Published in Cell on September 28, 2012
Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell (2013) 8.37
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 6.49
Revisiting global gene expression analysis. Cell (2012) 3.63
Epigenetic reprogramming in cancer. Science (2013) 3.47
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet (2014) 3.17
Transcriptional regulation and its misregulation in disease. Cell (2013) 2.92
The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature (2015) 2.63
Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature (2014) 2.38
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles. Nature (2014) 2.33
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell (2013) 2.24
From single-cell to cell-pool transcriptomes: stochasticity in gene expression and RNA splicing. Genome Res (2013) 2.23
MYC, metabolism, cell growth, and tumorigenesis. Cold Spring Harb Perspect Med (2013) 2.19
BET bromodomains mediate transcriptional pause release in heart failure. Cell (2013) 2.17
Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies. Nat Med (2013) 2.10
Mechanisms and models of somatic cell reprogramming. Nat Rev Genet (2013) 2.09
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med (2014) 2.08
Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming. Cell (2015) 2.06
Global regulation of promoter melting in naive lymphocytes. Cell (2013) 2.05
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature (2016) 1.95
MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis. Nature (2015) 1.90
Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis. Cancer Cell (2015) 1.88
MYC regulates the antitumor immune response through CD47 and PD-L1. Science (2016) 1.87
Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor. Cancer Cell (2014) 1.84
Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell (2013) 1.80
Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus. Elife (2014) 1.80
Chromatin dynamics during cellular reprogramming. Nature (2013) 1.79
Epigenetics of reprogramming to induced pluripotency. Cell (2013) 1.73
Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol (2013) 1.70
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nat Genet (2014) 1.67
A continuous molecular roadmap to iPSC reprogramming through progression analysis of single-cell mass cytometry. Cell Stem Cell (2015) 1.67
Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation. Cell Stem Cell (2015) 1.65
Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas. Nat Genet (2016) 1.63
Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. Nat Cell Biol (2015) 1.61
c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells. Nat Immunol (2014) 1.57
Regulation of MYC expression and differential JQ1 sensitivity in cancer cells. PLoS One (2014) 1.57
Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer. Clin Cancer Res (2013) 1.56
An overview of MYC and its interactome. Cold Spring Harb Perspect Med (2014) 1.53
Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov (2014) 1.53
MYC activation is a hallmark of cancer initiation and maintenance. Cold Spring Harb Perspect Med (2014) 1.51
Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms. Mol Cell (2015) 1.48
MYC: connecting selective transcriptional control to global RNA production. Nat Rev Cancer (2015) 1.47
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. Cancer Res (2013) 1.46
The role of histone demethylase KDM4B in Myc signaling in neuroblastoma. J Natl Cancer Inst (2015) 1.46
CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer. Cell (2014) 1.45
Replication stress and cancer. Nat Rev Cancer (2015) 1.43
MYC degradation. Cold Spring Harb Perspect Med (2014) 1.42
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep (2013) 1.41
Genome-wide control of RNA polymerase II activity by cohesin. PLoS Genet (2013) 1.38
MYC through miR-17-92 suppresses specific target genes to maintain survival, autonomous proliferation, and a neoplastic state. Cancer Cell (2014) 1.36
Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell (2014) 1.33
Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond. Nat Rev Cancer (2012) 1.33
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes Dev (2013) 1.30
MYC, Metabolism, and Cancer. Cancer Discov (2015) 1.29
MYC regulates the non-coding transcriptome. Oncotarget (2014) 1.29
RNA polymerase II transcription elongation control. Chem Rev (2013) 1.27
Direct reprogramming by oncogenic Ras and Myc. Proc Natl Acad Sci U S A (2013) 1.26
Transcription factor trapping by RNA in gene regulatory elements. Science (2015) 1.24
c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood (2014) 1.23
Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity. J Clin Invest (2015) 1.21
Genome-wide association of Yorkie with chromatin and chromatin-remodeling complexes. Cell Rep (2013) 1.19
Taming of the beast: shaping Myc-dependent amplification. Trends Cell Biol (2014) 1.19
Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci (2014) 1.16
Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC. Mol Cell (2015) 1.16
The transcriptional regulation of pluripotency. Cell Res (2012) 1.15
Inhibitor of MYC identified in a Kröhnke pyridine library. Proc Natl Acad Sci U S A (2014) 1.14
