Tumor stroma as targets for cancer therapy.

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🔗 View Article (PMC 3556178)

Published in Pharmacol Ther on October 12, 2012

Authors

Jing Zhang1, Jinsong Liu

Author Affiliations

1: Department of Pathology, State Key Laboratory of Tumor Biology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China. jzhang@fmmu.edu.cn

Associated clinical trials:

Axitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer | NCT00678392

A Study of Ramucirumab (IMC-1121B) Drug Product (DP) and Best Supportive Care (BSC) Versus Placebo and BSC as 2nd-Line Treatment in Participants With Hepatocellular Carcinoma After 1st-Line Therapy With Sorafenib (REACH) | NCT01140347

Study of IMC-1121B (Ramucirumab) With Best Supportive Care in Participants With Gastric Cancer and Adenocarcinoma | NCT00917384

Study of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer (COMET-2) | NCT01522443

A Study of Paclitaxel With or Without Ramucirumab (IMC-1211B) in Metastatic Gastric Adenocarcinoma (RAINBOW) | NCT01170663

Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Methylated Gene Promoter Status (CENTRIC) | NCT00689221

Efficacy and Tolerability of ABT-869 Versus Sorafenib in Advanced Hepatocellular Carcinoma (HCC) | NCT01009593

Study of Cabozantinib (XL184) Versus Prednisone in Men With Metastatic Castration-resistant Prostate Cancer Previously Treated With Docetaxel and Abiraterone or MDV3100 (COMET-1) | NCT01605227

A Study of Chemotherapy and Ramucirumab Versus Chemotherapy Alone in Second Line Non-Small Cell Lung Cancer (NSCLC) Participants Who Received Prior First Line Platinum-based Chemotherapy | NCT01168973

Aflibercept Versus Placebo in Combination With Irinotecan and 5-FU in the Treatment of Patients With Metastatic Colorectal Cancer After Failure of an Oxaliplatin Based Regimen (VELOUR) | NCT00561470

A Study in Second Line Metastatic Colorectal Cancer | NCT01183780

LUME-Lung 1: BIBF 1120 Plus Docetaxel as Compared to Placebo Plus Docetaxel in 2nd Line Non Small Cell Lung Cancer | NCT00805194

LUME-Ovar 1: Nintedanib (BIBF 1120) or Placebo in Combination With Paclitaxel and Carboplatin in First Line Treatment of Ovarian Cancer | NCT01015118

ARQ 197 Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer | NCT01244191

Phase III Study of Docetaxel + Ramucirumab or Placebo in Breast Cancer | NCT00703326

Safety and Tolerability of AP 12009, Administered I.V. in Patients With Advanced Tumors Known to Overproduce TGF-beta-2 | NCT00844064

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Cediranib in Combination With Lomustine Chemotherapy in Recurrent Glioblastoma (REGAL) | NCT00777153

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Axitinib (AG-013736) For the Treatment of Metastatic Renal Cell Cancer | NCT00920816

Aflibercept Compared to Placebo in Term of Efficacy in Patients Treated With Gemcitabine for Metastatic Pancreatic Cancer (VANILLA) | NCT00574275

Lume Lung 2 : BIBF 1120 Plus Pemetrexed Compared to Placebo Plus Pemetrexed in 2nd Line Nonsquamous NSCLC | NCT00806819

MONET1-MOtesanib NSCLC Efficacy and Tolerability Study | NCT00460317

A Phase 3, Randomized, Double-Blinded, Placebo-Controlled Study of ARQ 197 Plus Erlotinib Versus Placebo Plus Erlotinib (ATTENTION) | NCT01377376

Cediranib, Paclitaxel, and Carboplatin in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer | NCT00795340

Cediranib (AZD2171, RECENTIN™) in Addition to Chemotherapy in Patients With Untreated Metastatic Colorectal Cancer (HORIZON II) | NCT00399035

Phase IIb Clinical Trial With TGF-β2 Antisense Compound AP 12009 for Recurrent or Refractory High-grade Glioma | NCT00431561

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MEGA (Met or EGFR Inhibition in Gastroesophageal Adenocarcinoma): FOLFOX Alone or in Combination With AMG 102 or Panitumumab as First-line Treatment in Patients With Advanced Gastroesophageal Adenocarcinoma (MEGA) | NCT01443065

MEDI-522 in the Treatment of Patients With Metastatic Androgen-Independent Prostate Cancer | NCT00072930

Adjuvant Axitinib Therapy of Renal Cell Cancer in High Risk Patients (ATLAS) | NCT01599754

A Study of IMC-3G3 in Previously Treated Patients With Unresectable and/or Metastatic Gastrointestinal Stromal Tumors | NCT01316263

