Published in PLoS One on October 03, 2012
Glycation exacerbates the neuronal toxicity of β-amyloid. Cell Death Dis (2013) 0.88
The domestic cat as a natural animal model of Alzheimer's disease. Acta Neuropathol Commun (2015) 0.77
Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX. Acta Neuropathol Commun (2016) 0.76
Paraptosis triggers mitochondrial pathway-mediated apoptosis in Alzheimer's disease. Exp Ther Med (2015) 0.76
Identification of the PLA2G6 c.1579G>A Missense Mutation in Papillon Dog Neuroaxonal Dystrophy Using Whole Exome Sequencing Analysis. PLoS One (2017) 0.75
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51
Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (1991) 49.03
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science (2003) 18.18
Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci (2003) 8.44
Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J (1990) 3.36
The late Miocene radiation of modern Felidae: a genetic assessment. Science (2006) 3.35
Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science (1987) 3.23
Animal models of Alzheimer's disease and frontotemporal dementia. Nat Rev Neurosci (2008) 3.19
The GSK3 hypothesis of Alzheimer's disease. J Neurochem (2007) 3.16
Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol (2011) 2.94
A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci (2010) 2.22
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. Nat Med (2008) 2.01
Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. J Neurosci (2004) 1.92
Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci (2009) 1.88
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β. Nature (2012) 1.77
On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry (2006) 1.72
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. Proc Natl Acad Sci U S A (1998) 1.71
Argyrophilic grain disease is a sporadic 4-repeat tauopathy. J Neuropathol Exp Neurol (2002) 1.61
Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease. Brain Pathol (1999) 1.53
Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration. Neuropathol Appl Neurobiol (2007) 1.50
beta-amyloid is different in normal aging and in Alzheimer disease. J Biol Chem (2005) 1.48
Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies. Neuropathol Appl Neurobiol (2003) 1.44
Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II. Acta Neuropathol (1996) 1.44
Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis. Brain Res Mol Brain Res (1991) 1.44
Tau exon 10 alternative splicing and tauopathies. Mol Neurodegener (2008) 1.38
Tauopathy with paired helical filaments in an aged chimpanzee. J Comp Neurol (2008) 1.27
Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their tau isoform distribution and phosphorylation. Ann Neurol (1998) 1.25
REVIEW: tau protein pathology in Alzheimer's disease and related disorders. Neuropathol Appl Neurobiol (1999) 1.23
Specific pathological Tau protein variants characterize Pick's disease. J Neuropathol Exp Neurol (1996) 1.18
Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies. Neuropathology (2006) 1.18
Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease. EMBO J (1991) 1.16
Two Japanese wildcats, the Tsushima cat and the Iriomote cat, show the same mitochondrial DNA lineage as the leopard cat Felis bengalensis. Zoolog Sci (1995) 1.15
Biochemistry and molecular biology of tauopathies. Neuropathology (2006) 1.14
Immunological characterization of microtubule-associated proteins specific for the immature brain. FEBS Lett (1985) 1.11
Immunocytochemical characterization of glial fibrillary tangles in Alzheimer's disease brain. Am J Pathol (1995) 1.00
Natural non-trasgenic animal models for research in Alzheimer's disease. Curr Alzheimer Res (2009) 1.00
Recent rodent models for Alzheimer's disease: clinical implications and basic research. J Neural Transm (Vienna) (2011) 0.99
Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathies. Neuropathology (2006) 0.98
Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia. Prog Neurobiol (2012) 0.88
