Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients.

PubWeight™: 2.53‹?› | Rank: Top 2%

🔗 View Article (PMC 3488197)

Published in J Infect Dis on September 14, 2012

Authors

Gang Sun1, Tao Luo, Chongguang Yang, Xinran Dong, Jing Li, Yongqiang Zhu, Huajun Zheng, Weidong Tian, Shengyue Wang, Clifton E Barry, Jian Mei, Qian Gao

Author Affiliations

1: Key Laboratory of Medical Molecular Virology, Institutes of Biomedical Sciences and Institute of Medical Microbiology, Fudan University, Shanghai, China.

Articles citing this

Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis. Nat Genet (2013) 2.80

Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures. Nat Genet (2013) 2.59

Inferring patient to patient transmission of Mycobacterium tuberculosis from whole genome sequencing data. BMC Infect Dis (2013) 2.01

Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis. Nat Genet (2013) 1.93

The association between sterilizing activity and drug distribution into tuberculosis lesions. Nat Med (2015) 1.40

Microbial persistence and the road to drug resistance. Cell Host Microbe (2013) 1.37

Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis. Nat Commun (2015) 1.34

Whole genome sequencing reveals complex evolution patterns of multidrug-resistant Mycobacterium tuberculosis Beijing strains in patients. PLoS One (2013) 1.30

Whole-genome sequencing to control antimicrobial resistance. Trends Genet (2014) 1.25

Evolution of extensively drug-resistant Mycobacterium tuberculosis from a susceptible ancestor in a single patient. Genome Biol (2014) 1.17

High risk and rapid appearance of multidrug resistance during tuberculosis treatment in Moldova. Eur Respir J (2014) 1.04

Genomic diversity in autopsy samples reveals within-host dissemination of HIV-associated Mycobacterium tuberculosis. Nat Med (2016) 1.03

Epistasis between antibiotic resistance mutations drives the evolution of extensively drug-resistant tuberculosis. Evol Med Public Health (2013) 1.02

Complex genetics of drug resistance in Mycobacterium tuberculosis. Nat Genet (2013) 1.01

Genomic insights into the fate of colistin resistance and Acinetobacter baumannii during patient treatment. Genome Res (2013) 1.00

High proportion of heteroresistance in gyrA and gyrB in fluoroquinolone-resistant Mycobacterium tuberculosis clinical isolates. Antimicrob Agents Chemother (2014) 0.99

Acetylome analysis reveals diverse functions of lysine acetylation in Mycobacterium tuberculosis. Mol Cell Proteomics (2014) 0.99

Diversity and evolution of Mycobacterium tuberculosis: moving to whole-genome-based approaches. Cold Spring Harb Perspect Med (2014) 0.98

Correlation between GyrA substitutions and ofloxacin, levofloxacin, and moxifloxacin cross-resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother (2015) 0.96

Within-host evolution of bacterial pathogens. Nat Rev Microbiol (2016) 0.94

Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis. N Engl J Med (2015) 0.92

Within patient microevolution of Mycobacterium tuberculosis correlates with heterogeneous responses to treatment. Sci Rep (2015) 0.91

Frequency and geographic distribution of gyrA and gyrB mutations associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis isolates: a systematic review. PLoS One (2015) 0.90

Genome specialization and decay of the strangles pathogen, Streptococcus equi, is driven by persistent infection. Genome Res (2015) 0.87

Whole genome sequencing reveals genomic heterogeneity and antibiotic purification in Mycobacterium tuberculosis isolates. BMC Genomics (2015) 0.82

Succinylome analysis reveals the involvement of lysine succinylation in metabolism in pathogenic Mycobacterium tuberculosis. Mol Cell Proteomics (2015) 0.82

Diversity of Mycobacterium tuberculosis across Evolutionary Scales. PLoS Pathog (2015) 0.81