The developmental potential of iPSCs is greatly influenced by reprogramming factor selection. Cell Stem Cell (2014) 1.13
Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev (2016) 1.13
Oncogenic mechanisms in Burkitt lymphoma. Cold Spring Harb Perspect Med (2014) 1.12
MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells. Proc Natl Acad Sci U S A (2015) 1.11
4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells. Genome Biol (2014) 1.10
Genome recognition by MYC. Cold Spring Harb Perspect Med (2014) 1.10
The dynamic control of signal transduction networks in cancer cells. Nat Rev Cancer (2015) 1.09
MYC and metabolism on the path to cancer. Semin Cell Dev Biol (2015) 1.09
Regulation of mammalian nucleotide metabolism and biosynthesis. Nucleic Acids Res (2015) 1.08
Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes. Nat Genet (2015) 1.08
Amplitude modulation of androgen signaling by c-MYC. Genes Dev (2013) 1.08
CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. Genes Dev (2014) 1.07
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res (2015) 1.06
Roles for MYC in the establishment and maintenance of pluripotency. Cold Spring Harb Perspect Med (2013) 1.06
Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma. Haematologica (2013) 1.05
Molecular Pathways: Targeting MYC-induced metabolic reprogramming and oncogenic stress in cancer. Clin Cancer Res (2013) 1.04
Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis. Nat Med (2015) 1.04
Role of PI3K-AKT-mTOR and Wnt Signaling Pathways in Transition of G1-S Phase of Cell Cycle in Cancer Cells. Front Oncol (2013) 1.02
Epstein-Barr virus and Burkitt lymphoma. Chin J Cancer (2014) 1.02
Quantifying ChIP-seq data: a spiking method providing an internal reference for sample-to-sample normalization. Genome Res (2014) 1.02
New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK. Clin Cancer Res (2013) 1.02
Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis. Biochim Biophys Acta (2014) 1.02
Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Neuron (2015) 1.02
Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells. BMC Cancer (2014) 1.01
MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression. Oncotarget (2015) 1.01
Stability selection for regression-based models of transcription factor-DNA binding specificity. Bioinformatics (2013) 1.01
Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis. Mol Cell Biol (2013) 1.01
Regulation of miRNA biogenesis and turnover in the immune system. Immunol Rev (2013) 1.00
Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development. Epigenetics Chromatin (2013) 1.00
Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia. Blood (2013) 0.99
Transcriptome-wide variability in single embryonic development cells. Sci Rep (2014) 0.99
CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer. EMBO Mol Med (2013) 0.99
Small-molecule inhibitors of the Myc oncoprotein. Biochim Biophys Acta (2014) 0.98
Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs. Cancer Cell (2016) 0.98
L-Myc expression by dendritic cells is required for optimal T-cell priming. Nature (2014) 0.98
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol (2009) 235.12
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63
The landscape of somatic copy-number alteration across human cancers. Nature (2010) 31.88
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science (2002) 17.38
Direct multiplexed measurement of gene expression with color-coded probe pairs. Nat Biotechnol (2008) 15.90
Mediator and cohesin connect gene expression and chromatin architecture. Nature (2010) 14.34
Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science (1991) 12.00
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
Genomic targets of the human c-Myc protein. Genes Dev (2003) 9.67
MYC on the path to cancer. Cell (2012) 8.65
Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell (1999) 8.03
Myc's broad reach. Genes Dev (2008) 7.56
Reflecting on 25 years with MYC. Nat Rev Cancer (2008) 7.44
A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc Natl Acad Sci U S A (2003) 7.30
MYC oncogenes and human neoplastic disease. Oncogene (1999) 7.28
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet (2009) 6.99
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 6.49
Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature (1984) 6.23
Forcing cells to change lineages. Nature (2009) 5.99
The c-Myc target gene network. Semin Cancer Biol (2006) 5.98
Modelling Myc inhibition as a cancer therapy. Nature (2008) 5.81
Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation. Cell (1991) 5.76
Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A (2006) 5.27
Enhancer function: new insights into the regulation of tissue-specific gene expression. Nat Rev Genet (2011) 5.27
Functional and mechanistic diversity of distal transcription enhancers. Cell (2011) 5.22
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nat Cell Biol (2005) 4.89
Myc-binding-site recognition in the human genome is determined by chromatin context. Nat Cell Biol (2006) 4.71
An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol (2003) 4.49
Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol Cell (1999) 4.38
The transcriptional program of a human B cell line in response to Myc. Nucleic Acids Res (2001) 4.08
Control of cell growth by c-Myc in the absence of cell division. Curr Biol (1999) 3.90
c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription. Nat Cell Biol (2005) 3.79
MYC as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer (2010) 3.64
Myc pathways provoking cell suicide and cancer. Oncogene (2003) 3.49
Direct activation of RNA polymerase III transcription by c-Myc. Nature (2003) 3.32
Myc and Max associate in vivo. Genes Dev (1992) 3.16
RNA polymerase II elongation control. Annu Rev Biochem (2012) 3.09
Myc and the cell cycle. Front Biosci (1998) 2.88
The molecular role of Myc in growth and transformation: recent discoveries lead to new insights. FASEB J (1998) 2.86
Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma. Proc Natl Acad Sci U S A (2000) 2.81
Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells. Mol Cell Biol (2010) 2.80
Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. Cancer Res (2010) 2.77
The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming. Cell Stem Cell (2009) 2.72
Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter. J Biol Chem (2002) 2.68
Cell cycle activation by c-myc in a burkitt lymphoma model cell line. Int J Cancer (2000) 2.59
Apoptotic signaling by c-MYC. Oncogene (2008) 2.57
Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells. PLoS One (2008) 2.51
c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism. J Biol Chem (2001) 2.36
A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response. PLoS One (2009) 2.29
c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis. Oncogene (2003) 2.21
Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins. EMBO J (2004) 2.19
Endogenous Myc maintains the tumor microenvironment. Genes Dev (2011) 2.16
Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification. Oncogene (2006) 2.14
Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally. Mol Cell Biol (1991) 2.06
Function of the c-Myc oncoprotein in chromatin remodeling and transcription. Biochim Biophys Acta (2001) 2.02
Dissection of transcriptional programmes in response to serum and c-Myc in a human B-cell line. Oncogene (2005) 1.93
Chromosome crosstalk in three dimensions. Nature (2009) 1.91
Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer. J Cell Biochem (2008) 1.77
Transcription-independent functions of MYC: regulation of translation and DNA replication. Nat Rev Mol Cell Biol (2008) 1.72
Facilitating replication under stress: an oncogenic function of MYC? Nat Rev Cancer (2009) 1.56
The role of Myc-induced protein synthesis in cancer. Cancer Res (2009) 1.54
Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation. PLoS One (2011) 1.53
myc family oncogene amplification in tumor cell lines established from small cell lung cancer patients and its relationship to clinical status and course. J Clin Invest (1987) 1.43
P-TEFb is a crucial co-factor for Myc transactivation. Cell Cycle (2007) 1.39
Tumor angiogenesis: cause or consequence of cancer? Cancer Res (2007) 1.35
c-Myc: linking transformation and genomic instability. Curr Mol Med (2008) 1.35
Defining the temporal requirements for Myc in the progression and maintenance of skin neoplasia. Oncogene (2004) 1.32
Myc: a weapon of mass destruction. Cell (2004) 1.29
SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation. Mol Cell (2009) 1.26
An extended Myc network contributes to glucose homeostasis in cancer and diabetes. Front Biosci (Landmark Ed) (2011) 1.14
Determination of copy number of c-Myc protein per cell by quantitative Western blotting. Anal Biochem (1999) 1.13
c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc. Cell Cycle (2007) 1.12
c-Myc and eIF4F constitute a feedforward loop that regulates cell growth: implications for anticancer therapy. Cancer Res (2009) 1.08
Myc, cell competition, and compensatory proliferation. Cancer Res (2005) 1.00
Differential expression of myc, max and RB1 genes in human gliomas and glioma cell lines. Br J Cancer (1994) 0.98
Functions of myc:max in the control of cell proliferation and tumorigenesis. Int Rev Cytol (2004) 0.96
c-Myc, Genomic Instability and Disease. Genome Dyn (2006) 0.96
Reconstitution of an E box-binding Myc:Max complex with recombinant full-length proteins expressed in Escherichia coli. Protein Expr Purif (2004) 0.96
Myc Regulation of mRNA Cap Methylation. Genes Cancer (2010) 0.92
Kinetic analysis of the interaction of b/HLH/Z transcription factors Myc, Max, and Mad with cognate DNA. Biochemistry (2010) 0.90
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
Prediction of mammalian microRNA targets. Cell (2003) 53.70
Alternative isoform regulation in human tissue transcriptomes. Nature (2008) 52.76
Transcriptional regulatory networks in Saccharomyces cerevisiae. Science (2002) 43.52
Most mammalian mRNAs are conserved targets of microRNAs. Genome Res (2008) 37.16
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Transcriptional regulatory code of a eukaryotic genome. Nature (2004) 27.21
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science (2005) 20.51