Histopathological studies of senile plaques and cerebral amyloidosis in cynomolgus monkeys. J Med Primatol (1998) 0.87
Binding of curcumin to senile plaques and cerebral amyloid angiopathy in the aged brain of various animals and to neurofibrillary tangles in Alzheimer's brain. J Vet Med Sci (2011) 0.86
Glial tau pathology in neurodegenerative diseases: their nature and comparison with neuronal tangles. Neurobiol Aging (1998) 0.85
Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies. J Comp Pathol (2009) 0.84
Characterization of AβpN3 deposition in the brains of dogs of various ages and other animal species. Amyloid (2011) 0.82
Beta amyloid deposition and neurofibrillary tangles spontaneously occur in the brains of captive cheetahs (Acinonyx jubatus). Vet Pathol (2011) 0.81
Senile plaques in an aged two-humped (Bactrian) camel (Camelus bactrianus). Acta Neuropathol (1995) 0.80
Immunohistochemical analysis of constituents of senile plaques and cerebro-vascular amyloid in aged dogs. J Vet Med Sci (1992) 0.80
Amyloid angiopathy with cerebral hemorrhage and senile plaque in aged dogs. Nihon Juigaku Zasshi (1990) 0.79
Distribution of neprilysin and deposit patterns of Abeta subtypes in the brains of aged squirrel monkeys (Saimiri sciureus). Amyloid (2010) 0.78
Senile plaques and other senile changes in the brain of an aged American black bear. Vet Pathol (1995) 0.78
Cognitive dysfunction and the neurobiology of ageing in cats. J Small Anim Pract (2007) 0.77
Senile plaques in very aged cats. Acta Neuropathol (1996) 0.77
A comparative study of age-related brain pathology--are neurodegenerative diseases present in nonhuman animals ? Med Hypotheses (2004) 0.77
Fractal analysis of senile plaque observed in various animal species. Neurosci Lett (2001) 0.77
Three-dimensional structures of canine senile plaques. Acta Neuropathol (2001) 0.77
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature (2012) 4.46
Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy. Circulation (2002) 2.50
Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Mol Med (2006) 2.27
Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma. Blood (2009) 2.20
Continuous plasma outflows from the edge of a solar active region as a possible source of solar wind. Science (2007) 1.73
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling. Proc Natl Acad Sci U S A (2003) 1.73
Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy. J Mol Cell Cardiol (2004) 1.68
Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway. Kidney Int (2008) 1.67
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Proc Natl Acad Sci U S A (2004) 1.63
Mucosal imbalance of interleukin-1β and interleukin-1 receptor antagonist in canine inflammatory bowel disease. Vet J (2012) 1.49
The prognostic significance of minimal residual disease in the early phases of chemotherapy in dogs with high-grade B-cell lymphoma. Vet J (2012) 1.44
Involvement of sex, strain and age factors in high fat diet-induced obesity in C57BL/6J and BALB/cA mice. Exp Anim (2007) 1.36
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. J Mol Cell Cardiol (2010) 1.31
Involvement of reactive oxygen species-mediated NF-kappa B activation in TNF-alpha-induced cardiomyocyte hypertrophy. J Mol Cell Cardiol (2002) 1.29
Glycoprotein 130 cytokine signal as a therapeutic target against cardiovascular diseases. J Pharmacol Sci (2011) 1.21
Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes. Circ Res (2008) 1.16
Early death of mice cloned from somatic cells. Nat Genet (2002) 1.15
C-reactive protein concentration in dogs with various diseases. J Vet Med Sci (2008) 1.14
Loss of capsule among Streptococcus suis isolates from porcine endocarditis and its biological significance. J Med Microbiol (2011) 1.11
Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1. Mol Cell Biol (2005) 1.07
Decreased abundance of urinary exosomal aquaporin-1 in renal ischemia-reperfusion injury. Am J Physiol Renal Physiol (2009) 1.06
