Obesity: a transgenerational problem linked to nutrition during pregnancy.

PubWeight™: 0.87‹?›

🔗 View Article (PMC 3615704)

Published in Semin Reprod Med on October 16, 2012

Authors

Antonio E Frias1, Kevin L Grove

Author Affiliations

1: Department of Obstetrics and Gynecology, Oregon Health and Science University (OHSU) Portland, Oregon 97239, USA. friasa@ohsu.edu

Articles cited by this

Inflammation and metabolic disorders. Nature (2006) 33.33

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (1993) 25.54

Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA (2010) 23.45

The disease burden associated with overweight and obesity. JAMA (1999) 19.39

Obesity as a medical problem. Nature (2000) 15.12

Effect of in utero and early-life conditions on adult health and disease. N Engl J Med (2008) 14.46

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia (1992) 13.20

Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet (1986) 12.13

Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics (2005) 8.99

Glucose tolerance in adults after prenatal exposure to famine. Lancet (1998) 8.87

Annual deaths attributable to obesity in the United States. JAMA (1999) 8.62

Trajectories of growth among children who have coronary events as adults. N Engl J Med (2005) 7.29

Inflammatory links between obesity and metabolic disease. J Clin Invest (2011) 6.73

A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem (2007) 6.58

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature (2010) 6.23

Placental development: lessons from mouse mutants. Nat Rev Genet (2001) 6.03

Prepregnancy weight and the risk of adverse pregnancy outcomes. N Engl J Med (1998) 5.66

Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem (2001) 5.61

Fetal origins of obesity. Obes Res (2003) 5.48

Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation (2007) 5.10

Obesity in young men after famine exposure in utero and early infancy. N Engl J Med (1976) 4.91

Obesity at the age of 50 y in men and women exposed to famine prenatally. Am J Clin Nutr (1999) 4.07

Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming. Hypertension (2007) 3.62

Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest (2009) 3.10

Trends in pre-pregnancy obesity in nine states, 1993-2003. Obesity (Silver Spring) (2007) 3.08

Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. J Clin Endocrinol Metab (2002) 2.80

The influence of obesity and diabetes on the prevalence of macrosomia. Am J Obstet Gynecol (2004) 2.75

The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Invest (1996) 2.73

Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta (2008) 2.67

Increased fetal adiposity: a very sensitive marker of abnormal in utero development. Am J Obstet Gynecol (2003) 2.61

Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet. J Physiol (2008) 2.41

Composition of gestational weight gain impacts maternal fat retention and infant birth weight. Am J Obstet Gynecol (2003) 2.29

Animal models of human placentation--a review. Placenta (2006) 2.28

Pre-pregnancy weight and the risk of stillbirth and neonatal death. BJOG (2005) 2.28

Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol (2010) 2.28

Prepregnancy obesity and fetal death: a study within the Danish National Birth Cohort. Obstet Gynecol (2005) 2.17

Introduction: the use of body mass index to assess obesity in children. Am J Clin Nutr (1999) 2.11

Maternal obesity at conception programs obesity in the offspring. Am J Physiol Regul Integr Comp Physiol (2007) 2.08

Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes (2009) 2.00

Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension (2003) 2.00

Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress. Circulation (2007) 1.99

Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothers. J Clin Endocrinol Metab (2006) 1.97

A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring. Am J Physiol Regul Integr Comp Physiol (2004) 1.87

Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS One (2010) 1.83

Combined influence of body mass index and waist circumference on coronary artery disease risk factors among children and adolescents. Pediatrics (2005) 1.76

Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring. J Neurosci (2010) 1.73

Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutrition. Endocrinology (2011) 1.66

High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB J (2008) 1.66

Metabolic imprinting in obesity. Forum Nutr (2009) 1.58

Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. Am J Clin Nutr (2000) 1.57

Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans. Int J Obes Relat Metab Disord (2002) 1.54

Cytokine production by islets in health and diabetes: cellular origin, regulation and function. Trends Endocrinol Metab (2010) 1.46

Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-alpha system. J Clin Endocrinol Metab (2002) 1.43

The placenta in pre-eclampsia and intrauterine growth restriction. J Clin Pathol (2008) 1.41

Overweight and obesity in infants of mothers with long-term insulin-dependent diabetes or gestational diabetes. Int J Obes Relat Metab Disord (1997) 1.41

IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2. Am J Physiol Cell Physiol (2009) 1.37

Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet. Endocrinology (2010) 1.34

Animal models of placental angiogenesis. Placenta (2005) 1.31

The influence of obesity and gestational diabetes mellitus on accretion and the distribution of adipose tissue in pregnancy. Am J Obstet Gynecol (2003) 1.30

Fetal hyperinsulinism in offspring of diabetic mothers. Association with the subsequent development of childhood obesity. Ann N Y Acad Sci (1993) 1.28

Postprandial variations of plasma inflammatory markers in abdominally obese men. Obesity (Silver Spring) (2006) 1.25

