartment boosts liver regeneration. Stem Cells Dev (2013) 0.77
Epigenetic influences in the aetiology of cancers arising from breast and prostate: a hypothesised transgenerational evolution in chromatin accessibility. ISRN Oncol (2013) 0.77
Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm). Mol Cell Proteomics (2015) 0.77
Enhancement of lysine acetylation accelerates wound repair. Commun Integr Biol (2013) 0.76
Protect thee from the sins of thy fathers? Nat Med (2012) 0.76
DNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver disease. Clin Epigenetics (2016) 0.76
Environmentally induced epigenetic toxicity: potential public health concerns. Crit Rev Toxicol (2016) 0.76
The mechanisms of HSC activation and epigenetic regulation of HSCs phenotypes. Curr Pathobiol Rep (2014) 0.75
Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila. Nat Genet (2017) 0.75
Genetic and epigenetic regulation of intestinal fibrosis. United European Gastroenterol J (2016) 0.75
Linking the Epigenome with Exposure Effects and Susceptibility: The Epigenetic Seed and Soil Model. Toxicol Sci (2016) 0.75
EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent. Int J Nanomedicine (2016) 0.75
Selective measurement of α smooth muscle actin: why β-actin can not be used as a housekeeping gene when tissue fibrosis occurs. BMC Mol Biol (2017) 0.75
Dexamethasone treatment alters insulin, leptin, and adiponectin levels in male mice as observed in DIO but does not lead to alterations of metabolic phenotypes in the offspring. Mamm Genome (2015) 0.75
Paternal chronic colitis causes epigenetic inheritance of susceptibility to colitis. Sci Rep (2016) 0.75
Epigenetics and Liver Fibrosis. Cell Mol Gastroenterol Hepatol (2017) 0.75
Serum-mediated transgenerational effects on sperm: evidence for lamarckian inheritance? Hepatology (2013) 0.75
Decoding Lamarck-transgenerational control of metabolism by noncoding RNAs. Pflugers Arch (2016) 0.75
Multilineage potential of adult human mesenchymal stem cells. Science (1999) 66.19
Translating the histone code. Science (2001) 56.77
The language of covalent histone modifications. Nature (2000) 44.92
Fibroblasts in cancer. Nat Rev Cancer (2006) 18.95
Role for DNA methylation in genomic imprinting. Nature (1993) 12.65
Mechanisms of hepatic fibrogenesis. Gastroenterology (2008) 11.98
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology (1999) 11.76
Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett (2004) 11.00
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev (2008) 10.28
Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet (1997) 10.05
Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science (2005) 10.02
TGF-beta signaling and the fibrotic response. FASEB J (2004) 9.81
Histone and chromatin cross-talk. Curr Opin Cell Biol (2003) 8.69
RankProd: a bioconductor package for detecting differentially expressed genes in meta-analysis. Bioinformatics (2006) 6.50
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature (2010) 6.23
Distinctive chromatin in human sperm packages genes for embryo development. Nature (2009) 6.18
The origins of the developmental origins theory. J Intern Med (2007) 6.03
Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat Rev Genet (2008) 5.67
Idiopathic pulmonary fibrosis. Lancet (2011) 5.25
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell (2010) 5.22
Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks. Nature (2008) 4.20
Roles of TGF-beta in hepatic fibrosis. Front Biosci (2002) 4.15
Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology (2007) 4.06
Mechanisms of carbon tetrachloride toxicity. Pharmacol Ther (1989) 4.00
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell (2008) 3.90
DNA methylation and imprinting: why bother? Trends Genet (1997) 3.00
Immunocytochemical detection of desmin in fat-storing cells (Ito cells). Hepatology (1984) 2.75
Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet (1995) 2.64
Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J Biol Chem (2000) 2.58
Tissue-specific differences in DNA methylation in various mammals. Biochim Biophys Acta (1983) 2.40
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology (2009) 2.17
DNA methylation models histone acetylation. Nature (1998) 2.04
Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem (2003) 1.97
Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology (2005) 1.73
Fibrosis in chronic liver diseases: diagnosis and management. J Hepatol (2004) 1.60
Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury. Am J Pathol (2005) 1.53
Paternal DNA packaging in spermatozoa: more than the sum of its parts? DNA, histones, protamines and epigenetics. Reproduction (2009) 1.52
Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues. Epigenetics (2010) 1.41