Simplified microarray system for simultaneously detecting rifampin, isoniazid, ethambutol, and streptomycin resistance markers in Mycobacterium tuberculosis. J Clin Microbiol (2014) 0.81

Interpreting whole genome sequencing for investigating tuberculosis transmission: a systematic review. BMC Med (2016) 0.80

Detecting novel genetic variants associated with isoniazid-resistant Mycobacterium tuberculosis. PLoS One (2014) 0.80

The population genetics of drug resistance evolution in natural populations of viral, bacterial and eukaryotic pathogens. Mol Ecol (2015) 0.79

A phylogeny-based sampling strategy and power calculator informs genome-wide associations study design for microbial pathogens. Genome Med (2014) 0.79

The surprising diversity of Mycobacterium tuberculosis: change you can believe in. J Infect Dis (2012) 0.79

Transmission of multidrug-resistant Mycobacterium tuberculosis in Shanghai, China: a retrospective observational study using whole-genome sequencing and epidemiological investigation. Lancet Infect Dis (2016) 0.78

Deep Whole-Genome Sequencing to Detect Mixed Infection of Mycobacterium tuberculosis. PLoS One (2016) 0.77

Whole genome sequencing to complement tuberculosis drug resistance surveys in Uganda. Infect Genet Evol (2016) 0.77

Whole genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis Beijing isolates from an outbreak in Thailand. Mol Genet Genomics (2015) 0.77

Potential for adaptation overrides cost of resistance. Future Microbiol (2015) 0.76

Trade-Offs of Escherichia coli Adaptation to an Intracellular Lifestyle in Macrophages. PLoS One (2016) 0.76

Whole genome sequencing reveals mycobacterial microevolution among concurrent isolates from sputum and blood in HIV infected TB patients. BMC Infect Dis (2016) 0.76

Translating genomics research into control of tuberculosis: lessons learned and future prospects. Genome Biol (2014) 0.75

The Influence of HIV on The Evolution of Mycobacterium tuberculosis. Mol Biol Evol (2017) 0.75

Genome sequence comparisons of serial multi-drug-resistant Mycobacterium tuberculosis isolates over 21 years of infection in a single patient. Microb Genom (2015) 0.75

Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity. PLoS Pathog (2016) 0.75

The road to drug resistance in Mycobacterium tuberculosis. Genome Biol (2014) 0.75

Whole-Genome Sequencing Analysis of Serially Isolated Multi-Drug and Extensively Drug Resistant Mycobacterium tuberculosis from Thai Patients. PLoS One (2016) 0.75

The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy. Genome Biol (2017) 0.75

Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage. PLoS One (2016) 0.75

Treating tuberculosis with high doses of anti-TB drugs: mechanisms and outcomes. Ann Clin Microbiol Antimicrob (2017) 0.75

Articles cited by this

The Sequence Alignment/Map format and SAMtools. Bioinformatics (2009) 232.39

Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics (2009) 190.94

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature (1998) 60.62

A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet (2011) 59.36

The fate of competing beneficial mutations in an asexual population. Genetica (1998) 9.60

Variable host-pathogen compatibility in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2006) 8.90

Evaluation of the analytical performance of the Xpert MTB/RIF assay. J Clin Microbiol (2010) 7.90

The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. Science (2006) 5.41

Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis. Science (1996) 4.51

Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nat Genet (2011) 4.19

Tuberculosis drug resistance mutation database. PLoS Med (2009) 4.13

Relationship between rifampin MICs for and rpoB mutations of Mycobacterium tuberculosis strains isolated in Japan. Antimicrob Agents Chemother (1996) 3.82

Clonal interference and the evolution of RNA viruses. Science (1999) 3.68

Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa. PLoS One (2009) 3.68

Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes. Nat Genet (2011) 3.44

Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model. Infect Immun (2009) 3.31

Error correction of next-generation sequencing data and reliable estimation of HIV quasispecies. Nucleic Acids Res (2010) 3.31

