Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN status.

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Published in Mol Cancer on October 05, 2012

Authors

Sara A Byron1, David C Loch, Candice L Wellens, Andreas Wortmann, Jiayi Wu, John Wang, Kenichi Nomoto, Pamela M Pollock

Author Affiliations

1: Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA.

Associated clinical trials:

Investigate Safety, Pharmacokinetics and Pharmacodynamics of GSK2118436 & GSK1120212 | NCT01072175

A Study of Vemurafenib and GDC-0973 (Cobimetinib) in Participants With BRAFV600E Mutation-Positive Metastatic Melanoma | NCT01271803

NCT01510444

A Phase 1, Multicenter, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of E6201 in Subjects With Advanced Solid Tumors | NCT00794781

A Rollover Study to Provide Continued Treatment With GSK2118436 to Subjects With BRAF Mutation-Positive Tumors | NCT01231594

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