The role of long non-coding RNAs in chromatin structure and gene regulation: variations on a theme. Biol Chem (2008) 1.35
Isolation of four core histones from human sperm chromatin representing a minor subset of somatic histones. J Biol Chem (1990) 1.32
The sperm nucleus: chromatin, RNA, and the nuclear matrix. Reproduction (2010) 1.18
Carbon tetrachloride hepatotoxicity: an example of free radical-mediated injury. Semin Liver Dis (1990) 1.18
Epigenetics: differential DNA methylation in mammalian somatic tissues. FEBS J (2008) 1.18
Advances in the regulation of liver regeneration. Expert Rev Gastroenterol Hepatol (2011) 1.13
The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation. Hepatology (2010) 1.09
Blood as a surrogate marker for tissue-specific DNA methylation and changes due to folate depletion in post-partum female mice. Mol Nutr Food Res (2011) 1.09
Bioactivation of halogenated hydrocarbons by cytochrome P4502E1. Crit Rev Toxicol (1993) 1.08
H2A.Z and DNA methylation: irreconcilable differences. Trends Biochem Sci (2009) 0.98
Maternal folate supply and sex influence gene-specific DNA methylation in the fetal gut. Mol Nutr Food Res (2011) 0.90
Active demethylation of paternal genome in mammalian zygotes. J Reprod Dev (2009) 0.87
The fetus as a patient. Surgical considerations. Ann Surg (1991) 0.87
Noncoding RNAs and chromatin structure. Biochemistry (Mosc) (2007) 0.86
A histochemical study of the bile ducts in long-term biliary obstruction in the rat. J Pathol (1971) 0.84
Fetal wound healing: an in vitro explant model. J Pediatr Surg (1990) 0.82
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science (2007) 12.91
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet (2011) 6.77
The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology (2007) 6.68
Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N Engl J Med (2008) 3.76
Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markers. Hepatology (2008) 3.60
Prednisolone or pentoxifylline for alcoholic hepatitis. N Engl J Med (2015) 3.47
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun (2012) 2.90
Association between hepatitis C virus and very-low-density lipoprotein (VLDL)/LDL analyzed in iodixanol density gradients. J Virol (2006) 2.88
Tracking of obesity-related behaviours from childhood to adulthood: A systematic review. Maturitas (2011) 2.59
Assessing the survival of transgenic plant DNA in the human gastrointestinal tract. Nat Biotechnol (2004) 2.26
Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis. Hepatology (2007) 2.21
Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease. Gut (2010) 2.20
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology (2009) 2.17
Clinical evidence for the regression of liver fibrosis. J Hepatol (2012) 2.16
Investigating mildly abnormal serum aminotransferase values. BMJ (2010) 2.07
Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease. Lab Invest (2007) 2.01
Liver fibrosis. Biochem J (2008) 1.97
Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. Br J Nutr (2007) 1.95
Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. Gastroenterology (2009) 1.84
Characterization of the cartilage DNA methylome in knee and hip osteoarthritis. Arthritis Rheumatol (2014) 1.77
Quantifying hepatic steatosis - more than meets the eye. Histopathology (2012) 1.76
Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation. Arthritis Rheum (2013) 1.74
Nuclear factor-kappaB1: regulation and function. Int J Biochem Cell Biol (2007) 1.74
Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology (2007) 1.74
Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology (2005) 1.73
Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease. J Hepatol (2012) 1.70
A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis. Cancer Prev Res (Phila) (2011) 1.64
Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study). FASEB J (2007) 1.58
A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation. J Biol Chem (2003) 1.54
Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury. Am J Pathol (2005) 1.53
Degradation of transgenic DNA from genetically modified soya and maize in human intestinal simulations. Br J Nutr (2002) 1.48
Proteomic analysis reveals field-wide changes in protein expression in the morphologically normal mucosa of patients with colorectal neoplasia. Cancer Res (2006) 1.48
Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue. Clin Sci (Lond) (2009) 1.47
Human liver stem cells originate from the canals of Hering. Hepatology (2009) 1.46
Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease. Nat Med (2011) 1.45
Noninvasive in vivo magnetic resonance measures of glutathione synthesis in human and rat liver as an oxidative stress biomarker. Hepatology (2014) 1.41