Adaptive mutations in bacteria: high rate and small effects. Science (2007) 3.12

Genome-wide mutational diversity in an evolving population of Escherichia coli. Cold Spring Harb Symp Quant Biol (2009) 3.03

Mycobacterium tuberculosis growth at the cavity surface: a microenvironment with failed immunity. Infect Immun (2003) 3.01

Molecular characterization of clonal interference during adaptive evolution in asexual populations of Saccharomyces cerevisiae. Nat Genet (2008) 2.98

Feasibility of the GenoType MTBDRsl assay for fluoroquinolone, amikacin-capreomycin, and ethambutol resistance testing of Mycobacterium tuberculosis strains and clinical specimens. J Clin Microbiol (2009) 2.75

Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria. Nature (2004) 2.57

Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs. J Antimicrob Chemother (2011) 2.29

Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution. Res Microbiol (2004) 2.23

The effect of drug resistance on the fitness of Mycobacterium tuberculosis. Lancet Infect Dis (2003) 2.17

Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection. PLoS Pathog (2011) 2.13

Heteroresistance in Mycobacterium tuberculosis. Int J Tuberc Lung Dis (2001) 2.10

Fitness cost of chromosomal drug resistance-conferring mutations. Antimicrob Agents Chemother (2002) 2.07

Fitness of antibiotic-resistant microorganisms and compensatory mutations. Nat Med (1998) 1.94

The tempo and mode of molecular evolution of Mycobacterium tuberculosis at patient-to-patient scale. Infect Genet Evol (2009) 1.76

Genetic polymorphism in Mycobacterium tuberculosis isolates from patients with chronic multidrug-resistant tuberculosis. J Infect Dis (2004) 1.75

Genetic Manipulation of Mycobacterium tuberculosis. Curr Protoc Microbiol (2007) 1.68

The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa. BMC Genomics (2010) 1.54

Quantitative sputum bacillary load during rifampin-containing short course chemotherapy in human immunodeficiency virus-infected and non-infected adults with pulmonary tuberculosis. Int J Tuberc Lung Dis (2000) 1.51

Directed mutagenesis of Mycobacterium smegmatis 16S rRNA to reconstruct the in vivo evolution of aminoglycoside resistance in Mycobacterium tuberculosis. Mol Microbiol (2010) 1.47

Tuberculosis: drug resistance, fitness, and strategies for global control. Eur J Pediatr (2007) 1.41

Complete genome sequences of Mycobacterium tuberculosis strains CCDC5079 and CCDC5080, which belong to the Beijing family. J Bacteriol (2011) 1.38

Rapid detection of fluoroquinolone-resistant and heteroresistant Mycobacterium tuberculosis by use of sloppy molecular beacons and dual melting-temperature codes in a real-time PCR assay. J Clin Microbiol (2010) 1.30

Highly polymorphic variable-number tandem repeats loci for differentiating Beijing genotype strains of Mycobacterium tuberculosis in Shanghai, China. FEMS Microbiol Lett (2008) 1.29

Next-generation sequencing as a tool to study microbial evolution. Mol Ecol (2010) 1.20

Time to detection of Mycobacterium tuberculosis as an alternative to quantitative cultures. Tuberculosis (Edinb) (2011) 1.13

Selection of mutations to detect multidrug-resistant Mycobacterium tuberculosis strains in Shanghai, China. Antimicrob Agents Chemother (2009) 1.08

Deep resequencing of serial sputum isolates of Mycobacterium tuberculosis during therapeutic failure due to poor compliance reveals stepwise mutation of key resistance genes on an otherwise stable genetic background. J Infect (2011) 1.06

Dynamics of antibiotic resistant Mycobacterium tuberculosis during long-term infection and antibiotic treatment. PLoS One (2011) 1.06

The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis. Chem Biol (2009) 1.04

Stereological analysis of bacterial load and lung lesions in nonhuman primates (rhesus macaques) experimentally infected with Mycobacterium tuberculosis. Am J Physiol Lung Cell Mol Physiol (2011) 0.94