Impaired liver regeneration after partial hepatectomy in db/db mice. Exp Toxicol Pathol (2003) 1.05
Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. FASEB J (2005) 1.04
Regulation of sarco(endo)plasmic reticulum Ca2+ adenosine triphosphatase by phospholamban and sarcolipin: implication for cardiac hypertrophy and failure. Trends Cardiovasc Med (2003) 1.03
C-reactive protein concentration in canine idiopathic polyarthritis. J Vet Med Sci (2006) 1.03
Cell cycle progression is required for nuclear migration of neural progenitor cells. Brain Res (2006) 1.03
Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism. Intensive Care Med (2005) 1.02
Microminipig, a non-rodent experimental animal optimized for life science research:novel atherosclerosis model induced by high fat and cholesterol diet. J Pharmacol Sci (2011) 1.01
Immunohistochemical studies on cytokeratin 8 and 18 expressions in canine cutaneous adnexus and their tumors. J Vet Med Sci (2007) 0.99
The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B. J Biol Chem (2003) 0.99
Novel microminipig model of atherosclerosis by high fat and high cholesterol diet, established in Japan. In Vivo (2010) 0.99
Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction. Circ Res (2010) 0.97
The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro. Biochem Pharmacol (2005) 0.97
Pathological and immunohistochemical features of subdural histiocytic sarcomas in 15 dogs. J Vet Diagn Invest (2011) 0.96
A single intraperitoneal dose of carbon monoxide-saturated ringer's lactate solution ameliorates postoperative ileus in mice. J Pharmacol Exp Ther (2006) 0.95
Clinical characteristics and prognostic factors in dogs with histiocytic sarcomas in Japan. J Vet Med Sci (2014) 0.94
Mycobacterium bovis BCG vaccination modulates TNF-alpha production after pulmonary challenge with virulent Mycobacterium tuberculosis in guinea pigs. Tuberculosis (Edinb) (2007) 0.94
Molecular pathogenesis of feline leukemia virus-induced malignancies: insertional mutagenesis. Vet Immunol Immunopathol (2008) 0.94
Magnetic resonance imaging of GM2-gangliosidosis in a golden retriever. Can Vet J (2005) 0.94
Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2. EMBO Rep (2014) 0.93
Capsule loss or death: the position of mutations among capsule genes sways the destiny of Streptococcus suis. FEMS Microbiol Lett (2014) 0.93
Peripheral neuroblastoma in a young labrador retriever. J Vet Med Sci (2003) 0.93
Long-term voluntary exercise, representing habitual exercise, lowers visceral fat and alters plasma amino acid levels in mice. Environ Health Prev Med (2011) 0.93
Meat and milk compositions of bovine clones. Proc Natl Acad Sci U S A (2005) 0.93
Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity. Am J Physiol Heart Circ Physiol (2010) 0.92
STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+ cells both in vitro and in vivo. J Mol Cell Cardiol (2011) 0.92
Distribution of N-methyl-D-aspartate receptors (NMDARs) in the developing rat brain. Exp Mol Pathol (2003) 0.92
Immunohistochemical observation of canine degenerative myelopathy in two Pembroke Welsh Corgi dogs. J Vet Med Sci (2011) 0.92
Lymphocyte blastogenic responses to inciting food allergens in dogs with food hypersensitivity. J Vet Intern Med (2004) 0.92
Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice. Mol Cell Biol (2002) 0.91
A comparative pathological study on canine necrotizing meningoencephalitis and granulomatous meningoencephalomyelitis. J Vet Med Sci (2003) 0.91
Two cases of feline orbital aspergillosis due to Aspergillus udagawae and A. viridinutans. J Vet Med Sci (2012) 0.90
Analysis of the disease potential of a recombinant retrovirus containing Friend murine leukemia virus sequences and a unique long terminal repeat from feline leukemia virus. J Virol (2002) 0.90
Phylogenetic and structural diversity in the feline leukemia virus env gene. PLoS One (2013) 0.90
Protection of psbAII transcript from ribonuclease degradation in vitro by DnaK2 and DnaJ2 chaperones of the cyanobacterium Synechococcus elongatus PCC 7942. Biosci Biotechnol Biochem (2007) 0.89