Longitudinal change in food habits between adolescence (11-12 years) and adulthood (32-33 years): the ASH30 Study. J Public Health (Oxf) (2006) 1.39
Fatigue in primary sclerosing cholangitis is associated with sympathetic over-activity and increased cardiac output. Liver Int (2014) 1.38
The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes. J Hepatol (2010) 1.37
Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study. Mech Ageing Dev (2011) 1.36
Are behavioral interventions effective in increasing physical activity at 12 to 36 months in adults aged 55 to 70 years? A systematic review and meta-analysis. BMC Med (2013) 1.32
Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter. J Clin Invest (2010) 1.30
Quantification of mitochondrial DNA mutation load. Aging Cell (2009) 1.29
Splice variants of the human zinc transporter ZnT5 (SLC30A5) are differentially localized and regulated by zinc through transcription and mRNA stability. J Biol Chem (2007) 1.26
Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: interaction with sex. Am J Clin Nutr (2008) 1.26
Chronic renal allograft dysfunction: the role of T cell-mediated tubular epithelial to mesenchymal cell transition. J Am Soc Nephrol (2004) 1.25
A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. Am J Pathol (2006) 1.24
Randomised controlled trial evaluating lifestyle interventions in people with impaired glucose tolerance. Diabetes Res Clin Pract (2005) 1.24
Do we know enough? A scientific and ethical analysis of the basis for genetic-based personalized nutrition. Genes Nutr (2013) 1.23
Non-alcoholic fatty liver disease in older people. Gerontology (2009) 1.22
Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway. Rheumatology (Oxford) (2010) 1.21
A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. J Biol Chem (2002) 1.21
Global LINE-1 DNA methylation is associated with blood glycaemic and lipid profiles. Int J Epidemiol (2012) 1.20
Ectopic SOX9 mediates extracellular matrix deposition characteristic of organ fibrosis. J Biol Chem (2008) 1.20
Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr (2013) 1.19
Signal transduction via the NF-kappaB pathway: a targeted treatment modality for infection, inflammation and repair. Cell Biochem Funct (2004) 1.18
Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies. Genes Nutr (2010) 1.18
Towards measurement of the Healthy Ageing Phenotype in lifestyle-based intervention studies. Maturitas (2013) 1.17
Design and baseline characteristics of the Food4Me study: a web-based randomised controlled trial of personalised nutrition in seven European countries. Genes Nutr (2014) 1.17
Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment. Curr Pharm Des (2013) 1.16
Importance of weight loss maintenance and risk prediction in the prevention of type 2 diabetes: analysis of European Diabetes Prevention Study RCT. PLoS One (2013) 1.16
Prevention of type 2 diabetes in adults with impaired glucose tolerance: the European Diabetes Prevention RCT in Newcastle upon Tyne, UK. BMC Public Health (2009) 1.16
Chemotherapy-associated liver injury in patients with colorectal liver metastases: a systematic review and meta-analysis. Ann Surg Oncol (2012) 1.15
Low-strength T-cell activation promotes Th17 responses. Blood (2010) 1.15
Relative abundance of selenoprotein P isoforms in human plasma depends on genotype, se intake, and cancer status. Antioxid Redox Signal (2009) 1.15
Online dietary intake estimation: the Food4Me food frequency questionnaire. J Med Internet Res (2014) 1.14
Quality really matters: the need to improve specimen quality in biomedical research. Histopathology (2012) 1.14
Comparison of methods for quantification of global DNA methylation in human cells and tissues. PLoS One (2013) 1.14
Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study. Am J Clin Nutr (2008) 1.13
Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1. J Biol Chem (2003) 1.13
Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12. PLoS One (2012) 1.12
Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-kappaB, AP-1 and Sp1. Int J Biochem Cell Biol (2004) 1.12
Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer. Cancer Epidemiol Biomarkers Prev (2004) 1.12
CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1. J Biol Chem (2002) 1.12
Alcoholic liver disease. Semin Diagn Pathol (2007) 1.12
Bioethical considerations for human nutrigenomics. Annu Rev Nutr (2008) 1.11
Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis. Hepatology (2010) 1.11
ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells. J Biol Chem (2007) 1.10
Fibrosis and cirrhosis reversibility - molecular mechanisms. Clin Liver Dis (2008) 1.10
The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies. J Hepatol (2011) 1.09
The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation. Hepatology (2010) 1.09