Safety Study of a Chemokine Receptor (CXCR4) Antagonist in Multiple Myeloma Patients | NCT01010880

AMG 102 and Avastin for Recurrent Malignant Glioma | NCT01113398

NOX-A12 in Combination With Bendamustine and Rituximab in Relapsed Chronic Lymphocytic Leukemia (CLL) | NCT01486797

A Study of Liposomal Doxorubicin With or Without IMC-3G3 in Platinum-refractory or Resistant Advanced Ovarian Cancer | NCT00913835

A Phase II Study to Treat Subjects With Advanced Renal Cell Carcinoma | NCT00422019

Marimastat or No Further Therapy in Treating Women With Metastatic Breast Cancer That Is Responding or Stable Following Chemotherapy | NCT00003010

NOX-A12 in Combination With Bortezomib and Dexamethasone in Relapsed Multiple Myeloma | NCT01521533

Marimastat Following Chemotherapy in Treating Patients With Small Cell Lung Cancer | NCT00003011

Prinomastat and Combination Chemotherapy in Treating Patients With Metastatic or Recurrent Non-small Cell Lung Cancer | NCT00004199

Marimastat in Treating Patients With Stage III Non-small Cell Lung Cancer | NCT00002911

Chemotherapy in Treating Patients Who Have Metastatic Prostate Cancer | NCT00003343

A Phase II Study to Treat Advanced Malignant Glioma | NCT00427440

Combined Antiinflammatory and Angiostatic Therapy in Patients With Hormone-refractory Prostate Cancer (INV342) | NCT00427999

Sorafenib Dose Ramp-Up in Hepatocellular Carcinoma (HCC) | NCT01203787

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers | NCT00002752

Gemcitabine With or Without WX-671 in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed By Surgery | NCT00499265

A Study of Paclitaxel/Carboplatin With or Without IMC-3G3 in Previously Untreated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) | NCT00918203

Safety and Quality of Life Study of Aflibercept in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen | NCT01571284

Phase I and Consecutive Phase II, Two-arm, Randomized Multi-center Trial in Patients With Advanced Melanoma | NCT01614301

AMG 102, Pemetrexed Disodium, and Cisplatin in Treating Patients With Malignant Pleural Mesothelioma | NCT01105390

Study of M200 (Volociximab) in Patients With Metastatic Renal Cell Carcinoma (RCC) | NCT00100685

First Line Pazopanib in Poor Risk Patients With Metastatic Renal Cell Carcinoma (FLIPPER) | NCT01521715

Rilotumumab in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer | NCT01039207

Bevacizumab With or Without MEDI-522 in Treating Patients With Unresectable or Metastatic Kidney Cancer | NCT00684996

A Study of MEDI-575 in Subjects With Recurrent Glioblastoma Multiforme | NCT01268566

A Study of IMC-3G3 in Prostate Cancer | NCT01204710

Cyclooxygenase-2 Inhibitor for Adjuvant Anticancer Effect in Patients With Biliary-pancreas Cancer | NCT01111591

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A Study of Volociximab in Combination With Gemcitabine in Metastatic Pancreatic Cancer | NCT00401570

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Special Investigation For Gist Of Sunitinib Malate (Regulatory Post Marketing Commitment Plan). | NCT00716820

Palliative Treatments for Patients With Advanced Hepatocellular Carcinoma (HCC) (2011PTAHCC) | NCT01409499

A6 in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer | NCT00939809

SU-101 Compared With Procarbazine in Treating Patients With Glioblastoma Multiforme | NCT00003293

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Cytochrom p450 3A4 and 1A2 Phenotyping for the Individualization of Treatment With Sunitinib or Erlotinib in Cancer Patients | NCT01402089

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Safety And Efficacy Study Of Sunitinib Malate In Chinese Patients With Imatinib Resistant Or Intolerant Malignant Gastrointestinal Stromal Tumor (GIST) | NCT00793871

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A Phase 2, Single-Arm Study of Volociximab Monotherapy in Subjects With Platinum-Resistant Advanced Epithelial Ovarian Cancer or Primary Peritoneal Cancer | NCT00516841

Post Marketing Surveillance On The Safety And Tolerability Of Sunitinib Malate (Sutent) For Filipino Patients | NCT01073644

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Special Investigation For Renal Cell Carcinoma (RCC) Of Sunitinib Malate (Regulatory Post Marketing Commitment Plan) | NCT00716625

Evaluation of Approved Weight-Based Dose Compared to Fixed Dose of Plerixafor in Patients With Non-Hodgkin's Lymphoma (NHL) Weighing Less Than 70 Kilograms | NCT01164475

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