Capsular polysaccharide of Erysipelothrix rhusiopathiae, the causative agent of swine erysipelas, and its modification with phosphorylcholine. Infect Immun (2012) 0.89
Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period. J Biol Chem (2013) 0.89
IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis. Cardiovasc Res (2011) 0.88
A retrospective study of inflammatory colorectal polyps in miniature dachshunds. J Vet Med Sci (2011) 0.88
Pathological and serological evidence of Brucella-infection in baleen whales (Mysticeti) in the western North Pacific. Comp Immunol Microbiol Infect Dis (2003) 0.88
Studies on the role of HtpG in the tetrapyrrole biosynthesis pathway of the cyanobacterium Synechococcus elongatus PCC 7942. Biochem Biophys Res Commun (2006) 0.88
Effects of ethyl pyruvate and other α-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusion. J Surg Res (2009) 0.88
Oncolytic reovirus in canine mast cell tumor. PLoS One (2013) 0.88
Effects of pregnancy on CYPs protein expression in rat liver. Exp Mol Pathol (2005) 0.88
Seasonal atopic dermatitis in dogs sensitive to a major allergen of Japanese cedar (Cryptomeria japonica) pollen. Vet Dermatol (2002) 0.88
Neuronal ceroid-lipofuscinosis in longhaired Chihuahuas: clinical, pathologic, and MRI findings. J Am Anim Hosp Assoc (2011) 0.88
Influenza D Virus Infection in Herd of Cattle, Japan. Emerg Infect Dis (2016) 0.88
Prevalence of canine distemper virus, feline immunodeficiency virus and feline leukemia virus in captive African lions (Panthera leo) in Japan. J Vet Med Sci (2004) 0.87
A gene-targeted mouse model for chorea-acanthocytosis. J Neurochem (2005) 0.87
A frameshift mutation in the canine HEXB gene in toy poodles with GM2 gangliosidosis variant 0 (Sandhoff disease). Vet J (2012) 0.87
Neurotoxicity of MPTP to migrating neuroblasts: studies in acute and subacute mouse models of Parkinson's disease. Neurotoxicology (2008) 0.87
Multiple ferritins are vital to successful blood feeding and reproduction of the hard tick Haemaphysalis longicornis. J Exp Biol (2013) 0.87
Etoposide induces apoptosis and cell cycle arrest of neuroepithelial cells in a p53-related manner. Neurotoxicol Teratol (2006) 0.87
A protective role of unfolded protein response in mouse ischemic acute kidney injury. Eur J Pharmacol (2008) 0.87
Binding of curcumin to senile plaques and cerebral amyloid angiopathy in the aged brain of various animals and to neurofibrillary tangles in Alzheimer's brain. J Vet Med Sci (2011) 0.86
Decreased gallbladder emptying in dogs with biliary sludge or gallbladder mucocele. Vet Radiol Ultrasound (2012) 0.86
The effect of fasting on hepatic lipid accumulation and transcriptional regulation of lipid metabolism differs between C57BL/6J and BALB/cA mice fed a high-fat diet. Toxicol Pathol (2008) 0.86
Combining intermediate levels of the Endotoxin Activity Assay (EAA) with other biomarkers in the assessment of patients with sepsis: results of an observational study. Crit Care (2012) 0.86
Neoplasitic diseases in ferrets in Japan: a questionnaire study for 2000 to 2005. J Vet Med Sci (2009) 0.86
Identification of c-kit mutations-independent neoplastic cell proliferation of canine mast cells. Vet Immunol Immunopathol (2008) 0.86
Prevalence of autoantibody in cerebrospinal fluids from dogs with various CNS diseases. J Vet Med Sci (2004) 0.86
A comparative pathological study on granulomatous meningoencephalomyelitis and central malignant histiocytosis in dogs. J Vet Med Sci (2003) 0.86
A retrospective study in 21 Shiba dogs with chronic enteropathy. J Vet Med Sci (2010) 0.85
Different susceptibility to 1-methyl-4-phenylpyridium (MPP(+))-induced nigro-striatal dopaminergic cell loss between C57BL/6 and BALB/c mice is not related to the difference of monoamine oxidase-B (MAO-B). Exp Toxicol Pathol (2011) 0.85
CT characteristics of primary hepatic mass lesions in dogs. Vet Radiol Ultrasound (2012) 0.85