Maternal obesity and markers of inflammation in pregnancy. Cytokine (2009) 1.25

Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab (1987) 1.24

Longitudinal changes in energy expenditure and body composition in obese women with normal and impaired glucose tolerance. Am J Physiol Endocrinol Metab (2004) 1.23

Effect of increasing maternal body mass index on oxidative and nitrative stress in the human placenta. Placenta (2008) 1.21

The long-term consequences of intra-uterine protein malnutrition for glucose metabolism. Proc Nutr Soc (1999) 1.16

Maternal high fat diet is associated with decreased plasma n-3 fatty acids and fetal hepatic apoptosis in nonhuman primates. PLoS One (2011) 1.13

Perinatal outcome in pregnancy complicated by massive obesity. Am J Obstet Gynecol (1992) 1.13

Palmitic acid induces IP-10 expression in human macrophages via NF-kappaB activation. Biochem Biophys Res Commun (2007) 1.12

Maternal obesity and neonatal mortality according to subtypes of preterm birth. Obstet Gynecol (2007) 1.09

Blood flows and nutrient uptakes in growth-restricted pregnancies induced by overnourishing adolescent sheep. Am J Physiol Regul Integr Comp Physiol (2002) 1.07

Uterine artery function in pregnant rats fed a diet supplemented with animal lard. Exp Physiol (2003) 1.06

Placental findings contributing to fetal death, a study of 120 stillbirths between 23 and 40 weeks gestation. Placenta (2009) 1.05

Diet-induced obesity in gravid rats engenders early hyperadiposity in the offspring. Metabolism (2007) 1.05

Postprandial inflammation and endothelial dysfuction. Biochem Soc Trans (2007) 1.04

Macrophages, cytokines and beta-cell death in Type 2 diabetes. Biochem Soc Trans (2008) 1.03

Effects of intrauterine growth retardation in premature infants on early childhood growth. J Pediatr (1997) 1.00

Metabolic programming: fetal origins of obesity and metabolic syndrome in the adult. Am J Physiol Endocrinol Metab (2006) 0.99

Preterm delivery: correlations of fetal growth and placental pathology. Am J Perinatol (1992) 0.99

The relative contributions of birth weight, weight change, and current weight to insulin resistance in contemporary 5-year-olds: the EarlyBird Study. Diabetes (2002) 0.97

Maternal substrate utilization programs the development of the metabolic syndrome in male mice exposed to high fat in utero. Pediatr Res (2009) 0.90

Fetoplacental growth and vascular development in overnourished adolescent sheep at day 50, 90 and 130 of gestation. Reproduction (2009) 0.90

Inhibition of amino acid transport system a by interleukin-1beta in trophoblasts. J Soc Gynecol Investig (2005) 0.89

The offspring of gestational diabetes. J Perinat Med (2003) 0.88

Relationship between abdominal visceral fat and metabolic risk factors in obese adolescents. Am J Hum Biol (1999) 0.85

Serial measurement of uterine blood flow from mid to late gestation in growth restricted pregnancies induced by overnourishing adolescent sheep dams. Placenta (2008) 0.85

A piece in the puzzle of intrauterine fetal death: pathological findings in placentas from term and preterm intrauterine fetal death pregnancies. J Matern Fetal Neonatal Med (2009) 0.83

Articles by these authors

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron (2003) 6.05

Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab (2007) 3.43

Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest (2009) 3.10

Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes (2012) 1.91

Excess weight gain during the early postnatal period is associated with permanent reprogramming of brown adipose tissue adaptive thermogenesis. Endocrinology (2007) 1.77

Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring. J Neurosci (2010) 1.73

Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutrition. Endocrinology (2011) 1.66

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J Clin Invest (2014) 1.61

Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood. Neuroendocrinology (2010) 1.56

Early overnutrition results in early-onset arcuate leptin resistance and increased sensitivity to high-fat diet. Endocrinology (2010) 1.25

Characterisation of arcuate nucleus kisspeptin/neurokinin B neuronal projections and regulation during lactation in the rat. J Neuroendocrinol (2011) 1.17

Maternal high fat diet is associated with decreased plasma n-3 fatty acids and fetal hepatic apoptosis in nonhuman primates. PLoS One (2011) 1.13

Integration of the regulation of reproductive function and energy balance: lactation as a model. Front Neuroendocrinol (2002) 1.12

A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. FASEB J (2012) 1.11

Ghrelin--satisfying a hunger for the mechanism. Endocrinology (2004) 1.09

Developmental switch in neuropeptide Y and melanocortin effects in the paraventricular nucleus of the hypothalamus. Neuron (2007) 1.06

Regulation of food intake and gonadotropin-releasing hormone/luteinizing hormone during lactation: role of insulin and leptin. Endocrinology (2009) 0.99

Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain. Endocrinology (2015) 0.98