Drug resistance evolution of a Mycobacterium tuberculosis strain from a noncompliant patient. J Clin Microbiol (2005) 0.92

Mutations in extensively drug-resistant Mycobacterium tuberculosis that do not code for known drug-resistance mechanisms. J Infect Dis (2010) 0.90

Enhanced heterogeneity of rpoB in Mycobacterium tuberculosis found at low pH. J Antimicrob Chemother (2009) 0.85

Articles by these authors

Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67

Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30

Prevalence of and risk factors for resistance to second-line drugs in people with multidrug-resistant tuberculosis in eight countries: a prospective cohort study. Lancet (2012) 6.78

Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A (2008) 6.42

Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med (2011) 6.35

A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response. Nature (2004) 6.29

Linezolid for treatment of chronic extensively drug-resistant tuberculosis. N Engl J Med (2012) 5.87

Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell (2010) 5.77

Global diversity in the human salivary microbiome. Genome Res (2009) 5.16

Metabolite identification via the Madison Metabolomics Consortium Database. Nat Biotechnol (2008) 5.12

Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infect Immun (2008) 4.93

A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biol (2008) 4.78

The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action. J Biol Chem (2004) 4.75

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science (2008) 4.74

A large-scale evaluation of computational protein function prediction. Nat Methods (2013) 4.61

Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res (2011) 4.55

Confronting the scientific obstacles to global control of tuberculosis. J Clin Invest (2008) 4.41

Sequence and analysis of rice chromosome 4. Nature (2002) 4.39

Tuberculosis - metabolism and respiration in the absence of growth. Nat Rev Microbiol (2005) 4.38

Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science (2011) 4.13

IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest (2008) 4.12

Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol (2011) 4.09

Modification of kidney barrier function by the urokinase receptor. Nat Med (2007) 4.01

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2005) 3.97

Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. Nat Genet (2013) 3.89

Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis. Science (2009) 3.73

Exchange-coupled nanocomposite magnets by nanoparticle self-assembly. Nature (2002) 3.71

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55

Age and the epidemiology and pathogenesis of tuberculosis. Lancet (2010) 3.37

DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosis. Cell (2003) 3.36

Tuberculosis: what we don't know can, and does, hurt us. Science (2010) 3.29

Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Sci Transl Med (2011) 3.19

Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17

Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Lancet (2010) 3.15

Mycobacterium tuberculosis growth at the cavity surface: a microenvironment with failed immunity. Infect Immun (2003) 3.01

Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance. Infect Immun (2005) 2.89

Circulating suPAR in two cohorts of primary FSGS. J Am Soc Nephrol (2012) 2.83

Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phagosomes indicates pathogen-induced microenvironments within the host cell's endosomal system. J Immunol (2005) 2.80

Neutrophils are the predominant infected phagocytic cells in the airways of patients with active pulmonary TB. Chest (2009) 2.78

Whole-brain radiotherapy in the management of brain metastasis. J Clin Oncol (2006) 2.76

Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases. J Clin Oncol (2010) 2.72

Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J (2009) 2.69

STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol (2009) 2.67

Combinatorial lead optimization of [1,2]-diamines based on ethambutol as potential antituberculosis preclinical candidates. J Comb Chem (2003) 2.63

The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice. Proc Natl Acad Sci U S A (2003) 2.60

Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A (2003) 2.54

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A (2003) 2.50

Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli. J Infect Dis (2005) 2.50

Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis. Infect Immun (2004) 2.47

The W-Beijing lineage of Mycobacterium tuberculosis overproduces triglycerides and has the DosR dormancy regulon constitutively upregulated. J Bacteriol (2007) 2.42

SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob Agents Chemother (2012) 2.41

Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis. J Med Chem (2006) 2.37

N-Benzyl-2-(2,6-dichloro-phen-oxy)-acetamide. Acta Crystallogr Sect E Struct Rep Online (2008) 2.36

Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol (2006) 2.32

Control of the pattern-recognition receptor EFR by an ER protein complex in plant immunity. EMBO J (2009) 2.28

Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab (2011) 2.22

Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci U S A (2007) 2.20

Project management system for structural and functional proteomics: Sesame. J Struct Funct Genomics (2003) 2.19

New bioinformatics resources for metabolomics. Pac Symp Biocomput (2007) 2.19

Regulation of human airway epithelial cell IL-8 expression by MAP kinases. Am J Physiol Lung Cell Mol Physiol (2002) 2.19

Effects of vacuum-assisted closure on wound microcirculation: an experimental study. Asian J Surg (2005) 2.14

A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. Circ Res (2006) 2.12

Proteasomal protein degradation in Mycobacteria is dependent upon a prokaryotic ubiquitin-like protein. J Biol Chem (2008) 2.12

Generation of functional ion-channel tools by E3 targeting. Nat Biotechnol (2005) 2.08

The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Exp Diabetes Res (2009) 2.08

Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. Haematologica (2007) 2.07

Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease. Environ Health Perspect (2012) 2.05

Learning brain connectivity of Alzheimer's disease by sparse inverse covariance estimation. Neuroimage (2010) 2.04

A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. J Biol Chem (2005) 2.03

Isoform discovery by targeted cloning, 'deep-well' pooling and parallel sequencing. Nat Methods (2008) 2.03

Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv. PLoS One (2008) 2.01

Synthesis and functional analyses of nuclear clusterin, a cell death protein. J Biol Chem (2003) 2.01

Expression of midkine and endoglin in breast carcinomas with different immunohistochemical profiles. APMIS (2010) 2.00

The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis. J Biol Chem (2004) 1.99

Effect of otitis media with effusion and its clinical intervention on the development of mastoid in children. Acta Otolaryngol (2014) 1.98

TRPC channel activation by extracellular thioredoxin. Nature (2008) 1.97

Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem (2005) 1.95

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. Proc Natl Acad Sci U S A (2009) 1.94

Prospects for new antitubercular drugs. Curr Opin Microbiol (2004) 1.94

Transmission of MDR and XDR tuberculosis in Shanghai, China. PLoS One (2009) 1.93

Thermal difference spectra: a specific signature for nucleic acid structures. Nucleic Acids Res (2005) 1.91

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc Natl Acad Sci U S A (2009) 1.89

Hypoxic response of Mycobacterium tuberculosis studied by metabolic labeling and proteome analysis of cellular and extracellular proteins. J Bacteriol (2002) 1.86

Comprehensive analysis of NAC domain transcription factor gene family in Populus trichocarpa. BMC Plant Biol (2010) 1.84

Phase I study of ON 01910.Na, a novel modulator of the Polo-like kinase 1 pathway, in adult patients with solid tumors. J Clin Oncol (2008) 1.84

A conserved Tyr residue is required for sugar selectivity in a Pol alpha DNA polymerase. Biochemistry (2002) 1.81

Using spatial principles to optimize distributed computing for enabling the physical science discoveries. Proc Natl Acad Sci U S A (2011) 1.81

Chinese authors do need CONSORT: reporting quality assessment for five leading Chinese medical journals. Contemp Clin Trials (2008) 1.80

HIV incidence among men who have sex with men in China: a meta-analysis of published studies. PLoS One (2011) 1.79

Chlorophyllase 1, a damage control enzyme, affects the balance between defense pathways in plants. Plant Cell (2004) 1.76

Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation. Blood (2013) 1.75

EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One (2011) 1.73

Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci (2010) 1.73

Beta-AMYLASE4, a noncatalytic protein required for starch breakdown, acts upstream of three active beta-amylases in Arabidopsis chloroplasts. Plant Cell (2008) 1.72

Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions. Biochem Biophys Res Commun (2006) 1.72