A uniform system for microRNA annotation. RNA (2003) 20.28
Prediction of plant microRNA targets. Cell (2002) 19.20
Selective inhibition of BET bromodomains. Nature (2010) 18.79
The microRNAs of Caenorhabditis elegans. Genes Dev (2003) 17.70
Vertebrate microRNA genes. Science (2003) 17.42
Predictive identification of exonic splicing enhancers in human genes. Science (2002) 16.86
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
Genome-wide map of nucleosome acetylation and methylation in yeast. Cell (2005) 15.08
Mediator and cohesin connect gene expression and chromatin architecture. Nature (2010) 14.34
BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell (2011) 14.34
Control of pancreas and liver gene expression by HNF transcription factors. Science (2004) 12.05
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell (2003) 11.78
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature (2011) 11.44
Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science (2008) 11.33
Divergent transcription from active promoters. Science (2008) 11.03
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science (2007) 10.60
Analysis and design of RNA sequencing experiments for identifying isoform regulation. Nat Methods (2010) 10.13
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev (2002) 10.06
RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat Genet (2007) 9.56
Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell (2013) 9.55
Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals. J Comput Biol (2004) 9.00
Systematic identification and analysis of exonic splicing silencers. Cell (2004) 8.50
Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell (2013) 8.37
Super-enhancers in the control of cell identity and disease. Cell (2013) 7.50
An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data. PLoS Comput Biol (2009) 7.47
Chromatin immunoprecipitation and microarray-based analysis of protein location. Nat Protoc (2006) 7.29
Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell (2011) 7.03
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A (2006) 6.80
Computational discovery of gene modules and regulatory networks. Nat Biotechnol (2003) 6.55
Determinants of targeting by endogenous and exogenous microRNAs and siRNAs. RNA (2007) 6.44
Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays. Nat Genet (2004) 6.33
Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. RNA (2008) 6.29
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A (2005) 6.26
Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature (2007) 5.81
Variation in alternative splicing across human tissues. Genome Biol (2004) 5.70
Global and Hox-specific roles for the MLL1 methyltransferase. Proc Natl Acad Sci U S A (2005) 5.53
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res (2007) 5.45
Identification and analysis of alternative splicing events conserved in human and mouse. Proc Natl Acad Sci U S A (2005) 5.26
Human macrophage activation programs induced by bacterial pathogens. Proc Natl Acad Sci U S A (2002) 5.18
Evidence for an instructive mechanism of de novo methylation in cancer cells. Nat Genet (2006) 4.97
Direct inhibition of the NOTCH transcription factor complex. Nature (2009) 4.82
Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev (2007) 4.79
Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev (2008) 4.77
Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo. Genes Dev (2007) 4.59
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell (2010) 4.59
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues. Science (2012) 4.52
Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell (2008) 4.43
Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Mol Cell (2010) 4.36
Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. Mol Cell (2002) 4.35
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell (2010) 4.32
The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science (2013) 4.20
Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling. Cell (2003) 4.12
Insights into host responses against pathogens from transcriptional profiling. Nat Rev Microbiol (2005) 4.11
SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state. Genes Dev (2009) 4.09
Activated signal transduction kinases frequently occupy target genes. Science (2006) 4.01
Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell (2011) 3.94
Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex. Genes Dev (2002) 3.93
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell (2008) 3.90
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A (2005) 3.86
General and specific functions of exonic splicing silencers in splicing control. Mol Cell (2006) 3.76
Biased chromatin signatures around polyadenylation sites and exons. Mol Cell (2009) 3.74
High-resolution computational models of genome binding events. Nat Biotechnol (2006) 3.74
Global position and recruitment of HATs and HDACs in the yeast genome. Mol Cell (2004) 3.74
RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons. Nucleic Acids Res (2004) 3.70
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature (2012) 3.67
Revisiting global gene expression analysis. Cell (2012) 3.63