Melanocortin 4 receptor-mediated hyperphagia and activation of neuropeptide Y expression in the dorsomedial hypothalamus during lactation. J Neurosci (2004) 0.96

Peptide YY(3-36) inhibits morning, but not evening, food intake and decreases body weight in rhesus macaques. Diabetes (2005) 0.95

Orexin neurons express a functional pancreatic polypeptide Y4 receptor. J Neurosci (2003) 0.95

High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate. Mol Metab (2012) 0.94

Differential gene expression between neuropeptide Y expressing neurons of the dorsomedial nucleus of the hypothalamus and the arcuate nucleus: microarray analysis study. Brain Res (2010) 0.94

Proinflammatory endothelial activation detected by molecular imaging in obese nonhuman primates coincides with onset of insulin resistance and progressively increases with duration of insulin resistance. Circulation (2013) 0.94

Leptin stimulates neuropeptide Y and cocaine amphetamine-regulated transcript coexpressing neuronal activity in the dorsomedial hypothalamus in diet-induced obese mice. J Neurosci (2013) 0.94

Maternal high-fat diet modulates the fetal thyroid axis and thyroid gene expression in a nonhuman primate model. Mol Endocrinol (2012) 0.92

Melanocortinergic activation by melanotan II inhibits feeding and increases uncoupling protein 1 messenger ribonucleic acid in the developing rat. Endocrinology (2007) 0.92

Expression and function of endothelial nitric oxide synthase messenger RNA and protein are higher in internal mammary than in radial arteries. Ann Thorac Surg (2011) 0.92

Single-cell analysis of insulin-regulated fatty acid uptake in adipocytes. Am J Physiol Endocrinol Metab (2010) 0.91

Efferent projections of neuropeptide Y-expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models. J Comp Neurol (2013) 0.91

Inhibition of uncoupling protein expression during lactation: role of leptin. Endocrinology (2003) 0.91

Activity restriction, impaired capillary function, and the development of insulin resistance in lean primates. Am J Physiol Endocrinol Metab (2012) 0.91

Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexin fibers. Endocrinology (2003) 0.90

Suppression of basal spontaneous gonadotropin-releasing hormone neuronal activity during lactation: role of inhibitory effects of neuropeptide Y. Endocrinology (2008) 0.90

Targeting oxidized LDL improves insulin sensitivity and immune cell function in obese Rhesus macaques. Mol Metab (2013) 0.88

Melanin concentrating hormone (MCH): a novel neural pathway for regulation of GnRH neurons. Brain Res (2005) 0.88

Feeding induced by cannabinoids is mediated independently of the melanocortin system. PLoS One (2008) 0.88

Characterization of brainstem peptide YY (PYY) neurons. J Comp Neurol (2008) 0.87

Perinatal exposure to a high-fat diet is associated with reduced hepatic sympathetic innervation in one-year old male Japanese macaques. PLoS One (2012) 0.87

Deoxyribonucleic acid microarray analysis of gene expression pattern in the arcuate nucleus/ventromedial nucleus of hypothalamus during lactation. Endocrinology (2005) 0.86

Metabolic adaptations in skeletal muscle during lactation: complementary deoxyribonucleic acid microarray and real-time polymerase chain reaction analysis of gene expression. Endocrinology (2004) 0.85

Postweaning exposure to a high-fat diet is associated with alterations to the hepatic histone code in Japanese macaques. Pediatr Res (2013) 0.84

Beyond Leptin: Emerging Candidates for the Integration of Metabolic and Reproductive Function during Negative Energy Balance. Front Endocrinol (Lausanne) (2011) 0.84

Cocaine- and amphetamine-regulated transcript is a potent stimulator of GnRH and kisspeptin cells and may contribute to negative energy balance-induced reproductive inhibition in females. Endocrinology (2013) 0.84

Dual actions of cilnidipine in human internal thoracic artery: inhibition of calcium channels and enhancement of endothelial nitric oxide synthase. J Thorac Cardiovasc Surg (2010) 0.84

The nonhuman primate as a model for type 2 diabetes. Curr Opin Endocrinol Diabetes Obes (2014) 0.83

To be or NUCB2, is nesfatin the answer? Cell Metab (2006) 0.81

Galanin-like peptide as a possible link between metabolism and reproduction in the macaque. J Clin Endocrinol Metab (2004) 0.80

Neonatal overnutrition in mice exacerbates high-fat diet-induced metabolic perturbations. J Endocrinol (2013) 0.80

Distribution of corticotropin releasing hormone receptor immunoreactivity in the rat hypothalamus: coexpression in neuropeptide Y and dopamine neurons in the arcuate nucleus. Brain Res (2003) 0.78

Endogenous kisspeptin tone is a critical excitatory component of spontaneous GnRH activity and the GnRH response to NPY and CART. Neuroendocrinology (2014) 0.75

Brain angiotensinergic mediation of enhanced water consumption in lactating rats. Am J Physiol Regul Integr Comp Physiol (2002) 0.75